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Hlortalidon

Izvor: Wikipedija
Hlortalidon
(IUPAC) ime
2-hloro-5-(1-hidroksi-3-okso-2,3-dihidro-1H-izoindol-1-il)benzen-1-sulfonamid
Klinički podaci
Robne marke Higroton, Hydro-Long, Hygroton, Igroton
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 77-36-1
ATC kod C03BA04
PubChem[1][2] 2732
DrugBank DB00310
ChemSpider[3] 2631
ChEMBL[4] CHEMBL3654 DaY
Hemijski podaci
Formula C14H11ClN2O4S 
Mol. masa 338.766
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 239 °C (462 °F)
Farmakokinetički podaci
Poluvreme eliminacije 40 sati
Izlučivanje Renalno
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno

Hlortalidon je benzensulfonamid-ftalimidin koji se tautomerizuje do benzofenonske forme. On se smatra tiazidu sličnim diuretikom.[5][6]

Reference

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  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682. 
  6. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412. 

Spoljašnje veze

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Šablon:Diuretici