CN109069687A - A kind of antibacterial dressing and the preparation method and application thereof - Google Patents

A kind of antibacterial dressing and the preparation method and application thereof Download PDF

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Publication number
CN109069687A
CN109069687A CN201680079420.0A CN201680079420A CN109069687A CN 109069687 A CN109069687 A CN 109069687A CN 201680079420 A CN201680079420 A CN 201680079420A CN 109069687 A CN109069687 A CN 109069687A
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dressing
antibacterial
ammonium salt
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quaternary ammonium
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曾菊红
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Zhejiang Hongyu Medical Commodity Co ltd
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Zhejiang Hongyu Medical Commodity Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/07—Stiffening bandages
    • A61L15/14—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
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Abstract

A kind of antibacterial dressing and the preparation method and application thereof.The antibacterial dressing composition includes organosilicon antibacterial agent, buffer stabilizer and solvent.The pH value of the antibacterial dressing composition is 3.5-6.5.The preparation method of the antibacterial dressing includes: that buffer stabilizer is added into organosilicon quaternary ammonium salt compound solution to adjust pH value as 3.0-6.9, it is 3.5-6.5 that the silica of amination processing, which is added, and adjusts pH value with buffer stabilizer, water is added in the solution and forms soak, it is added in soak and applies core, and adjusting soak pH value is 3.5-6.5.The pH value can control the slightly acidic environment of dressing composition, so that the surface of a wound or wound maintenance faintly acid of the dressing are attached, to have the function that stabilization checking growth of pathogenic bacteria.

Description

A kind of antibacterial dressing and the preparation method and application thereof Technical field
The present invention relates to the preparation methods and application of a kind of dressing more particularly to a kind of antibacterial dressing and the dressing.Belong to medical dressing technical field.
Background technique
The defect of existing wound and surface of a wound diagnostic method:
Pathogenic bacteria are based on gram-positive bacteria (G+), including B groups of hemolytic streptococcus, staphylococcus, drug resistance golden staphylococci.The mode of common diagnosis infection clinical at present is blood routine examination.Blood routine is primarily to see leucocyte, if quantity, increasing proportion increase, it is believed that be bacterium infection.And the wound infection of part causes whole blood leucocyte to increase the one pathology time of needs, and is that could diagnose it after the pathogenic bacteria of infected wound reach certain amount by blood routine examination and be infected.But germ reproduction speed is that very fastly, a such as staphylococcus aureus can be multiplied into 17,000,000 in 24 hours.
Due to hydrogen ions influence metabolic process enzymatic activity, to influence most pathogen absorption of nutrient ingredients, therefore, the Reproduction Conditions and environmental pH of most pathogens are closely bound up.Such as: most pathogen breedings and existing optimum pH value are 7.2-7.6, such as: streptococcus optimum pH value is 7.4-7.6；Staphylococcus optimum pH value is 7.4.It is learnt through repetition test, streptococcus and staphylococcus decline with the acid pH that increases, and when pH drops to 5.5 or less, 89% streptococcus and staphylococcus breeding are inhibited and dead the growth of these unsuitable germs (environment at this time)；When pH drops to 4.5 or less, streptococcus and staphylococcus cannot grow and dead.It can be seen that, the environment of weak acid can destroy pathogenic bacteria metabolism, it is seen that maintain weakly acidic condition particularly important, due to hydrogen ions influence metabolic process enzymatic activity, to influence most pathogen absorption of nutrient ingredients, therefore the Reproduction Conditions of most pathogens and environmental pH are closely bound up.
When human skin is abraded, knife wound, burn and scald, tearing wound etc., it need to be protected in site of injury using medical grade dressing, avoid wound infection, accelerate wound healing.After skin damage, it will usually cause the exudation of a large amount of sepages, and the infection vulnerable to bacterial virus, cause to generate inflammation even tissue necrosis, and then seriously affect the normal operation of skin, at this point, the effect of wound dressing just seems very prominent.Existing medical dressing can be divided into traditional dressing and new pattern compress according to the material of dressing.Wherein, new pattern compress mainly has four classes, natural type dressing, medicinal dressing, synthesis type dressing, dressing organizational project class dressing.
