NPM1
Aspeto
A nucleofosfomina (fosfoproteína nucleolar B23, numatrina ou NPM1) é uma proteína nucleolar ubiquamente expressada que transloca-se entre o núcleo celular e o citoplasma. Está implicada em múltiplas funções celulares, incluindo codificação proteica ribossomal e transporte, controle da duplicação do centrossomo e regulação do gene supressor de tumor ARF.
Mutações que relocam a NPM1 do núcleo para o citoplasma estão associadas com o desenvolvimento da leucemia mielóide aguda.[3]
Referências
- ↑ «Drogas que interagem fisicamente com Nucleophosmin 1 ver/editar referências no wikidata»
- ↑ «Human PubMed Reference:»
- ↑ Schneider F; et al. (maio de 2009). «NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS)». Blood. 113 (21). pp. 5250–3
Leitura de apoio
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