REG3A

REG3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UV0, 2GO0, 4MTH
Identifiers
Aliases	REG3A , HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3, regenerating family member 3 alpha
External IDs	OMIM: 167805 MGI: 97478 HomoloGene: 130506 GeneCards: REG3A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	79,159,753 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	78,350,449 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; body of pancreas; ; pancreatic ductal cell; ; islet of Langerhans; ; pylorus; ; gallbladder; ; cardia; ; body of stomach; ; right adrenal gland;
	Top expressed in
	Paneth cell; ; jejunum; ; duodenum; ; crypt of lieberkuhn of small intestine; ; intestinal villus; ; ileum; ; pyloric antrum; ; islet of Langerhans; ; trigeminal ganglion; ; mucosa of large intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; carbohydrate binding ; identical protein binding ; transmembrane signaling receptor activity ; peptidoglycan binding ; oligosaccharide binding ;
Cellular component	cytoplasm ; extracellular region ; extracellular space ;
Biological process	inflammatory response ; multicellular organism development ; negative regulation of keratinocyte differentiation ; positive regulation of keratinocyte proliferation ; cell population proliferation ; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ; positive regulation of wound healing ; acute-phase response ; antimicrobial humoral response ; positive regulation of cell population proliferation ; response to peptide hormone ; cell wall disruption in other organism ; antimicrobial humoral immune response mediated by antimicrobial peptide ;
	Sources:Amigo / QuickGO
Orthologs
	5068
	18489
	ENSG00000172016
	ENSMUSG00000071356
	Q06141
	P35230
	NM_138938 ; NM_002580 ; NM_138937
	NM_011036
	NP_002571 ; NP_620354 ; NP_620355
	NP_035166
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Regenerating islet-derived protein 3 alpha (or Regenerating islet-derived protein III-alpha) formerly known as HIP/PAP (Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-Associated Protein) and peptide 23^[5] is a protein that in humans is encoded by the REG3A gene.^[6]^[7]

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known.^[7]

Reg3A (UniProt Q0614 1) is a bactericidal C-type lectin that is constitutively produced in the intestine that has antibacterial properties against Gram-positive bacteria. Bacterial killing is mediated by binding to surface-exposed carbohydrate moieties of bacterial peptidoglycan and executed by the formation of a hexameric pore in the membrane.^[8]^[9]^[10]

Related Research Articles

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Frizzled-5(Fz-5) is a protein that in humans is encoded by the FZD5 gene.

Pancreatic Stone Protein (PSP), also known as Lithostathine-1-alphaislet cells regeneration factor (ICRF) or islet of Langerhans regenerating protein (REG) is a protein that in humans is encoded by the REG1A gene as a single polypeptide of 144 amino acids further cleaved by trypsin to produce a 133 amino acid protein that is O-linked glycosylated on threonine 27. This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. The PSP is mostly produced in Human by the acinar cells of the pancreas and is secreted in the duodenum by the same pathway that pancreatic exocrine enzymes. It has C-terminal C-type lectin domain whose binding partner is currently unknown.

Glucosidase 2 subunit beta is an enzyme that in humans is encoded by the PRKCSH gene.

Lithostathine-1-beta is a protein that in humans is encoded by the REG1B gene.

Nuclear protein 1 is a protein that in humans is encoded by the NUPR1 gene.

40S ribosomal protein S9 is a protein that in humans is encoded by the RPS9 gene.

60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene.

40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.

60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene.

Homeobox protein CDX-1 is a protein in humans that is encoded by the CDX1 gene. CDX1 is expressed in the developing endoderm and its expression persists in the intestine throughout adulthood. CDX1 protein expression varies along the intestine, with high expression in intestinal crypts and diminishing expression along intestinal villi.

Regenerating islet-derived protein 4 is a protein that in humans is encoded by the REG4 gene.

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene. In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein"

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.

Transmembrane protein 49 is a protein that in humans is encoded by the TMEM49 gene.

Regenerating islet-derived protein 3 gamma is a protein that in humans is encoded by the REG3G gene.

The regenerating protein family often abbreviated as Reg family are a group of small secretory proteins that are involved in the proliferation and differentiation of diverse cell types. In addition they are important in protecting cells from death caused by damage or inflammation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172016 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071356 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chakraborty C, Sharma S, Katsumata N, Murphy LJ, Schroedter IC, Robertson MC, et al. (June 1995). "Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat". The Journal of Endocrinology. 145 (3): 461–469. doi:10.1677/joe.0.1450461. PMID 7636430.
↑ Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC, Iovanna JL (January 1994). "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene". Genomics. 19 (1): 108–114. doi:10.1006/geno.1994.1019. PMID 8188210.
1 2 "Entrez Gene: REG3A regenerating islet-derived 3 alpha".
↑ Murphy K, Weaver C (2017). Janeway's Immunobiology. Garland Science. p. 48. ISBN 978-0-8153-4505-3.
↑ Cash HL, Whitham CV, Behrendt CL, Hooper LV (August 2006). "Symbiotic bacteria direct expression of an intestinal bactericidal lectin". Science. 313 (5790): 1126–1130. Bibcode:2006Sci...313.1126C. doi:10.1126/science.1127119. PMC 2716667 . PMID 16931762.
↑ Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, et al. (October 2011). "The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine". Science. 334 (6053): 255–258. Bibcode:2011Sci...334..255V. doi:10.1126/science.1209791. PMC 3321924 . PMID 21998396.

