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{{PBB|geneid=2919}}
{{PBB|geneid=2919}}
-{'''CXCL1'''}-, ''hemokin (-{C-X-C}- motiv) ligand 1'', je mali [[citokin]] koji pripada -{CXC}- [[hemokin]] familiji. On se ranije zvao -{GRO1}- onkogen, -{GROα, KC}-, neutrofil-aktivirajući protein 3 (-{NAP-3}-) i melanoma rast stimulišuća aktivnost, alfa (-{MSGA-α}-). Kod ljudi, ovaj protein je kodiran -{''CXCL1''}- [[gen]]om.<ref name="pmid2217207">{{cite journal | author = Haskill S, Peace A, Morris J, Sporn SA, Anisowicz A, Lee SW, Smith T, Martin G, Ralph P, Sager R | title = Identification of three related human GRO genes encoding cytokine functions | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 19 | pages = 7732–6 | year = 1990 | month = October | pmid = 2217207 | pmc = 54822 | doi = 10.1073/pnas.87.19.7732| url = }}</ref><ref>{{MireSluisCytokines}}</ref>
'''-{CXCL1}-''', ''hemokin (-{C-X-C}- motiv) ligand 1'', je mali [[citokin]] koji pripada -{CXC}- [[hemokin]] familiji. On se ranije zvao -{GRO1}- [[onkogen]], -{GROα, KC}-, neutrofil-aktivirajući protein 3 (-{NAP-3}-) i melanoma rast stimulišuća aktivnost, alfa (-{MSGA-α}-). Kod ljudi, ovaj protein je kodiran -{''CXCL1''}- [[gen]]om.<ref name="pmid2217207">{{cite journal |vauthors=Haskill S, Peace A, Morris J, Sporn SA, Anisowicz A, Lee SW, Smith T, Martin G, Ralph P, Sager R | title = Identification of three related human GRO genes encoding cytokine functions | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 19 | pages = 7732–6 | year = 1990 | pmid = 2217207 | pmc = 54822 | doi = 10.1073/pnas.87.19.7732| url = }}</ref><ref>{{MireSluisCytokines}}</ref>


