SE9504661D0 - New compounds - Google Patents

New compounds

Info

Publication number
SE9504661D0
SE9504661D0 SE9504661A SE9504661A SE9504661D0 SE 9504661 D0 SE9504661 D0 SE 9504661D0 SE 9504661 A SE9504661 A SE 9504661A SE 9504661 A SE9504661 A SE 9504661A SE 9504661 D0 SE9504661 D0 SE 9504661D0
Authority
SE
Sweden
Prior art keywords
new compounds
formula
compounds
novel compounds
pain
Prior art date
Application number
SE9504661A
Other languages
Swedish (sv)
Inventor
Edward Roberts
Niklas Plobeck
Claes Wahlestedt
Original Assignee
Astra Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Inc filed Critical Astra Pharma Inc
Priority to SE9504661A priority Critical patent/SE9504661D0/en
Publication of SE9504661D0 publication Critical patent/SE9504661D0/en
Priority to UA98074034A priority patent/UA71538C2/en
Priority to ZA9610352A priority patent/ZA9610352B/en
Priority to KR1020057003491A priority patent/KR20050047534A/en
Priority to RU2002106503/04A priority patent/RU2307833C2/en
Priority to CA002239174A priority patent/CA2239174C/en
Priority to CN96180102A priority patent/CN1119336C/en
Priority to AU12162/97A priority patent/AU715547B2/en
Priority to RU98113786/04A priority patent/RU2194702C2/en
Priority to JP09523557A priority patent/JP2000502679A/en
Priority to KR10-1998-0704757A priority patent/KR100493832B1/en
Priority to IL124996A priority patent/IL124996A/en
Priority to BR9612204A priority patent/BR9612204A/en
Priority to PL327403A priority patent/PL193061B1/en
Priority to NZ324887A priority patent/NZ324887A/en
Priority to PCT/SE1996/001635 priority patent/WO1997023466A1/en
Priority to HU9901304A priority patent/HUP9901304A3/en
Priority to US08/836,830 priority patent/US6130222A/en
Priority to EE9800194A priority patent/EE04640B1/en
Priority to CZ0176898A priority patent/CZ296159B6/en
Priority to SK822-98A priority patent/SK282743B6/en
Priority to TR1998/01180T priority patent/TR199801180T2/en
Priority to EP96943426A priority patent/EP0915855A1/en
Priority to EP20030028149 priority patent/EP1408037A1/en
Priority to ARP960105834A priority patent/AR005420A1/en
Priority to TW085115800A priority patent/TW458971B/en
Priority to MYPI96005403A priority patent/MY115662A/en
Priority to EG19961162A priority patent/EG25688A/en
Priority to IS4769A priority patent/IS1839B/en
Priority to MXPA/A/1998/004798A priority patent/MXPA98004798A/en
Priority to NO19982807A priority patent/NO310869B1/en
Priority to US09/631,116 priority patent/US6680321B1/en
Priority to ARP010100517A priority patent/AR034116A2/en
Priority to US10/714,447 priority patent/US20040138228A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of the formula (I)as well as their pharmaceutically acceptable salts, and pharmaceutical compositions comprising the novel compounds. The novel compounds of the formula (I) are useful in the management of pain.
SE9504661A 1995-12-22 1995-12-22 New compounds SE9504661D0 (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
SE9504661A SE9504661D0 (en) 1995-12-22 1995-12-22 New compounds
UA98074034A UA71538C2 (en) 1995-12-22 1996-11-12 Piperazine or piperidine derivatives, a method for the preparation thereof (variants), a pharmaceutical composition and a method for treatment of diseases (variants)
ZA9610352A ZA9610352B (en) 1995-12-22 1996-12-09 Novel compounds with analgesic effect
EP20030028149 EP1408037A1 (en) 1995-12-22 1996-12-11 Novel diarylmethylpiperazine and diarylmethylphenyl compounds with analgesic effect
HU9901304A HUP9901304A3 (en) 1995-12-22 1996-12-11 Piperazine and piperidine derivatives with analgesic effect, process for their preparation and pharmaceutical compositions containing them
EE9800194A EE04640B1 (en) 1995-12-22 1996-12-11 Compounds with analgesic properties
CA002239174A CA2239174C (en) 1995-12-22 1996-12-11 Novel compounds with analgesic effect
CN96180102A CN1119336C (en) 1995-12-22 1996-12-11 Novel compounds with analgesic effect
AU12162/97A AU715547B2 (en) 1995-12-22 1996-12-11 Novel compounds with analgesic effect
RU98113786/04A RU2194702C2 (en) 1995-12-22 1996-12-11 Derivatives of piperazine and piperidine and pharmaceutical composition
JP09523557A JP2000502679A (en) 1995-12-22 1996-12-11 Novel compounds with analgesic action
KR10-1998-0704757A KR100493832B1 (en) 1995-12-22 1996-12-11 Novel Compounds with Analgesic Effect
IL124996A IL124996A (en) 1995-12-22 1996-12-11 Novel piperazine compounds, process for their preparation and use thereof in the manufacture of medicaments for treatment of pain
BR9612204A BR9612204A (en) 1995-12-22 1996-12-11 Compound use of the compound Pharmaceutical composition and process for preparing the compound and for treating pain
PL327403A PL193061B1 (en) 1995-12-22 1996-12-11 Novel agents exhibiting analgesic activity
NZ324887A NZ324887A (en) 1995-12-22 1996-12-11 Piperazine and piperidine compounds with analgesic effect
PCT/SE1996/001635 WO1997023466A1 (en) 1995-12-22 1996-12-11 Novel compounds with analgesic effect
KR1020057003491A KR20050047534A (en) 1995-12-22 1996-12-11 Pharmaceutical compositions comprising novel compounds with analgesic effect
US08/836,830 US6130222A (en) 1995-12-22 1996-12-11 Compounds with analgesic effect
RU2002106503/04A RU2307833C2 (en) 1995-12-22 1996-12-11 Method for reducing of broken opyoid receptor functions
CZ0176898A CZ296159B6 (en) 1995-12-22 1996-12-11 Piperazine derivatives, process of their preparation, their use and pharmaceutical composition in which the derivatives are comprised
SK822-98A SK282743B6 (en) 1995-12-22 1996-12-11 Piperazine compounds, their preparation method, pharmaceutical co mpositions containing them and their use
TR1998/01180T TR199801180T2 (en) 1995-12-22 1996-12-11 New compounds with analgesic effect.
EP96943426A EP0915855A1 (en) 1995-12-22 1996-12-11 Novel compounds with analgesic effect
MYPI96005403A MY115662A (en) 1995-12-22 1996-12-20 Novel compounds with analgesic effect
ARP960105834A AR005420A1 (en) 1995-12-22 1996-12-20 COMPOUNDS DERIVED FROM PIPERAZINES AND PIPERIDINES WITH AN ANALGESIC EFFECT, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A PROCESS FOR THE PREPARATION OF SUCH COMPOUNDS.
TW085115800A TW458971B (en) 1995-12-22 1996-12-20 Novel compounds with analgesic effect
EG19961162A EG25688A (en) 1995-12-22 1996-12-21 Novel compounds with analgesic effect
IS4769A IS1839B (en) 1995-12-22 1998-06-11 Piperazine derivatives having analgesic effect, production and use
MXPA/A/1998/004798A MXPA98004798A (en) 1995-12-22 1998-06-15 New compounds with analges effect
NO19982807A NO310869B1 (en) 1995-12-22 1998-06-18 New Compounds with Analgesic Effect, Pharmaceutical Preparation Containing Such Compounds, and Use thereof
US09/631,116 US6680321B1 (en) 1995-12-22 2000-08-02 Compounds with analgesic effect
ARP010100517A AR034116A2 (en) 1995-12-22 2001-02-05 DERIVATIVES OF PIPERAZINES AND PIPERIDINS WITH ANALGESICAL EFFECT, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A PROCESS FOR THE PREPARATION OF SUCH COMPOUNDS
US10/714,447 US20040138228A1 (en) 1995-12-22 2003-11-17 Novel compounds with analgesic effect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9504661A SE9504661D0 (en) 1995-12-22 1995-12-22 New compounds

