CN207964611U - A kind of blood glucose photoacoustic detection device of many reference amounts - Google Patents
A kind of blood glucose photoacoustic detection device of many reference amounts Download PDFInfo
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- CN207964611U CN207964611U CN201820377850.7U CN201820377850U CN207964611U CN 207964611 U CN207964611 U CN 207964611U CN 201820377850 U CN201820377850 U CN 201820377850U CN 207964611 U CN207964611 U CN 207964611U
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Abstract
The utility model discloses a kind of blood glucose photoacoustic detection devices of many reference amounts, including light source unit, optical path unit, tested tissue, probe unit and data analysis and processing unit to constitute.The utility model uses the probe unit that multiple and different type of sensors are built into, to be measured to the blood sugar concentration in tested tissue, the corresponding optoacoustic amplitude of different blood sugar concentrations can be not only obtained, the parameter values such as absorptivity, temperature value, coefficient of thermal expansion and the velocity of sound of corresponding concentration blood glucose can also be obtained simultaneously.The probe unit of the utility model design has drum type brake and planar configuration, is suitble to different detection positions.Compared with existing photoacoustic detection device, device disclosed by the utility model makes the stability of blood glucose photo-acoustic detection and accuracy higher, applicability stronger.
Description
Technical field
The utility model belongs to biologic medical detection technique field, and in particular to a kind of blood glucose photo-acoustic detection dress of many reference amounts
It sets.
Background technology
Blood glucose optical detective technology is due to noninvasive, signal-to-noise ratio is high, stability is good and the advantages such as convenient and efficient so that this
Class detection technique becomes the research hotspot of domestic and international many scholars and team's concern.Due to pure optical means, such as：Near-infrared and
Mid-infrared light spectrometry, being absorbed the factors such as stronger by the interference of scattering light, spectra overlapping and water is influenced so that spectroscopic data, which exists, makes an uproar
The deficiencies of sound, difficult needle position misalignment and feature extraction.And photoacoustic detection technique has had both pure optics high contrast and pure ultrasound is high
The advantages of resolution ratio, avoids the interference effect that tissue scatter's light belt comes, using the excitation side of pulsed laser irradiation from principle
Method can carry out photo-acoustic detection to the blood constituent in the blood and blood vessel of skin deeper.Up to the present, domestic
Outer some scholars theoretical and mechanism relevant to photoacoustic technique, and for the excitation of different measurand and different wave length
Source, it is proposed that different optoacoustic theories and model；Meanwhile it being carried out to different imitative body blood glucose, in vitro blood glucose and in body blood glucose
Experimental study has obtained mapping relations between the blood sugar concentration and photoacoustce signal intensity of different objects and blood sugar concentration
Prediction model.But past blood glucose photo-acoustic detection is only to be come and blood glucose with the blood glucose optoacoustic amplitude or peak-to-peak value that detect
Certain relational model is established between concentration gradient, this mode makes established blood sugar concentration prediction model too simple,
Without actual application value.The reason is that：During practical blood sugar test, blood glucose optoacoustic amplitude is influenced by many factors,
Such as：Hardware parameter variation, temperature change, the attribute change of substance, or even over time, also exist in body blood sugar concentration
Change etc., these factors will not only make the change of tested blood glucose optoacoustic amplitude, but also can make blood sugar concentration sheet
Body can also occur to change accordingly.Therefore, optoacoustic amplitude or peak-to-peak value is only relied only on to reflect to establish between blood glucose concentration gradient
The relationship of penetrating far can not be met the requirements.
Invention content
The utility model be solve blood glucose photo-acoustic detection presently, there are the technical issues of, a kind of blood glucose light of many reference amounts is provided
Sound detection device.
