CN110554207A - Optical detection device - Google Patents

Abstract

The invention discloses an optical detection device, comprising: a detection chamber, a transport vehicle mechanism arranged in the detection chamber for transporting test tube racks, and a mechanism for optically detecting samples in test tubes on the test tube rack. A photomultiplier tube, a lens shutter mechanism arranged in the detection chamber, and a chamber door mechanism arranged on the detection chamber. The present invention can realize the one-by-one automatic detection of multiple test tubes on the test tube rack in the detection chamber by setting the transport vehicle mechanism at one time, and the detection flux and efficiency are greatly improved; The door of the warehouse is opened automatically. When the transport vehicle returns to the inspection chamber, the door will return to its original position under the action of shrapnel and magnets, which is convenient and quick; by setting the lens shutter mechanism, the lens of the photomultiplier tube is blocked by the shutter when the inspection is not in progress. , when the detection is performed, the shutter is automatically moved away. The invention can realize fully automatic optical detection, and has high detection flux and high efficiency.

Description

Optical detection device

technical field

The invention relates to the technical field of in vitro diagnosis, in particular to an optical detection device.

Background technique

Optical detection devices are widely used in in vitro diagnostic technology, and they are one of the key components of fully automatic optical detection instruments. However, the current optical detection device usually only has one station, the detection throughput is low, and the degree of automation is not high. The sample usually enters and exits the optical detection device through the door. When the sample enters and exits, the door cannot be opened automatically or an additional drive mechanism is required. Opening the driver will affect the work efficiency and increase the cost of the equipment, making it difficult to meet the current market demand for fully automatic detection of samples.

Contents of the invention

The technical problem to be solved by the present invention is to provide an optical detection device for the above-mentioned deficiencies in the prior art.

In order to solve the above-mentioned technical problems, the technical solution adopted in the present invention is: an optical detection device, comprising: a detection chamber, a transport vehicle mechanism for transporting test tube racks arranged in the detection chamber, A photomultiplier tube for optical detection of the sample in the test tube on the top, a lens shutter mechanism arranged in the detection chamber, and a chamber door mechanism arranged on the detection chamber.

Preferably, the transport vehicle mechanism includes a transport vehicle body, a drive mechanism for driving the transport vehicle body to reciprocate in the Y direction, and a position detection mechanism for detecting the position of the transport vehicle body.

Preferably, the drive mechanism includes a first motor arranged on the detection chamber, a driving pulley connected to the output shaft of the first motor, and a driving pulley arranged on the opposite side of the driving pulley along the Y direction. The driven pulley, the belt arranged between the driving pulley and the driven pulley, the slide rail arranged on the bottom plate of the detection chamber along the Y direction, and the slide rail slidably arranged on the slide rail with one end connected to the The other end of the belt is connected to the slider connected to the transport vehicle body.

Preferably, the position detection mechanism includes a bar code ruler fixed on the slider, a plurality of position detection grooves provided on the bar code ruler along the Y direction, and a photoelectric sensor for cooperating with the position detection grooves. switch.

Preferably, the transport vehicle body is provided with an accommodating groove for accommodating the test tube rack, the test tube rack is inserted into the accommodation groove from the front end of the transport vehicle body, and the rear end of the test tube rack is provided with a shrapnel groove, and the rear end of the receiving groove is provided with a clamping elastic piece which is used to fit and be locked in the elastic piece groove.

Preferably, the bottom of the transport vehicle body is provided with a plurality of through holes corresponding to the position and quantity of the test tubes on the test tube rack.

Preferably, the clamping elastic piece is U-shaped, the U-shaped middle part is fixedly connected to the rear end of the receiving groove, and the two ends of the U-shaped protrude inward to form a clamping protrusion.

Preferably, a detection hole is opened on the bottom plate of the detection chamber, the photomultiplier tube is arranged below the detection hole, and the lens shutter mechanism includes a shutter arranged at the detection hole and is used to drive the The drive module for shutter movement.

Preferably, the bin door mechanism includes a bin door, a connecting rod seat, a connecting rod and a reset shrapnel, and the side of the detection bin is provided with an opening for the entry and exit of the transport vehicle body, and the bin door is arranged at the opening ; the connecting rod seat is fixed on the bottom surface of the bottom plate of the detection chamber, one end of the connecting rod is rotatably connected to the connecting rod seat, and the other end has an L-shaped connecting portion, and the door is connected to on said L-shaped connection;

One end of the reset elastic piece covers the connecting rod seat and is fixedly connected to the outer wall of the bottom of the detection chamber, and the other end covers the connecting rod.

Preferably, several magnet blocks are also arranged on the door.

