WAY-100635 — разлика између измена

WAY-100635
IUPAC ime
	N-[2-[4-(2-metoksifenil)-1-piperazinil]etil]- N-(2-piridil)cikloheksankarboksamid
Identifikatori
CAS broj	146714-97-8
ATC kod	none
PubChem	CID 5684
IUPHAR/BPS	80
ChEMBL	CHEMBL31354
Hemijski podaci
Formula	C25H34N4O2
Molarna masa	422,56 g/mol

Интерактиван преглед историје

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ВизуелноВикитекст

Инлајн

Тренутна верзија на датум 13. јануар 2024. у 22:25

WAY-100,635 je piperazinski lek koji je u širokoj upotrebi u naučnim istraživanjima. Za njega se originalno smatralo da deluje kao selektivni 5-HT_1A antagonist, ali su naknadna istraživanja pokazala da on isto tako deluje kao potentan pun agonist na D₄ receptoru.^[1]^[2]^[3] On se ponekad naziva nemim antagonistom 5-HT1A receptora.^[4] WAY-100,635 i WAY-100,135 su hemijski slični.

Reference

^ C. A. Fornal, C. W. Metzler, R. A. Gallegos, S. C. Veasey, A. C. McCreary and B. L. Jacobs (1996). „WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135”. The Journal of Pharmacology and Experimental Therapeutics. 278 (2): 752–762. PMID 8768728. Архивирано из оригинала 18. 02. 2009. г. Приступљено 10. 04. 2012.
^ Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts and David E. Nichols (2006). „WAY-100635 is a potent dopamine D4 receptor agonist”. Psychopharmacology. 188 (2): 244—251. PMID 16915381. doi:10.1007/s00213-006-0490-4. ^{[мртва веза]}
^ Marona-Lewicka D, Nichols DE (2009). „WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation”. Behav Pharmacol. 20 (1): 114—8. PMID 19179855. doi:10.1097/FBP.0b013e3283242f1a.
^ A. Fletcher, E. A. Forster, D. J. Bill, G. Brown, I. A. Cliffe, J. E. Hartley, D. E. Jones, A. McLenachan, K. J. Stanhope, D. J. Critchley, K. J. Childs, V. C. Middlefell, L. Lanfumey, R. Corradetti, A. M. Laporte, H. Gozlan, M. Hamon & C. T. Dourish (1996). „Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist”. Behavioural Brain Research. 73 (1-2): 337—333. PMID 8788530. doi:10.1016/0166-4328(96)00118-0.

Spoljašnje veze

Vesa Oikonen (2007). „Quantification of (carbonyl-¹¹C)WAY-100635 PET studies”. Turku PET center.

[1] C. A. Fornal, C. W. Metzler, R. A. Gallegos, S. C. Veasey, A. C. McCreary and B. L. Jacobs (1996). „WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135”. The Journal of Pharmacology and Experimental Therapeutics. 278 (2): 752–762. PMID 8768728. Архивирано из оригинала 18. 02. 2009. г. Приступљено 10. 04. 2012.

[2] Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts and David E. Nichols (2006). „WAY-100635 is a potent dopamine D4 receptor agonist”. Psychopharmacology. 188 (2): 244—251. PMID 16915381. doi:10.1007/s00213-006-0490-4. ^{[мртва веза]}

[pmid19179855-3] Marona-Lewicka D, Nichols DE (2009). „WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation”. Behav Pharmacol. 20 (1): 114—8. PMID 19179855. doi:10.1097/FBP.0b013e3283242f1a.

[4] A. Fletcher, E. A. Forster, D. J. Bill, G. Brown, I. A. Cliffe, J. E. Hartley, D. E. Jones, A. McLenachan, K. J. Stanhope, D. J. Critchley, K. J. Childs, V. C. Middlefell, L. Lanfumey, R. Corradetti, A. M. Laporte, H. Gozlan, M. Hamon & C. T. Dourish (1996). „Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist”. Behavioural Brain Research. 73 (1-2): 337—333. PMID 8788530. doi:10.1016/0166-4328(96)00118-0.

[1]

[2]

[3]

[4]

