Biotin

Biotin
	5-[(3aS,4S,6aR)-2-oksoheksahidro-1H-tieno[3,4-d]imidazol-4-il]pentanoinska kiselina
Drugi nazivi	Vitamin B7; Vitamin H; Koenzim R; Biopeiderm
Identifikacija
CAS registarski broj	58-85-5
PubChem	171548
ChemSpider	149962
UNII	6SO6U10H04
DrugBank	DB00121
KEGG	D00029
ChEBI	15956
ChEMBL	CHEMBL857
ATC code	A11HA05
Jmol-3D slike	Slika 1; Slika 2
SMILES
	O=C1N[C@@H]2[C@@H](SC[C@@H]2N1)CCCCC(=O)O C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2
InChI
	InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1 ; Kod: YBJHBAHKTGYVGT-ZKWXMUAHSA-N InChI=1/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1; Kod: YBJHBAHKTGYVGT-ZKWXMUAHBB
Svojstva
Molekulska formula	C10H16N2O3S
Molarna masa	244.31 g mol−1
Agregatno stanje	Bele krstalne igle
Tačka topljenja	232-233 °C
Rastvorljivost u vodi	22 mg/100 mL
Opasnost
NFPA 704	1 1 0
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Biotin je prisutan u svakodnevnom životu ćelije, sintezi masnih kiselina i amino kiselina.^[7] Ima bitnu ulogu u Krebsovom ciklusu, u kojem se stvara energija preko potrebna ćeliji. Biotin je takođe bitan u održavanju korektnog nivoa šećera u krvi. Osobe sa dijabetesom često imaju veoma nizak nivo biotina. Istraživanja su i dalje u toku, ali do sada je utvrđeno da je biotin uključen u sintezu insulina. Preporučuje se za ojačavanje kose i noktiju. Može se naći kao sastavni deo mnogih kozmetičkih proizvoda, naročito onih namenjenih za kosu i kožu.

Reference

↑ Merck Index, 11th Edition, 1244.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0.

Literatura

Vanjske veze

Portal Hemija

Biotin bound to proteins in the PDB
Egg-stremely useful interaction. Article at PDBe examining interaction with (strept)avidin

[1] Merck Index, 11th Edition, 1244.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[6] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[7] Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0.

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