Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene. [5] [6]
Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene. [5] [6]
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described. [6]
MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A [7] and RASSF1. [8]
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