MAF (gene)

MAF
Identifiers
Aliases	MAF , CCA4, c-AYGRP, CTRCT21, MAF bZIP transcription factor
External IDs	OMIM: 177075; MGI: 96909; HomoloGene: 74552; GeneCards: MAF; OMA:MAF - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	79,600,737 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	116,434,533 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; germinal epithelium; ; gums; ; gingival epithelium; ; trigeminal ganglion; ; skin of hip; ; parietal pleura; ; human penis; ; periodontal fiber; ; vulva;
	Top expressed in
	stroma of bone marrow; ; skin of external ear; ; molar; ; belly cord; ; epithelium of lens; ; left lung lobe; ; body of femur; ; migratory enteric neural crest cell; ; mesenteric lymph nodes; ; human fetus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity ; sequence-specific DNA binding ; DNA binding ; protein binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ;
Cellular component	cytoplasm ; chromatin ; nucleus ;
Biological process	inner ear development ; cytokine production ; regulation of chondrocyte differentiation ; positive regulation of gene expression ; lens development in camera-type eye ; lens fiber cell differentiation ; negative regulation of transcription by RNA polymerase II ; regulation of transcription, DNA-templated ; cell development ; transcription, DNA-templated ; positive regulation of transcription by RNA polymerase II ; transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	4094
	17132
	ENSG00000178573
	ENSMUSG00000055435
	O75444
	P54843
	NM_001031804 ; NM_005360
	NM_001025577
	NP_001026974 ; NP_005351
	NP_001020748
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 17, 2024

Transcription factor Maf, also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a transcription factor that in humans is encoded by the MAF gene.^[5]^[6]

Types

One type, MafA, also known as RIPE3b1,^[7] promotes pancreatic development, as well as insulin gene transcription.^[8]

Interactions

MAF has been shown to interact with:

Related Research Articles

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13.

<span class="mw-page-title-main">CEBPB</span> Protein-coding gene in humans

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.

Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper. Members of the extended SANT/Myb family also include the SANT domain and other similar all-helical homeobox-like domains.

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS family of transcription factors. It has been found to play a key role in the development of inflammatory bowel disease.

E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein inhibitor of activated STAT protein gamma, and is an enzyme that in humans is encoded by the PIAS4 gene.

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.

Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.

Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.

Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells. Dysregulation of the IRF4 gene can result in IRF4 functioning either as an oncogene or a tumor-suppressor, depending on the context of the modification.

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.

Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.

<span class="mw-page-title-main">BACH2</span> Protein-coding gene in the species Homo sapiens

Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene. It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer and a bZip_Maf domain at the C-terminus.

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.

Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene.

Transcription factor MafF is a bZip Maf transcription factor protein that in humans is encoded by the MAFF gene.

Transcription factor MafA is a protein that in humans is encoded by the MAFA gene. It is a member of the Maf family of transcription factors.

Small Maf proteins are basic region leucine zipper-type transcription factors that can bind to DNA and regulate gene regulation. There are three small Maf (sMaf) proteins, namely MafF, MafG, and MafK, in vertebrates. HUGO Gene Nomenclature Committee (HGNC)-approved gene names of MAFF, MAFG and MAFK are “v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F, G, and K”, respectively.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178573 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055435 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)".
↑ Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (Oct 1989). "v-maf, a viral oncogene that encodes a "leucine zipper" motif". Proceedings of the National Academy of Sciences of the United States of America. 86 (20): 7711–5. Bibcode:1989PNAS...86.7711N. doi: 10.1073/pnas.86.20.7711 . PMC 298140 . PMID 2554284.
↑ Olbrot M, Rud J, Moss LG, Sharma A (May 2002). "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proceedings of the National Academy of Sciences of the United States of America. 99 (10): 6737–42. Bibcode:2002PNAS...99.6737O. doi: 10.1073/pnas.102168499 . PMC 124472 . PMID 12011435.
↑ Melloul D, Marshak S, Cerasi E (Mar 2002). "Regulation of insulin gene transcription". Diabetologia. 45 (3): 309–26. doi: 10.1007/s00125-001-0728-y . PMID 11914736.
1 2 Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". The Journal of Biological Chemistry. 277 (27): 24081–9. doi: 10.1074/jbc.M201821200 . PMID 11943779.
↑ Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Molecular and Cellular Biology. 18 (5): 2729–37. doi:10.1128/MCB.18.5.2729. PMC 110652 . PMID 9566892.
↑ Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry. 277 (52): 50668–75. doi: 10.1074/jbc.M206544200 . PMID 12381733.

External links

MAF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178573 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055435 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)".

[pmid2554284-6] Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (Oct 1989). "v-maf, a viral oncogene that encodes a "leucine zipper" motif". Proceedings of the National Academy of Sciences of the United States of America. 86 (20): 7711–5. Bibcode:1989PNAS...86.7711N. doi: 10.1073/pnas.86.20.7711 . PMC 298140 . PMID 2554284.

[pmid12011435-7] Olbrot M, Rud J, Moss LG, Sharma A (May 2002). "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proceedings of the National Academy of Sciences of the United States of America. 99 (10): 6737–42. Bibcode:2002PNAS...99.6737O. doi: 10.1073/pnas.102168499 . PMC 124472 . PMID 12011435.

[pmid11914736-8] Melloul D, Marshak S, Cerasi E (Mar 2002). "Regulation of insulin gene transcription". Diabetologia. 45 (3): 309–26. doi: 10.1007/s00125-001-0728-y . PMID 11914736.

[pmid11943779-9] 1 2 Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". The Journal of Biological Chemistry. 277 (27): 24081–9. doi: 10.1074/jbc.M201821200 . PMID 11943779.

[pmid9566892-10] Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Molecular and Cellular Biology. 18 (5): 2729–37. doi:10.1128/MCB.18.5.2729. PMC 110652 . PMID 9566892.

[pmid12381733-11] Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry. 277 (52): 50668–75. doi: 10.1074/jbc.M206544200 . PMID 12381733.

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