The technical issues of in order to solve the utility model, the utility model are achieved through the following technical solutions：It is a kind of
The blood glucose photoacoustic detection device of many reference amounts, including at light source unit, optical path unit, tested tissue, probe unit and data analysis
Unit is managed, the tested tissue is placed in the probe unit, and the light beam of the light source unit laser enters by optical path unit
It is incident upon in tested tissue, the information of acquisition is sent to data analysis and processing unit by the probe unit；The light source unit packet
Light source, cooling component and light source driver module are included, the cooling component radiates to light source, to extend light source service life；
The optical path unit sets gradually collimation lens and condenser lens along optical propagation direction, the probe unit include quartz glass,
Annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor, coefficient of thermal expansion detector；The data analysis
Processing unit sets gradually multi channel signals amplifier, Multichannel data acquisition device and computer along signal transmission direction, described
Multi channel signals amplifier, Multichannel data acquisition device and computer are electrically connected successively；The light source driver module, light source and
The computer electrical connection, the control instruction sent by computer are realized to the beam excitation and energy of light source, wave
The adjusting of the parameters such as long and frequency；The arrival end of the multi channel signals amplifier respectively with annular absorbance detector, annular
Ultrasonic detector, annulus temperature detector are connected with 4 output ends of coefficient of thermal expansion detector, are used for above-mentioned 4 differences
The voltage signal of the detector of type is amplified；The input terminal of the Multichannel data acquisition device and multi channel signals amplifier
Output end be connected, for carrying out analog-to-digital conversion and acquisition to amplified voltage signal, then the digital signal of acquisition is passed
It send into computer and carries out analyzing processing.
Preferably, quartz glass, annular absorbance detector, ring-shaped ultrasonic sensor, annular temperature in the probe unit
Spend sensor, the axial centre axis of annular coefficient of thermal expansion detector and the collimating lens, focusing lens in optical path unit and
The axial centre axis of light source is point-blank.
Preferably, quartz glass, annular absorbance detector, ring-shaped ultrasonic sensor, annular temperature in the probe unit
Degree sensor, annular coefficient of thermal expansion detector are sequentially overlapped forms a similar hollow circle with quartz glass pedestal together
Tubular, the annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor and annular coefficient of thermal expansion detector
Arrangement position can be interchangeable as needed, the incident light light of the cross section and light source of the optical path unit and probe unit
Axis is at 90 degree.
Preferably, the quartz glass of the probe unit, annular absorbance detector, ring-shaped ultrasonic sensor, annular temperature
Degree sensor and annular coefficient of thermal expansion detector are that donut planar structure mode arranges, and the quartz glass, annular are inhaled
Photometric detector, ring-shaped ultrasonic sensor, annulus temperature sensor and annular coefficient of thermal expansion detector are flat in same level
On face, and the incident light axis of the plane and optical path unit and light source is at 90 degree.Meanwhile probe unit is followed successively by from the inside to the outside
The quartz glass of round, annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor and annular thermally expand system
Number detector.The annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor and annular coefficient of thermal expansion are visited
Surveying the arrangement position of device can also be interchangeable as needed.
Preferably, the tested tissue and the quartz glass in the probe unit, annular absorbance detector, annular are super
Detector of sound, annulus temperature detector and annular coefficient of thermal expansion detector are in close contact.
Preferably, the port number of the multi channel signals amplifier and Multichannel data acquisition device is more than 4, convenient for follow-up
The Function Extension of blood sugar test multi-parameter.
Compared with prior art, the advantageous effect of the utility model acquisition is：
A kind of blood glucose photoacoustic detection device disclosed by the utility model is come as a result of multiple type of sensors to tested
Blood sugar concentration in tissue is measured, and can obtain the corresponding optoacoustic amplitude of different blood sugar concentrations, absorptivity, temperature simultaneously
The parameter values such as value, coefficient of thermal expansion and the velocity of sound.The probe unit of the utility model design has drum type brake and planar configuration,
It is suitble to different detection positions.Compared with existing photoacoustic detection device, device disclosed by the utility model makes blood glucose optoacoustic
The stability and accuracy higher, applicability of detection are stronger.
Description of the drawings
Fig. 1 is the structure of the detecting device axial cross section principle schematic of embodiment 1.
Fig. 2 is the probe unit three-dimensional structure principle schematic of embodiment 1.
Fig. 3 is the structure of the detecting device axial cross section principle schematic of embodiment 2.
Fig. 4 is the probe unit cross section principle schematic of embodiment 2.
Reference numeral：1, light source unit；101, light source；102, cooling component；103, light source driver module；2, light path list
Member；201, collimation lens；202, convergent lens；3, tested tissue；4, probe unit；401, quartz glass；402, annular extinction
Spend detector；403, ring-shaped ultrasonic detector；404, annulus temperature detector；405, annular coefficient of thermal expansion detector；5, number
According to analysis and processing unit；501, multi channel signals amplifier；502, Multichannel data acquisition device；503, computer.
