DYNC1I2

DYNC1I2
Identifiers
Aliases	DYNC1I2 , DNCI2, IC2, DIC74, dynein cytoplasmic 1 intermediate chain 2, NEDMIBA
External IDs	OMIM: 603331 HomoloGene: 133934 GeneCards: DYNC1I2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	171,750,158 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; sural nerve; ; smooth muscle tissue; ; islet of Langerhans; ; popliteal artery; ; right coronary artery; ; rectum; ; gallbladder; ; ascending aorta;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity ; protein binding ; cytoskeletal motor activity ; plus-end-directed microtubule motor activity ; dynein light chain binding ; dynein heavy chain binding ;
Cellular component	vesicle ; cytosol ; centrosome ; dynein complex ; cytoskeleton ; cytoplasm ; microtubule ; cytoplasmic dynein complex ;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II ; endoplasmic reticulum to Golgi vesicle-mediated transport ; G2/M transition of mitotic cell cycle ; viral process ; microtubule-based movement ; ciliary basal body-plasma membrane docking ; transport along microtubule ; regulation of G2/M transition of mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	1781
	n/a
	ENSG00000077380
	n/a
	Q13409
	n/a
NM_001271785 ; NM_001271786 ; NM_001271787 ; NM_001271788 ; NM_001271789 ;
	NM_001271790 ; NM_001378 ; NM_001320882 ; NM_001320883 ; NM_001320884 ; NM_001378455 ; NM_001378456
	n/a
NP_001258714 ; NP_001258715 ; NP_001258716 ; NP_001258717 ; NP_001258718 ;
	NP_001258719 ; NP_001307811 ; NP_001307812 ; NP_001307813 ; NP_001369 ; NP_001365384 ; NP_001365385
	n/a
	Wikidata
View/Edit Human

Last updated December 03, 2023

Cytoplasmic dynein 1 intermediate chain 2 is a protein that in humans is encoded by the DYNC1I2 gene.^[3]^[4]^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077380 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.
↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247 . PMID 16260502.
↑ "Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2".

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Vaughan KT, Vallee RB (1996). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued". J. Cell Biol. 131 (6 Pt 1): 1507–16. doi:10.1083/jcb.131.6.1507. PMC 2120689 . PMID 8522607.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi: 10.1371/journal.pbio.0020207 . PMC 449870 . PMID 15252450.
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000077380 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10049579-3] Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.

[pmid16260502-4] Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247 . PMID 16260502.

[entrez-5] "Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2".

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DYNC1I2

Related Research Articles

References

Further reading