WO1995015982A3 - Process for generating specific antibodies - Google Patents

Process for generating specific antibodies Download PDF

Info

Publication number
WO1995015982A3
WO1995015982A3 PCT/US1994/014106 US9414106W WO9515982A3 WO 1995015982 A3 WO1995015982 A3 WO 1995015982A3 US 9414106 W US9414106 W US 9414106W WO 9515982 A3 WO9515982 A3 WO 9515982A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
variable regions
generating
specific antibodies
antibody variable
Prior art date
Application number
PCT/US1994/014106
Other languages
French (fr)
Other versions
WO1995015982A2 (en
Inventor
Gary Barsomian
Diane P Copeland
Dana Hillhouse
Tracy Johnson
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Priority to AU14321/95A priority Critical patent/AU696293B2/en
Priority to EP95905871A priority patent/EP0733070A1/en
Priority to JP7516337A priority patent/JPH09506262A/en
Publication of WO1995015982A2 publication Critical patent/WO1995015982A2/en
Publication of WO1995015982A3 publication Critical patent/WO1995015982A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a method for generating an antibody which is specific for an immunorecessive epitope, and nucleic acid encoding the antibody. The subject method generally comprises the steps of generating a variegated display library of antibody variable regions, and selecting from the library those antibody variable regions which have a desired binding specificity for the immunorecessive epitope. The antibody variable regions used to generate the display library are cloned from an immunotolerance-derived antibody repertoire.
PCT/US1994/014106 1993-12-08 1994-12-08 Process for generating specific antibodies WO1995015982A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU14321/95A AU696293B2 (en) 1993-12-08 1994-12-08 Process for generating specific antibodies
EP95905871A EP0733070A1 (en) 1993-12-08 1994-12-08 Process for generating specific antibodies
JP7516337A JPH09506262A (en) 1993-12-08 1994-12-08 Method for producing specific antibody

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16402293A 1993-12-08 1993-12-08
US08/164,022 1993-12-08
US35040094A 1994-12-06 1994-12-06
US08/350,400 1994-12-06

Publications (2)

Publication Number Publication Date
WO1995015982A2 WO1995015982A2 (en) 1995-06-15
WO1995015982A3 true WO1995015982A3 (en) 1995-12-28

Family

ID=26860180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/014106 WO1995015982A2 (en) 1993-12-08 1994-12-08 Process for generating specific antibodies

Country Status (4)

Country Link
EP (1) EP0733070A1 (en)
JP (1) JPH09506262A (en)
AU (1) AU696293B2 (en)
WO (1) WO1995015982A2 (en)

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