CN118512219A

CN118512219A - Biopsy sampler

Info

Publication number: CN118512219A
Application number: CN202410965136.XA
Authority: CN
Inventors: 赵亚洲; 赵磊; 王英杰; 王强
Original assignee: Xinshenghe Technology Beijing Co ltd; Shengyi Technology Beijing Co ltd
Current assignee: Xinshenghe Technology Beijing Co ltd; Shengyi Technology Beijing Co ltd
Priority date: 2024-07-18
Filing date: 2024-07-18
Publication date: 2024-08-20

Abstract

The present disclosure provides a biopsy sampler comprising: a base having a substantially cylindrical shape; at least one sampling portion located in the base and at least a portion of which is capable of extension and retraction relative to a side of the base; and an operation unit connected to the base and configured to operate the sampling unit; and the operation part is operated to enable at least one part of the sampling part to extend out of the side face of the base and scrape the sampled object on the surface of the sampled part to sample, and the sampled sampling part is retracted into the base to retain the scraped sampled object.

Description

Biopsy sampler

Technical Field

The present disclosure relates to the technical field of medical instruments, and more particularly, to a biopsy sampler, such as a reverse biopsy forceps, capable of grasping tissue attached to an inner wall of a viscera, and an endoscope including the biopsy sampler.

Background

Minimally invasive surgery is now becoming the mainstream in medicine, and biopsy sampling is a technique for taking out pathological tissue from a patient by incision, forceps, puncture, or the like, and performing pathological examination, as needed for diagnosis and treatment.

At present, biopsy is the most important part of diagnosis pathology, and clear histopathological diagnosis can be made for most of the delivery cases, and is taken as the final diagnosis in clinic. There are many medical devices that obtain tissue from human tissue, and some unnecessary tissue of the human body needs to be excised, such as nodules, myomas, and the like. In order to obtain tissue samples, various methods are known in the art.

Currently, endoscopes are frequently used, doctors prefer to use the endoscopes and biopsy forceps to sample living tissues of digestive tracts, respiratory tracts and bile ducts, and perform pathological analysis, so that the most accurate mode is provided for disease treatment. Part of the endoscope is provided with a forceps channel hole, a guide wire and a treatment accessory can be passed through the forceps channel hole, so that the treatment accessory can conveniently enter the digestive tract, the respiratory tract and the bile duct along with the endoscope, and the guide of the treatment accessory is determined by the guide wire in the guide wire hole. The biopsy forceps are positioned in the forceps channel and inserted into the alimentary canal, the respiratory tract and the bile duct together with the endoscope, and the forceps take biopsy tissue samples for pathological analysis. For example, patent document 1 (CN 202021992199.8) discloses a forward biopsy forceps that grips a biopsy sample. However, the existing bioptomes have the following problems: (1) The biliary wall is softer, and the biliary wall is more easily damaged under the condition of no guide wire guide; (2) The forward grasping tissue is incomplete, and the attached tissue on the gallbladder wall is not grasped.

Disclosure of Invention

In order to solve the problems that the forward grabbing tissue is incomplete, the tissue attached to the gallbladder wall is not grabbed, the gallbladder wall is easy to damage under the condition of no guide wire guide due to softer gallbladder wall and the like in the prior art, the invention provides a biopsy sampler which can collect the bile duct wall attachments without damaging the gallbladder wall and can scrape the bile duct wall tissue reversely.

The invention provides a biopsy sampler, which is characterized in that: comprising the following steps: a base having a substantially cylindrical shape; at least one sampling portion located in the base and at least a portion of which is capable of extension and retraction relative to a side of the base; and an operation unit connected to the base and configured to operate the sampling unit; and the operation part is operated to enable at least one part of the sampling part to extend out of the side face of the base and scrape the sampled object on the surface of the sampled part to sample, and the sampled sampling part is retracted into the base to retain the scraped sampled object.

Preferably, in the biopsy sampler of the present invention, the operation section includes: a body portion having a hollow rod shape; a circular ring portion provided at one end of the body portion; and a push handle portion detachably attached to the outer periphery of the body portion and reciprocally slidable within a predetermined range of the outer periphery of the body portion.

Preferably, in the biopsy sampler of the present invention, the body portion includes: a middle lever handle which is positioned at the other end of the body part and accommodates a spring sleeve inside; a handle cover covering the opening of the middle handle; and a top spring post located inside the middle lever handle and securing the spring sleeve.

Preferably, in the biopsy sampler of the present invention, a first transmission guide wire fixing block and a second transmission guide wire fixing block for fixing the transmission guide wire are connected in the pushing part.

