WO2003037930A1 - Novel human n-methyl-d-asparatate (nmda) glutamate receptor polypeptide and gene encoding the same - Google Patents

Novel human n-methyl-d-asparatate (nmda) glutamate receptor polypeptide and gene encoding the same Download PDF

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Publication number
WO2003037930A1
WO2003037930A1 PCT/JP2002/011207 JP0211207W WO03037930A1 WO 2003037930 A1 WO2003037930 A1 WO 2003037930A1 JP 0211207 W JP0211207 W JP 0211207W WO 03037930 A1 WO03037930 A1 WO 03037930A1
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Prior art keywords
nr3a
gene encoding
glutamate receptor
nmda
human
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PCT/JP2002/011207
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French (fr)
Japanese (ja)
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WO2003037930A8 (en
Inventor
Hiroshi Mori
Osamu Ohara
Takahiro Nagase
Reiko Kikuno
Keiji Yamagami
Yoshitaka Ohashi
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Kazusa Dna Research Institute Foundation
Mitsubishi Pharma Corporation
Iritani, Shuji
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Application filed by Kazusa Dna Research Institute Foundation, Mitsubishi Pharma Corporation, Iritani, Shuji filed Critical Kazusa Dna Research Institute Foundation
Priority to JP2003540211A priority Critical patent/JPWO2003037930A1/en
Publication of WO2003037930A1 publication Critical patent/WO2003037930A1/en
Publication of WO2003037930A8 publication Critical patent/WO2003037930A8/en

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    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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    • G01—MEASURING; TESTING
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract

It is intended to find out a novel substance relating to human NMDA glutamate receptor subunit 3A (NR3A). A novel cDNA originating in human brain is isolated and the full base sequence thereof is analyzed. Then this base sequence is translated into an amino acid sequence followed by homology searching. As a result, it is found out that this sequence has a 93% homology with rat NR3A and thus identified as human NR3A. Further, it is confirmed that a gene encoding NR3A is significantly increased in the brain of patients with schizophrenia. Thus, it is concluded that NR3A is a substance relating to the pathology of schizophrenia.
PCT/JP2002/011207 2001-10-29 2002-10-29 Novel human n-methyl-d-asparatate (nmda) glutamate receptor polypeptide and gene encoding the same WO2003037930A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003540211A JPWO2003037930A1 (en) 2001-10-29 2002-10-29 Novel human N-methyl-D-aspartate (NMDA) glutamate receptor polypeptide and gene encoding the same

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001331007 2001-10-29
JP2001-331007 2001-10-29
JP2001333258 2001-10-30
JP2001-333258 2001-10-30
JP2001-345262 2001-11-09
JP2001345262 2001-11-09

Publications (2)

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WO2003037930A1 true WO2003037930A1 (en) 2003-05-08
WO2003037930A8 WO2003037930A8 (en) 2004-06-03

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PCT/JP2002/011207 WO2003037930A1 (en) 2001-10-29 2002-10-29 Novel human n-methyl-d-asparatate (nmda) glutamate receptor polypeptide and gene encoding the same

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JP (1) JPWO2003037930A1 (en)
WO (1) WO2003037930A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2001044473A2 (en) * 1999-12-14 2001-06-21 Curagen Corporation Polypeptides and nucleic acids encoding same
WO2001081413A2 (en) * 2000-04-27 2001-11-01 Pe Corporation (Ny) Isolated human transporter proteins, nucleic acids and uses thereof
WO2002012340A2 (en) * 2000-08-03 2002-02-14 Incyte Genomics, Inc. Transporters and ion channels
WO2002024743A2 (en) * 2000-09-19 2002-03-28 Millennium Pharmaceuticals, Inc. 55063, a human nmda family member and uses thereof
WO2002040538A2 (en) * 2000-11-17 2002-05-23 Bayer Aktiengesellschaft Regulation of human nmda receptor

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2001044473A2 (en) * 1999-12-14 2001-06-21 Curagen Corporation Polypeptides and nucleic acids encoding same
WO2001081413A2 (en) * 2000-04-27 2001-11-01 Pe Corporation (Ny) Isolated human transporter proteins, nucleic acids and uses thereof
WO2002012340A2 (en) * 2000-08-03 2002-02-14 Incyte Genomics, Inc. Transporters and ion channels
WO2002024743A2 (en) * 2000-09-19 2002-03-28 Millennium Pharmaceuticals, Inc. 55063, a human nmda family member and uses thereof
WO2002040538A2 (en) * 2000-11-17 2002-05-23 Bayer Aktiengesellschaft Regulation of human nmda receptor

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANDERSSON O. ET AL.: "Nucleotide sequence, genomic organization and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B", GENOMICS, vol. 78, no. 3, December 2001 (2001-12-01), pages 178 - 184, XP002962975 *
DAS S. ET AL.: "Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A", NATURE, vol. 393, no. 6683, 28 May 1998 (1998-05-28), pages 377 - 381, XP002962970 *
ERIKSSON M. ET AL.: "Cloning and expression of the human N-methyl-D-aspartate receptor subunit NR3A", NEUROSCIENCE LETTERS, vol. 321, no. 3, 2002, pages 177 - 181, XP002962977 *
GOEBEL D.J. ET AL.: "NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A", MOL. BRAIN RES., vol. 69, no. 2, 8 June 1999 (1999-06-08), pages 164 - 170, XP002962971 *
PEREZ-OTANO I. ET AL.: "Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors", J. NEUROSCI., vol. 21, no. 4, 15 February 2001 (2001-02-15), pages 1228 - 1237, XP002962972 *
SASAKI Y.F. ET AL.: "Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons", J. NEUROPHYSIOL., vol. 87, no. 4, April 2002 (2002-04-01), pages 2052 - 2063, XP002962976 *
SUCHER N.J. ET AL.: "Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain", J. NEUROSCI., vol. 15, no. 10, October 1995 (1995-10-01), pages 6509 - 6520, XP001061256 *
TU S. ET AL.: "Generation of NR3A transgenic mice", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 2, 2001, pages 1850, XP002962974 *
VON EULER G. ET AL.: "Nucleotide sequence, genomic organization and chromosomal localization of the human NMDA receptor subunit NR3A", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, pages 920, XP002962973 *

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WO2003037930A8 (en) 2004-06-03

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