Wherein, traditional dressing refers mainly to the skin substitutes to be stopped blooding in wound, burn and exanthemv to wound, again more；Include mainly common cotton gauze, bandage, degreasing cotton gauze, cotton pad and petrolatum gauze etc., this kind of dressing is clinically most widely used dressing, the advantages of be that production cost is low.But water absorbing properties are poor, and can generate adhesion with wound, the process of wound healing can form a scab, and need to be replaced frequently, and be easy to cause the tissue newly formed It is easy to damage, when removing gauze, wound is also easy to produce secondary injury, while wound has the risk of dehydration.Such as dry gauze cannot be used for infected wound although can play the role of supervision covering wound, there is no facilitation to wound healing, sepage managerial ability is limited, adhesion wound, damage and cause bleeding, pain after patient's more change dressings again to newborn epithelial tissue.Oily yarn can play the role of adhesion wound containing vaseline or triglycerides；But there is no facilitation to the entire agglutination of wound, it is invalid to infected wound, sepage can be drained to two layers of dressing, sepage managerial ability is limited.The solvable gauze of traditional general fibre element without antibiotic property, need to smear antibiotic daily, then update and change gauze secondary injury easily also is caused to skin.
Natural type dressing mainly includes chitosan dressing, alginate dressing, the dressing of animal class and collagen dressing.Wherein, the series of biologic effect that chitosan has activation airframe systems, mediates airframe systems, improves the system function of phagocyte, and there are also antibacterial effects.But the drawbacks of chitosan gauze price is high, and it is prepared with Heavy environmental pollution.Seaweed salt medical dressing is mainly the dressing made of sodium alginate, alginic acid zinc or calcium alginate etc., and this kind of dressing has hydrophily and biocompatibility.Collagen type dressing is that dressing is prepared using the native protein that extracts from animal, and this kind of dressing is biodegradable and reabsorption, non-toxic, and can provide nutrition foundation for wound healing.But it equally exists expensive, collagen and purifies seriously polluted problem.
Drug class dressing includes interactive wound dressing, silver-colored dressing, calcium alginate dressings etc..General drug class dressing refers to addition antibacterial agent, such as sulfapryidine silver, Ciprofloxacin, to increase the antibiotic property of dressing.Silver ion can bind directly cell wall and kill bacterium in silver-colored dressing, control wound infection, and accelerating wound healing removes the peculiar smell generated by bacterium, is a kind of ideal anti-infective dressing；The disadvantage is that expensive, and metal ion is to using the patient to have certain health risk.Since the most raw material of drug class dressing is synthesis material, cannot biodegrade, and the problems such as synthetic antibiotic is also easy to produce drug resistance, antibiotic it is excessive using and bacterial drug resistance increase affect the effect of antibiotic in wound infection treatment.
The sixties in last century, British Winter propose " wet wound healing is theoretical ", i.e., wound is more advantageous to wound healing in the case where keeping moisture state, and cell travelling is helped to make skin smooth growth；People are allowed to have breakthrough understanding for the agglutination of wound.Therefore a series of moist wounds synthesis type casting products with better healing properties are developed, mainly includes film-type dressing, foam class dressing (foam dressing), Hydrogels dressing (hydrogel dressing), hydrocolloid class dressing (hydrocolloid dressing) etc..Such synthesis type dressing can replace damaged skin, and act on always to wound healing and skin lesion healing；External mechanical factor (such as foul, collision, inflammation) is such as resisted, pollution and chemical stimulation is resisted, prevents two degree of infection, prevents dry and body fluid from losing (electrolyte loss), preventing heat from losing.Also, other than carrying out protection comprehensively to wound, moreover it is possible to actively influence wound healing process by debridement, create the microenvironment for promoting wound healing.
