JPH09151112A - Microemulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a microemulsion exhibiting a liquid or milky lotion state, converted to creamy state by spreading on the skin, having high spreadability, etc., and useful for pharmaceuticals, etc. SOLUTION: A creaming force representing the force to induce the viscosity increase irreversible to shearing rate is defined for various substances as follows. 14-24C Higher alcohol = 5, 12-14C fatty acid = 2, 10-24C α-hydroxyfatty acid = 2, 12-24C fatty acid glyceryl monoester = 3 and 12-24C higher alcohol glyceryl monoether = 4. The objective emulsion composition containing hydrophilic nonionic surfactants can be produced by compounding one or more kinds of the above compounds in such a manner as to keep the sum of the products of the creaming power and the compounding wt.% to >=6.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention, which is a liquid or emulsion, has a creamy form when applied to the skin and stretched, and has good spreadability and moisturizing property, and further excellent stability and safety. It relates to a fine emulsion composition. More specifically, it relates to a fine emulsion composition prepared by blending a specific amount of an emulsification aid component that imparts a specific "creaming power".

[0002]

2. Description of the Related Art Conventionally, emulsion preparations have been very often used in the fields of pharmaceuticals, cosmetics, foods, etc., in particular, microemulsion, etc. due to their transparent or translucent appearance and fineness of particles. There is a demand for fine emulsions.

As such a fine emulsion, as a stable two-phase region microemulsion, one kind of oil having a hydrophilic nonionic surfactant and a certain range of carbon number and an inorganic value on an organic conceptual diagram is used. Alternatively, a microemulsion containing two or more kinds and water in a specific weight ratio is disclosed (Japanese Patent Publication No. 6-61454).

However, some nonionic surfactants have safety problems such as skin irritation, eye mucous membrane irritation and sensitization depending on the blending amount. To do. However, when the amount of the nonionic surfactant is reduced to reduce skin irritation, the emulsion stability is lowered. In order to increase the emulsion stability, higher aliphatic alcohols and the like may be blended as an emulsification aid, but generally, in such an emulsion system, the addition of the salt deteriorates the emulsion stability and it is difficult to blend the salt at a high concentration. Met. Furthermore, the influence of the change in pH was not small.

In general, liquid or emulsion formulations are preferred because they provide a fresh and moisturizing feel, but on the other hand, when applied and stretched on the skin, they tend to be slimy and do not stop. There was also a problem that it was difficult to obtain a refreshing feeling.

[0006]

Therefore, in the present invention, while exhibiting a liquid or an emulsion, it becomes a cream when applied to the skin and stretched, and has good spreadability and moisturizing property, and further stability. And it aimed at obtaining the fine emulsion composition excellent in safety. The present invention also aims to obtain a fine emulsion, which has low viscosity and is stable even under acidic conditions, has salt resistance, and can be added with a salt or an additive component containing a high concentration of salt. And

[0007]

[Means for Solving the Problems] In order to solve the above-mentioned problems, the present inventors examined the addition of an emulsification aid in an emulsification system containing a small amount of a hydrophilic nonionic surfactant. First, the creaming, which is a property required in the present invention, obtained by stretching on the skin is considered as a phenomenon in which the viscosity increases at a certain shear rate or more when the shear rate is increased at a constant rate. be able to.
Of the substances used as an emulsification aid, a search was made for substances that impart the above-mentioned properties to the emulsification system, and it was found that those shown in Table 1 were preferable. When the contribution ratio of the emulsification aid in imparting the above-mentioned creaming property is expressed by "creaming power" shown in Table 1, respectively, the product of the creaming power and the compounding amount expressed by weight percentage is calculated. It was found that very good results can be obtained by blending so that the sum becomes 6 or more, and the present invention has been completed.

