CN115068350A - Quality-guaranteeing type cleaning mask and preparation method thereof - Google Patents
Quality-guaranteeing type cleaning mask and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
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- 238000000576 coating method Methods 0.000 claims abstract description 45
- 239000000463 material Substances 0.000 claims abstract description 28
- 238000004108 freeze drying Methods 0.000 claims abstract description 19
- 239000004480 active ingredient Substances 0.000 claims abstract description 18
- 238000004132 cross linking Methods 0.000 claims abstract description 15
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- 239000002904 solvent Substances 0.000 claims abstract description 14
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 239000000178 monomer Substances 0.000 claims abstract description 10
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 9
- 239000003999 initiator Substances 0.000 claims abstract description 7
- 239000006185 dispersion Substances 0.000 claims abstract description 5
- 239000000017 hydrogel Substances 0.000 claims description 30
- 230000001815 facial effect Effects 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 239000002346 layers by function Substances 0.000 claims description 12
- 238000007710 freezing Methods 0.000 claims description 9
- 230000008014 freezing Effects 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 6
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims description 6
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- 229940055577 oleyl alcohol Drugs 0.000 claims description 6
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- YQIGLEFUZMIVHU-UHFFFAOYSA-N 2-methyl-n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C(C)=C YQIGLEFUZMIVHU-UHFFFAOYSA-N 0.000 claims description 4
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- 238000002156 mixing Methods 0.000 claims description 4
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 4
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- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims description 2
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- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 12
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 9
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
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- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
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- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
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Images
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention belongs to the technical field of functional mask preparation, and particularly relates to a quality-keeping type cleaning mask and a preparation method thereof. When the coating is prepared, the coating comprises active ingredients, temperature-sensitive monomers, a cross-linking agent and an initiator which are fully mixed in a dispersion solvent and is used as a coating material, the obtained coating material is coated on a base cloth carrier and then is subjected to a cross-linking reaction, and after the reaction is finished, the freeze-drying operation is carried out.
Description
Technical Field
The invention belongs to the technical field of preparation of functional facial masks, and particularly relates to a quality-guaranteeing type cleaning facial mask and a preparation method thereof.
Background
Although many masks are stored in sealed packages before use as a commodity, considering that some packages are not ideal in sealing property or the package is damaged during storage to affect the sealing property, the mask may be in contact with the outside during storage to affect the effectiveness and utilization rate of active substances in the mask. Therefore, it is possible to avoid the influence of the environment on the active substances in the mask by modifying the mask itself, and it is possible to reduce the demand and dependence of the mask product on the package in the near future.
Disclosure of Invention
In order to solve the technical problems, the invention provides a quality-keeping type cleaning facial mask and a preparation method thereof, the quality-keeping type cleaning facial mask comprises a base cloth carrier and a functional layer loaded on the base cloth carrier, the functional layer comprises temperature-sensitive hydrogel and active ingredients dispersed and loaded in the temperature-sensitive hydrogel, the temperature-sensitive hydrogel is hydrogel which expands in volume when the temperature decreases and contracts when the temperature increases,
the preparation method comprises the following steps:
fully mixing active ingredients, temperature-sensitive monomers, a cross-linking agent and an initiator in a dispersion solvent to obtain a coating material, coating the obtained coating material on a base cloth carrier, then carrying out cross-linking reaction, and carrying out freeze-drying operation after the reaction is finished to obtain the quality-guaranteeing type cleaning facial mask,
preferably, the method comprises the following steps: the active ingredients are selected from functional substances which are easy to deteriorate and lose efficacy in a humid environment, such as polypeptide ingredients, phenolic ingredients, saponin ingredients and the like,
the temperature sensitive monomer is one or more selected from N-isopropyl acrylamide, N-isopropyl methacrylamide, 2-methyl-2-acrylic acid-2- (2-methoxyethoxy) ethyl ester, methoxy polyethylene glycol methacrylate and hydroxypropyl acrylate,
the cross-linking agent is one or more selected from ethylene glycol dimethacrylate, N' -methylene bisacrylamide and polyethylene glycol diacrylate,
preferably, the method comprises the following steps: the dispersing solvent is one or more selected from glycerol, oleyl alcohol, caprylic/capric triglyceride, polyglycerol-10 glyceride, polyglycerol-10 stearate, and polysorbate 80,
the adding proportion of the active ingredients, the temperature-sensitive monomers, the cross-linking agent, the initiator and the dispersing solvent is 1-20: 50-100: 2-10: 0.5-1: 5 to 120 of the total amount of the organic compounds,
preferably, the method comprises the following steps: fully mixing active ingredients, temperature-sensitive monomers, a cross-linking agent and an initiator in a dispersion solvent, coating a coating material on a base cloth carrier and carrying out a cross-linking reaction under a protective atmosphere,
the crosslinking reaction is that the base cloth carrier coated with the coating material is placed in a thermal environment of 60-80 ℃ and kept for 1-24 hours,
the freeze-drying operation is that the base cloth carrier after the cross-linking reaction is transferred to an environment with the temperature of-70 ℃ to 5 ℃ for full freezing, and then is heated under the condition of negative pressure, specifically, after full freezing, under the condition that the vacuum degree (absolute vacuum degree, the same applies below) is 1Pa to 1000Pa, the temperature is heated to 10 ℃ to 20 ℃ higher than the freezing temperature, then is kept for 1 to 4 hours, the vacuum degree is kept unchanged, the temperature is continuously heated to 50 ℃ to 75 ℃ and then is kept for 1 to 4 hours,
when in use, water is added to the quality-guaranteeing type cleaning facial mask.