Hydrogel medical dressing is prepared using some polyether polyols high-molecular compounds with strong absorptive structure, and this kind of macromolecular structure can form tridimensional network by being crosslinked；And itself has hydrophilic radical, can absorb sepage and be overlying on wound surface as one layer of hydrogel to protect wound；The wettability that wound can be automatically adjusted has a small amount of ability for absorbing sepage, does not glue wound, easily remove.And have and use closed moisturizing principle compared with the bearing hydrocolloid dressing of high water absorption multiplying power, hydrophilic sodium carboxymethylcellulose (CMC) particle oozes out the effect of being in contact, the surface of a wound with wound Surface formed one layer of wet gelinite, persistently build moist environment, not with surface of a wound adhesion.It can be absorbed the normal saline solution for being equivalent to 20 times of own wt, but when encountering wound initial stage or larger compared with still showing slightly insufficient for gash, and influence its stickiness after moist wounds dressing moisture absorption, be easy to fall off it for disadvantage.Secondly, when encounter wound generate diffusate it is excessive when, wound because be in excessive moistening environment it is too long, be easy to produce exanthemv, or even cause bacterium infection, and then lead to wound secondary injury, dressing at this time is also limited for the absorbency of diffusate.Again, dressing used on the market at present does not have any warning function, and the infection conditions of wound can not be reminded to carry out more change dressings, can only artificially be replaced according to length of time.
Therefore, those skilled in the art is dedicated to developing a kind of new without antibiotic, antibacterial agent, fungicide or metal ion, the dressing with preferable fungistatic effect；Especially a kind of antibacterial dressing without chemical antimicrobials/bactericides, the antibacterial dressing can also have warning wound infection degree.
Summary of the invention
In view of the above drawbacks of the prior art, technical problem to be solved by the invention is to provide a kind of with the preferable antibacterial dressing for inhibiting bacterial growth effect, and the antibacterial dressing is without bacteriostatic agents or fungicide such as any antibiotic, metal ions.
To achieve the above object, the present invention provides a kind of novel antibacterial dressing, the standby inhibition bacterial growth function of matching in excellence or beauty with drug class dressing of the dressing especially can inhibit the growth of infectious bacteria.
The technical scheme of the invention to solve the technical problem is: a kind of antibacterial dressing, including antibacterial dressing composition, the pH value of the antibacterial dressing composition are 3.5-6.5, required pH can be obtained by the way that buffer is added in antibacterial dressing composition.In better embodiment of the invention, the pH value of antibacterial dressing composition is 4.4-5.5.
In a specific embodiment of the present invention, buffer is preferably glycine-HCI buffer, citric acid/disodium hydrogen phosphate buffer, citric acid/sodium citrate buffer, citric acid-sodium hydroxide-hydrochloride buffer or acetic acid/sodium acetate buffer etc..More preferably containing the buffer solution system of citric acid.Buffer can the amount of the antibacterial dressing composition weight of about 0.3%-2% exist, so as to stable pH system needed for keeping.
The pH environment that the present invention passes through control dressing, especially control the slightly acidic environment of dressing composition (deposited core), so that pasting any type of surface of a wound or wound and its pH maintains the faintly acid constant in surrounding (when no strong acid and strong base contacts) at least 36 hours of the dressing, to destroy the absorption of nutrient ingredients of wound circumference majority pathogenic bacteria, to have the function that stable inhibition growth of pathogenic bacteria.The dressing of present invention dressing composition containing subacidity is particularly suitable for inhibiting the growth of the infectious germ such as staphylococcus aureus, Escherichia coli, pylori.
Inventor has surprisingly found that, when antibacterial dressing contains silicon components, the presence that the pH of dressing composition can be stable enables fungistatic effect to maintain the longer time.Inventor estimates its principle when being containing organo-silicon compound, can be stablized by the synergistic effect between silicon components and quaternary ammonium salt ion and support the pH value of accompanying object rich in snubber elastomeric, keeps relative constant subacidity pH value to realize.