Preferably, in the biopsy sampler of the present invention, the sampling portion includes: a transmission guide wire seat connected with the spring sleeve and receiving the driving force from the spring sleeve; the transmission keys are multiple and connected with the transmission guide wire seat to transmit driving force; and at least one sampling end which is extended and retracted relative to the side of the base by the movement of the drive key to complete sampling.

Preferably, in the biopsy sampler of the present invention, the number of the sampling ends is 2, and the sampling ends can be extended from both sides of the base to scrape the sampling target object on the surface of the sampled portion to sample, and the sampled sampling ends are retracted into the base in a state that the sampling ends are attached to the sampling target object toward the base side to retain the sampling target object.

Preferably, in the biopsy sampler of the present invention, the drive keys are rotatably connected by pins.

Preferably, in the biopsy sampler of the present invention, a guide wire guiding hole is provided at a front end of the base, and a guide wire is inserted into the guide wire guiding hole.

The invention provides an endoscope, which is characterized in that: the biopsy sampler is provided.

Preferably, in the endoscope of the present invention, the sampling portion of the biopsy sampler is inserted into a jaw channel of the endoscope and moved into and out of a human body together with the endoscope.

The biopsy sampler provided by the invention can solve the problems that the tissue is not completely grasped in the forward direction, the tissue attached to the gallbladder wall is not grasped, and the gallbladder wall is easy to damage under the condition of no guide wire guide due to softer gallbladder wall and the like.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the disclosure and together with the description, serve to explain the principles of the disclosure.

In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, the drawings that are required to be used in the description of the embodiments or the prior art will be briefly described below, and it will be apparent to those skilled in the art that other drawings can be obtained from these drawings without inventive effort.

FIG. 1 is a schematic view of example 1 of a biopsy sampler according to the present invention;

FIG. 2 is a schematic view of the operative portion of the biopsy sampler according to the present invention;

FIG. 3 is a cross-sectional view of the operative portion of the biopsy sampler according to the present invention;

FIG. 4 is an exploded schematic view of the operative portion of the biopsy sampler according to the present invention;

FIG. 5 is a schematic view of a drive wire of a biopsy sampler according to the present invention;

FIG. 6 is a schematic view of a biopsy sampler according to the present invention with a sampling portion in an extended state;

FIG. 7 is a schematic view of a biopsy sampler according to the present invention with the sampling portion in a retracted state;

FIG. 8 is a schematic view of a sampling portion of a biopsy sampler according to the present invention;

FIG. 9 is a cross-sectional view of a portion of the operative portion of the biopsy sampler according to the present invention;

FIG. 10 is a schematic view of a portion of the operative portion of the biopsy sampler according to the present invention;

FIG. 11 is a schematic view showing a state in which a biopsy sampler according to the present invention is mounted in an endoscope;

FIG. 12 is another schematic view of a biopsy sampler according to the present invention in an endoscope installed state;

Fig. 13 is a schematic view of example 2 of a biopsy sampler according to the present invention.

In the figure: 101-spring sleeve, 102-handle gland, 103-middle handle, 104-push handle, 105-circular portion, 201-top spring post, 202-first drive wire fixing block, 203-second drive wire fixing block, 301-drive wire pressing tube, 302-drive wire sleeve, 303-drive wire, 401-base, 402-jaw, 403-guide wire guide hole, 404-pin, 405-drive key, 406-drive wire sleeve welding hole, 407-tissue collection area, 501-guide wire, 601-drive wire seat, 701-endoscope, 702-endoscope jaw, 703-endoscope camera, 801-biopsy sampler.

Detailed Description

In order that the above objects, features and advantages of the present disclosure may be more clearly understood, embodiments of the present disclosure will be further described below. It should be noted that, without conflict, the embodiments of the present disclosure and features in the embodiments may be combined with each other.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present disclosure, but the present disclosure may be practiced otherwise than as described herein; it will be apparent that the embodiments in the specification are only some, but not all, embodiments of the disclosure.

Example 1

As shown in fig. 1 to 12, a biopsy sampler 801 provided in embodiment 1 of the present invention includes: a base 401 having a substantially cylindrical shape; at least one sampling portion located in the base 401 and at least a portion of which (e.g., the jaw end 402) is capable of extension and retraction relative to the sides of the base 401; and an operation unit which is connected to the base 401 and operates the sampling unit; at least a part of the sampling portion (for example, the jaw 402) is extended from the side of the base 401 by the operation of the operation portion, and samples a sampling target (for example, a gallbladder wall tissue) on the surface of the sampling portion (for example, a gallbladder wall) by scraping, and the sampled sampling portion is retracted into the base 401 to retain the scraped sampling target.

Although the drawing shows a configuration in which one sampling unit is provided, a configuration in which two or more sampling units are provided may be employed.