The invention has the beneficial effects that:
the temperature-sensitive hydrogel is used as one of the functional components of the mask, the hydrogel has good water retention capacity, and the hydrogel with the temperature-sensitive function is selected in the scheme, and is subjected to freeze-drying treatment after being prepared by cross-linking with the active component under the condition of being mixed together, mainly aiming at causing the temperature-sensitive hydrogel to shrink to a certain degree in a dispersing solvent along with the temperature rising to the normal temperature in the freeze-drying process, so that a part of the active component originally and smoothly contacting the outside in a functional layer system is wrapped in the hydrogel or further limited in the hydrogel, namely the contact influence of the outside air on the part of the active component is reduced, the part of the active component is more favorably prevented from being affected with moisture and deteriorating, and the long-term storage is facilitated,
when the temperature-sensitive hydrogel is used as a drug delivery carrier, more drug active ingredients originally dispersed in a hydrogel system are extruded to realize drug release when the temperature-sensitive hydrogel is heated to shrink. However, in this scheme, the temperature-sensitive hydrogel is not an aqueous solution, but an organic mixed system whose viscosity (boiling point) is significantly greater than that of the aqueous solution at normal temperature, and the temperature-raising process performed by the temperature-sensitive hydrogel is not heating in a general sense, but a process of raising the temperature from a frozen state to normal temperature in a freeze-drying operation. In the temperature rising stage of freeze-drying, a large part of the organic mixture is wrapped and limited by the hydrogel in the process of converting from a solid state to a liquid state because the viscosity is high and the containing structure in the hydrogel is not ready to be discharged, so that the isolation protection is realized.
In the using process, water is added into the functional layer of the mask, the mask is applied to the skin, although the temperature of the mask is slightly higher than the normal temperature and the temperature-sensitive hydrogel in the mask is further contracted due to the fact that a certain amount of heat is emitted from the skin of a human body, the molecular structure of the hydrogel contains a large amount of hydrophilic groups, the mask is in an anhydrous state, once water is introduced, the water can still smoothly enter the hydrogel to enable the hydrogel to be greatly swelled, the hydrogel is not influenced by the temperature of the skin, the hydrogel can release the part of active ingredients limited in the hydrogel again through the swelling action, and the absorption of the active ingredients by the skin is not influenced on the whole.
The selected dispersing solvent is an organic matter with the function of the skin feeling agent, and not only plays a role of a solvent (because the boiling point of the solvent substances is higher, the content of the solvent substances in the facial mask is not reduced basically in the freeze-drying operation), but also can be directly used as the skin feeling agent after the facial mask is prepared.
Drawings
FIG. 1 is a liquid chromatogram showing the composition analysis of the mask prepared in example 1, wherein line 1 is the line detected for the sample of example 1, line 2 represents the control of cyanidin-3-O-glucoside, and line 3 represents the control of cyanidin without glucoside.
Detailed Description
The anthocyanin is used as a skin nutrient, has strong effects of resisting oxidation and eliminating free radicals, can restore collagen activity, enhance blood vessel elasticity, improve circulatory system, make skin smooth and elastic, prevent skin wrinkles from generating, but is easily oxidized and ineffective due to environmental influence. Therefore, in the examples of the present application, the functional layer of the mask was prepared using vaccinium myrtillus extract containing anthocyanins as an active ingredient, so as to compare the protection degree of the gel with the anthocyanins under different freeze-drying processes.
