RRAD (gene)

Last updated
RRAD
Protein RRAD PDB 2dpx.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RRAD , RAD, RAD1, REM3, Ras related glycolysis inhibitor and calcium channel regulator
External IDs OMIM: 179503 MGI: 1930943 HomoloGene: 3071 GeneCards: RRAD
Orthologs
SpeciesHumanMouse
Entrez

6236

56437

Ensembl

ENSG00000166592

ENSMUSG00000031880

UniProt

P55042

O88667

RefSeq (mRNA)

NM_004165
NM_001128850

NM_019662

RefSeq (protein)

NP_001122322
NP_004156

n/a

Location (UCSC) Chr 16: 66.92 – 66.93 Mb Chr 8: 105.35 – 105.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras Related Glycolysis Inhibitor and Calcium Channel Regulator (RRAD) is a protein that in humans is encoded by the RRAD gene. [5] [6] RRAD is a Ras-related small GTPase that is regulated by p53 and plays a role in the regulation of aerobic glycolysis. [7]

Contents

Interactions

RRAD has been shown to interact with CAMK2G [8] and TPM2. [9]

Related Research Articles

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<span class="mw-page-title-main">NCK1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">CAMK2D</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">GEM (gene)</span> Protein-coding gene in humans

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166592 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031880 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS (March 1995). "Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q". Diabetes. 44 (2): 243–7. doi:10.2337/diabetes.44.2.243. PMID   7859947.
  6. ↑ "Entrez Gene: RRAD Ras-related associated with diabetes".
  7. ↑ Zhang, Cen (2014). "Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD". Oncotarget. 4 (14): 5535–5546. doi:10.18632/oncotarget.2137. PMC   4170611 . PMID   25114038.
  8. ↑ Moyers JS, Bilan PJ, Zhu J, Kahn CR (May 1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi: 10.1074/jbc.272.18.11832 . PMID   9115241.
  9. ↑ Zhu J, Bilan PJ, Moyers JS, Antonetti DA, Kahn CR (January 1996). "Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin". J. Biol. Chem. 271 (2): 768–73. doi: 10.1074/jbc.271.2.768 . PMID   8557685.

Further reading



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