US20060134147A1 - Cosmetic compositions having carnitine creatinate and methods for using - Google Patents

Cosmetic compositions having carnitine creatinate and methods for using Download PDF

Info

Publication number
US20060134147A1
US20060134147A1 US11/018,901 US1890104A US2006134147A1 US 20060134147 A1 US20060134147 A1 US 20060134147A1 US 1890104 A US1890104 A US 1890104A US 2006134147 A1 US2006134147 A1 US 2006134147A1
Authority
US
United States
Prior art keywords
composition
skin
present
carnitine creatinate
carnitine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/018,901
Inventor
Robert Kalafsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avon Products Inc
Original Assignee
Avon Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avon Products Inc filed Critical Avon Products Inc
Priority to US11/018,901 priority Critical patent/US20060134147A1/en
Assigned to AVON PRODUCTS INC. reassignment AVON PRODUCTS INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KALAFSKY, ROBERT E.
Priority to EP05826087A priority patent/EP1827360A4/en
Priority to PCT/US2005/040480 priority patent/WO2006068715A2/en
Publication of US20060134147A1 publication Critical patent/US20060134147A1/en
Priority to US11/880,167 priority patent/US7763655B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/06Preparations for care of the skin for countering cellulitis

Definitions

  • the present invention relates to a topical composition that improves the aesthetic appearance of skin.
  • the present invention also relates to a topical composition that inhibits induced lipid synthesis in skin.
  • the present invention further relates to a topical composition that inhibits the formation of cellulite in skin.
  • Fat may build up underneath the surface of the skin due to induced lipid synthesis in the adipose layer of the skin.
  • the buildup may take the form of a multiplicity of small but recognizable pockets of fat underneath the surface of the skin. Such buildup is commonly referred to as cellulite.
  • Cellulite may impart an unnatural appearance to the skin. Skin can appear lumpy and discontinuous.
  • topical composition that inhibited induced lipid synthesis in the skin. It would also be desirable to have a topical composition that inhibited the formation of cellulite in skin. It would further be desirable to have a topical composition that improves the aesthetic appearance of skin.
  • the active ingredient in the composition is carnitine creatinate.
  • Carnitine creatinate is represented by the following structure:
  • X is an integer of 0 to about 5.
  • Carnitine creatinate is a salt of the acid-base reaction between carnitine and creatine.
  • Carnitine creatinate is available commercially as a 100% active from American International Chemical, Inc.
  • Carnitine creatinate is further described in U.S. Pat. No. 5,994,581, which is incorporated herein by reference in its entirety.
  • the carnitine creatinate is present in an amount effective to improve the aesthetic appearance of skin.
  • the carnitine creatinate may also be present in an amount effective to inhibit induced lipid synthesis.
  • the carnitine creatinate may further be present in an amount effective to inhibit formation of cellulite.
  • the carnitine creatinate is present at about 0.01 wt % to about 25 wt % based on the total weight of the composition. More preferably, the carnitine creatinate is present at about 0.05 wt % to about 10 wt %. Most preferably, the carnitine creatinate is present at about 0.1 wt % to about 5 wt %.
  • compositions useful in the present method have a vehicle that is pharmaceutically or cosmetically acceptable.
  • vehicles include, but are not limited to, one or more lower alcohols, fatty alcohols, fatty ethers, fatty esters, isododecane, polyols, glycols, liposomes, laminar lipid materials, water, or any combinations thereof.
  • the composition may take any product form known in the art.
  • Useful forms include, but are not limited to, aerosol spray, cream, lotion, gel, foam, ointment, mask, mousse, patch, powder, pump spray, stick, tape, towelette, and pomade.
  • Liquid forms of the composition may be any type, such as a solution, suspension, dispersion, or emulsion.
  • Useful emulsion forms include oil-in-water, water-in-oil, silicone-in-water, water-in-silicone, and triple emulsions.
  • the composition may be aqueous or anhydrous.