As shown in fig. 2, in the biopsy sampler 801 provided in embodiment 1 of the present invention, the operation section includes: a body portion having a hollow rod shape; a circular ring portion 105 provided at one end of the body portion; and a push handle portion 104 detachably attached to the outer periphery of the body portion and reciprocally slidable within a predetermined range of the outer periphery of the body portion.

As shown in fig. 2 to 4, in the biopsy sampler 801 provided in embodiment 1 of the present invention, a body portion includes: a middle lever handle 103 which is located at the other end of the body portion and accommodates the spring bushing 101 therein; a handle cover 102 covering an opening of the center handle 103; and a top spring post 201 that is located inside the center rod grip 103 and secures the spring sleeve 101.

As shown in fig. 7, in a biopsy sampler 801 provided in embodiment 1 of the present invention, a sampling section includes: a transmission guide wire holder 601 connected to the spring sleeve 101 and receiving a driving force from the spring sleeve 101; a plurality of driving keys 405 connected to the driving wire holder 601 to transmit driving force; and at least one sampling end (e.g., jaw end 402) that is extended and retracted relative to the side of the base by movement of drive key 405 to complete the sampling.

As shown in fig. 5 to 7, in the biopsy sampler 801 provided in embodiment 1 of the present invention, the number of sampling ends, that is, the forceps ends 402, is 2, and can be extended from both sides of the base 401 to scrape a sampling target object on the surface of a sampled portion to sample, and the sampled sampling ends, that is, the forceps ends 402, are retracted into the base 401 in a state where the sampling target object is attached to the side of the sampling end facing the base (for example, the tissue collection region 407 on the upper surface of the forceps end 402 located on the lower side in the drawing) to retain the sampling target object.

Here, it should be noted that although the number of the jaw ends 402 in the drawing is 2 and can protrude from both sides of the base, for example, a structure in which four jaw ends protrude from four sides of the base, respectively, may be adopted.

As shown in fig. 7, in the biopsy sampler 801 according to embodiment 1 of the present invention, the transmission keys 405 are rotatably connected via the pin shaft 404.

As shown in fig. 9, in a biopsy sampler 801 provided in embodiment 1 of the present invention, a first transmission guide wire fixing block 202 and a second transmission guide wire fixing block 203 for fixing a transmission guide wire 303 are connected in a push handle portion 104.

As shown in fig. 9, the force of the biopsy sampler 801 is mainly transmitted by a transmission guide wire 303, the transmission guide wire 303 is positioned in a transmission guide wire sleeve 302 and a transmission guide wire pressing tube 301, and the transmission guide wire 303 is fixed by pressing and crushing deformation. After crushing, the workpiece is placed in the first transmission guide wire fixing block 202 and the second transmission guide wire fixing block 203, and the first transmission guide wire fixing block 202 and the second transmission guide wire fixing block 203 are connected in the pushing handle 104 in a threaded manner. A stable driving guide wire 303 is constructed to drive the advancing and retreating mechanism.

The top post 201, the spring bushing 101, and the middle handle 103 are assembled as follows.

As shown in fig. 10, the top spring 201 is connected to one side of the spring sleeve 101, and then the top spring 201 is clamped in the middle lever handle 103. Such a connection secures one side of the spring sleeve 101 to the center lever handle 103 such that the drive wire 303 does not cause relative movement between the spring sleeve 101 and the center lever handle 103 during forward and reverse movement in the spring sleeve 101. The other side of the spring sleeve 101 is assembled with the base 401 by laser spot welding through the drive wire sleeve weld hole 406 as shown in fig. 6 and 7.

The procedure using the biopsy sampler of the present invention is as follows.

As shown in fig. 11, 12, the jaw end 402 of the sampling portion of the biopsy sampler 801 is closed prior to surgery) and the base 401 of the biopsy sampler is slowly inserted into the jaws 702 of the endoscope 701. The biopsy sampler 801 is extended into the body along with the endoscope 701, and reaches a desired tissue site by the visual function of the endoscope camera 703. The biopsy sampler 801 is pushed forward. Pushing the pusher 104 toward the head of the biopsy sampler 801, the pusher 104 is now tightly coupled to the drive wire 303, and the jaw 402 is opened by the transmission of force from the drive wire 303. Pushing the pusher 104 away from the head of the biopsy sampler 801 after tissue is taken closes the jaw 402. At this point, tissue collection region 407 of jaw 402 has collected focal tissue. When the operation of the endoscope 701 is completed, the biopsy sampler 801 is detached from the human body together with the endoscope 701. The biopsy sampler 801 is then withdrawn from the jaws 702 of the endoscope 701 outside the body. Pushing the pusher 104 forward opens the jaw 402 and removes the biopsy tissue for biopsy experiments.

Example 2

As shown in fig. 13, the structure of embodiment 2 is different from that of embodiment 1 in that: the front end of the base 401 is provided with a guide wire guide hole 403, and a guide wire 501 is inserted into the guide wire guide hole 403.

