MD4633B1 - Anticorpi umanizaţi anti-CD134 (OX40) şi utilizarea acestora - Google Patents

Anticorpi umanizaţi anti-CD134 (OX40) şi utilizarea acestora

Info

Publication number
MD4633B1
MD4633B1 MDA20150102A MD20150102A MD4633B1 MD 4633 B1 MD4633 B1 MD 4633B1 MD A20150102 A MDA20150102 A MD A20150102A MD 20150102 A MD20150102 A MD 20150102A MD 4633 B1 MD4633 B1 MD 4633B1
Authority
MD
Moldova
Prior art keywords
human
antibodies
lymphocytes
humanized anti
specifically bind
Prior art date
Application number
MDA20150102A
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English (en)
Russian (ru)
Other versions
MD20150102A2 (ro
Inventor
Петрус Йоханнес Симонс
Лауис БОН
Цзиньцюань Ло
Рэндалл Брезски
Моника Голдберг
Original Assignee
Biocerox Products B.V.
Janssen Pharmaceuticals Inc.
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47891522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD4633(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biocerox Products B.V., Janssen Pharmaceuticals Inc. filed Critical Biocerox Products B.V.
Publication of MD20150102A2 publication Critical patent/MD20150102A2/ro
Publication of MD4633B1 publication Critical patent/MD4633B1/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Invenţia se referă la anticorpi, care se leagă specific cu CD134 uman. Anticorpii anti-CD134 umani se leagă specific la domeniul extracelular al CD134 uman, inclusiv la domeniile de legare a ligandului non-OX40 (OX40L) al CD134 uman, care este exprimat, de exemplu, pe limfocitele T efectoare (Teff) CD4 şi/sau CD8 umane activate uzual şi pe limfocitele T reglatoare supresoare (Treg) CD4 umane activate. Anticorpii anti-CD134 umanizaţi sunt utili pentru tratamentul cancerului, de exemplu, pentru stimularea funcţiei efectoare anticanceroase a Teff şi/sau pentru inhibarea funcţiei de supresie a Treg.Secvenţe: 151
MDA20150102A 2013-03-18 2014-03-18 Anticorpi umanizaţi anti-CD134 (OX40) şi utilizarea acestora MD4633B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13159794 2013-03-18
PCT/NL2014/050162 WO2014148895A1 (en) 2013-03-18 2014-03-18 Humanized anti-cd134 (ox40) antibodies and uses thereof

Publications (2)

Publication Number Publication Date
MD20150102A2 MD20150102A2 (ro) 2016-02-29
MD4633B1 true MD4633B1 (ro) 2019-06-30

Family

ID=47891522

Family Applications (2)

Application Number Title Priority Date Filing Date
MDA20150102A MD4633B1 (ro) 2013-03-18 2014-03-18 Anticorpi umanizaţi anti-CD134 (OX40) şi utilizarea acestora
MDA20180107A MD20180107A2 (ro) 2013-03-18 2014-03-18 Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora

Family Applications After (1)

Application Number Title Priority Date Filing Date
MDA20180107A MD20180107A2 (ro) 2013-03-18 2014-03-18 Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora

Country Status (32)

Country Link
US (3) US9790281B2 (ro)
EP (2) EP2976361B1 (ro)
JP (1) JP2016515544A (ro)
KR (1) KR20160006168A (ro)
CN (1) CN105229032A (ro)
AU (2) AU2014238546C1 (ro)
BR (1) BR112015023862A2 (ro)
CA (1) CA2907436A1 (ro)
CL (2) CL2015002793A1 (ro)
CR (1) CR20150498A (ro)
CY (1) CY1120752T1 (ro)
DK (1) DK2976361T3 (ro)
EA (1) EA201591495A1 (ro)
ES (1) ES2687282T3 (ro)
HK (1) HK1215035A1 (ro)
HR (1) HRP20181478T1 (ro)
HU (1) HUE040234T2 (ro)
IL (1) IL241701A0 (ro)
LT (1) LT2976361T (ro)
MD (2) MD4633B1 (ro)
MX (2) MX2015013288A (ro)
NZ (1) NZ712903A (ro)
PE (1) PE20160690A1 (ro)
PH (1) PH12015502185A1 (ro)
PL (1) PL2976361T3 (ro)
PT (1) PT2976361T (ro)
RS (1) RS57840B1 (ro)
SG (2) SG11201507781VA (ro)
SI (1) SI2976361T1 (ro)
UA (1) UA119319C2 (ro)
WO (1) WO2014148895A1 (ro)
ZA (1) ZA201507021B (ro)

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