  • Compositions may also include one or more of the following optional ingredients: amino acids, anesthetics, anti-acne agents, anti-allergenics, antifungals, antimicrobials, anti-inflammatory agents, anti-irritants, antioxidants, antiseptics, antivirals, chelating agents, colorants, depigmenting agents, emollients, emulsifiers, exfoliants, for example, ⁇ -hydroxy acids such as lactic acid and glycolic acid, ⁇ -hydroxy acids, sugar acids, oxa acids, and oxa diacids, film formers, fragrances, humectants, hyper- and hypopigmenting agents, self-tanning agents, insect repellents, lubricants, moisturizers, peptides, pharmaceutical agents, photostabilizing agents, preservatives, retinoids, vitamins and vitamin derivatives such as niacin (nicotinic acid) and ascorbic acid and its derivatives, salicylic acid, skin protectants, skin penetration enhance
  • composition is also useful in preventing, ameliorating or treating acne; preventing, ameliorating or treating oily skin; preventing, ameliorating or treating oily hair; preventing, ameliorating or treating oily scalp; preventing, ameliorating or treating skin blemishes; preventing, ameliorating or treating skin breakouts; and improving skin texture.
  • the composition may be applied to the skin one or more times per day as needed or desired. If desired, the composition may be applied twice or more per day. Generally, the composition is applied as often as needed to impart and maintain a desirable aesthetic appearance to the skin or to maintain a skin appearance substantially free of cellulite. Typically, beneficial results are observed following daily application of the topical composition for a period of one week, preferably two weeks, especially four weeks, and most preferably after eight weeks.
  • hydrogel patch that incorporates the carnitine creatinate, which is admixed with the hydrogel base.
  • the patch can be affixed to an area of the skin of the user in need of fat reduction, for example, the inner thigh of the user.
  • the patch is applied to the skin for a period of time effective for treatment, e.g., four or more hours per day for one day or two days, after which time the patch is removed.
  • a second patch is then affixed, and the process is repeated over an extended period of time, i.e., about four weeks, preferably eight weeks, and most preferably 12 weeks.
  • compositions of the present invention in gel (Composition A) and cream (Composition B) forms are prepared. Ingredients of the compositions are set forth in Table 1 below. TABLE 1 Composition A (Gel) Composition B (Cream) Ingredients (Wt. %) (Wt. %) Carnitine creatinate 0.1-5.0 0.1-5.0 Glycerin 3.0-5.0 3.0-7.0 Propylene glycol 1.0-3.0 Thickener 0.5-1.0 0.5-1.0 Ethanol 0.1-5.0 Emulsifier 1.0-10.0 Oil 1.0-10.0 Ester 1.0-10.0 Wax 0.1-5.0 Silicone oil 0.1-5.0 Powder 0.0-2.0 Preservative 0.1-0.7 0.1-0.7 Water QS 100.0% QS 100.0% QS 100.0%
  • Composition A is prepared by admixing the ingredients together at 25° C. to 30° C. and allowing the mixture to thicken to form a gel.
  • Composition B is made by forming an aqueous phase premix of water and water soluble components, which premix is heated to 80° C. and an oil phase premix of oil, silicone, wax, ester components, and an emulsifier, which premix is heated to 80° C. The oil phase is then blended with the water phase, and cooled to room temperature.
  • Compositions A and B are applied to areas of the body in need of fat reduction, in particular to the arms, thighs, and buttocks. Compositions A and B are applied daily for a period of time, typically about eight weeks, to effect an improvement in the appearance of the skin, in particular, an observable reduction in fat density, circumference and the unwanted appearance of cellulite.
  • a hydrogel patch is prepared by premixing the carnitine creatinate and the hydrogel base.
  • the patch is affixed to the area of the skin of the user in need of fat reduction, for example, the inner thigh of the user.
  • the patch is removed after 1 to 2 days and a second patch is then affixed. The process is then repeated over a period of eight weeks.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

There is a topical composition having carnitine creatinate and a cosmetically acceptable vehicle. There is also provided a method for improving the aesthetic appearance of skin. There is also provided a method for inhibiting the induced lipid synthesis in skin. There is also provided a method for inhibiting the formation of cellulite in skin.