Specific implementation mode
Below in conjunction with the accompanying drawings, embodiment is described in detail.
Embodiment 1：
Referring to attached drawing 1 and attached drawing 2, a kind of blood glucose photoacoustic detection device of many reference amounts, including light source unit 1, optical path unit
2, tested tissue 3, probe unit 4 and data analysis and processing unit 5, the tested tissue 3 are placed in the probe unit 4,
The light beam of 1 laser of the light source unit is incident to by optical path unit 2 in tested tissue 3, and the probe unit 4 is by the letter of acquisition
Breath is sent to data analysis and processing unit 5；The light source unit 1 includes light source 101, cooling component 102 and light source driver module
103, the cooling component 102 radiates to light source 101, to extend 101 service life of light source；The optical path unit 2 is along light
The direction of propagation sets gradually collimation lens 201 and condenser lens 202, and the probe unit 4 includes quartz glass 401, annular suction
Photometric detector 402, ring-shaped ultrasonic sensor 403, annulus temperature sensor 404 and coefficient of thermal expansion detector 405；The number
According to analysis and processing unit 5 multi channel signals amplifier 501, Multichannel data acquisition device 502 are set gradually along signal transmission direction
With computer 503, the multi channel signals amplifier 501, Multichannel data acquisition device 502 and computer 503 electrically connect successively
It connects；The light source driver module 103, light source 101 and the computer 503 are electrically connected, the control sent by computer 503
The adjusting of the parameters such as beam excitation and energy to light source 101, wavelength and frequency is realized in instruction；The multi channel signals are put
The arrival end of big device 501 respectively with annular absorbance detector 402, ring-shaped ultrasonic detector 403, annulus temperature detector 404
It is connected with 4 output ends of coefficient of thermal expansion detector 405, is used for the voltage signal of above-mentioned 4 different types of detectors
It is amplified；The input terminal of the Multichannel data acquisition device 502 is connected with the output end of multi channel signals amplifier 501, uses
In carrying out analog-to-digital conversion and acquisition to amplified voltage signal, then the digital signal of acquisition is sent in computer 503
Carry out analyzing processing.
Further, quartz glass 401, annular absorbance detector 402, ring-shaped ultrasonic sensing in the probe unit 4
Device 403, the axial centre axis of annulus temperature sensor 404 and annular coefficient of thermal expansion detector 405 and the standard in optical path unit 2
The axial centre axis of straight lens 201, condenser lens 202 and light source 101 is point-blank.
Further, quartz glass 401, annular absorbance detector 402, ring-shaped ultrasonic sensing in the probe unit 4
Device 403, annulus temperature sensor 404 are sequentially overlapped one similar band of formation together with annular coefficient of thermal expansion detector 405
The hollow cylindrical of quartz glass pedestal, the annular absorbance detector 402, ring-shaped ultrasonic sensor 403, annulus temperature pass
The arrangement position of sensor 404 and annular coefficient of thermal expansion detector 405 can be interchangeable as needed, the optical path unit 2
With the cross section of probe unit 4 and the incident light axis of light source 101 at 90 degree.
Further, the preferred detection position of the tested tissue 3 is finger, and the tested tissue 3 is for ease of in insertion
Tissue in the probe unit 4 of empty tube shape, the tested tissue 3 and quartz glass 401, the ring in the probe unit 4
Shape absorbance detector 402, ring-shaped ultrasonic sensor 403, annulus temperature sensor 404 and annular coefficient of thermal expansion detector
405 are in close contact.
Further, the port number of the multi channel signals amplifier 501 and Multichannel data acquisition device 502 is more than 4,
Convenient for the Function Extension of follow-up blood sugar test multi-parameter.
Embodiment 2：
2 difference from Example 1 of embodiment is only embodied in the structure of probe unit 4, remaining apparatus structure is equal
It is same as Example 1.