Otherwise, the structure of embodiment 2 may be the same as that of embodiment 1.

The installation and use of the guide wire 501 is as follows.

First, the operation part holding the biopsy sampler 801 is set, the thumb of the right hand (or the left hand) is inserted into the ring part 105 of the middle lever handle 103, the index finger and the middle finger hold the pushing part 104, and thus the pushing part 104 is pushed to slide, so that the opening and closing of the jaw 402 can be realized. The guide wire 501 is inserted into the guide wire guide hole 403 as shown in fig. 13, and is inserted into the jaw channel 702 of the endoscope 701 as a whole. The endoscope 701 is inserted into the human body and the desired biopsy site is determined by the endoscope camera 703. The biopsy guide wire 501 is extended to the working position of the biopsy sampler (because the biliary wall is thinner and more vulnerable to damage if guided without the guide wire), and the biopsy sampler 801 is then extended from the jaw 702 of the endoscope 701 along the guide wire 501 to the working position. Pushing the pushing portion 104 opens the jaw 402. The biopsy sampler 801 is pulled back a distance of about 10mm, and after the jaw 402 is scraped full of biopsy tissue to the tissue collection region 407, the jaw 402 is closed and the sampling portion of the biopsy sampler 801 is retracted into the jaw 702 of the endoscope 701. After the endoscope 701 is completed, the human body is withdrawn together. The tissue removed can be used for biopsy experiments.

The endoscope of the present invention includes the biopsy sampler described in any one of embodiment 1 and embodiment 2.

It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.

In the description of the invention, it should be understood that the terms "center," "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships that are based on the orientation or positional relationships shown in the drawings, merely to facilitate describing the invention and simplify the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be configured and operate in a particular orientation, and therefore should not be construed as limiting the invention. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", etc. may explicitly or implicitly include one or more such feature. In the description of the invention, unless otherwise indicated, the meaning of "a plurality" is two or more.

In the description of the invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the creation of the present invention can be understood by those of ordinary skill in the art in a specific case.

Any modifications or variations, which are apparent to those skilled in the art in light of the above teachings, are intended to be included within the scope of this invention without departing from its spirit.

Claims

1. A biopsy sampler, characterized in that:

Comprising the following steps:

a base having a substantially cylindrical shape;

At least one sampling portion located in the base and at least a portion of which is capable of extension and retraction relative to a side of the base; and

An operation unit which is connected to the base and which operates the sampling unit;

And the operation part is operated to enable at least one part of the sampling part to extend out of the side face of the base and scrape the sampled object on the surface of the sampled part to sample, and the sampled sampling part is retracted into the base to retain the scraped sampled object.

2. The biopsy sampler of claim 1, wherein:

the operation section includes:

A body portion having a hollow rod shape;

a circular ring portion provided at one end of the body portion; and

And a pushing portion detachably attached to the outer periphery of the body portion and reciprocally slidable within a predetermined range of the outer periphery of the body portion.

3. The biopsy sampler of claim 2, wherein:

the body portion includes:

a middle lever handle which is positioned at the other end of the body part and accommodates a spring sleeve inside;

a handle cover covering the opening of the middle handle; and

And the top spring column is positioned in the middle rod handle and used for fixing the spring sleeve.

4. The biopsy sampler of claim 2, wherein:

The pushing part is connected with a first transmission guide wire fixing block and a second transmission guide wire fixing block for fixing the transmission guide wire.

5. The biopsy sampler of claim 1, wherein:

The sampling section includes:

A transmission guide wire seat connected with the spring sleeve and receiving the driving force from the spring sleeve;

The transmission keys are multiple and connected with the transmission guide wire seat to transmit driving force; and

At least one sampling end which is extended and retracted relative to the side of the base by movement of the drive key to complete sampling.

6. The biopsy sampler of claim 5, wherein:

The number of the sampling ends is 2, the sampling ends can extend out from two side surfaces of the base to scrape sampling targets on the surface of the sampled part for sampling, and the sampled sampling ends are retracted into the base to retain the sampling targets in a state that the sampling ends are attached to one side of the sampling ends, which faces the base.

7. The biopsy sampler of claim 5, wherein:

The transmission keys are rotatably connected through a pin shaft.

8. The biopsy sampler of claim 1, wherein:

the front end of the base is provided with a guide wire guide hole, and a guide wire is inserted into the guide wire guide hole.

9. An endoscope, characterized in that:

A biopsy sampler as claimed in any one of claims 1 to 8.

10. An endoscope as defined in claim 9, wherein:

the sampling part of the biopsy sampler is inserted into the forceps channel of the endoscope and enters and exits the human body together with the endoscope.