Description

    BACKGROUND OF THE INVENTION
  • 1. Field of the Invention
  • The present invention relates to a topical composition that improves the aesthetic appearance of skin. The present invention also relates to a topical composition that inhibits induced lipid synthesis in skin. The present invention further relates to a topical composition that inhibits the formation of cellulite in skin.
  • 2. Description of the Related Art
  • Fat may build up underneath the surface of the skin due to induced lipid synthesis in the adipose layer of the skin. The buildup may take the form of a multiplicity of small but recognizable pockets of fat underneath the surface of the skin. Such buildup is commonly referred to as cellulite. Cellulite may impart an unnatural appearance to the skin. Skin can appear lumpy and discontinuous.
  • It would be desirable to have a topical composition that inhibited induced lipid synthesis in the skin. It would also be desirable to have a topical composition that inhibited the formation of cellulite in skin. It would further be desirable to have a topical composition that improves the aesthetic appearance of skin.
  • SUMMARY OF THE INVENTION
  • It is an object of the present invention to provide a topical composition that improves the aesthetic appearance of skin.
  • It is another object of the present invention to provide a topical composition that inhibits the induced lipid synthesis in skin.
  • It is still another object of the present invention to provide a topical composition that inhibits the formation of cellulite in skin.
  • It is yet another object of the present invention to provide a topical composition having carnitine creatinate and a cosmetically acceptable vehicle.
  • It is a further object of the present invention to provide a method for improving the aesthetic appearance of skin by providing a composition having a cosmetically acceptable vehicle and an effective amount of carnitine creatinate that is topically applied to the skin.
  • It is yet a further object of the present invention to provide a method for inhibiting induced lipid synthesis in skin by providing a composition having a cosmetically acceptable vehicle and an effective amount of carnitine creatinate that is topically applied to the skin.
  • It is still yet a further object of the present invention to provide also a method for inhibiting the formation of cellulite in skin by providing a composition having a cosmetically acceptable vehicle and an effective amount of carnitine creatinate that is topically applied to the skin.
  • DETAILED DESCRIPTION OF THE INVENTION
  • The active ingredient in the composition is carnitine creatinate. Carnitine creatinate is represented by the following structure:
    Figure US20060134147A1-20060622-C00001
  • wherein X is an integer of 0 to about 5.
  • Carnitine creatinate is a salt of the acid-base reaction between carnitine and creatine. Carnitine creatinate is available commercially as a 100% active from American International Chemical, Inc. Carnitine creatinate is further described in U.S. Pat. No. 5,994,581, which is incorporated herein by reference in its entirety.
  • The carnitine creatinate is present in an amount effective to improve the aesthetic appearance of skin. The carnitine creatinate may also be present in an amount effective to inhibit induced lipid synthesis. The carnitine creatinate may further be present in an amount effective to inhibit formation of cellulite. Preferably, the carnitine creatinate is present at about 0.01 wt % to about 25 wt % based on the total weight of the composition. More preferably, the carnitine creatinate is present at about 0.05 wt % to about 10 wt %. Most preferably, the carnitine creatinate is present at about 0.1 wt % to about 5 wt %.
  • Compositions useful in the present method have a vehicle that is pharmaceutically or cosmetically acceptable. Such vehicles include, but are not limited to, one or more lower alcohols, fatty alcohols, fatty ethers, fatty esters, isododecane, polyols, glycols, liposomes, laminar lipid materials, water, or any combinations thereof.
  • The composition may take any product form known in the art. Useful forms include, but are not limited to, aerosol spray, cream, lotion, gel, foam, ointment, mask, mousse, patch, powder, pump spray, stick, tape, towelette, and pomade. Liquid forms of the composition may be any type, such as a solution, suspension, dispersion, or emulsion. Useful emulsion forms include oil-in-water, water-in-oil, silicone-in-water, water-in-silicone, and triple emulsions. The composition may be aqueous or anhydrous.
