HGS (gene)

HGS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D3G, 3F1I, 3OBQ, 3ZYQ, 4AVX
Identifiers
Aliases	HGS , HRS, hepatocyte growth factor-regulated tyrosine kinase substrate
External IDs	OMIM: 604375 MGI: 104681 HomoloGene: 37954 GeneCards: HGS
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,703,138 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,374,805 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; anterior pituitary; ; canal of the cervix; ; skin of abdomen; ; minor salivary gland; ; right lobe of thyroid gland; ; body of stomach; ; upper lobe of left lung; ; left lobe of thyroid gland;
	Top expressed in
	entorhinal cortex; ; seminiferous tubule; ; spermatid; ; spermatocyte; ; internal carotid artery; ; lip; ; external carotid artery; ; superior frontal gyrus; ; yolk sac; ; tracheobronchial tree;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding ; metal ion binding ; protein binding ; ubiquitin-like protein ligase binding ;
Cellular component	endosome ; early endosome membrane ; multivesicular body membrane ; intracellular membrane-bounded organelle ; membrane ; early endosome ; extracellular exosome ; cytoplasm ; lysosome ; cytosol ; ESCRT-0 complex ;
Biological process	protein localization to membrane ; protein targeting to lysosome ; negative regulation of epidermal growth factor receptor signaling pathway ; membrane invagination ; multivesicular body assembly ; endosomal transport ; positive regulation of gene expression ; regulation of protein catabolic process ; protein transport ; regulation of MAP kinase activity ; positive regulation of exosomal secretion ; intracellular protein transport ; signal transduction ; negative regulation of cell population proliferation ; negative regulation of receptor signaling pathway via JAK-STAT ; macroautophagy ; protein deubiquitination ; membrane organization ; transport ; negative regulation of platelet-derived growth factor receptor signaling pathway ; negative regulation of angiogenesis ; negative regulation of vascular endothelial growth factor receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	9146
	15239
	ENSG00000185359
	ENSMUSG00000025793
	O14964
	Q99LI8
	NM_004712
	NM_001159328 ; NM_008244
	NP_004703
	NP_001152800 ; NP_032270
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 24, 2023

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.^[5]^[6]^[7]

Interactions

HGS has been shown to interact with:

CLTC ^[8]
DLG4,^[9]
EPS15,^[10]^[11]
IL2RB,^[12]
Merlin,^[13]^[14]
STAM2,^[10]^[15]
Signal transducing adaptor molecule ^[5]^[10]^[15]
TSG101.^[15]^[16]

Related Research Articles

Merlin is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in neurofibromatosis type II. Sequence data reveal its similarity to the ERM protein family.

<span class="mw-page-title-main">PTPN11</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family, the IL-4 receptor family, the gp130 receptor family. It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.

Mitogen-activated protein kinase 1, also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.

Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene.

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.

Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene.

Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185359 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025793 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K (1997). "Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule: Its suppressive effect on cytokine-induced cell growth". Journal of Biological Chemistry. 272 (52): 32785–32791. doi: 10.1074/jbc.272.52.32785 . ISSN 0021-9258. PMID 9407053.
↑ Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene. 213 (1–2): 125–32. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.
↑ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate".
↑ Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (September 2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. PMC 125612 . PMID 11532964.
↑ Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (August 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". J. Neurosci. 22 (15): 6415–25. doi: 10.1523/JNEUROSCI.22-15-06415.2002 . PMC 6758133 . PMID 12151521.
1 2 3 Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14): 12513–21. doi: 10.1074/jbc.M210843200 . PMID 12551915.
↑ Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. doi: 10.1074/jbc.275.20.15271 . PMID 10809762.
↑ Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell Sci. 121 (Pt 10): 1727–38. doi: 10.1242/jcs.024455 . PMID 18445679.
↑ Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (April 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. doi: 10.1093/hmg/10.8.825 . PMID 11285248.
↑ Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (July 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. doi: 10.1093/hmg/9.11.1567 . PMID 10861283.
1 2 3 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
↑ Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7626–31. Bibcode:2003PNAS..100.7626L. doi: 10.1073/pnas.0932599100 . PMC 164637 . PMID 12802020.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)

