PT1136477E - BENZOFURAN DERIVATIVES PROCESS FOR THEIR PREPARATION AND ITS UTILIZATIONS - Google Patents
BENZOFURAN DERIVATIVES PROCESS FOR THEIR PREPARATION AND ITS UTILIZATIONSInfo
- Publication number
- PT1136477E PT1136477E PT99973289T PT99973289T PT1136477E PT 1136477 E PT1136477 E PT 1136477E PT 99973289 T PT99973289 T PT 99973289T PT 99973289 T PT99973289 T PT 99973289T PT 1136477 E PT1136477 E PT 1136477E
- Authority
- PT
- Portugal
- Prior art keywords
- group
- indicates
- chem
- formula
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Seasonings (AREA)
Abstract
Compounds represented by the formula: <CHEM> wherein R<1> and R<2> are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R<1> and R<2> may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: <CHEM> wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: <CHEM> wherein R<4> indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R<5> is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R<3> is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R<3> indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34536598 | 1998-12-04 | ||
JP34535598 | 1998-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1136477E true PT1136477E (en) | 2004-08-31 |
Family
ID=26578009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99973289T PT1136477E (en) | 1998-12-04 | 1999-12-02 | BENZOFURAN DERIVATIVES PROCESS FOR THEIR PREPARATION AND ITS UTILIZATIONS |
Country Status (14)
Country | Link |
---|---|
US (3) | US6479536B1 (en) |
EP (1) | EP1136477B1 (en) |
JP (1) | JP4778570B2 (en) |
KR (1) | KR100660788B1 (en) |
CN (1) | CN1297550C (en) |
AT (1) | ATE261435T1 (en) |
AU (1) | AU1414600A (en) |
CA (1) | CA2352786C (en) |
DE (1) | DE69915508T2 (en) |
ES (1) | ES2213407T3 (en) |
HU (1) | HU226652B1 (en) |
NO (1) | NO327924B1 (en) |
PT (1) | PT1136477E (en) |
WO (1) | WO2000034262A1 (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2352786C (en) * | 1998-12-04 | 2009-02-03 | Takeda Chemical Industries, Ltd. | Benzofuran derivatives, process for the preparation of the same and uses thereof |
ATE420869T1 (en) * | 2000-10-05 | 2009-01-15 | Takeda Pharmaceutical | PROMOTORS FOR PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR PRECUSSIONS OF NEURON CELLS |
CA2432410A1 (en) | 2000-12-28 | 2002-07-11 | Takeda Chemical Industries, Ltd. | Process for preparing optically active 2,3-dihydro- benzofuran compounds |
ATE527247T1 (en) * | 2001-07-05 | 2011-10-15 | Takeda Pharmaceutical | BENZOCONDENSED 5-MEMBED HETEROCYCLIC COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
CN100345835C (en) * | 2001-07-13 | 2007-10-31 | 武田药品工业株式会社 | Method for producing benzofuran derivative |
EP1457207A4 (en) * | 2001-12-19 | 2008-05-28 | Takeda Pharmaceutical | Solid compositions containng compounds unstable to oxygen and method for stabilization thereof |
US6653346B1 (en) * | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
US7078541B2 (en) * | 2002-02-07 | 2006-07-18 | Galileo Pharmaceuticals, Inc. | Benzofuran derivatives |
JP4537011B2 (en) * | 2002-03-01 | 2010-09-01 | 武田薬品工業株式会社 | Antidepressant |
EP1481679B1 (en) * | 2002-03-01 | 2010-08-25 | Takeda Pharmaceutical Company Limited | Antidepressant |
PT1637527E (en) * | 2003-06-26 | 2013-06-28 | Takeda Pharmaceutical | Cannabinoid receptor modulator |
US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
EP1589016A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
CN100540546C (en) * | 2004-05-05 | 2009-09-16 | 弗·哈夫曼-拉罗切有限公司 | Be used to regulate 5-HT6 acceptor, 5-HT2A acceptor or both aryl sulfonyl benzos two alkane |
KR20070046136A (en) * | 2004-08-27 | 2007-05-02 | 다케다 야쿠힌 고교 가부시키가이샤 | Azo compounds and process for production thereof |
US20060125084A1 (en) * | 2004-12-15 | 2006-06-15 | Fazzio Ronald S | Integration of micro-electro mechanical systems and active circuitry |
CA2591937C (en) * | 2004-12-21 | 2013-08-06 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
KR100965190B1 (en) | 2004-12-21 | 2010-06-24 | 에프. 호프만-라 로슈 아게 | Chroman derivatives and uses thereof in the treatment of cns disorders |