  • Compositions may also include one or more of the following optional ingredients: amino acids, anesthetics, anti-acne agents, anti-allergenics, antifungals, antimicrobials, anti-inflammatory agents, anti-irritants, antioxidants, antiseptics, antivirals, chelating agents, colorants, depigmenting agents, emollients, emulsifiers, exfoliants, for example, α-hydroxy acids such as lactic acid and glycolic acid, β-hydroxy acids, sugar acids, oxa acids, and oxa diacids, film formers, fragrances, humectants, hyper- and hypopigmenting agents, self-tanning agents, insect repellents, lubricants, moisturizers, peptides, pharmaceutical agents, photostabilizing agents, preservatives, retinoids, vitamins and vitamin derivatives such as niacin (nicotinic acid) and ascorbic acid and its derivatives, salicylic acid, skin protectants, skin penetration enhancers, staining agents, sunscreens, stabilizers, surfactants, thickeners, viscosity and/or rheology modifiers, or any combinations thereof.
  • The composition is also useful in preventing, ameliorating or treating acne; preventing, ameliorating or treating oily skin; preventing, ameliorating or treating oily hair; preventing, ameliorating or treating oily scalp; preventing, ameliorating or treating skin blemishes; preventing, ameliorating or treating skin breakouts; and improving skin texture.
  • The composition may be applied to the skin one or more times per day as needed or desired. If desired, the composition may be applied twice or more per day. Generally, the composition is applied as often as needed to impart and maintain a desirable aesthetic appearance to the skin or to maintain a skin appearance substantially free of cellulite. Typically, beneficial results are observed following daily application of the topical composition for a period of one week, preferably two weeks, especially four weeks, and most preferably after eight weeks.
  • In another aspect of the invention, there is a hydrogel patch that incorporates the carnitine creatinate, which is admixed with the hydrogel base. The patch can be affixed to an area of the skin of the user in need of fat reduction, for example, the inner thigh of the user. The patch is applied to the skin for a period of time effective for treatment, e.g., four or more hours per day for one day or two days, after which time the patch is removed. A second patch is then affixed, and the process is repeated over an extended period of time, i.e., about four weeks, preferably eight weeks, and most preferably 12 weeks.
  • In view of the foregoing, it is surprising that the aesthetic appearance of the skin can be improved by the topical application of the compositions of the present invention. It is further surprising that induced lipid synthesis in the skin can also be inhibited by the topical application of the compositions of the present invention. It is still further surprising that the formation of cellulite can be inhibited by such topical application.
  • The following are examples of the present invention. Unless otherwise indicated, all percentages or parts are by weight.
  • EXAMPLES Examples 1 and 2
  • Compositions of the present invention in gel (Composition A) and cream (Composition B) forms are prepared. Ingredients of the compositions are set forth in Table 1 below.
    TABLE 1
    Composition A (Gel) Composition B (Cream)
    Ingredients (Wt. %) (Wt. %)
    Carnitine creatinate 0.1-5.0 0.1-5.0
    Glycerin 3.0-5.0 3.0-7.0
    Propylene glycol 1.0-3.0
    Thickener 0.5-1.0 0.5-1.0
    Ethanol 0.1-5.0
    Emulsifier  1.0-10.0
    Oil  1.0-10.0
    Ester  1.0-10.0
    Wax 0.1-5.0
    Silicone oil 0.1-5.0
    Powder 0.0-2.0
    Preservative 0.1-0.7 0.1-0.7
    Water QS 100.0% QS 100.0%
  • Composition A is prepared by admixing the ingredients together at 25° C. to 30° C. and allowing the mixture to thicken to form a gel.
  • Composition B is made by forming an aqueous phase premix of water and water soluble components, which premix is heated to 80° C. and an oil phase premix of oil, silicone, wax, ester components, and an emulsifier, which premix is heated to 80° C. The oil phase is then blended with the water phase, and cooled to room temperature.
  • Compositions A and B are applied to areas of the body in need of fat reduction, in particular to the arms, thighs, and buttocks. Compositions A and B are applied daily for a period of time, typically about eight weeks, to effect an improvement in the appearance of the skin, in particular, an observable reduction in fat density, circumference and the unwanted appearance of cellulite.
  • Example 3
  • A hydrogel patch is prepared by premixing the carnitine creatinate and the hydrogel base. The patch is affixed to the area of the skin of the user in need of fat reduction, for example, the inner thigh of the user. The patch is removed after 1 to 2 days and a second patch is then affixed. The process is then repeated over a period of eight weeks.
  • It should be understood that the foregoing description is only illustrative of the present invention. Various alternatives and modifications can be devised by those skilled in the art without departing from the invention. Accordingly, the present invention is intended to embrace all such alternatives, modifications and variances that fall within the scope of the appended claims.