The following bilberry extracts are all prepared by adding bilberry fruits into an ethanol water solution for normal-temperature ultrasonic extraction, filtering after the extraction is finished, retaining filtrate, adsorbing the filtrate by a macroporous adsorption resin column, eluting and freeze-drying to obtain the bilberry fruit extract.
Example 1
According to the weight portion, 6 portions of vaccinium myrtillus extract, 58 portions of 2-methyl-2-acrylic acid-2- (2-methoxyethoxy) ethyl ester, 7 portions of ethylene glycol dimethacrylate, 0.5 portion of azobisisobutyronitrile, 12 portions of glycerol, 10 portions of oleyl alcohol and 8 portions of polyglycerol-10-stearate are fully mixed at about 37 ℃ to be used as coating materials, the obtained coating materials are evenly brushed and coated on one surface of non-woven fabric, and the average coating weight is 15g/m 2 Transferring the coated non-woven fabric into a 70 ℃ oven for 8 hours, cooling along with the oven (the components are mixed, coated and heated and crosslinked in the nitrogen atmosphere after coating), transferring the non-woven fabric into a vacuum freeze dryer, freezing for 2 hours at the temperature of-45 ℃ under normal pressure, adjusting the vacuum degree in the freeze dryer to 50Pa, raising the temperature to-25 ℃ for 4 hours, and keeping the vacuum degree in the freeze dryer unchanged and the temperature to 30 ℃ for 1 hour to obtain the quality-guaranteeing clean facial mask.
Example 2
According to the weight portion, 4 portions of vaccinium myrtillus extract, 16 portions of N-isopropyl methacrylamide, 35 portions of methoxy polyethylene glycol methacrylate, 3.5 portions of N, N' -methylene bisacrylamide, 0.8 portion of azobisisobutyronitrile, 15 portions of caprylic/capric triglyceride and 10 portions of polysorbate 80 are fully mixed at about 40 ℃ to be used as coating materials, the obtained coating materials are evenly brushed and coated on one surface of non-woven fabric, and the average coating weight is 12g/m 2 Transferring the coated nonwoven fabric toKeeping the non-woven fabric in an oven at 65 ℃ for 9.5 hours, cooling the non-woven fabric along with the oven (the components are mixed, coated and heated and crosslinked in the oven after coating in a nitrogen atmosphere), transferring the non-woven fabric into a vacuum freeze dryer, freezing the non-woven fabric for 2 hours at the temperature of 60 ℃ below zero under normal pressure, adjusting the vacuum degree in the freeze dryer to 10Pa, raising the temperature to 32 ℃ below zero for 2 hours, keeping the vacuum degree in the freeze dryer unchanged, and keeping the temperature at 25 ℃ for 2 hours to obtain the quality-guaranteeing type clean facial mask.
Example 3
According to the weight portion, 13 portions of vaccinium myrtillus extract, 70 portions of 2-methyl-2-acrylic acid-2- (2-methoxyethoxy) ethyl ester, 18 portions of hydroxypropyl acrylate, 6 portions of ethylene glycol dimethacrylate, 0.5 portion of azobisisobutyronitrile, 20 portions of oleyl alcohol and 15 portions of caprylic/capric triglyceride are fully mixed at about 35 ℃ to be used as coating material, the obtained coating material is evenly brushed and coated on one surface of non-woven fabric, and the average coating weight is 15g/m 2 Transferring the coated non-woven fabric into a 65 ℃ oven for 8 hours, cooling along with the oven (the components are mixed, coated and heated and crosslinked in the oven after coating are carried out in nitrogen atmosphere), transferring the non-woven fabric into a vacuum freeze dryer, freezing for 4 hours at the temperature of 50 ℃ under normal pressure, adjusting the vacuum degree in the freeze dryer to 5Pa, raising the temperature to 25 ℃ for 2 hours, keeping the vacuum degree in the freeze dryer unchanged, raising the temperature to 25 ℃ and keeping for 2 hours, thus obtaining the quality-guaranteeing type clean facial mask.