== Funkcija ==
== Funkcija ==
-{CXCL1}- izlučuju ljudske ćelije [[melanom]]a. On ima [[mitogen|mitogene]] osobine i učestvuje u [[patogeneza|patogenezi]] melanoma.<ref name="pmid2890161">{{cite journal | author = Anisowicz A, Bardwell L, Sager R | title = Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 20 | pages = 7188–92 | year = 1987 | month = October | pmid = 2890161 | pmc = 299255 | doi = 10.1073/pnas.84.20.7188| url = }}</ref><ref name="pmid3356754">{{cite journal | author = Richmond A, Thomas HG | title = Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution | journal = J. Cell. Biochem. | volume = 36 | issue = 2 | pages = 185–98 | year = 1988 | month = February | pmid = 3356754 | doi = 10.1002/jcb.240360209 | url = }}</ref>
-{CXCL1}- izlučuju ljudske ćelije [[melanom]]a. On ima [[mitogen]]e osobine i učestvuje u [[patogeneza|patogenezi]] melanoma.<ref name="pmid2890161">{{cite journal |vauthors=Anisowicz A, Bardwell L, Sager R | title = Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 20 | pages = 7188–92 | year = 1987 | pmid = 2890161 | pmc = 299255 | doi = 10.1073/pnas.84.20.7188| url = }}</ref><ref name="pmid3356754">{{cite journal |vauthors=Richmond A, Thomas HG | title = Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution | journal = J. Cell. Biochem. | volume = 36 | issue = 2 | pages = 185–98 | year = 1988 | pmid = 3356754 | doi = 10.1002/jcb.240360209 | url = }}</ref>
-{CXCL1}- izražavaju [[makrofag]]e, [[neutrofil]]i i [[epitelska ćelija|epitelske ćelije]],<ref name="pmid2078213">{{cite journal | author = Iida N, Grotendorst GR | title = Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue | journal = Mol. Cell. Biol. | volume = 10 | issue = 10 | pages = 5596–9 | year = 1990 | month = October | pmid = 2078213 | pmc = 361282 | doi = | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=2078213 | issn = }}</ref><ref name="pmid8166297">{{cite journal | author = Becker S, Quay J, Koren HS, Haskill JS | title = Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages | journal = Am. J. Physiol. | volume = 266 | issue = 3 Pt 1 | pages = L278–86 | year = 1994 | month = March | pmid = 8166297 | doi = | url = http://ajplung.physiology.org/cgi/pmidlookup?view=reprint&pmid=8166297 | issn = }}</ref> i dejstvuje kao [[neutrofil]]ni hemoatraktant.<ref name="pmid2185333">{{cite journal | author = Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M | title = Neutrophil-activating properties of the melanoma growth-stimulatory activity | journal = J. Exp. Med. | volume = 171 | issue = 5 | pages = 1797–802 | year = 1990 | month = May | pmid = 2185333 | pmc = 2187876 | doi = 10.1084/jem.171.5.1797| url = }}</ref><ref name="pmid1438244">{{cite journal | author = Schumacher C, Clark-Lewis I, Baggiolini M, Moser B | title = High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 21 | pages = 10542–6 | year = 1992 | month = November | pmid = 1438244 | pmc = 50375 | doi = 10.1073/pnas.89.21.10542| url = }}</ref> -{CXCL1}- igra ulogu u razvoju kičmene moždine putem inhibicije migracije oligodendrocit prekursora, i učestvuje u procesima [[angiogeneza|angiogeneze]], [[zapaljenje|inflamacije]], [[zarastanje rane|zarastanja rana]], i [[tumorigeneza|tumorigeneze]].<ref name="pmid12176324">{{cite journal | author = Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH | title = The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration | journal = Cell | volume = 110 | issue = 3 | pages = 373–83 | year = 2002 | month = August | pmid = 12176324 | doi = 10.1016/S0092-8674(02)00838-3| url = }}</ref><ref name="pmid10951241">{{cite journal | author = Devalaraja RM, Nanney LB, Du J, Qian Q, Yu Y, Devalaraja MN, Richmond A | title = Delayed wound healing in CXCR2 knockout mice | journal = J. Invest. Dermatol. | volume = 115 | issue = 2 | pages = 234–44 | year = 2000 | month = August | pmid = 10951241 | doi = 10.1046/j.1523-1747.2000.00034.x | url = | pmc = 2664868 }}</ref><ref name="pmid10647998">{{cite journal | author = Haghnegahdar H, Du J, Wang D, Strieter RM, Burdick MD, Nanney LB, Cardwell N, Luan J, Shattuck-Brandt R, Richmond A | title = The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma | journal = J. Leukoc. Biol. | volume = 67 | issue = 1 | pages = 53–62 | year = 2000 | month = January | pmid = 10647998 | doi = | url = http://www.jleukbio.org/cgi/pmidlookup?view=long&pmid=10647998 | issn = | pmc = 2669312 }}</ref><ref name="pmid9334815">{{cite journal | author = Owen JD, Strieter R, Burdick M, Haghnegahdar H, Nanney L, Shattuck-Brandt R, Richmond A | title = Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins | journal = Int. J. Cancer | volume = 73 | issue = 1 | pages = 94–103 | year = 1997 | month = September | pmid = 9334815 | doi = 10.1002/(SICI)1097-0215(19970926)73:1<94::AID-IJC15>3.0.CO;2-5| url = }}</ref>
-{CXCL1}- izražavaju [[makrofag]]e, [[neutrofil]]i i [[epitelska ćelija|epitelske ćelije]],<ref name="pmid2078213">{{cite journal | vauthors = Iida N, Grotendorst GR | title = Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue | journal = Mol. Cell. Biol. | volume = 10 | issue = 10 | pages = 5596–9 | year = 1990 | pmid = 2078213 | pmc = 361282 | doi = |url=https://archive.org/details/sim_molecular-and-cellular-biology_1990-10_10_10/page/5596| issn = }}</ref><ref name="pmid8166297">{{cite journal | vauthors = Becker S, Quay J, Koren HS, Haskill JS | title = Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages | journal = Am. J. Physiol. | volume = 266 | issue = 3 Pt 1 | pages = L278–86 | year = 1994 | pmid = 8166297 | doi = | url = http://ajplung.physiology.org/cgi/pmidlookup?view=reprint&pmid=8166297 | issn = }}{{Мртва веза}}</ref> i dejstvuje kao [[neutrofil]]ni hemoatraktant.<ref name="pmid2185333">{{cite journal |vauthors=Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M | title = Neutrophil-activating properties of the melanoma growth-stimulatory activity | journal = J. Exp. Med. | volume = 171 | issue = 5 | pages = 1797–802 | year = 1990 | pmid = 2185333 | pmc = 2187876 | doi = 10.1084/jem.171.5.1797| url = }}</ref><ref name="pmid1438244">{{cite journal |vauthors=Schumacher C, Clark-Lewis I, Baggiolini M, Moser B | title = High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 21 | pages = 10542–6 | year = 1992 | pmid = 1438244 | pmc = 50375 | doi = 10.1073/pnas.89.21.10542| url = }}</ref> -{CXCL1}- igra ulogu u razvoju kičmene moždine putem inhibicije migracije oligodendrocit prekurzora, i učestvuje u procesima [[angiogeneza|angiogeneze]], [[zapaljenje|inflamacije]], [[zarastanje rane|zarastanja rana]], i [[tumorigeneza|tumorigeneze]].<ref name="pmid12176324">{{cite journal |vauthors=Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH | title = The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration | journal = Cell | volume = 110 | issue = 3 | pages = 373–83 | year = 2002 | pmid = 12176324 | doi = 10.1016/S0092-8674(02)00838-3| url = }}</ref><ref name="pmid10951241">{{cite journal |vauthors=Devalaraja RM, Nanney LB, Du J, Qian Q, Yu Y, Devalaraja MN, Richmond A | title = Delayed wound healing in CXCR2 knockout mice | journal = J. Invest. Dermatol. | volume = 115 | issue = 2 | pages = 234–44 | year = 2000 | pmid = 10951241 | doi = 10.1046/j.1523-1747.2000.00034.x | url =https://archive.org/details/sim_journal-of-investigative-dermatology_2000-08_115_2/page/234| pmc = 2664868 }}</ref><ref name="pmid10647998">{{cite journal | vauthors = Haghnegahdar H, Du J, Wang D, Strieter RM, Burdick MD, Nanney LB, Cardwell N, Luan J, Shattuck-Brandt R, Richmond A | title = The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma | journal = J. Leukoc. Biol. | volume = 67 | issue = 1 | pages = 53–62 | year = 2000 | pmid = 10647998 | doi = | url = http://www.jleukbio.org/cgi/pmidlookup?view=long&pmid=10647998 | issn = | pmc = 2669312 }}{{Мртва веза|date=09. 2018 |bot=InternetArchiveBot |fix-attempted=yes }}</ref><ref name="pmid9334815">{{cite journal |vauthors=Owen JD, Strieter R, Burdick M, Haghnegahdar H, Nanney L, Shattuck-Brandt R, Richmond A | title = Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins | journal = Int. J. Cancer | volume = 73 | issue = 1 | pages = 94–103 | year = 1997 | pmid = 9334815 | doi = 10.1002/(SICI)1097-0215(19970926)73:1<94::AID-IJC15>3.0.CO;2-5| url = }}</ref>