Claims (18)

1. A topical composition, comprising:
carnitine creatinate; and
a cosmetically acceptable vehicle.
2. The composition of claim 1, wherein the carnitine creatinate is present in an amount effective to improve the aesthetic appearance of skin.
3. The composition of claim 1, wherein the carnitine creatinate is present in an amount effective to inhibit induced lipid synthesis in skin.
4. The composition of claim 1, wherein the carnitine creatinate is present in an amount effective to inhibit cellulite formation in skin.
5. The composition of claim 1, wherein the carnitine creatinate is present at about 0.01 wt % to about 25 wt % based on the total weight of the composition.
6. The composition of claim 1, wherein the carnitine creatinate is present at about 0.05 wt % to about 10 wt % based on the total weight of the composition.
7. The composition of claim 1, wherein the carnitine creatinate is present at about 0.1 wt % to about 5 wt % based on the total weight of the composition.
8. A method for improving the aesthetic appearance of skin, comprising: topically applying to the skin a composition having a cosmetically acceptable vehicle and an effective amount of carnitine creatinate.
9. The method of claim 8, wherein the carnitine creatinate is present at about 0.01 wt % to about 25 wt % based on the total weight of the composition.
10. The method of claim 8, wherein the carnitine creatinate is present at about 0.05 wt % to about 10 wt % based on the total weight of the composition.
11. The method of claim 8, wherein the carnitine creatinate is present at about 0.1 wt % to about 5 wt % based on the total weight of the composition.
12. The method of claim 8, wherein the vehicle has an adjuvant selected from the group consisting of one or more lower alcohols, fatty alcohols, fatty ethers, fatty esters, isododecane, polyols, glycols, liposomes, laminar lipid materials, water, and any combinations thereof.
13. The method of claim 8, wherein the composition is in the form of a product selected from the group consisting of aerosol spray, cream, lotion, gel, foam, ointment, mask, mousse, patch, powder, pump spray, stick, tape, towelette, patch, and pomade.
14. The method of claim 8, further comprising one or more optional ingredients selected from the group consisting of amino acids, anesthetics, anti-acne agents, anti-allergenics, antifungals, antimicrobials, anti-inflammatory agents, anti-irritants, antioxidants, antiseptics, antivirals, chelating agents, colorants, hyperpigmenting agents, self-tanning agents, emollients, emulsifiers, exfoliants, film formers, fragrances, humectants, hypopigmenting agents, insect repellents, lubricants, moisturizers, pharmaceutical agents, peptides, vitamins and vitamin derivatives, photostabilizing agents, preservatives, retinoids, skin protectants, skin penetration enhancers, staining agents, sunscreens, stabilizers, surfactants, thickeners, viscosity and/or rheology modifiers, and any combinations thereof.
15. A method for inhibiting the induced lipid synthesis in skin, comprising: topically applying to the skin a composition having a cosmetically acceptable vehicle and an effective amount of carnitine creatinate.
16. The method of claim 15, wherein the carnitine creatinate is present at about 0.01 wt % to about 25 wt % based on the total weight of the composition.
17. A method for inhibiting the formation of cellulite in skin, comprising: topically applying to the skin a composition having a cosmetically acceptable vehicle and an effective amount of carnitine creatinate.
18. The method of claim 17, wherein the carnitine creatinate is present at about 0.01 wt % to about 25 wt % based on the total weight of the composition.
US11/018,901 2004-12-21 2004-12-21 Cosmetic compositions having carnitine creatinate and methods for using Abandoned US20060134147A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/018,901 US20060134147A1 (en) 2004-12-21 2004-12-21 Cosmetic compositions having carnitine creatinate and methods for using
EP05826087A EP1827360A4 (en) 2004-12-21 2005-11-08 Cosmetic compositions having carnitine creatinate and methods for using
PCT/US2005/040480 WO2006068715A2 (en) 2004-12-21 2005-11-08 Cosmetic compositions having carnitine creatinate and methods for using
US11/880,167 US7763655B2 (en) 2004-12-21 2007-07-20 Cosmetic compositions having carnitine creatinate and methods for using

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/018,901 US20060134147A1 (en) 2004-12-21 2004-12-21 Cosmetic compositions having carnitine creatinate and methods for using

