Objective: It is generally believed that after the first episode of schizophrenia, the risk of relapse decreases with time in patients who are stabilized. Many treatment guidelines recommend that after stabilization, antipsychotic treatment should be ...

Objectives: The authors sought to study the safety of antipsychotic polypharmacy compared with monotherapy in specific dosage categories.Methods: Patients with schizophrenia (N=61,889; median follow-up, 14.8 years [IQR=7.4–22.0]) were identified from the ...

Objective: The authors used longitudinal biobank data with up to 25 years of follow-up on over 2,600 clozapine users to derive reliable estimates of the real-world burden of clozapine adverse drug events (ADEs).Methods: A total of 2,659 participants in the ...

Objective: Antipsychotic effectiveness in preventing relapse declines around menopausal age in women with schizophrenia or schizoaffective disorder (SSD). It is not known whether systemic menopausal hormone therapy (MHT) can help to prevent psychosis ...

Objective: The authors sought to determine whether antipsychotic use, compared with nonuse, is associated with lower work disability in first-episode nonaffective psychosis, and if so, for how long.Methods: A within-subject design was used to study the risk ...