Ovaj [[hemokin]] dejstvuje putem signaliziranja kroz hemokin receptor [[CXC hemokin receptori#CXCR2|-{CXCR2}-]].<ref name="pmid12176324"/> [[Gen]] za -{CXCL1}- je lociran na ljudskom [[hromozom 4 (čovek)|hromozomu 4]] među genima za drugih -{CXC}- hemokina.<ref name="pmid2970963">{{cite journal | author = Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R | title = Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin | journal = EMBO J. | volume = 7 | issue = 7 | pages = 2025–33 | year = 1988 | month = July | pmid = 2970963 | pmc = 454478 | doi = | url = | issn = }}</ref> Jedna početna studija na miševima je proizvela evidenciju da -{CXCL1}- umanjuje težinu [[multipla skleroza|multiple skleroze]] i da možda može da ima neuroprotektivnu ulogu.<ref name="pmid19095949">{{cite journal | author = Omari KM, Lutz SE, Santambrogio L, Lira SA, Raine CS | title = Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1 | journal = Am. J. Pathol. | volume = 174 | issue = 1 | pages = 164–76 | year = 2009 | month = January | pmid = 19095949 | doi = 10.2353/ajpath.2009.080350 | url = | issn = | pmc = 2631329 }}</ref>
Ovaj [[hemokin]] dejstvuje putem signaliziranja kroz hemokin receptor [[CXC hemokin receptori#CXCR2|-{CXCR2}-]].<ref name="pmid12176324"/> [[Gen]] za -{CXCL1}- je lociran na ljudskom [[hromozom 4 (čovek)|hromozomu 4]] među genima za drugih -{CXC}- hemokina.<ref name="pmid2970963">{{cite journal |vauthors=Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R | title = Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin | journal = EMBO J. | volume = 7 | issue = 7 | pages = 2025–33 | year = 1988 | pmid = 2970963 | pmc = 454478 | doi = | url =https://archive.org/details/sim_embo-journal_1988-07_7_7/page/2025| issn = }}</ref> Jedna početna studija na miševima je proizvela evidenciju da -{CXCL1}- umanjuje težinu [[multipla skleroza|multiple skleroze]] i da možda može da ima neuroprotektivnu ulogu.<ref name="pmid19095949">{{cite journal |vauthors=Omari KM, Lutz SE, Santambrogio L, Lira SA, Raine CS | title = Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1 | journal = Am. J. Pathol. | volume = 174 | issue = 1 | pages = 164–76 | year = 2009 | pmid = 19095949 | doi = 10.2353/ajpath.2009.080350 | url = | issn = | pmc = 2631329 }}</ref>