Comparative example 1
Compared with the example 1, the mixed coating material is subjected to freeze-drying operation and then is subjected to heat crosslinking:
according to the weight portion, 6 portions of vaccinium myrtillus extract, 58 portions of 2-methyl-2-acrylic acid-2- (2-methoxyethoxy) ethyl ester, 7 portions of ethylene glycol dimethacrylate, 0.5 portion of azobisisobutyronitrile, 12 portions of glycerol, 10 portions of oleyl alcohol and 8 portions of polyglycerol-10-stearate are fully mixed at about 37 ℃ to be used as coating materials, and the obtained coating materials (including non-woven fabrics used for subsequent coating) are put in a vacuum freeze dryer before normal pressureFreezing at 45 deg.C for 2 hr, adjusting vacuum degree in freeze dryer to 50Pa, heating to-25 deg.C, maintaining for 4 hr, maintaining the vacuum degree in freeze dryer, heating to 30 deg.C, maintaining for 1 hr, recovering normal pressure, taking out coating material, and uniformly brushing on one cloth surface of the non-woven fabric with average coating weight of 15g/m 2 Transferring the coated non-woven fabric into an oven at 70 ℃ for 8 hours, cooling along with the oven (the components are mixed, coated, and the heating and crosslinking of the coated oven are carried out in a nitrogen atmosphere), and obtaining the quality-guaranteeing type cleaning facial mask.
Comparative example 2
Compared with the example 2, the mixed coating material is subjected to freeze-drying operation and then is subjected to heat crosslinking:
according to the weight portion, 4 portions of vaccinium myrtillus extractive, 16 portions of N-isopropyl methacrylamide, 35 portions of methoxy polyethylene glycol methacrylate, 3.5 portions of N, N' -methylene bisacrylamide, 0.8 portion of azobisisobutyronitrile, 15 portions of caprylic/capric triglyceride and 10 portions of polysorbate 80 are fully mixed at about 40 ℃ to be used as coating materials, the obtained coating materials (including non-woven fabrics to be used for subsequent coating) are frozen in a vacuum freeze dryer for 2 hours at the temperature of between normal pressure and 60 ℃, the vacuum degree in the freeze dryer is adjusted to 10Pa, the temperature is increased to-32 ℃ for 2 hours, then the vacuum degree in the freeze dryer is kept unchanged, the temperature is increased to 25 ℃ for 2 hours, the coating materials are taken out after the normal pressure is recovered, and are evenly brushed and coated on one cloth surface of the non-woven fabrics, the average coating weight was 12g/m 2 Transferring the coated non-woven fabric into a 65 ℃ oven, keeping for 9.5 hours, and cooling along with the oven (the components are mixed, coated, and the heating and crosslinking of the coated oven are carried out in a nitrogen atmosphere), thus obtaining the quality-guaranteeing type cleaning facial mask.
Comparative example 3
Compared with example 3, the mixed coating material is subjected to freeze-drying operation and then to heat crosslinking:
13 parts of vaccinium myrtillus extract and 70 parts of 2-methyl-2-acrylic acid-2- (2-methyl) are calculated according to the parts by weightOxyethoxy) ethyl ester, 18 parts of hydroxypropyl acrylate, 6 parts of ethylene glycol dimethacrylate, 0.5 part of azobisisobutyronitrile, 20 parts of oleyl alcohol and 15 parts of caprylic/capric triglyceride are fully mixed at about 35 ℃ to form a coating material, the obtained coating material (including non-woven fabrics to be used for subsequent coating) is frozen in a vacuum freeze dryer for 4 hours at the temperature of between normal pressure and 50 ℃, the vacuum degree in the freeze dryer is adjusted to be 5Pa, the temperature is increased to be 25 ℃ for 2 hours, the temperature in the freeze dryer is kept unchanged to be 25 ℃ for 2 hours, the coating material is taken out after the normal pressure is recovered, and is uniformly brushed on one cloth surface of the non-woven fabrics, the average coating weight is 15g/m 2 Transferring the coated non-woven fabric into a 65 ℃ oven, keeping for 8 hours, and cooling along with the oven (the components are mixed, coated, and the heating and crosslinking of the coated oven are carried out in a nitrogen atmosphere), thus obtaining the quality-guaranteeing type cleaning facial mask.