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/880,167 Continuation US7763655B2 (en) 2004-12-21 2007-07-20 Cosmetic compositions having carnitine creatinate and methods for using

Publications (1)

Publication Number Publication Date
US20060134147A1 true US20060134147A1 (en) 2006-06-22

Family

ID=36596083

Family Applications (2)

Application Number Title Priority Date Filing Date
US11/018,901 Abandoned US20060134147A1 (en) 2004-12-21 2004-12-21 Cosmetic compositions having carnitine creatinate and methods for using
US11/880,167 Expired - Fee Related US7763655B2 (en) 2004-12-21 2007-07-20 Cosmetic compositions having carnitine creatinate and methods for using

Family Applications After (1)

Application Number Title Priority Date Filing Date
US11/880,167 Expired - Fee Related US7763655B2 (en) 2004-12-21 2007-07-20 Cosmetic compositions having carnitine creatinate and methods for using

Country Status (3)

Country Link
US (2) US20060134147A1 (en)
EP (1) EP1827360A4 (en)
WO (1) WO2006068715A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043312A1 (en) * 2003-07-25 2005-02-24 Shea Thomas B. Formulations for reducing neuronal degeneration
US20080038300A1 (en) * 2005-05-13 2008-02-14 Beiersdorf Ag Self-Adhesive Skin Patch and Combination Set for Cosmetic Skin Care
WO2009046819A2 (en) * 2007-10-01 2009-04-16 Beiersdorf Ag Method for reducing signs of ageing on skin
US20090110745A1 (en) * 2007-10-31 2009-04-30 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20150713A1 (en) 2012-10-09 2015-05-16 Sigma Tau Ind Farmaceuti MODIFIED HYALURONIC ACID DERIVATIVES AND THE USE OF THEM
US9345659B2 (en) * 2012-12-11 2016-05-24 Avon Products, Inc. Use of melicope extracts to improve conditions caused by excess lipids
TW201422250A (en) * 2012-12-11 2014-06-16 Avon Prod Inc Use of nesprin-2 expression modulators and compositions thereof
WO2018067844A1 (en) 2016-10-06 2018-04-12 Mivi Neuroscience, Inc. Hydraulic displacement and removal of thrombus clots, and catheters for performing hydraulic displacement

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994581A (en) * 1998-03-09 1999-11-30 Amt Labs, Inc. Carnitine creatinate
US20020044913A1 (en) * 2000-02-11 2002-04-18 Hamilton Nathan D. Cosmetics to support skin metabolism
US20020106388A1 (en) * 2000-11-24 2002-08-08 Pugliese Peter T. Formulation of flavones and isoflavones for treatment of cellulite
US6432424B1 (en) * 2000-06-29 2002-08-13 Johnson & Johnson Consumer Companies, Inc. Cosmetic compositions containing creatine, carnitine, and/or pyruvic acid
US20030215506A1 (en) * 2002-05-17 2003-11-20 Kuhrts Eric H Methods and compositions for enhancement of creatine transport
US6653504B1 (en) * 1999-09-03 2003-11-25 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same
US20040029969A1 (en) * 2000-07-06 2004-02-12 Beiersdorf Ag Use of creatine or creatine derivatives in cosmetic or dematological preparations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2619007B1 (en) * 1987-08-07 1990-09-28 Dermatologiques Et COSMETIC PREPARATIONS WITH LIPOLYTIC ACTION
FR2694195B1 (en) 1992-07-30 1994-09-23 Sederma Sa New slimming cosmetic compositions.
JP4182183B2 (en) 1999-08-24 2008-11-19 ディーエスエム アイピー アセッツ ビー.ブイ. Slimming skin cosmetics
AU2001238511A1 (en) 2000-08-07 2002-02-18 Juvenon, Inc. Cosmetics to support skin metabolism
DE10056400A1 (en) * 2000-11-14 2002-05-23 Merck Patent Gmbh Galenic formulation
ITMI20030315A1 (en) * 2003-02-21 2004-08-22 Vama Farmacosmetica S R L SALT OF CARNITINA, PRELIPOSOME CONTAINING IT AND DERMOCOSMETIC FORMULATION FOR TOPICAL USE BASED ON THE SAID CARNITINA SALT.