==Literatura==
== Reference ==
{{Reflist|2}}
{{reflist|}}


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[[Категорија:Цитокини]]
[[Категорија:Цитокини]]
[[Категорија:Онкогени]]

[[en:CXCL1]]
[[zh:CXCL1]]

Тренутна верзија на датум 1. октобар 2024. у 19:19

Hemokin (C-X-C motiv) ligand 1 (melanom rast stimulišuća aktivnost, alfa)
PDB prikaz baziran na 1mgs​.
Dostupne strukture
1mgs​, 1msg​, 1msh​
Identifikatori
Simboli CXCL1; GRO1; GROa; MGSA; MGSA alpha; MGSA-a; NAP-3; SCYB1
Vanjski ID OMIM: 155730 MGI: 3037818 HomoloGene: 84701 GeneCards: CXCL1 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 2919 330122
Ensembl ENSG00000163739 ENSMUSG00000029379
UniProt P09341 n/a
RefSeq (mRNA) NM_001511 NM_203320
RefSeq (protein) NP_001502 NP_976065
Lokacija (UCSC) Chr 4:
74.95 - 74.97 Mb		 Chr 5:
91.86 - 91.86 Mb
PubMed pretraga [1] [2]

CXCL1, hemokin (C-X-C motiv) ligand 1, je mali citokin koji pripada CXC hemokin familiji. On se ranije zvao GRO1 onkogen, GROα, KC, neutrofil-aktivirajući protein 3 (NAP-3) i melanoma rast stimulišuća aktivnost, alfa (MSGA-α). Kod ljudi, ovaj protein je kodiran CXCL1 genom.[1][2]

Funkcija

[уреди | уреди извор]

CXCL1 izlučuju ljudske ćelije melanoma. On ima mitogene osobine i učestvuje u patogenezi melanoma.[3][4] CXCL1 izražavaju makrofage, neutrofili i epitelske ćelije,[5][6] i dejstvuje kao neutrofilni hemoatraktant.[7][8] CXCL1 igra ulogu u razvoju kičmene moždine putem inhibicije migracije oligodendrocit prekurzora, i učestvuje u procesima angiogeneze, inflamacije, zarastanja rana, i tumorigeneze.[9][10][11][12]