Dressing composition can exist for solution form, which can be used as the solution maceration extract that is spraying or can impregnating dressing applied to dressing.In a specific embodiment of the present invention, antibacterial dressing composition of the invention includes organosilicon antibacterial agent, buffer stabilizer, solvent.By mass percentage, it is preferable that organosilicon antibacterial agent content is 0.01%-3%, It is more preferably 0.01%-1.5%, more preferably 0.01%-1%.When organosilicon antibacterial agent content is higher than 3%, antibacterial dressing of the invention is more stable, but its cost also greatly increases.Buffer stabiliser content is 0.001%-3%, preferably 0.01%-1.5%, more preferably 0.01%-1%.
In a specific embodiment of the present invention, the organosilicon antibacterial agent mainly includes organosilicon quarternary ammonium salt compound and/or silica.In a preferred embodiment of the invention, organosilicon antibacterial agent is organosilicone quaternary ammonium salt compound and silica, and by mass percentage, the ratio of silica and organosilicone quaternary ammonium salt compound is preferably 1: 30-10: 1.
Although existing document report organosilicon quaternary ammonium salt has an excellent antibacterial bacteriostatic performance, especially to staphylococcus aureus, Escherichia coli and candida albicans for 24 hours after bacteriostasis rate all may be up to 95% or more, and it is safe and non-toxic, without causing enzyme reaction.Such as there is polysiloxanes absorption property on pure cotton sheeting of the patent report with benzyl dimethyl silicon propyl ammonium chloride side group and its have stronger bactericidal activity to Escherichia coli and staphylococcus aureus.It can also be thus widely applied on the materials high-grade fabric antibacterial and mouldproof such as cotton, terylene, polyamide fibre, such as underskirt underpants, towel, insole, socks antibacterial.But organosilicon quaternary ammonium salt is used for dressing and is not yet had been reported that.Also, it the use of the great advantage that organosilicon quaternary ammonium salt is antibacterial agent is that Environmental Safety is nontoxic, it is to no skin irritation and good anti-bacterial effect, lasting, washable.When using silicon as medium, its surface that ammonium cation group with bacteriostasis property can be forcefully adsorbed in bacterium, to change the permeability of bacteria cell wall, so that endobacillary enzyme, coenzyme and metabolic intermediate overflow, cause bacterial micro-organism dehydration dead, to have the function that antibacterial.
In the present invention, organosilicone quaternary ammonium salt compound is chosen as the organosilicone quaternary ammonium salt compound as antibacterial agent commonly used in the art, this is not particularly limited in the present invention, and those skilled in the art selection and deployment or can buy commercial known compound according to actual needs.Organosilicone quaternary ammonium salt compound is preferably mono-quaternaries, bi-quaternary ammonium salt, three quaternary ammonium salts, the multi-quaternary ammonium salt, hyperbranched quaternary ammonium salt of organo-silicon compound；Such as monoalkyltrimethyl ammonium salts, dialkyl dimethyl ammonium salt or monoalkyl monobenzyl dimethyl ammonium, the quaternary ammonium salt of trialkoxy silane etc.；The wherein alkyl that alkyl is carbon atoms 1~20.The organo-silicon compound for more preferably all being replaced by alkyl comprising four hydrogen atoms in ammonium ion and generating.Organo-silicon compound are preferably ethyl orthosilicate, 3- chloropropyl triethoxysilane etc..It is highly preferred that organosilicone quaternary ammonium salt compound is the N that U.S. Dow Corn-ing company develops, N- dimethyl-N-octadecyl base TSL 8330 quaternary ammonium salt (DC-5700).In the present invention, it is also possible to which organic titanic compound substitutes organosilicone quaternary ammonium salt compound, and the two fungistatic effect is similar, but from cost of manufacture, hence it is evident that organic titanic compound is higher than organosilicone quaternary ammonium salt compound.
In the present invention, silica is preferably mesoporous SiO of the aperture in 2nm-50nm range2；The mesoporous SiO that more preferable aperture is 20nm-50nm2, such as mesopore molecular sieve (MCM41).
Buffer stabilizer (pH stable agent) role of the invention is that pH value buffering is provided for antibacterial dressing of the invention, and the antibacterial dressing is enabled to stablize lasting holding pH 3.5-6.5.Buffer stabilizer is preferably triethanolamine.Solvent of the invention is preferably deionized water.
