CLEC1B

CLEC1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C6U, 3WSR, 3WWK
Identifiers
Aliases	CLEC1B , 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B
External IDs	OMIM: 606783 MGI: 1913287 HomoloGene: 49468 GeneCards: CLEC1B
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,013,424 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,386,298 bp
RNA expression pattern
	Top expressed in
	monocyte; ; liver; ; right lobe of liver; ; spongy bone; ; blood; ; bone marrow; ; bone marrow cells; ; right lung; ; spleen; ; upper lobe of left lung;
	Top expressed in
	blood; ; spleen; ; hepatobiliary system; ; liver; ; right lung; ; right lung lobe; ; left lobe of liver; ; yolk sac; ; body of femur; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; carbohydrate binding ; transmembrane signaling receptor activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	platelet activation ; defense response ; cell surface receptor signaling pathway ; platelet formation ; signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	51266
	56760
	ENSG00000165682
	ENSMUSG00000030159
	Q9P126
	Q9JL99
	NM_001099431 ; NM_016509 ; NM_001393342
	NM_001204239 ; NM_001204253 ; NM_019985
	NP_001092901 ; NP_057593
	NP_001191168 ; NP_001191182 ; NP_064369
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.^[5]^[6]^[7]

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]^[7]

Related Research Articles

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C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Expression is found on myeloid dendritic cells, monocytes, macrophages and B cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

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Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.

Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.

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C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.

C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165682 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030159 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi: 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . PMID 10671229.
↑ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. S2CID 42415487.
1 2 "Entrez Gene: CLEC1B C-type lectin domain family 1, member B".

External links

Human CLEC1B genome location and CLEC1B gene details page in the UCSC Genome Browser .
Human CLEC2B genome location and CLEC2B gene details page in the UCSC Genome Browser .

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Suzuki-Inoue K, Fuller GL, García A, et al. (2006). "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2". Blood. 107 (2): 542–9. doi:10.1182/blood-2005-05-1994. PMID 16174766. S2CID 168505.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Watson AA, O'Callaghan CA (2006). "Crystallization and X-ray diffraction analysis of human CLEC-2". Acta Crystallographica Section F. 61 (Pt 12): 1094–6. doi:10.1107/S1744309105037991. PMC 1978148 . PMID 16511244.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi: 10.1038/nature04569 . PMID 16541075.
Chaipan C, Soilleux EJ, Simpson P, et al. (2006). "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets". J. Virol. 80 (18): 8951–60. doi:10.1128/JVI.00136-06. PMC 1563896 . PMID 16940507.
Watson AA, Brown J, Harlos K, et al. (2007). "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2". J. Biol. Chem. 282 (5): 3165–72. doi: 10.1074/jbc.M610383200 . PMID 17132623.
Suzuki-Inoue K, Kato Y, Inoue O, et al. (2007). "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells". J. Biol. Chem. 282 (36): 25993–6001. doi: 10.1074/jbc.M702327200 . PMID 17616532.
Watson AA, Eble JA, O'Callaghan CA (2008). "Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2". Protein Science. 17 (9): 1611–6. doi:10.1110/ps.035568.108. PMC 2525532 . PMID 18583525.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165682 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030159 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10671229-5] Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi: 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . PMID 10671229.

[pmid11745369-6] Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. S2CID 42415487.

[entrez-7] 1 2 "Entrez Gene: CLEC1B C-type lectin domain family 1, member B".

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CLEC1B

Contents

Related Research Articles

References

External links

Further reading