[Table 1]

In the present invention, in an emulsifying system containing a small amount of a hydrophilic nonionic surfactant, a higher alcohol having 14 to 24 carbon atoms, a fatty acid having 12 to 24 carbon atoms, and 10 to 10 carbon atoms shown in Table 1 are used. One or more selected from 24 α-hydroxy fatty acids, monoglyceryl esters of fatty acids having 12 to 24 carbon atoms, and monoglyceryl ethers of higher alcohols having 14 to 24 carbon atoms are blended. At that time, the sum of the products of the respective "creaming power" shown in Table 1 and the blending amount expressed as a percentage is 6 or more.

The hydrophilic nonionic surfactant used in the present invention preferably has an HLB value of 8.0 or more, and examples thereof include polyoxyethylene (6 E.O.) sorbitan monostearate and polyoxy. Ethylene (2
0E.O.) sorbitan monolaurate, polyoxyethylene (20E.O.) sorbitan monostearate and other polyoxyethylene sorbitan fatty acid esters,
Polyoxyethylene (6E.O.) sorbitol monolaurate, polyoxyethylene (20E.O.) sorbitol monolaurate, polyoxyethylene (6E.O.)
Polyoxyethylene sorbitol fatty acid esters such as sorbitol tetraoleate, hexaglyceryl monolaurate, hexaglyceryl monomyristate, decaglyceryl monolaurate, decaglyceryl monoisostearate, and other polyglyceryl fatty acid esters, polyoxyethylene (10E.O.) glyceryl monostearate, polyoxyethylene (15E.O.) glyceryl monostearate, polyoxyethylene (5E.O.) glyceryl monooleate, polyoxyethylene (15E.O.) ) Ethylene oxide derivatives of glyceryl fatty acid esters such as glyceryl monooleate, polyoxyethylene (6E.
O.) Monolauric acid ester, polyoxyethylene (10E.
O) Monolauric acid ester, polyoxyethylene (20E.
O.) Polyethylene glycol fatty acid esters such as tristearate, polyoxyethylene (21E.O.) lauryl ether, polyoxyethylene (10E.O.) cetyl ether, polyoxyethylene (15E.O.) oleyl ether , Polyoxyethylene alkyl ethers such as polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene alkyl ethers such as polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene (10E.O.) nonylphenyl ether, polyoxyethylene (15E.O. ) Polyoxyethylene alkyl phenyl ethers such as octyl phenyl ether, polyoxyethylene (40 E.O.) castor oil, polyoxyethylene (50 E.O.) hydrogenated castor oil and other polyoxyethylene castor oil, hydrogenated castor oil derivatives , Polyoxyethylene (10E.O.) stearylamine, polyoxye Ren (10
EO) polyoxyethylene alkyl amides such as steric acid amides and fatty acid amides, sucrose lauric acid esters, sucrose myristic acid ester sucrose fatty acid esters, etc., and one or more of them are selected. To use. It is suitable that the compounding amount is about 0.1 to 10.0% by weight.

Among the emulsification aids used in the present invention, higher alcohols having a "creaming power" of 5 in Table 1 and having 14 to 24 carbon atoms include n-tetradecanol (myristyl alcohol) to tetracosanol (carner). Up to straight chain saturated aliphatic alcohols, 2-tetradecanol to 2-eicosanol, 2-hexyldecanol, isostearyl alcohol, and other branched saturated aliphatic alcohols, oleyl alcohol, linoleyl alcohol, etc. Unsaturated aliphatic alcohols and the like can be mentioned.

In Table 1, "creaming power" is 2 and carbon number is 12
~ As the fatty acid of 24, dodecanoic acid (lauric acid) ~
Linear saturated fatty acids such as docosanoic acid (behenic acid), linear monoenoic acids such as 2-dodecenoic acid (2-lauroleic acid) to cis-15-tetracosenoic acid, cis-9, cis-12-octadecadienoic acid (Linoleic acid), trans-9, trans-12-octadecadienoic acid (linoelaidic acid), 9,13-docosadienoic acid, 9,1
Dienoic acid such as 5-tetracosadienoic acid, cis-9, cis-12, cis
-15-Octadecatrienoic acid (linolenic acid), trans-9, tr
Examples thereof include trienoic acid such as ans-12, trans-15-octadecatrienoic acid (linolene elaidic acid) and tetraenoic acid such as 5,8,11,14-eicosatetraenoic acid (arachidonic acid).

