CN212327216U

CN212327216U - Phased array acoustic power tumor and tumor blood vessel diagnosis and treatment integrated system

Info

Publication number: CN212327216U
Application number: CN202021427449.3U
Authority: CN
Inventors: 郝良适; 郝长宁
Original assignee: Shanghai Shikang Enterprise Management Consulting Partnership LP
Current assignee: Shanghai Shikang Enterprise Management Consulting Partnership LP
Priority date: 2020-07-14
Filing date: 2020-07-20
Publication date: 2021-01-12
Anticipated expiration: 2030-07-20

Abstract

The utility model discloses a phased array acoustic power tumour and tumour blood vessel unification system of diagnosing, including the array, the layer is drawn forth to the electrode, PCB board and controller, the array includes a plurality of array elements, the back welding of array has the stitch, the layer is drawn forth to the electrode is installed through the mode of contact pin to the array, the stitch that the layer was drawn forth to the electrode is corresponding array element, the electrode is drawn forth the layer and is pasted on the PCB board, the transmission of the corresponding array element of PCB control is postponed, the PCB board is connected with the controller, the controller is used for setting up the focus angle, the degree of depth, intensity and the action time of phased array probe. The utility model discloses utilize tumour blood vessel specific molecule or tumour specific molecule to expressing in the medical research, under quantum dot and sound sensitive agent to this molecule simultaneous marking basis, through space, the time resolution technique of phased array acoustic dynamic force, pinpoint, accurate acoustic energy release realize the purpose to the accurate treatment of acoustic dynamic force of tumour blood vessel or tumour targeting molecule focus imaging and ration targeting molecule.

Description

Phased array acoustic power tumor and tumor blood vessel diagnosis and treatment integrated system

Technical Field

The utility model relates to a phased array sound power technology especially relates to a phased array sound power diagnoses unification system to accurate positioning, accurate sound energy release to tumour and tumour blood vessel focus based on time, spatial resolution under to.

Background

The ultrasonic phased array is formed by combining a plurality of independent array elements according to a certain shape and size, and focuses with different characteristics can be generated by different array element shapes and arrangement modes through electronic control. The ultrasonic phased array technology can realize the focus domain modes of various forms of a sound field, theoretically perform time resolution and spatial resolution, accurately position and accurately release acoustic energy to treat tumors and tumor vascular lesions, and make accurate positioning and quantitative ultrasonic energy supply to the lesions possible.

The basic principle of sonodynamic therapy (SDT) is: under the action of ultrasonic wave (cavitation), the sonosensitizer produces active oxygen substance (singlet oxygen) with cytotoxicity by biochemical reaction¹O₂Free radical, etc.), these sonochemical reaction products and the biological effect of ultrasonic cavitation act synergistically to cause irreversible damage to tumor cells, so that cancer cells die and die, and non-operative tumor location treatment is realized. Because the ultrasound can easily penetrate into biological soft tissues of several centimeters or even more than ten centimeters (depending on the ultrasound frequency) and can be focused on a small area, the novel ultrasonic acoustic dynamic therapy device simultaneously marks target molecules by utilizing quantum dots and acoustic sensitizers to carry out targeted acoustic dynamic therapy. Can be popularized and applied to the treatment of all targeted molecules, and is a non-drug-pair targeted treatment method.

SUMMERY OF THE UTILITY MODEL

The utility model provides a phased array acoustic power tumour and tumour blood vessel diagnose unification system utilizes the focus domain mode that ultrasonic phased array technique can realize the multiple form of sound field, through time resolution, spatial resolution, to tumour and tumour blood vessel focus to accurate positioning, accurate acoustic energy release treatment, pinpointing the focus, the ration provides ultrasonic energy and carries out accurate treatment and become possible, realizes tumour blood vessel or tumour focus formation of image and accurate target acoustic power treatment to reach the mesh that tumour and tumour blood vessel diagnose the unification.