In one particular embodiment of the present invention, buffer solution system is the buffer system containing citric acid, and pH stable agent is triethanolamine.Wherein, it is entirely hydrionic compound that citric acid, which is the cation generated when ionizing in the solution,；With Zeolite synthesis, using long chain alkyl ammonium salt and matched organic silicon source ethyl orthosilicate, inorganic silicon are hydrolyzed The silica solution in source forms effectively stable carrier.
Preferably, antibacterial dressing of the invention also has alarm function, for a kind of antibacterial dressing of discoloration, that is, can be used to the sensing wound dressing for reminding wound infection.
In another better embodiment of the invention, antibacterial dressing also contains soda acid instruction component, when the antibacterial dressing for having alarm function is applied to the wound surface of skin, the effect of component can be indicated by soda acid, color change after absorbing diffusate using dressing, reminds user to carry out the replacement of dressing.
Soda acid instruction component of the invention can be specifically chosen according to practical application, be not particularly limited.Such as soda acid instruction component can be one of reindeer moss, methyl orange, phenolphthalein or other natural acid-base indicators etc..Since dressing is in practical applications to the usage amount very little of indicator, thereby indicate that agent range of choice is wide, it is specific unlimited.It such as can also be the one or more of crystal violet, picric acid, methyl chloride, peacock green, cresol red, thymol blue, Xi Suhuang, dimethyl yellow, methyl orange, bromophenol blue, reindeer moss, Congo red, bromocresol green, methyl red, dibromophenolphthalein, bromocresol purple, bromthymol blue, dimethyl diaminophenazine chloride, phenol red, cresol red, phenolphthalein, thymolphthalein and titan yellow；Or selected from one or more of preserved carrot, blueberry, carrot, cherry, curry powder, delphinium petal, fish pelargonium petal, grape, the leaf of horse chestnut, laurustinus, onion, morning glory petal, Primula vulgaris, opium poppy petal, Paeonia delavayi, red autumnal leaves cabbage, carrot, rheum officinale, roseleaf, strawberry, tea, thyme, turmeric, tulip petals, violet petal and purple Koryo vegetable juice.
The characteristics of component itself is indicated due to soda acid, even those skilled in the art are according to the common knowledge of this field it is found that the soda acid instruction component of micro content can also change according to pH value of solution and be changed.Therefore, the content of soda acid instruction component is not particularly limited in the antibacterial dressing of discoloration of the invention.Preferably, the weight content of soda acid instruction component is 0.001%-10%, more preferably 0.001%-1%；Content is conducive to cost control less.
As another object of the present invention, the present invention also provides a kind of preparation methods of antibacterial dressing that changes colour, specifically includes the following steps:
(1) deionized water (1000mL) is added into organosilicon quaternary ammonium salt compound solution (20-100mL)；Buffer, which is added, is adjusted to pH 3.0-6.9 simultaneously, at room temperature, which is placed in magnetic stirrer, obtains prefabricated acid solution；
(2) amination being added in prefabricated acid solution treated silica continues stirring and is placed on centrifuge centrifugation, and filtering filters off insoluble matter, acid-base indicator is added into filtrate, adjusts pH3.5-6.5 with buffer stabilizer；
(3) deionized water is added in solution obtained, forms soak, initial contaminating bacteria deposited core up to standard is added in soak, adjusted soak pH value and maintain to 3.5-6.5, impregnate；It drains, low temperature drying；Up to the antibacterial dressing of discoloration.
Wherein treated that silica refers to Nano-meter SiO_2 for amination described in step 22It is amination modified, the SiO of amino functional2I.e. functional mesoporous material has than SiO2Bigger specific surface area, controllable pore size and pore-size distribution, good thermal stability and mechanicalness.
In a particular embodiment, each group in dressing preparation can be calculated by calculating the pH value of immersion object dressing substrate Divide dosage.
On the other hand, the present invention also provides a kind of antibacterial dressing that changes colour in the application for preparing Medical dressing equipment.
