WO2010074992A3 - Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders - Google Patents

Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders Download PDF

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Publication number
WO2010074992A3
WO2010074992A3 PCT/US2009/067552 US2009067552W WO2010074992A3 WO 2010074992 A3 WO2010074992 A3 WO 2010074992A3 US 2009067552 W US2009067552 W US 2009067552W WO 2010074992 A3 WO2010074992 A3 WO 2010074992A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
methods
controlled release
sensory cell
compositions
Prior art date
Application number
PCT/US2009/067552
Other languages
French (fr)
Other versions
WO2010074992A2 (en
Inventor
Jay Lichter
Benedikt Vollrath
Andrew M. Trammel
Sergio G. DURÓN
Fabrice Piu
Luis A. Dellamary
Qiang Ye
Carl Lebel
Michael Christopher Scaife
Jeffrey P. Harris
Original Assignee
Otonomy, Inc.
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0907070A external-priority patent/GB2461962B/en
Priority claimed from US12/504,553 external-priority patent/US8496957B2/en
Application filed by Otonomy, Inc., The Regents Of The University Of California filed Critical Otonomy, Inc.
Priority to CN2009801305625A priority Critical patent/CN102112111A/en
Priority to JP2011542272A priority patent/JP6013736B2/en
Priority to CA2732686A priority patent/CA2732686C/en
Priority to AU2009330458A priority patent/AU2009330458B2/en
Priority to EP09835529.0A priority patent/EP2299976A4/en
Publication of WO2010074992A2 publication Critical patent/WO2010074992A2/en
Publication of WO2010074992A3 publication Critical patent/WO2010074992A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with auris sensory cell modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
PCT/US2009/067552 2008-12-22 2009-12-10 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders WO2010074992A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2009801305625A CN102112111A (en) 2008-12-22 2009-12-10 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
JP2011542272A JP6013736B2 (en) 2008-12-22 2009-12-10 Controlled release of an ear sensory cell modulator composition for the treatment of otic disorders and methods thereof
CA2732686A CA2732686C (en) 2008-12-22 2009-12-10 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
AU2009330458A AU2009330458B2 (en) 2008-12-22 2009-12-10 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
EP09835529.0A EP2299976A4 (en) 2008-12-22 2009-12-10 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US14003308P 2008-12-22 2008-12-22
US61/140,033 2008-12-22
US16023309P 2009-03-13 2009-03-13
US61/160,233 2009-03-13
US16481209P 2009-03-30 2009-03-30
US61/164,812 2009-03-30
GB0907070.7 2009-04-24
GB0907070A GB2461962B (en) 2008-07-25 2009-04-24 Slow release NMDA receptor antagonist for otic disorders
US17442109P 2009-04-30 2009-04-30
US61/174,421 2009-04-30
US12/504,553 US8496957B2 (en) 2008-07-21 2009-07-16 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US12/504,553 2009-07-16

Publications (2)

Publication Number Publication Date
WO2010074992A2 WO2010074992A2 (en) 2010-07-01
WO2010074992A3 true WO2010074992A3 (en) 2010-10-21

Family

ID=42288363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/067552 WO2010074992A2 (en) 2008-12-22 2009-12-10 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders

Country Status (6)

Country Link
EP (1) EP2299976A4 (en)
JP (4) JP6013736B2 (en)
CN (2) CN102112111A (en)
AU (1) AU2009330458B2 (en)
CA (1) CA2732686C (en)
WO (1) WO2010074992A2 (en)

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JP6170047B2 (en) 2011-08-31 2017-07-26 ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド Apoptosis-targeting nanoparticles
ES2669561T3 (en) 2012-02-17 2018-05-28 University Of Georgia Research Foundation, Inc. Nanoparticles for mitochondrial transport of agents
US10398663B2 (en) 2014-03-14 2019-09-03 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
US20170216439A1 (en) * 2014-07-29 2017-08-03 Otonomy, Inc. Otic formulations for the treatment of ceruminosis
US11110175B2 (en) 2015-08-05 2021-09-07 Children's Medical Center Corporation Compositions with permeation enhancers for drug delivery
US20200261417A1 (en) 2016-05-18 2020-08-20 Sound Pharmaceuticals Incorporated Treatment of meniere's disease
KR20190053215A (en) * 2016-09-14 2019-05-17 칠드런'즈 메디컬 센터 코포레이션 Compositions containing penetration enhancers for drug delivery
EP3512523A4 (en) * 2016-09-16 2020-05-06 Viking Therapeutics, Inc. Method of reducing thyroid-associated side effects
BR112019010249A2 (en) 2016-11-21 2019-09-10 Viking Therapeutics Inc glycogen storage disease treatment method
CN110099999B (en) * 2016-12-22 2022-12-27 南京大学 Animal model for hearing loss syndrome and treatment method thereof
BR112019025659A2 (en) 2017-06-05 2020-08-25 Viking Therapeutics, Inc. compositions for the treatment of fibrosis
US11787828B2 (en) 2018-03-22 2023-10-17 Viking Therapeutics, Inc. Crystalline forms and methods of producing crystalline forms of a compound
JPWO2020045162A1 (en) * 2018-08-30 2021-08-12 学校法人慶應義塾 Carrier for drug delivery
WO2020117962A1 (en) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

Citations (3)

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US5292516A (en) * 1990-05-01 1994-03-08 Mediventures, Inc. Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers
US20030092776A1 (en) * 1998-08-04 2003-05-15 Ron Eyal S. End modified thermal responsive hydrogels
US20040101560A1 (en) * 2002-11-27 2004-05-27 Sawchuk Ronald J. Methods and compositions for applying pharmacologic agents to the ear

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EP0551626A1 (en) * 1991-12-19 1993-07-21 LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation
US6998137B2 (en) * 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
US6589549B2 (en) * 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
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US20040101560A1 (en) * 2002-11-27 2004-05-27 Sawchuk Ronald J. Methods and compositions for applying pharmacologic agents to the ear

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Also Published As

Publication number Publication date
CN102112111A (en) 2011-06-29
JP2018138585A (en) 2018-09-06
CN106344495A (en) 2017-01-25
JP6013736B2 (en) 2016-10-25
EP2299976A2 (en) 2011-03-30
AU2009330458B2 (en) 2013-08-22
WO2010074992A2 (en) 2010-07-01
AU2009330458A1 (en) 2010-07-01
JP6207093B2 (en) 2017-10-04
CA2732686A1 (en) 2010-07-01
JP2012513394A (en) 2012-06-14
CA2732686C (en) 2017-10-03
JP2015164943A (en) 2015-09-17
EP2299976A4 (en) 2014-07-23
JP2017160232A (en) 2017-09-14

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