In Table 1, "creaming power" is 2 and carbon number is 1
As the α-hydroxy fatty acid of 0 to 24, 2-hydroxydecanoic acid (capric acid) to 2-hydroxytetracosanoic acid (lignoceric acid), a linear saturated fatty acid having a hydroxyl group at the α-position, 2-hydroxy-9 -Linear monoenoic acid having a hydroxyl group in the α-position, such as decenoic acid (caproleic acid) to 2-hydroxy-cis-15-tetracosenoic acid (ceracoleic acid), 2-hydroxy-cis-9, cis-12-octa 2-hydroxy-cis-9, cis-, a dienoic acid having a hydroxyl group at the α-position such as decadienoic acid (linoleic acid) and 2-hydroxy-trans-9, trans-12-octadecadienoic acid (linoelaidic acid) 12, cis-15
-Octadecatrienoic acid (linolenic acid), 2-hydroxy-
Trans-9, trans-12, trans-15-octadecatrienoic acid (linolenic elaidic acid) and other hydroxyl groups at the α-position Trienoic acid, 2-hydroxyisopalmitic acid, 2-hydroxyisostearic acid and other hydroxyl groups at the α-position Branched-chain fatty acids having

In Table 1, "creaming power" is 3, carbon number 1
As the glyceryl monoester of 2 to 24 fatty acids,
Glyceryl monoesters of straight chain saturated fatty acids from glyceryl monolaurate to glyceryl monotetracolate, glyceryl monoesters of straight chain monoenoic acid such as glyceryl monooleate, glyceryl monolinate of glyceryl monolinoleate, etc. Examples thereof include esters and glyceryl monoesters of branched chain fatty acids such as glyceryl isostearate.

In Table 1, "creaming power" is 4, carbon number 1
Examples of glyceryl monoethers of higher alcohols of 4 to 24 include glyceryl monomyristyl ether to glyceryl monocarnervir ether, saturated monohydric alcohols glyceryl monoether, glyceryl monooleyl ether, glyceryl monolinoleinyl ether, and glyceryl monolinolenyl ether. Glyceryl monoether of unsaturated monohydric alcohol such as glyceryl monoether, glyceryl monohexadecyl ether, glyceryl monoisostearyl ether and other branched alcohol glyceryl monoether.

In the present invention, oily components other than the emulsification aids shown in Table 1 can be blended. Examples of such oily components include vegetable oils such as avocado oil, almond oil and olive oil, animal oils such as turtle oil and mink oil,
Cocoa butter, mokuro, coconut oil and other vegetable fats, beef tallow,
Animal fats such as lard, hardened oils, carnauba wax, candelilla wax, plant waxes such as jojoba oil, beeswax, whale wax, animal waxes such as lanolin, liquid paraffin, petrolatum, isoparaffin, ceresin, Hydrocarbon oils such as squalane, esters such as octyldodecyl myristate, cetyl isooctanoate and glyceryl triisooctanoate, silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, etc., and one or two of these The above is selected and used. The blending amount of the oily component is preferably 50.0% by weight or less.

In the fine emulsion composition of the present invention, an oil phase may further contain an antioxidant such as tocopherol acetate and an oil-soluble additive such as an ultraviolet absorber, and the water phase may be water-soluble such as ascorbic acid. Vitamins,
Amino acids, polyhydric alcohols, mucopolysaccharides, moisturizing agents such as collagen, preservatives and the like can be added.

