EP0733122A4 - Fusion proteins containing adeno-associated virus rep protein and bacterial protein - Google Patents

Fusion proteins containing adeno-associated virus rep protein and bacterial protein

Info

Publication number
EP0733122A4
EP0733122A4 EP94919252A EP94919252A EP0733122A4 EP 0733122 A4 EP0733122 A4 EP 0733122A4 EP 94919252 A EP94919252 A EP 94919252A EP 94919252 A EP94919252 A EP 94919252A EP 0733122 A4 EP0733122 A4 EP 0733122A4
Authority
EP
European Patent Office
Prior art keywords
protein
fusion proteins
associated virus
proteins containing
virus rep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94919252A
Other languages
German (de)
French (fr)
Other versions
EP0733122A1 (en
Inventor
Robert Kotin
Brian Safer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Genetic Therapy Inc
Original Assignee
US Department of Health and Human Services
Genetic Therapy Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, Genetic Therapy Inc filed Critical US Department of Health and Human Services
Publication of EP0733122A1 publication Critical patent/EP0733122A1/en
Publication of EP0733122A4 publication Critical patent/EP0733122A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP94919252A 1993-05-26 1994-05-26 Fusion proteins containing adeno-associated virus rep protein and bacterial protein Withdrawn EP0733122A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6723693A 1993-05-26 1993-05-26
US67236 1993-05-26
PCT/US1994/005940 WO1994028157A1 (en) 1993-05-26 1994-05-26 Fusion proteins containing adeno-associated virus rep protein and bacterial protein

Publications (2)

Publication Number Publication Date
EP0733122A1 EP0733122A1 (en) 1996-09-25
EP0733122A4 true EP0733122A4 (en) 1998-06-10

Family

ID=22074622

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94919252A Withdrawn EP0733122A4 (en) 1993-05-26 1994-05-26 Fusion proteins containing adeno-associated virus rep protein and bacterial protein

Country Status (4)

Country Link
EP (1) EP0733122A4 (en)
JP (1) JPH09501309A (en)
CA (1) CA2162271A1 (en)
WO (1) WO1994028157A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342390B1 (en) * 1994-11-23 2002-01-29 The United States Of America As Represented By The Secretary Of Health And Human Services Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
US5843742A (en) * 1994-12-16 1998-12-01 Avigen Incorporated Adeno-associated derived vector systems for gene delivery and integration into target cells
US6281010B1 (en) 1995-06-05 2001-08-28 The Trustees Of The University Of Pennsylvania Adenovirus gene therapy vehicle and cell line
US5756283A (en) * 1995-06-05 1998-05-26 The Trustees Of The University Of Pennsylvania Method for improved production of recombinant adeno-associated viruses for gene therapy
DE19545126A1 (en) * 1995-12-04 1997-06-05 Hoechst Ag ATP and nucleic acid binding protein with helicase properties
US6521225B1 (en) * 1996-09-06 2003-02-18 Chiron Corporation AAV vectors
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
CN1263854C (en) 1997-11-06 2006-07-12 启龙股份公司 Neisserial antigens
DE69941567D1 (en) 1998-01-14 2009-12-03 Novartis Vaccines & Diagnostic ANTIGENE FROM NEISSERIA MENINGITIDIS
EP2261344A3 (en) 1998-05-01 2012-01-04 Novartis Vaccines and Diagnostics, Inc. Neisseria meningitidis antigens and compositions
ES2477194T3 (en) 1999-04-30 2014-07-16 Novartis Vaccines And Diagnostics S.R.L. Neisserial antigens conserved
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
ES2541830T3 (en) 1999-10-29 2015-07-27 Novartis Vaccines And Diagnositics S.R.L. Neisseria antigenic peptides
DK1248647T3 (en) 2000-01-17 2010-09-27 Novartis Vaccines & Diagnostic Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins
NZ593617A (en) 2000-10-27 2012-04-27 Novartis Vaccines & Diagnostic Nucleic acids and proteins from streptococcus groups A & B
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
AU2002366592B2 (en) 2001-12-12 2008-01-10 Novartis Vaccines And Diagnostics S.R.L. Immunisation against Chlamydia trachomatis
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
CA2561696C (en) 2004-03-29 2013-09-03 Galpharma Co., Ltd. Novel modified galectin 9 proteins and use thereof
DK2054431T3 (en) 2006-06-09 2012-01-02 Novartis Ag Conformers of bacterial adhesins

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486917A2 (en) * 1990-11-17 1992-05-27 BEHRINGWERKE Aktiengesellschaft Antiviral activity from the rep gene of adenoassociated virus-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) * 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486917A2 (en) * 1990-11-17 1992-05-27 BEHRINGWERKE Aktiengesellschaft Antiviral activity from the rep gene of adenoassociated virus-2

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHIORINI J A ET AL: "BIOLOGICALLY ACTIVE REP PROTEINS OF ADENO-ASSOCIATED VIRUS TYPE 2 PRODUCED AS FUSION PROTEINS IN ESCHERICHIA COLI", JOURNAL OF VIROLOGY, vol. 68, no. 2, February 1994 (1994-02-01), pages 797 - 804, XP000608411 *
IM D.S: & MUZYCZKA N.: "The AAV origin bvinding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity.", CELL, vol. 61, 4 May 1990 (1990-05-04), pages 447 - 457, XP002060793 *
NEW ENGLAND BIOLABS CATALOG, 1992, pages 96 - 97, XP002061117 *
See also references of WO9428157A1 *

Also Published As

Publication number Publication date
EP0733122A1 (en) 1996-09-25
WO1994028157A1 (en) 1994-12-08
CA2162271A1 (en) 1994-12-08
JPH09501309A (en) 1997-02-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19951202

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RHK1 Main classification (correction)

Ipc: C12N 15/62

A4 Supplementary search report drawn up and despatched

Effective date: 19980428

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18D Application deemed to be withdrawn

Effective date: 19980723