Comoglio PM (1993). "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells". EXS. 65: 131–65. PMID 8380735.
Komada M, Masaki R, Yamamoto A, Kitamura N (1997). "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes". J. Biol. Chem. 272 (33): 20538–44. doi: 10.1074/jbc.272.33.20538 . PMID 9252367.
Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi: 10.1074/jbc.274.42.30080 . PMID 10514494.
Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. doi: 10.1074/jbc.275.20.15271 . PMID 10809762.
Kwong J, Roundabush FL, Hutton Moore P, Montague M, Oldham W, Li Y, Chin LS, Li L (2000). "Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis". J. Cell Sci. 113 (12): 2273–84. doi:10.1242/jcs.113.12.2273. PMID 10825299.
Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. doi: 10.1093/hmg/9.11.1567 . PMID 10861283.
Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, Parton RG, Stenmark H (2000). "Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells". EMBO J. 19 (17): 4577–88. doi:10.1093/emboj/19.17.4577. PMC 302054 . PMID 10970851.
Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K (2000). "Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA". Mol. Cell. Biol. 20 (24): 9346–55. doi:10.1128/MCB.20.24.9346-9355.2000. PMC 102191 . PMID 11094085.
Chin LS, Raynor MC, Wei X, Chen HQ, Li L (2001). "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor". J. Biol. Chem. 276 (10): 7069–78. doi: 10.1074/jbc.M004129200 . PMID 11110793.
Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. doi: 10.1093/hmg/10.8.825 . PMID 11285248.
Sasaki Y, Sugamura K (2001). "Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1". J. Biol. Chem. 276 (32): 29943–52. doi: 10.1074/jbc.M104230200 . PMID 11397816.
Raiborg C, Bremnes B, Mehlum A, Gillooly DJ, D'Arrigo A, Stang E, Stenmark H (2001). "FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes". J. Cell Sci. 114 (Pt 12): 2255–63. doi:10.1242/jcs.114.12.2255. PMID 11493665.
Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. PMC 125612 . PMID 11532964.
Steen H, Kuster B, Fernandez M, Pandey A, Mann M (2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway". J. Biol. Chem. 277 (2): 1031–9. doi: 10.1074/jbc.M109992200 . PMID 11687594.
Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates". J. Cell Biol. 157 (1): 91–101. doi:10.1083/jcb.200112080. PMC 2173266 . PMID 11916981.
Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. doi:10.1007/BF03402003. PMC 2039936 . PMID 11984006.
Li Y, Chin LS, Levey AI, Li L (2002). "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking". J. Biol. Chem. 277 (31): 28212–21. doi: 10.1074/jbc.M111612200 . PMID 12021262.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185359 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025793 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9407053-5] 1 2 Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K (1997). "Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule: Its suppressive effect on cytokine-induced cell growth". Journal of Biological Chemistry. 272 (52): 32785–32791. doi: 10.1074/jbc.272.52.32785 . ISSN 0021-9258. PMID 9407053.

[pmid9630564-6] Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene. 213 (1–2): 125–32. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.

[entrez-7] "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate".

[pmid11532964-8] Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (September 2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. PMC 125612 . PMID 11532964.

[pmid12151521-9] Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (August 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". J. Neurosci. 22 (15): 6415–25. doi: 10.1523/JNEUROSCI.22-15-06415.2002 . PMC 6758133 . PMID 12151521.

[pmid12551915-10] 1 2 3 Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14): 12513–21. doi: 10.1074/jbc.M210843200 . PMID 12551915.

[pmid10809762-11] Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. doi: 10.1074/jbc.275.20.15271 . PMID 10809762.

[pmid18445679-12] Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell Sci. 121 (Pt 10): 1727–38. doi: 10.1242/jcs.024455 . PMID 18445679.

[pmid11285248-13] Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (April 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. doi: 10.1093/hmg/10.8.825 . PMID 11285248.

[pmid10861283-14] Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (July 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. doi: 10.1093/hmg/9.11.1567 . PMID 10861283.

[pmid16189514-15] 1 2 3 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid12802020-16] Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7626–31. Bibcode:2003PNAS..100.7626L. doi: 10.1073/pnas.0932599100 . PMC 164637 . PMID 12802020.

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HGS (gene)

Contents

Interactions

Related Research Articles

References

External links

Further reading