The beneficial effects of the present invention are: the optical detection device of the present invention can automatically detect a plurality of test tubes on the test tube rack in the detection chamber one by one by setting the transport vehicle mechanism, and the detection flux and efficiency are greatly improved; The detection mechanism can realize the alignment of each test tube with the photomultiplier tube at the detection position; the door mechanism of the present invention, when the transport vehicle body moves out of the detection room, the door is automatically opened, and when the transport vehicle returns to the detection room, the door will automatically It returns to the original position under the action of shrapnel and magnet, which is convenient and quick; by setting the lens shutter mechanism, the lens of the photomultiplier tube is blocked by the shutter when not testing, and the shutter is automatically moved away when testing. The invention can realize fully automatic optical detection, such as fluorescent immunodetection, chemiluminescent detection, etc., has high detection throughput and efficiency, simple structure, and can also be used as an independent module in automatic detection and analysis equipment.

Description of drawings

1 is a schematic diagram of the internal structure of the optical detection device of the present invention;

Fig. 2 is a schematic structural view of the bottom of the optical detection device of the present invention;

Fig. 3 is a structural schematic diagram of the door mechanism of the present invention;

Fig. 4 is the structural representation of the transport vehicle body of the present invention;

Fig. 5 is a schematic structural view of the test tube rack corresponding to the transport vehicle body in an embodiment of the present invention;

Fig. 6 is a structural schematic diagram of the barcode ruler of the present invention.

Explanation of reference signs:

1—detection bin; 2—conveyor mechanism; 3—photomultiplier tube; 4—lens shutter mechanism; 5—door mechanism; 6—test tube rack; 7—test tube; 10—detection hole; 11—opening; 20—transport Car body; 21—drive mechanism; 22—position detection mechanism; 23—adapter plate; 24—through hole; 40—shutter; 41—drive module; 53—reset shrapnel; 60—shrapnel slot; 200—accommodating groove; 201—clamping shrapnel; 202—clamping protrusion; 210—first motor; 211—driving pulley; 212—driven pulley; 213—belt 214—slide rail; 215—slider block; 220—bar code ruler; 221—position detection groove; 222—photoelectric switch; 500—magnet block; 520—L-shaped connection part.

Detailed ways

The present invention will be further described in detail below in conjunction with the embodiments, so that those skilled in the art can implement it with reference to the description.

It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

As shown in Figures 1-6, an optical detection device of this embodiment includes: a detection chamber 1, a transport vehicle mechanism 2 arranged in the detection chamber 1 for transporting the test tube rack 6, and a transport vehicle mechanism 2 for transporting the test tube rack 6 The photomultiplier tube 3 for optical detection of the sample in the test tube, the lens shutter mechanism 4 arranged in the detection chamber 1 and the chamber door mechanism 5 arranged on the detection chamber 1 .

The transport vehicle mechanism 2 includes a transport vehicle body 20 , a drive mechanism 21 for driving the transport vehicle body 20 to reciprocate in the Y direction, and a position detection mechanism 22 for detecting the position of the transport vehicle body 20 .

In one embodiment, the drive mechanism 21 includes a first motor 210 arranged on the detection chamber 1, a driving pulley 211 connected to the output shaft of the first motor 210, and arranged on the opposite side of the driving pulley 211 along the Y direction. The driven pulley 212, the belt 213 arranged between the driving pulley 211 and the driven pulley 212, the slide rail 214 arranged on the bottom plate of the detection chamber 1 along the Y direction and slidably arranged on the slide rail 214 and One end is connected to the belt 213 and the other end is connected to the slider 215 of the transport vehicle body 20 . The first motor 210 is preferably a stepping motor. The rotation of the first motor 210 drives the slider 215 to move through the belt 213. By controlling the forward and reverse rotation of the motor, the transport vehicle body 20 is driven to reciprocate in the Y direction. In this embodiment, the transport vehicle body 20 is connected to the slider 215 through an adapter plate 23 .

Wherein, the transport vehicle body 20 is provided with an accommodating groove 200 for accommodating the test tube rack 6, and the test tube rack 6 is inserted into the accommodation groove 200 from the front end of the transport vehicle body 20, and a number of test tubes 7 are loaded on the test tube rack 6, and the samples in the test tube 7 pass through Photomultiplier tubes perform optical detection. Referring to FIG. 5 , it is a structural diagram of a test tube rack 6 that cooperates with the transport vehicle body 20 of the present invention. The rear end of the test tube rack 6 is provided with a shrapnel groove 60 . Referring to FIG. 4 , the rear end of the receiving groove 200 is provided with a clamping elastic piece 201 which is used to be locked in the elastic piece groove 60 . The clamping elastic piece 201 is U-shaped, the U-shaped middle part is fixedly connected with the rear end of the receiving groove 200 , and the two ends of the U-shaped protrude inward to form a clamping protrusion 202 . After the test tube rack 6 is pushed into the receiving groove 200, the clamping elastic piece 201 snaps into the elastic piece groove 60 at the rear end of the test tube rack 6 to realize locking and ensure the tight connection between the test tube rack 6 and the transport vehicle body 20.

