IL18BP

Last updated

IL18BP
Identifiers
Aliases IL18BP , IL18BPa, interleukin 18 binding protein, FVH
External IDs OMIM: 604113; MGI: 1333800; HomoloGene: 7781; GeneCards: IL18BP; OMA:IL18BP - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10068

16068

Ensembl

ENSG00000137496

ENSMUSG00000070427

UniProt

O95998

Q9Z0M9

RefSeq (mRNA)

NM_010531
NM_001363982
NM_001382458

RefSeq (protein)

NP_034661
NP_001350911
NP_001369387

Location (UCSC) Chr 11: 72 – 72.01 Mb Chr 7: 101.66 – 101.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene. [5] [6]

Contents

The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137496 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070427 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity. 10 (1): 127–36. doi: 10.1016/S1074-7613(00)80013-8 . PMID   10023777.
  6. 1 2 "Entrez Gene: IL18BP interleukin 18 binding protein".

Further reading

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