Publications (1)

Publication Number Publication Date
SE9504661D0 true SE9504661D0 (en) 1995-12-22

Family

ID=20400739

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9504661A SE9504661D0 (en) 1995-12-22 1995-12-22 New compounds

Country Status (27)

Country Link
US (3) US6130222A (en)
EP (2) EP1408037A1 (en)
JP (1) JP2000502679A (en)
KR (2) KR100493832B1 (en)
CN (1) CN1119336C (en)
AR (2) AR005420A1 (en)
AU (1) AU715547B2 (en)
BR (1) BR9612204A (en)
CA (1) CA2239174C (en)
CZ (1) CZ296159B6 (en)
EE (1) EE04640B1 (en)
EG (1) EG25688A (en)
HU (1) HUP9901304A3 (en)
IL (1) IL124996A (en)
IS (1) IS1839B (en)
MY (1) MY115662A (en)
NO (1) NO310869B1 (en)
NZ (1) NZ324887A (en)
PL (1) PL193061B1 (en)
RU (2) RU2307833C2 (en)
SE (1) SE9504661D0 (en)
SK (1) SK282743B6 (en)
TR (1) TR199801180T2 (en)
TW (1) TW458971B (en)
UA (1) UA71538C2 (en)
WO (1) WO1997023466A1 (en)
ZA (1) ZA9610352B (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410537B1 (en) * 1994-09-09 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Compositions having neuroprotective and analgesic activity
SE9504661D0 (en) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
GB9709972D0 (en) * 1997-05-19 1997-07-09 Pfizer Ltd Tetrazoles
DK1049676T3 (en) * 1997-12-24 2006-01-16 Ortho Mcneil Pharm Inc 4- [Aryl (piperidin-4-yl)] aminobenzamides which bind to the delta opioid receptor
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
SE9904673D0 (en) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (en) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
WO2001046191A1 (en) 1999-12-22 2001-06-28 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives
BR0108965A (en) 2000-03-03 2002-11-26 Ortho Mcneil Pharm Inc Derivatives of 3- (diarylmethylene) -8-azabicyclo [3,2,1] octane
SE0001207D0 (en) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0001209D0 (en) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
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