After the cleansing facial masks prepared in the above examples and comparative examples were exposed to an air atmosphere (room at room temperature of 25 ℃ C., and under normal pressure) for 4 days (96 hours) with the functional layer facing upward, 1cm × 1cm was cut out from each cleansing facial mask as a sample, and each sample was added to a nonwoven fabric so that the anthocyanin on the sample was separated as much as possible, in a volume ratio of 10mL of ethanol to deionized water of 7: 3, sufficiently stirring to separate the functional layer on the sample from the non-woven fabric, dispersing and dissolving the functional layer in the mixed solvent, filtering, retaining filtrate, and adding the filtered non-woven fabric into the non-woven fabric again, wherein the volume ratio of 10mL of ethanol to deionized water is 7: 3, stirring fully, filtering out non-woven fabrics, combining the two filtrates, centrifuging, taking supernatant, filtering with 0.22 μm filter membrane to obtain sample solution,
taking 10ul of sample solution, injecting into a high performance liquid chromatograph, detecting, and recording chromatograms at 535nm wavelength, so as to obtain the content (the weight ratio of anthocyanin to the whole functional layer) of anthocyanin (mainly cyanidin-3-O-glucoside is taken as an example as shown in the attached figure 1) remained in the product through corresponding computer program operation based on the peak areas of target components in the sample solution and the reference sample solution, as shown in the following table 1:
TABLE 1
| Example 1 | 1.28％ |
| Example 2 | 1.15％ |
| Example 3 | 2.17％ |
| Comparative example 1 | 0.91％ |
| Comparative example 2 | 0.75％ |
| Comparative example 3 | 1.44％ |
And (3) data analysis: although the freeze-drying operation exists in each of the above examples and comparative examples, the freeze-drying is performed in the comparative example, which is similar to the freeze-drying treatment directly performed on the raw material mixture, wherein when the material temperature rises after the freezing stage is finished, the temperature-sensitive monomers in the system are not effectively crosslinked together to form a temperature-sensitive hydrogel system, so that the hydrogel system is shrunk by means of the rise of the temperature in the late freeze-drying stage to limit a part of the active ingredients to form a certain blocking and protection, and therefore, after the exposure experiment is performed on the product, more active ingredients in the system are affected by the air environment and are deteriorated compared with each example.
On each of the cleaning masks of examples 1 to 3 after the exposure test, a size of 10cm × 10cm was cut as a sample, each sample was added (immersed) into 25mL of deionized water, left to stand at room temperature for 20 minutes, and then a volume ratio of 25mL of ethanol to deionized water was added thereto, which was 9: 1, standing for 5 minutes, filtering out non-woven fabrics, centrifuging the filtered filtrate, taking supernatant, and filtering through a 0.22-micron filter membrane to obtain a sample solution, wherein the weight ratio (dissolution content) of the anthocyanin dissolved out of the filtrate to the whole functional layer is obtained according to the same liquid chromatography, and is shown in the following table 2:
TABLE 2
| Example 1 | 1.03％ |
| Example 2 | 0.88％ |
| Example 3 | 1.76％ |
The specific gravities of the dissolution contents in the table 2, which respectively correspond to the corresponding inherent contents in the table 1, are all kept at a high percentage, namely 70% -80%, so that the normal dissolution range of the mask is met, and therefore, the active ingredients can still be successfully dissolved and absorbed under a static condition.
Claims (10)
1. A quality-guaranteeing type cleaning mask is characterized in that: the quality-guaranteeing type cleaning mask comprises a base cloth carrier and a functional layer loaded on the base cloth carrier, wherein the functional layer comprises temperature-sensitive hydrogel and active ingredients dispersed and loaded in the temperature-sensitive hydrogel, and the temperature-sensitive hydrogel is hydrogel which expands in volume when the temperature drops and contracts in volume when the temperature rises.
2. A method of preparing a shelf-stable cleansing mask according to claim 1, wherein: the preparation method comprises the steps of fully mixing active ingredients, temperature-sensitive monomers, a cross-linking agent and an initiator in a dispersion solvent to obtain a coating material, coating the obtained coating material on a base cloth carrier, then carrying out cross-linking reaction, and carrying out freeze-drying operation after the reaction is finished to obtain the quality-guaranteeing type cleaning facial mask.
3. The method of preparing a shelf-stable cleansing mask according to claim 2, wherein: the active ingredient is an effect substance which is easy to deteriorate and lose efficacy in a humid environment.
4. The method of preparing a shelf-stable cleansing mask according to claim 2, wherein: the temperature-sensitive monomer is one or more of N-isopropyl acrylamide, N-isopropyl methacrylamide, 2-methyl-2-acrylic acid-2- (2-methoxyethoxy) ethyl ester, methoxypolyethylene glycol methacrylate and hydroxypropyl acrylate.