Ovaj hemokin dejstvuje putem signaliziranja kroz hemokin receptor CXCR2.[9] Gen za CXCL1 je lociran na ljudskom hromozomu 4 među genima za drugih CXC hemokina.[13] Jedna početna studija na miševima je proizvela evidenciju da CXCL1 umanjuje težinu multiple skleroze i da možda može da ima neuroprotektivnu ulogu.[14]

Reference

[уреди | уреди извор]
  1. ^ Haskill S, Peace A, Morris J, Sporn SA, Anisowicz A, Lee SW, Smith T, Martin G, Ralph P, Sager R (1990). „Identification of three related human GRO genes encoding cytokine functions”. Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7732—6. PMC 54822 Слободан приступ. PMID 2217207. doi:10.1073/pnas.87.19.7732. 
  2. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  3. ^ Anisowicz A, Bardwell L, Sager R (1987). „Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells”. Proc. Natl. Acad. Sci. U.S.A. 84 (20): 7188—92. PMC 299255 Слободан приступ. PMID 2890161. doi:10.1073/pnas.84.20.7188. 
  4. ^ Richmond A, Thomas HG (1988). „Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution”. J. Cell. Biochem. 36 (2): 185—98. PMID 3356754. doi:10.1002/jcb.240360209. 
  5. ^ Iida N, Grotendorst GR (1990). „Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue”. Mol. Cell. Biol. 10 (10): 5596—9. PMC 361282 Слободан приступ. PMID 2078213. 
  6. ^ Becker S, Quay J, Koren HS, Haskill JS (1994). „Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages”. Am. J. Physiol. 266 (3 Pt 1): L278—86. PMID 8166297. [мртва веза]
  7. ^ Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M (1990). „Neutrophil-activating properties of the melanoma growth-stimulatory activity”. J. Exp. Med. 171 (5): 1797—802. PMC 2187876 Слободан приступ. PMID 2185333. doi:10.1084/jem.171.5.1797. 
  8. ^ Schumacher C, Clark-Lewis I, Baggiolini M, Moser B (1992). „High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils”. Proc. Natl. Acad. Sci. U.S.A. 89 (21): 10542—6. PMC 50375 Слободан приступ. PMID 1438244. doi:10.1073/pnas.89.21.10542. 
  9. ^ а б Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH (2002). „The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration”. Cell. 110 (3): 373—83. PMID 12176324. doi:10.1016/S0092-8674(02)00838-3. 
  10. ^ Devalaraja RM, Nanney LB, Du J, Qian Q, Yu Y, Devalaraja MN, Richmond A (2000). „Delayed wound healing in CXCR2 knockout mice”. J. Invest. Dermatol. 115 (2): 234—44. PMC 2664868 Слободан приступ. PMID 10951241. doi:10.1046/j.1523-1747.2000.00034.x. 
  11. ^ Haghnegahdar H, Du J, Wang D, Strieter RM, Burdick MD, Nanney LB, Cardwell N, Luan J, Shattuck-Brandt R, Richmond A (2000). „The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma”. J. Leukoc. Biol. 67 (1): 53—62. PMC 2669312 Слободан приступ. PMID 10647998. [мртва веза]
  12. ^ Owen JD, Strieter R, Burdick M, Haghnegahdar H, Nanney L, Shattuck-Brandt R, Richmond A (1997). „Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins”. Int. J. Cancer. 73 (1): 94—103. PMID 9334815. doi:10.1002/(SICI)1097-0215(19970926)73:1<94::AID-IJC15>3.0.CO;2-5. 
  13. ^ Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R (1988). „Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin”. EMBO J. 7 (7): 2025—33. PMC 454478 Слободан приступ. PMID 2970963. 
  14. ^ Omari KM, Lutz SE, Santambrogio L, Lira SA, Raine CS (2009). „Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1”. Am. J. Pathol. 174 (1): 164—76. PMC 2631329 Слободан приступ. PMID 19095949. doi:10.2353/ajpath.2009.080350. 
Преузето из „https://sr.wikipedia.org/w/index.php?title=CXCL1&oldid=28477210”