DE69329240D1 - 17-ether und thioether von 4-aza-steroiden - Google Patents

17-ether und thioether von 4-aza-steroiden

Info

Publication number
DE69329240D1
DE69329240D1 DE69329240T DE69329240T DE69329240D1 DE 69329240 D1 DE69329240 D1 DE 69329240D1 DE 69329240 T DE69329240 T DE 69329240T DE 69329240 T DE69329240 T DE 69329240T DE 69329240 D1 DE69329240 D1 DE 69329240D1
Authority
DE
Germany
Prior art keywords
pct
thioether
ether
date nov
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69329240T
Other languages
English (en)
Inventor
E Witzel
L Tolman
H Rasmusson
K Bakshi
Shu Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69329240D1 publication Critical patent/DE69329240D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69329240T 1992-05-20 1993-05-19 17-ether und thioether von 4-aza-steroiden Expired - Lifetime DE69329240D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88603192A 1992-05-20 1992-05-20
PCT/US1993/004746 WO1993023040A1 (en) 1992-05-20 1993-05-19 17-ethers and thioethers of 4-aza-steroids

Publications (1)

Publication Number Publication Date
DE69329240D1 true DE69329240D1 (de) 2000-09-21

Family

ID=25388234

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329240T Expired - Lifetime DE69329240D1 (de) 1992-05-20 1993-05-19 17-ether und thioether von 4-aza-steroiden

Country Status (9)

Country Link
US (1) US5536727A (de)
EP (1) EP0641204B1 (de)
JP (1) JPH07508038A (de)
AT (1) ATE195530T1 (de)
AU (1) AU668180B2 (de)
CA (1) CA2135174A1 (de)
DE (1) DE69329240D1 (de)
ES (1) ES2148229T3 (de)
WO (1) WO1993023040A1 (de)

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US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
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US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
LT2489659T (lt) 2004-06-24 2018-03-26 Vertex Pharmaceuticals Incorporated Atp rišančios kasetės transporterių moduliatoriai
EP1794130A1 (de) * 2004-09-20 2007-06-13 Biolipox AB Pyrazolverbindungen die in der behandlung von entzündungen nützlich sind
EP1794145A1 (de) * 2004-09-20 2007-06-13 Biolipox AB Pyrazolverbindungen die in der behandlung von entzündungen nützlich sind
US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
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WO2007033002A1 (en) 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
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AU2006310367A1 (en) * 2005-10-31 2007-05-10 Biolipox Ab Triazole compounds as lipoxygenase inhibitors
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JP4824092B2 (ja) 2005-12-01 2011-11-24 エフ．ホフマン−ラ ロシュ アーゲー 新規なビニル様酸誘導体
WO2007075901A2 (en) * 2005-12-24 2007-07-05 Vertex Pharmaceuticals Incorporated Quinolin- 4 - one derivatives as modulators of abc transporters
SI3219705T1 (sl) 2005-12-28 2020-08-31 Vertex Pharmaceuticals Incorporated Farmacevtski sestavki amorfne oblike N-(2,4-bis(1,1-dimetiletil)-5- hidroksifenil)-1,4-dihidro-4-oksokinolin-3-karboksamid
EP2460793A1 (de) 2006-02-03 2012-06-06 Bionomics Limited Substituierte Benzofure, Benzothiophene, Benzoselenophene und Indole sowie ihre Verwendung als Tubulinpolymerisierungshemmer
WO2007143600A2 (en) * 2006-06-05 2007-12-13 Incyte Corporation Sheddase inhibitors combined with cd30-binding immunotherapeutics for the treatment of cd30 positive diseases
EP2061760A1 (de) 2006-09-07 2009-05-27 Amgen, Inc Benzokondensierte verbindungen zur verwendung bei der behandlung von stoffwechselerkrankungen
US7714008B2 (en) 2006-09-07 2010-05-11 Amgen Inc. Heterocyclic GPR40 modulators
US7705034B2 (en) 2006-10-13 2010-04-27 Hoffmann-La Roche Inc. Vinylogous acid derivatives
CN101668751A (zh) 2006-12-12 2010-03-10 先灵公司 天冬氨酰蛋白酶抑制剂
JP2010524932A (ja) 2007-04-16 2010-07-22 アムジエン・インコーポレーテツド 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸ｇｐｒ４０調節物質
AU2008298545B2 (en) 2007-09-14 2013-12-12 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US8030354B2 (en) 2007-10-10 2011-10-04 Amgen Inc. Substituted biphenyl GPR40 modulators
MX2010009654A (es) 2008-03-06 2010-09-28 Amgen Inc Derivados de acido carboxilico de conformacion restringida utiles para tratar trastornos metabolicos.
CA2739888C (en) 2008-10-15 2013-11-19 Amgen Inc. Spirocyclic gpr40 modulators
KR101955863B1 (ko) 2009-03-20 2019-03-07 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
NZ629199A (en) 2012-02-27 2017-01-27 Vertex Pharma Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

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CA970692A (en) * 1971-11-08 1975-07-08 Walter Voigt METHODS OF INHIBITING THE ACTIVITY OF TESTOSTERONE 5.alpha.-REDUCTASE
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Also Published As

Publication number Publication date
AU668180B2 (en) 1996-04-26
AU4252193A (en) 1993-12-13
ATE195530T1 (de) 2000-09-15
EP0641204A1 (de) 1995-03-08
JPH07508038A (ja) 1995-09-07
EP0641204B1 (de) 2000-08-16
ES2148229T3 (es) 2000-10-16
WO1993023040A1 (en) 1993-11-25
CA2135174A1 (en) 1993-11-25
US5536727A (en) 1996-07-16
EP0641204A4 (de) 1995-08-23

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Legal Events

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8332 No legal effect for de