Lasserre C, Christa L, Simon MT, Vernier P, Bréchot C (September 1992). "A novel gene (HIP) activated in human primary liver cancer". Cancer Research. 52 (18): 5089–5095. PMID 1325291.
Orelle B, Keim V, Masciotra L, Dagorn JC, Iovanna JL (December 1992). "Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases". The Journal of Clinical Investigation. 90 (6): 2284–2291. doi:10.1172/JCI116115. PMC 443380 . PMID 1469087.
Itoh T, Teraoka H (February 1993). "Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1172 (1–2): 184–186. doi:10.1016/0167-4781(93)90290-t. PMID 7679928.
Itoh T, Sawabu N, Motoo Y, Funakoshi A, Teraoka H (April 1995). "The human pancreatitis-associated protein (PAP)-encoding gene generates multiple transcripts through alternative use of 5' exons". Gene. 155 (2): 283–287. doi:10.1016/0378-1119(94)00799-X. PMID 7721106.
Lasserre C, Simon MT, Ishikawa H, Diriong S, Nguyen VC, Christa L, et al. (August 1994). "Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer". European Journal of Biochemistry. 224 (1): 29–38. doi:10.1111/j.1432-1033.1994.tb19991.x. PMID 8076648.
Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, et al. (December 1996). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells". The American Journal of Physiology. 271 (6 Pt 1): G993-1002. doi:10.1152/ajpgi.1996.271.6.G993. PMID 8997243.
Rafaeloff R, Pittenger GL, Barlow SW, Qin XF, Yan B, Rosenberg L, et al. (May 1997). "Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters". The Journal of Clinical Investigation. 99 (9): 2100–2109. doi:10.1172/JCI119383. PMC 508040 . PMID 9151782.
Bödeker H, Keim V, Fiedler F, Dagorn JC, Iovanna JL (2000). "PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha". Molecular Cell Biology Research Communications. 2 (3): 150–154. doi:10.1006/mcbr.1999.0166. PMID 10662590.
Graf R, Schiesser M, Scheele GA, Marquardt K, Frick TW, Ammann RW, Bimmler D (June 2001). "A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation". The Journal of Biological Chemistry. 276 (24): 21028–21038. doi: 10.1074/jbc.M010717200 . PMID 11278730.
Simon MT, Pauloin A, Normand G, Lieu HT, Mouly H, Pivert G, et al. (August 2003). "HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway". FASEB Journal. 17 (11): 1441–1450. doi:10.1096/fj.02-1013com. PMID 12890698. S2CID 13990589.
Lieu HT, Batteux F, Simon MT, Cortes A, Nicco C, Zavala F, et al. (September 2005). "HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice". Hepatology. 42 (3): 618–626. doi:10.1002/hep.20845. PMID 16116631. S2CID 10970433.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Cash HL, Whitham CV, Behrendt CL, Hooper LV (August 2006). "Symbiotic bacteria direct expression of an intestinal bactericidal lectin". Science. 313 (5790): 1126–1130. Bibcode:2006Sci...313.1126C. doi:10.1126/science.1127119. PMC 2716667 . PMID 16931762.
Ho MR, Lou YC, Lin WC, Lyu PC, Huang WN, Chen C (November 2006). "Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation". The Journal of Biological Chemistry. 281 (44): 33566–33576. doi: 10.1074/jbc.M604513200 . PMID 16963458.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172016 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071356 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7636430-5] Chakraborty C, Sharma S, Katsumata N, Murphy LJ, Schroedter IC, Robertson MC, et al. (June 1995). "Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat". The Journal of Endocrinology. 145 (3): 461–469. doi:10.1677/joe.0.1450461. PMID 7636430.

[pmid8188210-6] Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC, Iovanna JL (January 1994). "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene". Genomics. 19 (1): 108–114. doi:10.1006/geno.1994.1019. PMID 8188210.

[entrez-7] 1 2 "Entrez Gene: REG3A regenerating islet-derived 3 alpha".

[8] Murphy K, Weaver C (2017). Janeway's Immunobiology. Garland Science. p. 48. ISBN 978-0-8153-4505-3.

[9] Cash HL, Whitham CV, Behrendt CL, Hooper LV (August 2006). "Symbiotic bacteria direct expression of an intestinal bactericidal lectin". Science. 313 (5790): 1126–1130. Bibcode:2006Sci...313.1126C. doi:10.1126/science.1127119. PMC 2716667 . PMID 16931762.

[10] Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, et al. (October 2011). "The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine". Science. 334 (6053): 255–258. Bibcode:2011Sci...334..255V. doi:10.1126/science.1209791. PMC 3321924 . PMID 21998396.

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REG3A

Related Research Articles

References

Further reading