The utility model adopts the technical proposal that:

the utility model provides a phased array acoustic power tumour and tumour blood vessel unification system of diagnosing, draws forth layer, PCB board and controller including array, electrode, the array includes a plurality of array elements, the back welding of array has the stitch, the array is installed through the mode of contact pin the layer is drawn forth to the electrode, the stitch that the layer was drawn forth to the electrode is corresponding array element, the electrode is drawn forth the layer and is pasted on the PCB board, PCB control is corresponding array element's transmission is delayed, the PCB board with the controller is connected, the controller is used for setting up focus angle, degree of depth, intensity and the action time of phased array probe.

Preferably, glue filling processing is performed among the array elements, and the array elements are controlled by the controller to work independently.

Preferably, the array elements are formed by cutting piezoelectric wafers.

Preferably, the size of the array element is 1mm × 1 mm.

Preferably, the center-to-center spacing of the array elements is 1.5 mm.

Preferably, the number of the array elements is 20 × 20.

Preferably, when transmitting signals, each row of the array elements forms a focus point, the focus points of all the array elements in the horizontal direction form a scanning line, and scanning is realized by rapidly moving the scanning line along the scanning direction; during receiving, 20 array elements at the central position of the array are selected for receiving imaging, and the position is determined according to the time delay of the array elements for receiving signals.

Preferably, the array elements are rectangular array elements.

Preferably, the number of the array elements is 14-40000, the emission frequency is 0.5MHz-5MHz, and the sound intensity of the focusing area of the array is 0.3-10W/cm²The scanning width is 0.5cm-20cm, and the focusing depth is 2cm-20 cm.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model adopts a two-dimensional plane phased array, each array element is controlled to work independently through the electron, the signal transmitted by each array element reaches the focus point at the same time through transmitting delay, and the energy is concentrated at the focus point, thereby realizing the acoustic dynamic therapy; when the phased array probe transmits signals, each line array element forms a focus point, the focus points of all the array elements in the horizontal direction form a scanning line, the scanning is realized by moving the scanning line along the scanning direction, and then the array elements in the central position of the phased array perform receiving imaging, so that tumor blood vessels or tumor focusing imaging is realized; finally, the purpose of diagnosis and treatment integrating accurate positioning and accurate treatment of the tumor and the tumor blood vessel is achieved.

Drawings

Fig. 1 is a schematic structural diagram of a matrix according to an embodiment of the present invention;

fig. 2 is a diagram illustrating a focusing effect of each array element of the phased array probe according to an embodiment of the present invention after a delay;

fig. 3 is a focusing effect diagram of each array element of the phased array probe according to an embodiment of the present invention after delay and angular deflection;

fig. 4 is a schematic diagram of a phased array scanning process according to an embodiment of the present invention;

fig. 5 is a schematic diagram of a phased array scanning process according to an embodiment of the present invention;

fig. 6 is a schematic diagram illustrating a process of transmitting signals by the phased array probe according to an embodiment of the present invention;

fig. 7 is a schematic diagram of a process of receiving signals by a phased array probe according to an embodiment of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention clearer, the following will explain in detail each embodiment of the present invention with reference to the accompanying drawings.

As shown in fig. 1 to 7, a phased array acoustic power tumour and tumour blood vessel unification system of diagnosing, including the base array, the layer is drawn forth to the electrode, PCB board and controller, the base array includes a plurality of array elements, the back welding of base array has the stitch, the electrode is drawn forth the layer through the mode installation of contact pin to the base array, the stitch that the layer was drawn forth to the electrode is corresponding array element, the electrode is drawn forth the layer and is pasted on the PCB board, the transmission of the corresponding array element of PCB control is delayed, the PCB board is connected with the controller, the controller is used for setting up the focus angle of phased array probe, the degree of depth, intensity and action time.

The phased array of the embodiment has the following technical indexes:

the system adopts a two-dimensional planar phased array, the physical size is 20cm multiplied by 20cm, the number of array elements is 14-40000, the emission frequency is 0.5MHz-5MHz, and the sound intensity of a focusing area of the array is 0.3-10W/cm²The scanning width is 0.5cm-20cm, and the focusing depth is 2cm-20 cm.

The process of the two-dimensional planar phased array of the embodiment is as follows:

1. cutting piezoelectric ceramic array

The piezoelectric chip with the physical size of 29.5mm multiplied by 29.5mm is cut into a basic array consisting of a plurality of rectangular array elements, the number of the array elements is 20 multiplied by 20 (400), the size of the array elements is 1mm multiplied by 1mm, the center distance of the array elements is 1.5mm, and the transmitting frequency of the array elements is 2 MHz.