Referring to attached drawing 3 and attached drawing 4, a kind of blood glucose photoacoustic detection device of many reference amounts, including light source unit 1, optical path unit
2, tested tissue 3, probe unit 4 and data analysis and processing unit 5, the tested tissue 3 are placed in the probe unit 4,
The light beam of 1 laser of the light source unit is incident to by optical path unit 2 in tested tissue 3, and the probe unit 4 is by the letter of acquisition
Breath is sent to data analysis and processing unit 5；The light source unit 1 includes light source 101, cooling component 102 and light source driver module
103, the cooling component 102 radiates to light source 101, to extend 101 service life of light source；The optical path unit 2 is along light
The direction of propagation sets gradually collimation lens 201 and condenser lens 202, and the probe unit 4 includes quartz glass 401, annular suction
Photometric detector 402, ring-shaped ultrasonic sensor 403, annulus temperature sensor 404 and coefficient of thermal expansion detector 405；The number
According to analysis and processing unit 5 multi channel signals amplifier 501, Multichannel data acquisition device 502 are set gradually along signal transmission direction
With computer 503, the multi channel signals amplifier 501, Multichannel data acquisition device 502 and computer 503 electrically connect successively
It connects；The light source driver module 103, light source 101 and the computer 503 are electrically connected, the control sent by computer 503
The adjusting of the parameters such as beam excitation and energy to light source 101, wavelength and frequency is realized in instruction；The multi channel signals are put
The arrival end of big device 501 respectively with annular absorbance detector 402, ring-shaped ultrasonic detector 403, annulus temperature detector 404
It is connected with 4 output ends of coefficient of thermal expansion detector 405, is used for the voltage signal of above-mentioned 4 different types of detectors
It is amplified；The input terminal of the Multichannel data acquisition device 502 is connected with the output end of multi channel signals amplifier 501, uses
In carrying out analog-to-digital conversion and acquisition to amplified voltage signal, then the digital signal of acquisition is sent in computer 503
Carry out analyzing processing.
Further, quartz glass 401, annular absorbance detector 402, ring-shaped ultrasonic sensing in the probe unit 4
Device 403, the axial centre axis of annulus temperature sensor 404 and annular coefficient of thermal expansion detector 405 and the standard in optical path unit 2
The axial centre axis of straight lens 201, condenser lens 202 and light source 101 is point-blank.
Further, the quartz glass 401 of the probe unit 4, annular absorbance detector 402, ring-shaped ultrasonic sensing
Device 403, annulus temperature sensor 404 and annular coefficient of thermal expansion detector 405 arrange for donut planar structure mode, institute
State quartz glass 401, annular absorbance detector 402, ring-shaped ultrasonic sensor 403, annulus temperature sensor 404 and annular heat
Coefficient of expansion detector 405 is in same level plane, and the incident light light of the plane and optical path unit 2 and light source 101
Axis is at 90 degree.Meanwhile probe unit 4 be followed successively by from the inside to the outside the quartz glass 401 of round, annular absorbance detector 402,
Ring-shaped ultrasonic sensor 403, annulus temperature sensor 404 and annular coefficient of thermal expansion detector 405.The annular absorbance is visited
Survey the arrangement position of device 402, ring-shaped ultrasonic sensor 403, annulus temperature sensor 404 and annular coefficient of thermal expansion detector 405
Set to be interchangeable as needed.
Further, the tested tissue 3 can be the relatively flat positions of whole bodies such as palm, arm, ear-lobe, thigh,
The tested tissue 3 is sensed with quartz glass 401, annular absorbance detector 402, the ring-shaped ultrasonic in the probe unit 4
Device 403, annulus temperature sensor 404 and annular coefficient of thermal expansion detector 405 are in close contact.
Further, the port number of the multi channel signals amplifier 501 and Multichannel data acquisition device 502 is more than 4,
Convenient for the Function Extension of follow-up blood sugar test multi-parameter.
Listed above is only one of specific embodiment of the utility model.Obviously, the utility model is not limited to the above reality
Example is applied, it can also be there are many similar reshaping.Those skilled in the art can be direct from content disclosed by the utility model
All deformations for exporting or associating, are considered as the utility model scope of the claimed.