The fine emulsion composition of the present invention may further contain salts or seaweed extracts. The salt is preferably one or more selected from alkali metal salts and alkaline earth metal salts, and examples thereof include lithium chloride, sodium chloride, potassium chloride, rubidium chloride, cesium chloride, sodium carbonate, sodium hydrogen carbonate and hydrogen carbonate. Examples thereof include potassium, potassium carbonate, sodium sulfate, magnesium chloride, calcium chloride, strontium chloride, barium chloride, magnesium carbonate, calcium carbonate, strontium carbonate, barium carbonate, magnesium sulfate, calcium sulfate, barium sulfate. As a seaweed extract, brown algae ( Phaeophyceae )
Belonging to the genus Fucus , genus Laminari ( Laminari
a ), Rhodophyta genus ( Chond)
rus ), Gigartina , etc. extracted with purified water, propylene glycol, 1,3-butylene glycol, ethylene glycol monobutyl ether, ethanol, or a mixture thereof.
One kind or two or more kinds are selected and used.

Since the fine emulsion composition of the present invention is preferably in a liquid or emulsion form before being applied to the skin, the second method of measuring viscosity in the general test method based on cosmetic raw materials. When the viscosity after 1 minute was measured at 6 revolutions for 1 minute using No. 3 rotor according to
It is appropriate to set it to 0 cps or less.

The fine emulsion composition according to the present invention can be prepared by using a usual surface chemistry method or a mechanical method such as a high pressure homogenizer. However, a surfactant, an oil component and an emulsification aid are used. The contained oil phase is mixed and homogenized and heated to 70 to 75 ° C, and an aqueous phase which is previously mixed and homogenized and heated to 70 to 75 ° C is added with stirring to emulsify and cool. The emulsification method is preferable for obtaining fine emulsion particles.

[0020]

The fine emulsion composition according to the present invention is a fine and uniform emulsion having an average particle size of 400 nm or less, and has a low viscosity of 10,000 cps or less, but it is very stable. Furthermore, it is stable in the acidic region, has high safety, and has excellent salt resistance.
When it is applied on the skin and stretched, it immediately becomes creamy, and good moisturizing properties and spreadability are obtained.

[0021]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention is used in the form of a base for pharmaceutical preparations such as emulsions and emulsion type ointments, cosmetics such as lotions and emulsions, and food emulsions. Further, it can be used as a paint by adding a coloring material. In particular, it is suitable for liquid or emulsion formulations having low viscosity.

[0022]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, Example 1 and Example 2 of the present invention
Shows the prescription of.

Example 1 (1) Liquid paraffin 7.0 (wt%) (2) Glyceryl monostearyl ether 1.5 (3) Stearic acid 0.8 (4) Glyceryl monostearate 0.3 ( 5) Polyoxyethylene (10 E.O.) monostearic acid 3.5 ester (6) 1,3-butylene glycol 10.0 (7) Methyl paraoxybenzoate 0.1 (8) Perfume 0.1 (9) Purified water 76.7 Production method: The oil phase components (1) to (5) are mixed and homogenized and heated to 75 ° C. (6), (7) and (9) which were mixed and homogenized in advance and heated to 75 ° C. were gradually added with stirring to emulsify, and after cooling, (8) was added at 40 ° C.

Example 2 (1) Octyldodecyl myristate 5.0 (% by weight) (2) Hardened oil 1.0 (3) Cetanol 2.3 (4) Polyoxyethylene (20E.O.) sorbitan 3.0 Tristearate (5) Glycerin 6.0 (6) Hydroxyethyl cellulose 0.1 (7) Ethanol 3.0 (8) Methyl paraoxybenzoate 0.1 (9) Perfume 0.2 (10) Purification Water 79.3 Production method: Mix the oil phase components (1) to (4), homogenize them, and heat to 75 ° C. On the other hand, (5), (8) and (10) were mixed and homogenized, and then (6) was added to thicken the mixture and heated to 75 ° C., which was added to the oil phase while stirring. Emulsify and cool to 40
(9) is dissolved in (7) at ℃ and added.