AU2005318595B2 (en) * | 2004-12-21 | 2011-03-03 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
PL1831191T3 (en) * | 2004-12-21 | 2008-10-31 | Hoffmann La Roche | Chroman derivatives and their use as 5-ht receptor ligands |
ES2314749T3 (en) * | 2004-12-21 | 2009-03-16 | F. Hoffmann-La Roche Ag | DERIVATIVES OF TETRALINA AND INDANO AND USES OF THE SAME AS 5-HT ANTAGONISTS. |
PE20070077A1 (en) * | 2005-06-10 | 2007-02-07 | Takeda Pharmaceutical | COMPRESSED WITH SUGAR COATED |
ES2359735T3 (en) * | 2005-11-03 | 2011-05-26 | F. Hoffmann-La Roche Ag | ARYLSULPHONYL CHROMANES AS 5-HT6 INHIBITORS. |
EP1964924B1 (en) | 2005-12-15 | 2015-09-30 | Seikagaku Corporation | Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin |
WO2007147771A2 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
AU2007263075A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonamidyl tetralin derivatives and uses thereof |
KR101060451B1 (en) * | 2006-06-20 | 2011-08-29 | 에프. 호프만-라 로슈 아게 | Arylsulfonyl naphthalene derivatives and uses thereof |
ATE456365T1 (en) * | 2006-11-09 | 2010-02-15 | Takeda Pharmaceutical | PHARMACEUTICAL COMPOSITION CONTAINING A DIHYDROBENZOFURANYL-ISOINDOLINE AND A LIPOPHILIC COMPONENT |
PE20120357A1 (en) * | 2009-03-10 | 2012-05-03 | Takeda Pharmaceutical | BENZOFURAN DERIVATIVES |
US20130005710A1 (en) | 2009-11-18 | 2013-01-03 | Tetsuya Tsukamoto | Aminopyridine derivative |
EP2516595A1 (en) | 2009-12-24 | 2012-10-31 | SCG Chemicals Co., Ltd. | Process for reducing the bromine index of a hydrocarbon |
CN105294662B (en) * | 2015-09-11 | 2018-04-20 | 中山大学 | Benzofuran quinoline and its application in the medicine for preparing treatment Alzheimer illness |
CN115260136B (en) * | 2022-08-09 | 2023-08-15 | 嘉兴学院 | Phthalide compound and preparation method thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU163046B (en) | 1970-08-25 | 1973-05-28 | ||
US4212865A (en) | 1978-12-26 | 1980-07-15 | Riker Laboratories, Inc. | Amine derivatives of 2-nitro-3-phenylbenzofuran |
US4881967A (en) | 1986-12-10 | 1989-11-21 | E. I. Du Pont De Nemours And Company | Heterocyclic 2,3-dihydrobenzofuran herbicides |
IE68675B1 (en) * | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
ATE192446T1 (en) | 1990-12-28 | 2000-05-15 | Teijin Ltd | CONDENSED BENZOXA RING COMPOUND, PRODUCTION THEREOF AND MEDICINAL PRODUCT CONTAINING SAME |
JP3168728B2 (en) | 1991-09-18 | 2001-05-21 | 富士レビオ株式会社 | 3,5-dihydroxyheptanoic acid derivative |
EP0539709A1 (en) * | 1991-09-18 | 1993-05-05 | FUJIREBIO Inc. | 3,5-Dihydroxyheptanoic acid derivatives and lactones thereof as HMG-CoA reductase inhibitors |
GB9408577D0 (en) * | 1994-04-29 | 1994-06-22 | Fujisawa Pharmaceutical Co | New compound |
EP0685475B1 (en) | 1994-05-31 | 1999-01-13 | Bayer Ag | Amino-benzofuryl-and thienyl-derivatives |
GB9522007D0 (en) | 1995-10-27 | 1996-01-03 | Fujisawa Pharmaceutical Co | New compound |
ATE234298T1 (en) | 1996-08-29 | 2003-03-15 | Takeda Chemical Industries Ltd | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS |
US7008950B1 (en) | 1997-06-05 | 2006-03-07 | Takeda Chemical Industries, Ltd. | Benzofurans as suppressors of neurodegeneration |
CA2352786C (en) * | 1998-12-04 | 2009-02-03 | Takeda Chemical Industries, Ltd. | Benzofuran derivatives, process for the preparation of the same and uses thereof |
-
1999
- 1999-12-02 CA CA002352786A patent/CA2352786C/en not_active Expired - Fee Related
- 1999-12-02 HU HU0105480A patent/HU226652B1/en not_active IP Right Cessation
- 1999-12-02 ES ES99973289T patent/ES2213407T3/en not_active Expired - Lifetime
- 1999-12-02 KR KR1020017006999A patent/KR100660788B1/en not_active IP Right Cessation
- 1999-12-02 DE DE69915508T patent/DE69915508T2/en not_active Expired - Lifetime
- 1999-12-02 CN CNB998156825A patent/CN1297550C/en not_active Expired - Fee Related
- 1999-12-02 EP EP99973289A patent/EP1136477B1/en not_active Expired - Lifetime
- 1999-12-02 PT PT99973289T patent/PT1136477E/en unknown
- 1999-12-02 AT AT99973289T patent/ATE261435T1/en active
- 1999-12-02 US US09/857,293 patent/US6479536B1/en not_active Expired - Lifetime
- 1999-12-02 AU AU14146/00A patent/AU1414600A/en not_active Abandoned
- 1999-12-02 WO PCT/JP1999/006764 patent/WO2000034262A1/en not_active Application Discontinuation
-
2001
- 2001-06-01 NO NO20012726A patent/NO327924B1/en not_active IP Right Cessation
-
2002
- 2002-04-11 US US10/120,102 patent/US7101867B2/en not_active Expired - Fee Related
-
2005
- 2005-03-17 US US11/081,615 patent/US7456162B2/en not_active Expired - Fee Related
-
2009
- 2009-04-08 JP JP2009094172A patent/JP4778570B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HUP0105480A2 (en) | 2002-11-28 |
US20020160996A1 (en) | 2002-10-31 |
EP1136477B1 (en) | 2004-03-10 |
CA2352786C (en) | 2009-02-03 |
US7456162B2 (en) | 2008-11-25 |
NO327924B1 (en) | 2009-10-19 |
NO20012726L (en) | 2001-07-31 |
AU1414600A (en) | 2000-06-26 |
DE69915508D1 (en) | 2004-04-15 |
ATE261435T1 (en) | 2004-03-15 |
CA2352786A1 (en) | 2000-06-15 |
JP4778570B2 (en) | 2011-09-21 |
HU226652B1 (en) | 2009-05-28 |
NO20012726D0 (en) | 2001-06-01 |
US7101867B2 (en) | 2006-09-05 |
US20050187238A1 (en) | 2005-08-25 |
CN1333764A (en) | 2002-01-30 |
EP1136477A4 (en) | 2002-04-10 |
HUP0105480A3 (en) | 2003-07-28 |
EP1136477A1 (en) | 2001-09-26 |
JP2009185049A (en) | 2009-08-20 |
KR100660788B1 (en) | 2007-02-28 |
ES2213407T3 (en) | 2004-08-16 |
WO2000034262A1 (en) | 2000-06-15 |
KR20010081113A (en) | 2001-08-27 |
CN1297550C (en) | 2007-01-31 |
DE69915508T2 (en) | 2005-01-27 |
US6479536B1 (en) | 2002-11-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT1136477E (en) | BENZOFURAN DERIVATIVES PROCESS FOR THEIR PREPARATION AND ITS UTILIZATIONS | |
RU2203274C2 (en) | Spirocyclic inhibitors of metalloproteases | |
BG104998A (en) | Isothiazole derivatives useful as anticancer agents | |
AU7350694A (en) | Remedy for nervous diseases | |
GEP19960656B (en) | Method for production of phenylalkylamines or its pharmaceutically acceptable salts | |
HUP0002057A2 (en) | Indazole amide compounds, process for producing them, pharmaceutical compositions containing them and their intermediers | |
PT81855B (en) | PREPARATION PROCESS OF ARILCYCLOBUTILALQUILAMINS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
PT649846E (en) | GALANTAMINE DERIVATIVES PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | |
CA2240060A1 (en) | O-carbamoyl-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same | |
ATE138571T1 (en) | USE OF DIOXABICYCLO (3.3.0>OCTANE DERIVATIVES FOR THE PRODUCTION OF A DRUG FOR INHIBITING CHOLESTEROL METABOLISM. | |
ATE206926T1 (en) | USE OF A PHOSPHORIC ACID DIESTER FOR PRODUCING A MEDICINAL PRODUCT FOR THE TREATMENT OF ACNE | |
EP0567090A3 (en) | ||
DE3683822D1 (en) | CHARTER REIN DERIVATIVES AND SALTS, THESE ANTITUARY COMPOSITIONS AND METHOD FOR THEIR PRODUCTION. | |
HUT63409A (en) | Process for producing 4-amino-2-ureidopyrimidine-5-carboxylic acid amide derivatives and pharmaceutical compositions comprising same | |
EA199700287A1 (en) | BENZAMIDES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | |
ES8604960A1 (en) | 1,6-Naphthyridine derivatives, process for their preparation and medicament containing them. | |
ATE99318T1 (en) | 4-SUBSTITUTED ANTHRACYCLINONES AND ANTHRACYCLINE GLYCOSIDES AND PROCESS FOR THEIR PRODUCTION. | |
PT92671A (en) | PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACTIVE ARYLOXIPROPANOLAMINOTETHALINES | |
DE60136566D1 (en) | PROCESS FOR PREPARING OPTICALLY ACTIVE 2,4-DIHYDROBENZOFURAN COMPOUNDS | |
KR880013896A (en) | Benzofuro [3,2-C] quinoline compound | |
EP1213290A4 (en) | Dihydrobenzofuran derivatives, process for the preparation thereof and agents | |
DE3689080D1 (en) | BERBAND DERIVATIVES AND THEIR PRODUCTION AND PHARMACEUTICAL PREPARATION. | |
CA2270026A1 (en) | Substituted bicyclic derivatives for treating central nervous system disorders | |
ATE265212T1 (en) | USE OF 4-ACYLAMINOPYRIDINE DERIVATIVES FOR THE PRODUCTION OF A MEDICATION FOR THE TREATMENT OF CEREBROVASCULAR DISEASES | |
IT1304656B1 (en) | RETINOIC ACID DERIVATIVES FOR MEDICINAL USE AND RELATED METHOD OF PREPARATION. |