In the practical application of Medical dressing equipment, general dressing, which contains, absorbs bed course (being also deposited core), adhesion layer (some special dressing are free of this layer, such as bearing hydrocolloid dressing), substrate layer (fixed deposited core and contact surface).The above-mentioned antibacterial dressing of discoloration formed that impregnated by soak is the deposited core in applying, and after the deposited core cutting after immersion and will be adhered on dressing substrate and forms dressing.
One of in preferred specific embodiment, dressing substrate is selected from cotton, cellulose derivative class, polysulfones, polyamide-based, polyimide, polyesters, polyolefins, polyvinyls, silicon-containing polymer, fluoropolymer or chitin kind).It is highly preferred that dressing substrate is one of non-woven fabrics, polyurethane film, polyethylene film.
Preferably, Medical dressing equipment is selected from one of bandage, adhesive-bonded fabric dressing, gauze dressing, oily yarn dressing, inviscid dressing, transparent film dressing, hydrogel, bearing hydrocolloid dressing, alginate dressing, hydrophilic fibre, super-absorbert wound pad, dressing containing collagen, hypertonic salt dressing, foam dressing, carbon containing dressing, silver dressings, soft silicone dressing or liquid dressing.It is highly preferred that Medical dressing equipment is selected from one of bandage, bandage, hydrocolloid, hydrogel, scar plaster.
In practical applications, the antibacterial dressing of discoloration of the invention further includes the application on amenities and daily necessities.Purposes such as on sanitary napkin, and the purposes on the fabric of special purpose.
Women is in menstrual period, the skin of sensitive part most subject to damage or infection.Investigation shows to have 38% people can suffer from serious gynecological disease；73% women can feel local skin itch, cusalgia in menstrual period；80% or so women there is also the symptoms such as high fever, headache, abdominal pain；It is as caused by the sanitary napkin used that this is mostly.The reason is that female pelvic cavity, uterus, uterine neck vitro all communicate, such structure makes the reproductive system of women be subject to the invasion of extraneous causative agent.Especially intermenstrual period, the resistance decline of reproductive organs is more fragile than usual, if having used sub-standard sanitary napkin, is easy for infecting.There is nutriment abundant in menses, also therefore becomes " culture medium " that bacterium breeds without restraint.After one experiment shows that conventional sanitary napkin is used continuously 2 hours, surface layer total number of bacteria is up to 107 every square centimeter.Therefore, Yao Andu menstrual period select suitable sanitary napkin most important.Sanitary napkin is generally made of superficial layer, absorbed layer and bottom three parts.The absorbed layer that antibacterial dressing of the invention is used for sanitary napkin can reach to the effect for inhibiting bacterium, simultaneously, replacing construction can be also judged according to sanitary napkin color change when in use, energy is timely, effectively inhibits the growth of some germs, there is great meaning for women's health.
Antibacterial dressing of the invention applies also on daily necessities such as clothes, the textile fabric consisted of fibers, since the chemical structure of its more empty formula body form and high molecular polymer is conducive to microorganism attachment, become the good parasitic body of microorganism (such as intrinsic smell of bacterial decomposition human sweat, skin stench generated, corrupt substance, chemical substance) existence, breeding.Parasitic body can also pollute fiber other than the harm to human body, textile fabric after antibacterial dressing immersion treatment of the invention can eliminate these adverse effects significantly, people can be made to play antibacterial effect during everyday general purpose, achieve the effect that antibacterial especially by bacterium increment is inhibited.
Technical effect
Compared with the prior art, the advantages of the present invention are as follows: antibacterial dressing of the invention has superior absorption diffusate Performance keeps wound moist, and wound healing mitigates pain, reduces dressing change frequency, can apply for a long time, waterproof, ventilative, inhibition pathogen, especially inhibition streptococcus and staphylococcic growth；With preferable antibacterial/antibacterial effect, wound climate can be detected in time, facilitates observation, can change prompt replacing construction in time according to product colour.Tests prove that, antibacterial dressing of the invention can reach and the use of nano silver is the same fungistatic effect of the dressing of bacteriostatic agent, since silver dressings can constantly release silver ion in use, and the national regulations such as America and Europe, silver-colored ppm is no more than 0.5PPM in water body, otherwise it will cause heavy metal pollution, huge destruction caused to water body.Also, if nano silver antimicrobials are absorbed by human body viscera, it can accumulate and lesion occurs, be detrimental to health.Therefore, antibacterial dressing of the invention is pollution-free, harmless, no cytotoxicity, nonirritant, extremely low sensitization；There is good commercial promise to silver-colored dressing is substituted.