Next, the formulations of Comparative Examples 1 to 4 for Examples 1 and 2 are shown in Tables 2 and 3, respectively. Comparative Examples 1 and 3 are those in which a hydrophilic nonionic surfactant is blended in an amount of more than 10.0% by weight, and Comparative Examples 2 and 4 are the emulsification aid's creaming power and weight. The sum of products with the compounding amount expressed as a percentage is less than 6.0. These were prepared in the same manner as in Example 1 and Example 2.

[Table 2]

[Table 3]

For the above Examples 1 and 2 and Comparative Examples 1 to 4, the average particle size and viscosity were measured, and the results are shown in Table 4 together with the sum of the products of the creaming power of the emulsification aid and the compounding amount expressed as a weight percentage. Described. The viscosity is 1 using a No. 3 rotor according to the second method of measuring viscosity in the general test method based on cosmetic raw materials.
The viscosity after 1 minute was measured at 6 revolutions per minute. In addition, storage stability at 25 ° C, stability when 0.5% by weight of sodium chloride as a salt is added, p of emulsion composition
The stability when H was set to 4.0, the creaminess when applied to the skin, and the skin irritation were examined. Regarding storage stability, each sample was stored at 25 ° C. for 3 months, and the state of the emulsion was observed, and “○; transparency and change in state were not observed”,
It was evaluated as “Δ: increase in turbidity is recognized”, “x: Significant increase in turbidity or phase separation is recognized”.
Regarding the stability when sodium chloride was added, the change in the state after the addition of sodium chloride was observed, and the pH was 4.
The stability at 0 was evaluated in the same manner as above by observing changes in the state after adjusting the pH of the emulsion composition to 4.0 with citric acid. Regarding the creaminess when applied to the skin, the sample of each of the Examples and Comparative Examples was applied to the skin and stretched, and the state of changing into a cream was observed, and “○; Increase, it becomes a good creaminess ”,“ △: it takes a considerable stretching time to notice an increase in viscosity and change to a cream ”,“ x: increase in viscosity due to stretching, creaminess ” No change was observed ". The skin irritation was evaluated by a 48-hour occlusion patch test conducted by 20 male panelists, and the results were evaluated according to the criteria shown in Table 5 and 2
The average value of skin irritation index of 0 persons was shown. The above results are summarized in Table 6.

[Table 4]

[Table 5]

[Table 6]

From Table 4, Example 1 and Example 2 of the present invention
In, a uniform fine emulsion with an average particle size of 320 to 350 nm was obtained, and the viscosity was 1200 to 1,500.
It showed a low value of cps. Further, from Table 6, all showed good storage stability, and the stability was also good when sodium chloride was added and when the pH was adjusted to 4.0. Further, good creaming properties were observed in all of them, and the skin irritation index was 0.10 or less in all, showing that the skin irritation was extremely low. On the other hand, in Comparative Examples 1 and 3, fine emulsions having good storage stability and the like were obtained and creaming properties were almost good, but skin irritation indexes were 1.55 points and 1.65 points. Some skin irritation was observed. Further, in Comparative Example 2 and Comparative Example 4, the average particle diameter was larger than that of the Examples, and both were poor in stability at the time of salt addition and at pH 4.0, and in Comparative Example 4, storage stability at 25 ° C. was also very good. There wasn't. Moreover, when applied to the skin and stretched, no clear creaming was observed.

Next, the formulation of another embodiment according to the present invention will be shown. [Example 3] Microemulsion liquid (1) Palmitic acid 0.5 (% by weight) (2) Behenic acid 0.5 (3) Oleyl alcohol 0.8 (4) Polyoxyethylene (6E.O.) sorbitol 1 .5 Monolauric acid ester (5) Tocopherol acetate 0.2 (6) Ethanol 2.0 (7) Phenoxyethanol 0.2 (8) Perfume 0.1 (9) Purified water 94.2 Manufacturing method: (1) to (5 ) Are mixed and heated to homogeneity and maintained at 75 ° C. To this, (9) heated to 75 ° C. is added with stirring to emulsify and then cooled, and (7) and (8) are dissolved in (6) at 40 ° C. and added.

