Furosemid
(IUPAC ) ime
4-hloro-2-(furan-2-ilmetilamino)- 5-sulfamoilbenzojeva kiselina
Klinički podaci
Identifikatori
CAS broj
54-31-9
ATC kod
C03 CA01
PubChem [ 1] [ 2] 3440
DrugBank
DB00695
ChemSpider [ 3] 3322
UNII
7LXU5N7ZO5 Y
KEGG [ 4] D00331 Y
ChEBI
CHEBI:47426 Y
ChEMBL [ 5] CHEMBL35 Y
Hemijski podaci
Formula
C 12 H 11 Cl N 2 O 5 S
Mol. masa
330,745 g/mol
SMILES
eMolekuli PubHem
InChI InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) Y Y
Farmakokinetički podaci
Bioraspoloživost
43-69%
Metabolizam
hepatički i renalna glukuronidacija
Poluvreme eliminacije
do 100 minuta
Izlučivanje
renalno 66%, bilijarno 33%
Farmakoinformacioni podaci
Licenca
US Daily Med :link
Trudnoća
C(AU ) C(US )
Pravni status
℞ Prescription only
Način primene
Oralno, IV , IM
Furosemid [ 6] frusemid je diuretik Henleove petlje koji se koristi u tretmanu kongestivnog zatajenja srca i edema . Ovaj lek proizvodi i prodaje preduzeće Sanofi pod imenom Lasix . On je takođe dostupan pod imenima Fusid i Frumex .[ 7]
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.” . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining” . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . edit ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG” . Yeast 17 (1): 48–55. DOI :10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H . ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948594 . edit ↑ Changes to medicines names: BANs to rINNs ↑ Frumex
Šablon:Diuretici
„Golan” preusmjerava ovdje. Za visoravan, v. Golan (visoravan).