It is described further below with reference to technical effect of the attached drawing to design of the invention, specific structure and generation, to fully understand the purposes, features and effects of the present invention.
Specific embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, below with reference to specific example, specific embodiments of the present invention will be described in detail.
In the following description, numerous specific details are set forth in order to facilitate a full understanding of the present invention, but the present invention can also take other modes to implement, those skilled in the art can do similar popularization under conditions of without prejudice to intension of the present invention, therefore the present invention is not limited by the specific embodiments disclosed below.
Secondly, " one embodiment " or " embodiment " referred to herein refers to a particular feature, structure, or characteristic that may be included at least one implementation of the invention.What different places occurred in the present specification is not necessarily referring to the same embodiment " in one embodiment ", nor the individual or selective embodiment mutually exclusive with other embodiments.
Embodiment 1
A kind of preparation of non-woven fabrics (for substrate) wound dressing
(1) preparation of organosilicone quaternary ammonium salt compound
In four-hole boiling flask, N, the mixture (mass ratio 3: 5) of N- diethylaminopropyl methyl dimethoxysilane and organic solvent is added；45 DEG C are warming up to, the mixture (mass ratio 1: 2) of epoxychloropropane and solvent is slowly added dropwise, is added dropwise, reaction a period of time；It is down to room temperature, rotary evaporation falls most solvents；It is washed 3 times with ether, is dried in vacuo 5h, obtains epoxy type organosilicon quaternary ammonium salt.
(2) amination handles silica
SiO2Material preparation: weighing 2g CTAB and be dissolved in hydrochloric acid solution (1.6mol/L, 75mL), and 4mL TMB is added and stirs evenly as oily phase.(40 DEG C) of a certain amount of ethyl orthosilicate (TEOS) water-bath reactions are slowly added dropwise for 24 hours, (110 DEG C) reactions are placed in autoclave again for 24 hours, after products therefrom is filtered, is washed for several times, it puts and spontaneously dries 2 days in air, aerobic calcining 5h can obtain mesoporous SiO to remove surfactant to gained white powder at 550 DEG C in Muffle furnace2Material.
The immobilization of amino: the SiO that TEOS hydrolysis generates2Work as addition there are a large amount of Si-OH key in skeleton surface Ethyoxyl and SiO when ATES, in ATES2Condensation reaction occurs for the hydroxyl on surface, and amino can be grafted onto SiO2Surface.
(3) the organosilicone quaternary ammonium salting liquid (0.12g, 50mL) that will be prepared, is added in the deionized water of 500mL；It is added citric acid-sodium citrate buffer solution (0.2mol/L, 3.4mL) simultaneously, triethanolamine (1.5mL) adjusts pH to 3.0；At room temperature, which is placed in magnetic stirrer 4h, obtains prefabricated acid solution；
(4) amination treated silica (1g is added in prefabricated acid solution, pH≤4.5, aperture is 20nm), continue to stir 1h and is placed on the centrifuges of 2000 revolving speeds and is centrifuged, filter out insoluble matter, reindeer moss (0.01g, pH >=6.1) are added in the solution obtained after centrifugation；Acquired solution pH is 3.5 at this time；
(5) deionized water 1200mL is added in above-mentioned solution obtained, forms soak.Initial contaminating bacteria non-woven fabrics up to standard is added in soak and applies core (pH 8.8), it is about 3.5 that entire volume, which is dipped to soak pH value, then impregnates to take out after 30min and drain, and low temperature drying tunnel, which is dried, covers volume；
(6) it is required after non-woven fabrics obtained is applied core cutting according to preparation, is adhered on non-woven fabrics (pH=8.8) substrate using adhesive (pH=5.2) and forms the antibacterial dressing that changes colour.