5. The method of preparing a shelf-stable cleansing mask according to claim 2, wherein: the cross-linking agent is one or more of ethylene glycol dimethacrylate, N' -methylene bisacrylamide and polyethylene glycol diacrylate.
6. The method of preparing a shelf-stable cleansing mask according to claim 2, wherein: the dispersing solvent is one or more of glycerol, oleyl alcohol, caprylic/capric triglyceride, polyglycerol-10 glyceride, polyglycerol-10 stearate and polysorbate 80.
7. The method of preparing a shelf-stable cleansing mask according to claim 2, wherein: the adding proportion of the active ingredient, the temperature-sensitive monomer, the cross-linking agent, the initiator and the dispersing solvent is 1-20: 50-100: 2-10: 0.5-1: 5 to 120.
8. The method of preparing a shelf-stable cleansing mask according to claim 2, wherein: the preparation method comprises the steps of fully mixing an active ingredient, a temperature-sensitive monomer, a cross-linking agent and an initiator in a dispersion solvent, coating a coating material on a base fabric carrier, and carrying out a cross-linking reaction under a protective atmosphere.
9. The method of preparing a shelf-stable cleansing mask according to claim 2, wherein: the freeze-drying operation is that the base cloth carrier after the cross-linking reaction is transferred to an environment with the temperature of-70 ℃ to 5 ℃ for full freezing, then the temperature is raised to 10 ℃ to 20 ℃ higher than the freezing temperature under the condition that the vacuum degree is 1Pa to 1000Pa, the temperature is kept for 1 to 4 hours, the vacuum degree is kept unchanged, and the temperature is continuously raised to 50 ℃ to 75 ℃ and then kept for 1 to 4 hours.
10. Use of a shelf-stable cleansing mask according to claim 1, wherein: the application is that water is added to the quality-guaranteeing type cleaning facial mask when the facial mask is applied.
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| CN1883438A (en) * | 2005-06-21 | 2006-12-27 | 香港理工大学 | Temperature responsive intelligent facial mask and method for preparing same |
| CN102198098A (en) * | 2011-06-02 | 2011-09-28 | 华东理工大学 | Temperature-sensitive core-shell vesicle controlled-release drug carrier, preparation method and application thereof |
| CN107519022A (en) * | 2017-09-30 | 2017-12-29 | 李和伟 | A kind of Modified Membrane cloth preparation technology and its application |
| CN109364016A (en) * | 2018-12-12 | 2019-02-22 | 杞源堂(天津)生物工程有限公司 | A kind of anti-oxidant gel mask and preparation method thereof that fructus lycii nourishes |
| CN112168714A (en) * | 2019-07-02 | 2021-01-05 | 常州伟博海泰生物科技有限公司 | Clean skin-brightening freeze-dried mask and package |
| CN112675057A (en) * | 2020-12-29 | 2021-04-20 | 常州琉璃光生物科技有限公司 | Production process for freeze-dried mask |
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2022
- 2022-06-20 CN CN202210698614.6A patent/CN115068350A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883438A (en) * | 2005-06-21 | 2006-12-27 | 香港理工大学 | Temperature responsive intelligent facial mask and method for preparing same |
| CN102198098A (en) * | 2011-06-02 | 2011-09-28 | 华东理工大学 | Temperature-sensitive core-shell vesicle controlled-release drug carrier, preparation method and application thereof |
| CN107519022A (en) * | 2017-09-30 | 2017-12-29 | 李和伟 | A kind of Modified Membrane cloth preparation technology and its application |
| CN109364016A (en) * | 2018-12-12 | 2019-02-22 | 杞源堂(天津)生物工程有限公司 | A kind of anti-oxidant gel mask and preparation method thereof that fructus lycii nourishes |
| CN112168714A (en) * | 2019-07-02 | 2021-01-05 | 常州伟博海泰生物科技有限公司 | Clean skin-brightening freeze-dried mask and package |
| CN112675057A (en) * | 2020-12-29 | 2021-04-20 | 常州琉璃光生物科技有限公司 | Production process for freeze-dried mask |
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Address after: 213000 No. 15, beitanghe East Road, Tianning District, Changzhou City, Jiangsu Province Applicant after: Changzhou Weibo Haitai Cosmetics Co.,Ltd. Address before: 213000 No. 15, beitanghe East Road, Tianning District, Changzhou City, Jiangsu Province Applicant before: Changzhou liuliguang Biotechnology Co.,Ltd. |
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Application publication date: 20220920 |