[Example 4] Moisturizing liquid (1) Jojoba oil 5.0 (% by weight) (2) 2-hydroxycapric acid 0.5 (3) 2-hydroxypalmitic acid 0.5 (4) 2-hydroxy Arachic acid 0.5 (5) Glyceryl monomyristate S L 1.5 (6) Decaglyceryl monolaurate 2.0 (7) Sorbitol 3.0 (8) 1,3-Butylene glycol 5.0 (9) Hyaluronic acid Sodium acid salt 0.2 (10) Methyl paraoxybenzoate 0.1 (11) Perfume 0.1 (12) Purified water 81.6 Production method: Mix the oil phase components of (1) to (6) to homogenize, 75 Heat to ℃. On the other hand, the water phase components (7), (8), (10), and (12) are mixed and heated to homogenize and keep at 75 ° C. This was gradually added to the oil phase component while stirring to emulsify, and after cooling, 40
Add (9) and (11) at ℃ and mix.

Example 5 Emulsion (1) Liquid paraffin 10.0 (wt%) (2) Squalane 5.0 (3) Glyceryl monomyristyl ether 1.5 (4) 2-Hydroxyundecanoic acid 1.0 ( 5) Glyceryl monoisostearate 1.0 (6) Polyoxyethylene (50 E.O.) hydrogenated castor oil 3.0 (7) Glycerin 6.0 (8) Hydroxypropyl cellulose 0.1 (9) Seaweed extract 0.2 (10) Methyl paraoxybenzoate 0.1 (11) Perfume 0.1 (12) Purified water 72.0 Production method: Mix the oil phase components (1) to (6) to homogenize the mixture to 75 ° C. To heat. On the other hand, the water phase components (7), (8), (10), and (12) are mixed and heated to homogenize and keep at 75 ° C. This was gradually added to the oil phase component while stirring to emulsify, and after cooling, 40
Add (9) and (11) at ℃ and mix.

Example 6 Sunscreen Emulsion (1) Isoparaffin 4.0 (wt%) (2) Dimethylpolysiloxane 6.0 (3) Isostearate 0.6 (4) 2-Octyldodecanol 2. 2 (5) Polyoxyethylene (15 E.O.) glyceryl 3.5 monostearate (6) 2-ethylhexyl paramethoxycinnamate 6.0 (7) Tocopherol acetate 0.5 (8) Propylene glycol 8.0 ( 9) Methyl paraoxybenzoate 0.1 (10) Perfume 0.1 (11) Purified water 69.0 Production method: Mix the oil phase components (1) to (7) to homogenize and heat to 75 ° C. On the other hand, by mixing the water phase components (8), (9), and (11),
Heat to homogenize and maintain at 75 ° C. This is gradually added to the oil phase component while stirring to emulsify, and after cooling, at 40 ° C.
Add (10) and mix.

Example 7 Massage Agent (1) Beeswax 2.0 (wt%) (2) Squalane 10.0 (3) Isopropyl myristate 5.0 (4) Isostearyl alcohol 2.2 (5) Glyceryl Monolauric acid ester 0.3 (6) Polyoxyethylene (10E.O.) Monostearic acid 1.0 ester (7) Polyoxyethylene (15E.O.) cetyl ether 2.4 (8) Glycerin 5.0 ( 9) 1,3-butylene glycol 5.0 (10) Sodium chloride particles (particle diameter 0.1 mm) 0.1 (11) Magnesium chloride particles (particle diameter 0.1 mm) 0.1 (12) Methyl paraoxybenzoate 0.1 (13) Perfume 0.1 (14) Purified water 66.7 Production method: Mix the oil phase components (1) to (7) to homogenize and heat to 75 ° C. On the other hand, the water phase components (8), (9), (12), and (14) are mixed and heated to homogenize and keep at 75 ° C. This was gradually added to the oil phase component while stirring to emulsify, and after cooling, 40
(13) is added and mixed at ℃, and then (10) and (11) are dispersed.