2. Matrix glue filling treatment

Glue pouring treatment is carried out between the array elements, so that the array elements become independent individuals, and the independent work of each array element is controlled through electrons.

3. Leading out each array element electrode of array

Welding pins on the back of the array, and then installing the array on the electrode leading-out layer in a pin inserting mode, wherein the pins of the electrode leading-out layer correspond to corresponding array elements.

4. Paste PCB board

And attaching the electrode lead-out layer provided with the piezoelectric array to a PCB.

5. Control algorithm write-in on PCB

And compiling a control algorithm on the PCB to control the transmission delay of the corresponding array element.

6. The controller sets the focusing angle, depth, intensity and action time

The PCB is connected with a controller, the interface of the controller is provided with the focusing angle, the focusing depth, the focusing intensity and the focusing action time, and the focusing action effect of the phased array probe can be flexibly controlled by setting the focusing angle, the focusing depth, the focusing intensity and the focusing action time through the controller.

As shown in fig. 2, the phased array probe has a focusing effect after each array element is delayed; as shown in fig. 3, each array element of the phased array probe has a focusing effect after time delay and angular deflection.

And calculating the sound path difference between each array element and the focusing position to obtain the signal transmission delay time of each array element, wherein the array element far away from the focusing point is transmitted firstly, and the array element close to the focusing point is transmitted later, so that the signals transmitted by each array element reach the focusing point at the same time, and the energy is concentrated at the focusing point.

As shown in fig. 4 and 5, the scanning process of the phased array.

As shown in fig. 6, the process of transmitting a signal by a phased array probe; the process of receiving a signal by a phased array probe is shown in figure 7.

When the phased array probe transmits signals, each array element forms a focus point (all 400 array elements participate in scanning), so that the focus points of all the array elements in the horizontal direction form a scanning line, and the scanning is realized by rapidly moving the scanning line along the scanning direction; during receiving, 20 array elements (in the vertical direction) at the central position of the phased array are selected for receiving and imaging, and the position of the obstacle is finally determined according to the time delay of the array elements for receiving signals.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention should be covered by the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. The utility model provides a phased array acoustic power tumour and tumour blood vessel unification system of diagnosing, its characterized in that, draw forth layer, PCB board and controller including base array, electrode, the base array includes a plurality of array elements, the back side welding of base array has the stitch, the base array is installed through the mode of contact pin the layer is drawn forth to the electrode, the stitch that the layer was drawn forth to the electrode is corresponding array element, the electrode is drawn forth the layer and is pasted on the PCB board, PCB control is corresponding array element's transmission is delayed, the PCB board with the controller is connected, the controller is used for setting up focus angle, the degree of depth, intensity and the action time of phased array probe.

2. The system of claim 1, wherein each array element is encapsulated by glue, and each array element is controlled by the controller to work independently.

3. The system of claim 1, wherein the array elements are cut from a piezoelectric wafer.

4. The system of claim 1, wherein the array elements are 1mm x 1mm in size.

5. The system of claim 4, wherein the array elements are spaced apart by 1.5 mm.

6. The system of claim 1, wherein the number of the array elements is 20 x 20.

7. The phased array acoustic dynamic tumor and tumor blood vessel diagnosis and treatment integrated system according to claim 6, wherein when transmitting signals, each row of the array elements forms a focus point, the focus points of all the array elements in the horizontal direction form a scanning line, and scanning is realized by rapidly moving the scanning line along the scanning direction; during receiving, 20 array elements at the central position of the array are selected for receiving imaging, and the position is determined according to the time delay of the array elements for receiving signals.

8. The system of claim 1, wherein the array elements are rectangular array elements.

9. The phased array acoustic dynamic tumor and tumor blood vessel diagnosis and treatment integrated system according to claim 1, wherein the number of the array elements is 14-40000, the emission frequency is 0.5MHz-5MHz, and the acoustic intensity of the focusing area of the array is 0.3-10W/cm²The scanning width is 0.5cm-20cm, and the focusing depth is 2cm-20 cm.