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994581A (en) * 1998-03-09 1999-11-30 Amt Labs, Inc. Carnitine creatinate
US6653504B1 (en) * 1999-09-03 2003-11-25 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same
US20020044913A1 (en) * 2000-02-11 2002-04-18 Hamilton Nathan D. Cosmetics to support skin metabolism
US6432424B1 (en) * 2000-06-29 2002-08-13 Johnson & Johnson Consumer Companies, Inc. Cosmetic compositions containing creatine, carnitine, and/or pyruvic acid
US20040029969A1 (en) * 2000-07-06 2004-02-12 Beiersdorf Ag Use of creatine or creatine derivatives in cosmetic or dematological preparations
US20020106388A1 (en) * 2000-11-24 2002-08-08 Pugliese Peter T. Formulation of flavones and isoflavones for treatment of cellulite
US20030215506A1 (en) * 2002-05-17 2003-11-20 Kuhrts Eric H Methods and compositions for enhancement of creatine transport

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043312A1 (en) * 2003-07-25 2005-02-24 Shea Thomas B. Formulations for reducing neuronal degeneration
US8173618B2 (en) 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
US20080038300A1 (en) * 2005-05-13 2008-02-14 Beiersdorf Ag Self-Adhesive Skin Patch and Combination Set for Cosmetic Skin Care
US8101216B2 (en) 2005-05-13 2012-01-24 Beiersdorf Ag Self-adhesive skin patch and combination set for cosmetic skin care
WO2009046819A2 (en) * 2007-10-01 2009-04-16 Beiersdorf Ag Method for reducing signs of ageing on skin
WO2009046819A3 (en) * 2007-10-01 2009-08-06 Beiersdorf Ag Method for reducing signs of ageing on skin
US20090110745A1 (en) * 2007-10-31 2009-04-30 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
US8597640B2 (en) 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging

Also Published As

Publication number Publication date
US20070264205A1 (en) 2007-11-15
WO2006068715A2 (en) 2006-06-29
EP1827360A2 (en) 2007-09-05
US7763655B2 (en) 2010-07-27
WO2006068715A3 (en) 2006-11-23
EP1827360A4 (en) 2009-03-04

Similar Documents

Publication Publication Date Title
US7763655B2 (en) Cosmetic compositions having carnitine creatinate and methods for using
US9750750B2 (en) Compositions and methods for stimulating hair growth
EP2376198B1 (en) A composition comprising a retinoid and method of treating skin conditions
JP5572318B2 (en) Arginine heteromer for topical administration
US20180177703A1 (en) Niacinamide Mononucleotide Formulations For Skin Aging
AU2010248292B2 (en) Composition for preventing hair loss or for stimulating hair growth
JP2002255725A (en) Treatment of skin
US20220183947A1 (en) Cosmetic Compositions Comprising Sucrose Esters And Solvents
JP2023543917A (en) Hair, scalp and skin treatment compositions
US12090223B2 (en) Method of manufacturing cosmetic compositions comprising sucrose esters and solvents
KR101734801B1 (en) Methods of reducing signs of skin aging using a combination of extracts
KR101734802B1 (en) Topical composition including a combination of extracts for reducing signs of skin aging
US11020334B2 (en) Compounds, compositions and use thereof
JPH08268866A (en) Dermal preparation for external use
JP2000063255A (en) Preparation for external use for skin
WO2024056566A1 (en) Use of thioethylamine composition for skin rejuvenation and improved synergistic effect when combined with an organic acid and/or azabenzene-4-carboxamide
JPH10245393A (en) Composition containing triterpenes
CN114727928A (en) Composition for inducing and promoting change of environment around aged skin cells
WO2013180229A1 (en) Composition for hair growth
CN113194910A (en) Cosmetic composition for skin regeneration
JP2000256163A (en) Skin lotion
JP2001199805A (en) Antiseptic mildewproofing agent and composition for external use formulated with the same
JP2001122739A (en) Hair tonic
JP2002114645A (en) Hair tonic
JPH11279032A (en) Antidandruff agent composition

Legal Events

Date Code Title Description
AS Assignment

Owner name: AVON PRODUCTS INC., NEW YORK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KALAFSKY, ROBERT E.;REEL/FRAME:016117/0248

Effective date: 20041216

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION