PT1136477E - BENZOFURAN DERIVATIVES PROCESS FOR THEIR PREPARATION AND ITS UTILIZATIONS - Google Patents

BENZOFURAN DERIVATIVES PROCESS FOR THEIR PREPARATION AND ITS UTILIZATIONS

Info

Publication number
PT1136477E
PT1136477E PT99973289T PT99973289T PT1136477E PT 1136477 E PT1136477 E PT 1136477E PT 99973289 T PT99973289 T PT 99973289T PT 99973289 T PT99973289 T PT 99973289T PT 1136477 E PT1136477 E PT 1136477E
Authority
PT
Portugal
Prior art keywords
group
indicates
chem
formula
hydrogen atom
Prior art date
Application number
PT99973289T
Other languages
Portuguese (pt)
Inventor
Shigenori Ohkawa
Yasuyoshi Arikawa
Kouki Kato
Masahiro Okura
Masaki Setoh
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of PT1136477E publication Critical patent/PT1136477E/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/056Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)

Abstract

Compounds represented by the formula: <CHEM> wherein R<1> and R<2> are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R<1> and R<2> may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: <CHEM> wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: <CHEM> wherein R<4> indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R<5> is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R<3> is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R<3> indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.
PT99973289T 1998-12-04 1999-12-02 BENZOFURAN DERIVATIVES PROCESS FOR THEIR PREPARATION AND ITS UTILIZATIONS PT1136477E (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34536598 1998-12-04
JP34535598 1998-12-04

Publications (1)

Publication Number Publication Date
PT1136477E true PT1136477E (en) 2004-08-31

Family

ID=26578009

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99973289T PT1136477E (en) 1998-12-04 1999-12-02 BENZOFURAN DERIVATIVES PROCESS FOR THEIR PREPARATION AND ITS UTILIZATIONS

Country Status (14)

Country Link
US (3) US6479536B1 (en)
EP (1) EP1136477B1 (en)
JP (1) JP4778570B2 (en)
KR (1) KR100660788B1 (en)
CN (1) CN1297550C (en)
AT (1) ATE261435T1 (en)
AU (1) AU1414600A (en)
CA (1) CA2352786C (en)
DE (1) DE69915508T2 (en)
ES (1) ES2213407T3 (en)
HU (1) HU226652B1 (en)
NO (1) NO327924B1 (en)
PT (1) PT1136477E (en)
WO (1) WO2000034262A1 (en)

Families Citing this family (33)

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CA2352786C (en) * 1998-12-04 2009-02-03 Takeda Chemical Industries, Ltd. Benzofuran derivatives, process for the preparation of the same and uses thereof
ATE420869T1 (en) * 2000-10-05 2009-01-15 Takeda Pharmaceutical PROMOTORS FOR PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR PRECUSSIONS OF NEURON CELLS
CA2432410A1 (en) 2000-12-28 2002-07-11 Takeda Chemical Industries, Ltd. Process for preparing optically active 2,3-dihydro- benzofuran compounds
ATE527247T1 (en) * 2001-07-05 2011-10-15 Takeda Pharmaceutical BENZOCONDENSED 5-MEMBED HETEROCYCLIC COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
CN100345835C (en) * 2001-07-13 2007-10-31 武田药品工业株式会社 Method for producing benzofuran derivative
EP1457207A4 (en) * 2001-12-19 2008-05-28 Takeda Pharmaceutical Solid compositions containng compounds unstable to oxygen and method for stabilization thereof
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
JP4537011B2 (en) * 2002-03-01 2010-09-01 武田薬品工業株式会社 Antidepressant
EP1481679B1 (en) * 2002-03-01 2010-08-25 Takeda Pharmaceutical Company Limited Antidepressant
PT1637527E (en) * 2003-06-26 2013-06-28 Takeda Pharmaceutical Cannabinoid receptor modulator
US7119214B2 (en) * 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
EP1589016A1 (en) * 2004-04-13 2005-10-26 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
CN100540546C (en) * 2004-05-05 2009-09-16 弗·哈夫曼-拉罗切有限公司 Be used to regulate 5-HT6 acceptor, 5-HT2A acceptor or both aryl sulfonyl benzos two alkane
KR20070046136A (en) * 2004-08-27 2007-05-02 다케다 야쿠힌 고교 가부시키가이샤 Azo compounds and process for production thereof
US20060125084A1 (en) * 2004-12-15 2006-06-15 Fazzio Ronald S Integration of micro-electro mechanical systems and active circuitry
CA2591937C (en) * 2004-12-21 2013-08-06 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
KR100965190B1 (en) 2004-12-21 2010-06-24 에프. 호프만-라 로슈 아게 Chroman derivatives and uses thereof in the treatment of cns disorders
AU2005318595B2 (en) * 2004-12-21 2011-03-03 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
PL1831191T3 (en) * 2004-12-21 2008-10-31 Hoffmann La Roche Chroman derivatives and their use as 5-ht receptor ligands
ES2314749T3 (en) * 2004-12-21 2009-03-16 F. Hoffmann-La Roche Ag DERIVATIVES OF TETRALINA AND INDANO AND USES OF THE SAME AS 5-HT ANTAGONISTS.
PE20070077A1 (en) * 2005-06-10 2007-02-07 Takeda Pharmaceutical COMPRESSED WITH SUGAR COATED
ES2359735T3 (en) * 2005-11-03 2011-05-26 F. Hoffmann-La Roche Ag ARYLSULPHONYL CHROMANES AS 5-HT6 INHIBITORS.
EP1964924B1 (en) 2005-12-15 2015-09-30 Seikagaku Corporation Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin
WO2007147771A2 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
AU2007263075A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonamidyl tetralin derivatives and uses thereof
KR101060451B1 (en) * 2006-06-20 2011-08-29 에프. 호프만-라 로슈 아게 Arylsulfonyl naphthalene derivatives and uses thereof
ATE456365T1 (en) * 2006-11-09 2010-02-15 Takeda Pharmaceutical PHARMACEUTICAL COMPOSITION CONTAINING A DIHYDROBENZOFURANYL-ISOINDOLINE AND A LIPOPHILIC COMPONENT
PE20120357A1 (en) * 2009-03-10 2012-05-03 Takeda Pharmaceutical BENZOFURAN DERIVATIVES
US20130005710A1 (en) 2009-11-18 2013-01-03 Tetsuya Tsukamoto Aminopyridine derivative
EP2516595A1 (en) 2009-12-24 2012-10-31 SCG Chemicals Co., Ltd. Process for reducing the bromine index of a hydrocarbon
CN105294662B (en) * 2015-09-11 2018-04-20 中山大学 Benzofuran quinoline and its application in the medicine for preparing treatment Alzheimer illness
CN115260136B (en) * 2022-08-09 2023-08-15 嘉兴学院 Phthalide compound and preparation method thereof

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Also Published As

Publication number Publication date
HUP0105480A2 (en) 2002-11-28
US20020160996A1 (en) 2002-10-31
EP1136477B1 (en) 2004-03-10
CA2352786C (en) 2009-02-03
US7456162B2 (en) 2008-11-25
NO327924B1 (en) 2009-10-19
NO20012726L (en) 2001-07-31
AU1414600A (en) 2000-06-26
DE69915508D1 (en) 2004-04-15
ATE261435T1 (en) 2004-03-15
CA2352786A1 (en) 2000-06-15
JP4778570B2 (en) 2011-09-21
HU226652B1 (en) 2009-05-28
NO20012726D0 (en) 2001-06-01
US7101867B2 (en) 2006-09-05
US20050187238A1 (en) 2005-08-25
CN1333764A (en) 2002-01-30
EP1136477A4 (en) 2002-04-10
HUP0105480A3 (en) 2003-07-28
EP1136477A1 (en) 2001-09-26
JP2009185049A (en) 2009-08-20
KR100660788B1 (en) 2007-02-28
ES2213407T3 (en) 2004-08-16
WO2000034262A1 (en) 2000-06-15
KR20010081113A (en) 2001-08-27
CN1297550C (en) 2007-01-31
DE69915508T2 (en) 2005-01-27
US6479536B1 (en) 2002-11-12

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