ATP6V1C2

ATP6V1C2
Identifiers
Aliases	ATP6V1C2 , ATP6C2, VMA5, ATPase H+ transporting V1 subunit C2
External IDs	OMIM: 618070 MGI: 1916025 HomoloGene: 15866 GeneCards: ATP6V1C2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	10,785,110 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	17,379,360 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; secondary oocyte; ; minor salivary gland; ; anterior pituitary; ; kidney; ; parotid gland; ; placenta; ; vulva; ; human penis; ; corpus epididymis;
	Top expressed in
	lip; ; esophagus; ; olfactory epithelium; ; left lung; ; left lung lobe; ; right lung; ; right lung lobe; ; skin of back; ; morula; ; stria vascularis;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; protein dimerization activity ; proton transmembrane transporter activity ; P-type proton-exporting transporter activity ; proton-transporting ATPase activity, rotational mechanism ;
Cellular component	proton-transporting V-type ATPase, V1 domain ; lysosomal membrane ; cytosol ; extracellular exosome ; vacuolar proton-transporting V-type ATPase, V1 domain ;
Biological process	positive regulation of Wnt signaling pathway ; insulin receptor signaling pathway ; ion transmembrane transport ; ion transport ; transferrin transport ; regulation of macroautophagy ; phagosome acidification ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	245973
	68775
	ENSG00000143882
	ENSMUSG00000020566
	Q8NEY4
	Q99L60
	NM_001039362 ; NM_144583
	NM_001159632 ; NM_133699
	NP_001034451 ; NP_653184
	NP_001153104 ; NP_598460
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

V-type proton ATPase subunit C 2 is an enzyme that in humans is encoded by the ATP6V1C2 gene.^[5]^[6]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.

V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms.^[6]

Related Research Articles

V-type proton ATPase subunit B, kidney isoform is an enzyme that in humans is encoded by the ATP6V1B1 gene.

V-type proton ATPase subunit E 1 is an enzyme that in humans is encoded by the ATP6V1E1 gene.

V-type proton ATPase 16 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0C gene.

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.

V-type proton ATPase 116 kDa subunit a isoform 4 is an enzyme that in humans is encoded by the ATP6V0A4 gene.

V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.

V-type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP6V1A gene.

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.

V-type proton ATPase subunit G 2 is an enzyme that in humans is encoded by the ATP6V1G2 gene.

V-type proton ATPase subunit H is an enzyme that in humans is encoded by the ATP6V1H gene.

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.

V-type proton ATPase subunit F is an enzyme that in humans is encoded by the ATP6V1F gene.

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

V-type proton ATPase subunit e 1 is an enzyme that in humans is encoded by the ATP6V0E1 gene.

V-type proton ATPase 116 kDa subunit a isoform 2 also known as V-ATPase 116 kDa isoform a2 is an enzyme that in humans is encoded by the ATP6V0A2 gene.

V-type proton ATPase subunit E 2 is an enzyme that in humans is encoded by the ATP6V1E2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143882 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020566 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Smith AN, Borthwick KJ, Karet FE (Oct 2002). "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis". Gene. 297 (1–2): 169–77. doi:10.1016/S0378-1119(02)00884-3. PMID 12384298.
1 2 "Entrez Gene: ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2".

External links

Human ATP6V1C2 genome location and ATP6V1C2 gene details page in the UCSC Genome Browser .

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143882 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020566 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12384298-5] Smith AN, Borthwick KJ, Karet FE (Oct 2002). "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis". Gene. 297 (1–2): 169–77. doi:10.1016/S0378-1119(02)00884-3. PMID 12384298.

[entrez-6] 1 2 "Entrez Gene: ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2".

[1]

[2]

[3]

[4]

[5]

[6]