Example 8 Emulsion (1) Vaseline 10.0 (2) Cholesterol 10.0 (3) Linoleic acid 0.3 (4) Arachidonic acid 0.3 (5) Behenyl alcohol 2.5 (6) Show Sugar fatty acid ester 3.0 (7) Tocopherol acetate 0.5 (8) Methyl paraoxybenzoate 0.1 (9) Purified water 73.3 Process: Mix (1) to (7) and heat to homogenize, Keep at 75 ° C. On the other hand, (8) is dissolved in (9) by heating to 75 ° C., and the oil phase component is added thereto, mixed, treated with a high pressure homogenizer to emulsify, and cooled.

The average particle size and viscosity of Examples 3 to 8 were measured in the same manner as above, and the storage stability and creaminess at 25 ° C. were also evaluated by the above methods. At the same time, 20 male and 20 female panelists were set as one group, and each example was used blindly, and sensory evaluation was performed on the moist feeling, spreadability, and skin irritation. Regarding moist feeling, there are "5 points", "somewhat 4"
"Point", "Neither can be said; 3 points", "Slightly;2"
"No", "No;1", and spreadability is "Good;5"
"Point", "Slightly good; 4 points", "Normal; 3 points", "Slightly bad; 2 points", "Poor; 1 point", as a feeling of skin irritation,
“Very sensitive; 4 points”, “Feeling; 3 points”, “Slightly felt; 2 points”, “Feeling subtly; 1 point”, “Not felt;
It was scored as "0 point" and the average value of 20 people was obtained. The above results are shown in Tables 7 and 8.

[0035]

[Table 7]

[Table 8] Table 7 shows that each of the examples of the present invention is a fine emulsion having an average particle size of approximately 260 to 390 nm, a viscosity as low as 1800 cps or less, and good storage stability and creaminess. Was admitted. In addition, Table 8 shows that when used on the skin, a good moist feeling and spreadability are obtained. Regarding skin irritation, although slight irritation was observed in Example 6 and Example 7, it was shown that skin irritation was generally low.

[0036]

As described in detail above, according to the present invention, while exhibiting a liquid or emulsion, it becomes creamy when applied to the skin and stretched, and has good spreadability and moisturizing property, and further stable. It was possible to obtain a fine emulsion composition having excellent properties and safety. Further, according to the present invention, it has a low viscosity and is stable even in acid, and has salt resistance,
It was possible to obtain a fine emulsion in which salts, an additive component containing a high concentration of salt, and the like can be blended.

Claims (5)

[Claims] 1. In an emulsion composition containing a hydrophilic nonionic surfactant, the force that imparts an irreversible increase in viscosity with respect to the shear rate is expressed as "creaming power", and is as follows. When specified, a higher alcohol having 14 to 24 carbon atoms, a fatty acid having 2 to 12 carbon atoms, an α-hydroxy fatty acid having 2 to 10 carbon atoms, a glyceryl monoester of a fatty acid having 12 to 24 carbon atoms, and 3 having 14 to 24 carbon atoms One or two or more of the above components are blended so that the sum of the products of the glyceryl monoether 4 creaming power of higher alcohols and the blending amount represented by weight percentage (%) is 6 or more. Fine emulsion composition. 2. The fine emulsion composition according to claim 2, which further comprises up to 50.0% by weight of an oil component. 3. The fine emulsion composition according to claim 1, which is an oil-in-water emulsion having an average particle size of 400 nm or less. 4. The fine emulsion composition according to claim 1, wherein the content of the hydrophilic nonionic surfactant is 0.1 to 10.0% by weight. 5. A viscosity of 10,000 centipoise (cp)
s) or less, claim 1 to claim 4 characterized in that
The fine emulsion composition described in 1.