Claims (6)
1. a kind of blood glucose photoacoustic detection device of many reference amounts, it is characterised in that：Including light source unit, optical path unit, tested tissue,
Probe unit and data analysis and processing unit, the tested tissue are placed in the probe unit, the light source unit laser
Light beam be incident in tested tissue by optical path unit, the information of acquisition is sent to Data Analysis Services by the probe unit
Unit；The light source unit includes light source, cooling component and light source driver module, and the cooling component radiates to light source；
The optical path unit sets gradually collimation lens and condenser lens along optical propagation direction, the probe unit include quartz glass,
Annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor, coefficient of thermal expansion detector；The data analysis
Processing unit sets gradually multi channel signals amplifier, Multichannel data acquisition device and computer along signal transmission direction, described
Multi channel signals amplifier, Multichannel data acquisition device and computer are electrically connected successively；The light source driver module, light source and
The computer electrical connection；The arrival end of the multi channel signals amplifier is super with annular absorbance detector, annular respectively
Detector of sound, annulus temperature detector are connected with the output end of coefficient of thermal expansion detector；The Multichannel data acquisition device
Input terminal is connected with the output end of multi channel signals amplifier, and the digital signal of acquisition is sent in computer and is carried out at analysis
Reason.
2. a kind of blood glucose photoacoustic detection device of many reference amounts as described in claim 1, it is characterised in that：In the probe unit
Quartz glass, annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor, annular coefficient of thermal expansion detector
Axial centre axis and optical path unit in collimating lens, focusing lens and light source axial centre axis point-blank.
3. a kind of blood glucose photoacoustic detection device of many reference amounts as claimed in claim 2, it is characterised in that：In the probe unit
Quartz glass, annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor, annular coefficient of thermal expansion detector
It is sequentially overlapped and forms hollow cylindrical together, the annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensing
The arrangement position of device and annular coefficient of thermal expansion detector is interchangeable, the cross section and light source of the optical path unit and probe unit
Incident light axis at 90 degree.
4. a kind of blood glucose photoacoustic detection device of many reference amounts as claimed in claim 2, it is characterised in that：The probe unit
Quartz glass, annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor and annular coefficient of thermal expansion detector
It is arranged for donut planar structure mode, the quartz glass, annular absorbance detector, ring-shaped ultrasonic sensor, annular
Temperature sensor and annular coefficient of thermal expansion detector are in same level plane, and the plane and optical path unit and light source
Incident light axis at 90 degree；The annular absorbance detector, ring-shaped ultrasonic sensor, annulus temperature sensor and annular heat
The arrangement position of coefficient of expansion detector is interchangeable.
5. a kind of blood glucose photoacoustic detection device of many reference amounts as described in claim 1, it is characterised in that：The tested tissue with
Quartz glass, annular absorbance detector, ring-shaped ultrasonic detector, annulus temperature detector in the probe unit and annular
Coefficient of thermal expansion detector is in close contact.
6. a kind of blood glucose photoacoustic detection device of many reference amounts as described in claim 1, it is characterised in that：The multi channel signals
The port number of amplifier and Multichannel data acquisition device is more than 4.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820377850.7U CN207964611U (en) | 2018-03-20 | 2018-03-20 | A kind of blood glucose photoacoustic detection device of many reference amounts |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201820377850.7U CN207964611U (en) | 2018-03-20 | 2018-03-20 | A kind of blood glucose photoacoustic detection device of many reference amounts |
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| CN207964611U true CN207964611U (en) | 2018-10-12 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108152214A (en) * | 2018-03-20 | 2018-06-12 | 江西科技师范大学 | The blood glucose photoacoustic detection device and method of a kind of many reference amounts |
| CN116138771A (en) * | 2023-04-18 | 2023-05-23 | 江西科技师范大学 | Energy correction method for multispectral blood glucose photoacoustic detection |
-
2018
- 2018-03-20 CN CN201820377850.7U patent/CN207964611U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108152214A (en) * | 2018-03-20 | 2018-06-12 | 江西科技师范大学 | The blood glucose photoacoustic detection device and method of a kind of many reference amounts |
| CN108152214B (en) * | 2018-03-20 | 2023-08-22 | 江西科技师范大学 | Multi-parameter blood glucose photoacoustic detection device and method |
| CN116138771A (en) * | 2023-04-18 | 2023-05-23 | 江西科技师范大学 | Energy correction method for multispectral blood glucose photoacoustic detection |
| CN116138771B (en) * | 2023-04-18 | 2023-06-30 | 江西科技师范大学 | Energy correction method for multispectral blood glucose photoacoustic detection |
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Granted publication date: 20181012 Termination date: 20190320 |