Wherein, the bottom of the transport vehicle body 20 is provided with a plurality of through holes 24 corresponding to the positions and quantities of the test tubes 7 on the test tube rack 6 . After the test tube rack 6 is pushed into the receiving tank 200 , the through holes 24 at the bottom of the transport vehicle body 20 correspond to the test tubes 7 one by one, and are directly below the test tubes 7 . When the transport vehicle body 20 reaches the detection position, the test tube 7 on the detection hole 10 can be optically detected by the photomultiplier tube 3 below.

In one embodiment, the position detection mechanism 22 includes a bar code ruler 220 fixed on the slider 215, a plurality of position detection grooves 221 provided on the bar code ruler 220 along the Y direction and a Photoelectric switch 222. The bar code ruler 220 is fixedly connected to the slider 215 through the adapter plate 23 . The position of the position detection groove 221 on the bar code ruler 220 is detected by the photoelectric switch 222 to realize the positioning of the test tube rack 6 on the transport vehicle body 20 to ensure that the test tubes on the test tube rack 6 are optically detected on the detection hole 10 in turn.

For example, in this embodiment, the test tube rack 6 is provided with 12 test tubes, and the bar code ruler 220 is provided with at least 13 position detection grooves 221, and each test tube has a corresponding position detection groove 221 to realize its location detection. Driven by the first motor 210, the test tube rack 6 moves on the slide rail 214 from front to back. The position of the switch 222 realizes positioning; the test tube rack 6 gradually moves, and the test tubes arrive at the top of the detection hole 10 for optical detection in turn, and the photoelectric switch 222 cooperates with the detection slots 221 of each position to realize the positioning of the 12 test tubes one by one. In a further embodiment, the photoelectric switch 222 can also detect the connection position of the transport vehicle body 20 . The test tube rack 6 is transported to the transport vehicle body 20 by an external transport mechanism, and after the detection is completed, the test tube rack 6 is transported to the next station by the transport mechanism. When the front end of the transport vehicle body 20 stretches out by 30 mm, it is used as the connection position. At this time, the position detection groove 221 corresponding to the connection position on the bar code ruler 220 is at the position detection groove 221 to realize positioning.

In one embodiment, a detection hole 10 is provided on the bottom plate of the detection chamber 1, the photomultiplier tube 3 is arranged below the detection hole 10, and the lens shutter mechanism 4 includes a shutter 40 arranged at the detection hole 10, and is used to drive the shutter. 40 moving drive module 41 . In a preferred embodiment, the driving module 41 is an electromagnet. When detecting, the electromagnet is energized, and the electromagnet drives the shutter 40 to open; 40 blocks. Certainly, the driving module 41 may also be other power mechanisms capable of driving the shutter 40 to repeatedly move on the detection hole 10 .

In one embodiment, the bin door mechanism 5 includes a bin door 50, a connecting rod seat 51, a connecting rod 52, and a reset spring 53. The side of the detection bin 1 is provided with an opening 11 for the transport vehicle body 20 to enter and exit. The bin door 50 It is arranged at the opening 11; the connecting rod seat 51 is fixedly connected to the bottom surface of the bottom plate of the detection chamber 1, and one end of the connecting rod 52 is rotatably connected to the connecting rod seat 51, and the other end has an L-shaped connecting portion 520, and the door 50 Connected to the L-shaped connecting part 520 ; one end of the reset elastic piece 53 covers the connecting rod seat 51 and is fixedly connected to the outer wall of the bottom of the detection chamber 1 , and the other end covers the connecting rod 52 . Several magnet blocks 500 are also arranged on the door 50 .

When the conveying vehicle body 20 moves out of the detection chamber 1, the door 50 is pushed open by the conveying vehicle body 20, and when the conveying vehicle returns to the detection chamber 1, the chamber door 50 will return to its original position under the action of the shrapnel and the magnet. Specifically, when the transport vehicle body 20 moves out of the detection compartment 1, the transport vehicle body 20 presses the compartment door 50 from the inside to the outside, and the compartment door 50 and the connecting rod 52 rotate counterclockwise around the connecting rod seat 51 to overcome the upward (or clockwise) movement of the shrapnel. direction), the door 50 opens; when the transport vehicle returns to the detection chamber 1, the upward (or clockwise) elastic force of the shrapnel pushes the connecting rod 52 to rotate clockwise around the connecting rod seat 51, the door 50 is closed, and the warehouse The magnets around the door 50 are attracted to the detection chamber 1 to ensure that the chamber door 50 is closed tightly, as shown in FIG. 2 .