@@ Ред 4: / Ред 4: @@
 | verifiedrevid = 401667456
 | IUPAC_name = -{''N''}--[2-[4-(2-metoksifenil)-1-piperazinil]etil]- -{''N''}--(2-piridil)cikloheksankarboksamid
-| OtherNames =
 | image = WAY-100,635.png
 | width = 200
+| image2 =
+| width2 =
 <!--Clinical data-->
 | tradename =
 <!--Identifiers-->
@@ Ред 20: / Ред 21: @@
 | ChEMBL_Ref = {{ebicite|correct|EBI}}
 | ChEMBL = 31354
+| DrugBank_Ref =
+| DrugBank =
 <!--Chemical data-->
 | C=25 | H=34 | N=4 | O=2
 | molecular_weight = 422,56 -{g/mol}-
+| smiles =
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI =
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey =
 }}
--{'''WAY-100,635'''}- je [[piperazin]]ski [[lek]] koji je u širokoj upotrebi u naučnim istraživanjima. Za njega se originalno smatralo da deluje kao selektivni [[5-HT1A|-{5-HT<sub>1A</sub>}-]] [[antagonist (farmakologija)|antagonist]], ali su naknadna istraživanja pokazala da on isto tako deluje kao potentan [[pun agonist]] na [[D4 receptor|D<sub>4</sub>]] receptoru.<ref>{{Cite journal | author = C. A. Fornal, C. W. Metzler, R. A. Gallegos, S. C. Veasey, A. C. McCreary and B. L. Jacobs | title = WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135 | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 278 | issue = 2 | pages = 752&ndash;762 | year = 1996 | url = http://jpet.aspetjournals.org/cgi/content/abstract/278/2/752 | pmid = 8768728 }}</ref><ref>{{Cite journal | author = Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts and David E. Nichols | title = WAY-100635 is a potent dopamine D4 receptor agonist | journal = Psychopharmacology | month = October | volume = 188 | issue = 2 | pages = 244–251 | year = 2006 | pmid = 16915381 | url = http://www.springerlink.com/content/vt36125287348028/  | doi = 10.1007/s00213-006-0490-4}}</ref><ref name="pmid19179855">{{cite journal |author=Marona-Lewicka D, Nichols DE |title=WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation |journal=Behav Pharmacol |volume=20 |issue=1 |pages=114–8 |year=2009 |pmid=19179855 |doi=10.1097/FBP.0b013e3283242f1a |url=}}</ref> On se ponekad naziva nemim antagonistom -{5-HT1A}- receptora.<ref>{{Cite journal | author = A. Fletcher, E. A. Forster, D. J. Bill, G. Brown, I. A. Cliffe, J. E. Hartley, D. E. Jones, A. McLenachan, K. J. Stanhope, D. J. Critchley, K. J. Childs, V. C. Middlefell, L. Lanfumey, R. Corradetti, A. M. Laporte, H. Gozlan, M. Hamon & C. T. Dourish | title = Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist | journal = Behavioural Brain Research | volume = 73 | issue = 1-2 | pages = 337–333 | year = 1996 | month =  | pmid = 8788530 | doi = 10.1016/0166-4328(96)00118-0 }}</ref> -{WAY-100,635}- i -{[[WAY-100,135]]}- su hemijski sličani.
+-{'''WAY-100,635'''}- je [[piperazin]]ski [[lek]] koji je u širokoj upotrebi u naučnim istraživanjima. Za njega se originalno smatralo da deluje kao selektivni [[5-HT1A|-{5-HT<sub>1A</sub>}-]] [[antagonist (farmakologija)|antagonist]], ali su naknadna istraživanja pokazala da on isto tako deluje kao potentan [[agonist (farmakologija)|pun agonist]] na [[D4 receptor|D<sub>4</sub>]] receptoru.<ref>{{Cite journal | author = C. A. Fornal, C. W. Metzler, R. A. Gallegos, S. C. Veasey, A. C. McCreary and B. L. Jacobs | title = WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135 | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 278 | issue = 2 | pages = 752&ndash;762 | year = 1996 | url = http://jpet.aspetjournals.org/cgi/content/abstract/278/2/752 | pmid = 8768728 | access-date = 10. 04. 2012 | archive-date = 18. 02. 2009 | archive-url = https://web.archive.org/web/20090218135753/http://jpet.aspetjournals.org/cgi/content/abstract/278/2/752 | url-status =  }}</ref><ref>{{Cite journal | author = Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts and David E. Nichols | title = WAY-100635 is a potent dopamine D4 receptor agonist | journal = Psychopharmacology | volume = 188 | issue = 2 | pages = 244–251 | year = 2006 | pmid = 16915381 | url = http://www.springerlink.com/content/vt36125287348028/ | doi = 10.1007/s00213-006-0490-4 }}{{Мртва веза|date=04. 2020 |bot=InternetArchiveBot |fix-attempted=yes }}</ref><ref name="pmid19179855">{{cite journal |vauthors=Marona-Lewicka D, Nichols DE |title=WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation |journal=Behav Pharmacol |volume=20 |issue=1 |pages=114–8 |year=2009 |pmid=19179855 |doi=10.1097/FBP.0b013e3283242f1a |url=}}</ref> On se ponekad naziva nemim antagonistom -{5-HT1A}- receptora.<ref>{{Cite journal | author = A. Fletcher, E. A. Forster, D. J. Bill, G. Brown, I. A. Cliffe, J. E. Hartley, D. E. Jones, A. McLenachan, K. J. Stanhope, D. J. Critchley, K. J. Childs, V. C. Middlefell, L. Lanfumey, R. Corradetti, A. M. Laporte, H. Gozlan, M. Hamon & C. T. Dourish | title = Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist | journal = Behavioural Brain Research | volume = 73 | issue = 1-2 | pages = 337–333 | year = 1996 | pmid = 8788530 | doi = 10.1016/0166-4328(96)00118-0 }}</ref> -{WAY-100,635}- i -{[[WAY-100,135]]}- su hemijski slični.
 == Reference ==
@@ Ред 32: / Ред 40: @@
 == Spoljašnje veze ==
+{{Portal-lat|Medicina|Hemija}}
 * {{Cite web
  | url = http://www.turkupetcentre.net/analysis/doc/tracer/way100635.html
@@ Ред 42: / Ред 51: @@
 {{Serotonergici-lat}}
 {{Dopaminergici-lat}}
+{{normativna kontrola}}
+[[Категорија:Серотонински антагонисти]]
+[[Категорија:Допамински агонисти]]
+[[Категорија:Пиперазини]]
+[[Категорија:Фенолни етри]]
+[[Категорија:Амиди]]
+[[Категорија:Пиридини]]