The working process of the present invention is: before detection, the first motor 210 works, and the delivery car body 20 is pushed out of the detection chamber 1 (the door 50 is pushed open), and the delivery car body 20 arrives at the connection position (state as shown in Figure 1 ), the external transport mechanism pushes the test tube rack 6 into the transport vehicle body 20, the first motor 210 works so that the transport vehicle body 20 returns to the detection chamber 1, and the door 50 is automatically closed; the transport vehicle body 20 moves along the slide rail 214, and the The test tubes in the test tube rack 6 are aligned with the lens of the photomultiplier tube 3 in turn, the shutter 40 in front of the lens is opened, and the optical detection is completed sequentially; The mechanism removes the test tube rack 6 and moves to the next working position.

Although the embodiment of the present invention has been disclosed as above, it is not limited to the use listed in the specification and implementation, it can be applied to various fields suitable for the present invention, and it can be easily understood by those skilled in the art Therefore, the invention is not limited to the specific details without departing from the general concept defined by the claims and their equivalents.

Claims (10)

1. An optical detection device, characterized in that it comprises: a detection chamber, a transport cart mechanism for transporting a test tube rack arranged in the detection chamber, for optically performing an optical test on a sample in a test tube on the test tube rack. The photomultiplier tube for detection, the lens shutter mechanism arranged in the detection chamber and the chamber door mechanism arranged on the detection chamber. 2. The optical detection device according to claim 1, wherein the transport vehicle mechanism comprises a transport vehicle body, a drive mechanism for driving the transport vehicle body to reciprocate along the Y direction, and a drive mechanism for driving the transport vehicle body A position detection mechanism that detects the position of the vehicle body. 3. The optical detection device according to claim 2, wherein the drive mechanism comprises a first motor arranged on the detection chamber, a driving pulley connected to the output shaft of the first motor, The driven pulley arranged on the opposite side of the driving pulley in the Y direction, the belt arranged between the driving pulley and the driven pulley, and the slide rail arranged on the bottom plate of the detection chamber along the Y direction And a slider that is slidably arranged on the slide rail and is connected to the belt at one end and connected to the vehicle body at the other end. 4. The optical detection device according to claim 3, wherein the position detection mechanism comprises a bar code ruler fixedly connected to the slider, and a plurality of position detection devices set on the bar code ruler along the Y direction. slot and a photoelectric switch for cooperating with the position detection slot. 5. The optical detection device according to claim 2, characterized in that, the transport cart body is provided with an accommodating groove for accommodating the test tube rack, and the test tube rack is inserted into the transport cart body from the front end. The receiving groove, the rear end of the test tube rack is provided with a shrapnel groove, and the rear end of the accommodating groove is provided with a clamping shrapnel used to fit and be clamped in the shrapnel groove. 6 . The optical detection device according to claim 5 , wherein a plurality of through holes corresponding to the position and quantity of the test tubes on the test tube rack are opened at the bottom of the transport vehicle body. 7 . 7. The optical detection device according to claim 1, characterized in that, the clamping elastic piece is U-shaped, the U-shaped middle part is fixedly connected to the rear end of the accommodating groove, and the two ends of the U-shape protrude inward out to form a locking protrusion. 8. The optical detection device according to claim 1, wherein a detection hole is provided on the bottom plate of the detection chamber, the photomultiplier tube is arranged below the detection hole, and the lens shutter mechanism includes a The shutter at the detection hole and the driving module for driving the shutter to move. 9. The optical detection device according to claim 1, wherein the door mechanism includes a door, a connecting rod seat, a connecting rod and a reset shrapnel, and the side of the detection chamber is provided with a The opening for the body to enter and exit, the door is set at the opening; the connecting rod seat is fixed on the bottom surface of the bottom plate of the detection chamber, and one end of the connecting rod is rotatably connected to the connecting rod seat. The other end has an L-shaped connecting portion, and the door is connected to the L-shaped connecting portion; One end of the reset elastic piece covers the connecting rod seat and is fixedly connected to the outer wall of the bottom of the detection chamber, and the other end covers the connecting rod. 10. The optical detection device according to claim 9, characterized in that, several magnet blocks are also arranged on the door.