(7) anti-microbial property test
Using E.coli (ATCC25922) and S.aureus (ATCC6538) as strains tested.Antibacterial test is carried out referring to the sample of ASTME2149:2001 " the active dynamic method of testing of anchorage antibacterial antiplaque agent " to not washed numbers different with washing.Sample is placed in the bacteria suspension of CFU105~106, after 37 DEG C of 4~12h of shaken cultivation, by suspension dilution certain multiple coating agar plate, its antibacterial effect is calculated by formula.
P (%)=[(Co-C)/Co] × 100%
In formula: P- Bacteria suppression percentage；Clump count after the non-antimicrobial treatment object co-cultivation of Co-；Clump count after the co-cultivation of C- antibacterial.
Through detecting, gained non-woven fabrics change colour antibacterial dressing apply core bacteriostasis rate bacteriostasis rate be staphylococcus aureus: 90%, Escherichia coli: 92%, pylori: 90%.
Embodiment 2
A kind of preparation of polyurethane (for substrate) wound dressing
(1) amination of organosilicone quaternary ammonium salt compound and silica is handled with embodiment 1；
(2) the organosilicon quaternary ammonium salt DC-5700 solution (0.5g, 30mL) that will be prepared, is added in the deionized water of 500mL；It is added citric acid-sodium citrate buffer solution (0.2mol/L, 2.6mL) simultaneously, triethanolamine (1mL) adjusts pH to 4.4；At room temperature, which is placed in magnetic stirrer 2h, obtains prefabricated acid solution；
(4) amination treated silica (0.6g is added in prefabricated acid solution, pH≤4.5, aperture is 2nm), continue to stir 1h and is placed on the centrifuges of 2000 revolving speeds and is centrifuged, filter out insoluble matter, reindeer moss (0.01g, pH >=6.1) are added in the solution obtained after centrifugation；Acquired solution pH is 4.4 at this time；
(5) deionized water 1000mL is added in above-mentioned solution obtained, forms soak.It is added in soak Initial contaminating bacteria polyurethane film non-woven fabrics (pH >=7.4) up to standard applies core, and it is 4.0-4.5 that entire volume, which is dipped to soak pH value, then impregnates to take out after 30min and drain, and low temperature drying tunnel, which is dried, covers volume；
(6) it is required after non-woven fabrics obtained is applied core cutting according to preparation, is adhered on polyurethane film (pH >=7.4) substrate using adhesive (pH=5.2) and forms the antibacterial dressing that changes colour.
Through detecting, the change colour bacteriostasis rate of antibacterial dressing of gained is staphylococcus aureus: 93%, Escherichia coli: and 91%, pylori: 89%.
Embodiment 3
A kind of preparation of polyethylene (for substrate) wound dressing
(1) amination of organosilicone quaternary ammonium salt compound and silica is handled with embodiment 1；
(2) the organosilicon quaternary ammonium salt DC-5700 solution (3.5g, 60mL) that will be prepared, is added in the deionized water of 500mL；It is added citric acid-sodium hydroxide-hydrochloride buffer (0.05mol/L, 1.6mL) simultaneously, triethanolamine (1mL) adjusts pH to 6.5；At room temperature, which is placed in magnetic stirrer 2h, obtains prefabricated acid solution；
(4) amination treated silica (1.2g is added in prefabricated acid solution, pH≤4.5, aperture is 50nm), continue to stir 1h and is placed on the centrifuges of 2000 revolving speeds and is centrifuged, filter out insoluble matter, reindeer moss (0.01g, pH >=6.1) are added in the solution obtained after centrifugation；Acquired solution pH is 6.5 at this time；
(5) deionized water 1000mL is added in above-mentioned solution obtained, forms soak.Initial contaminating bacteria polyethylene film non-woven fabrics (pH >=8.0) up to standard is added in soak and applies core, it is 6.0-6.5 that entire volume, which is dipped to soak pH value, then impregnates to take out after 30min and drain, and low temperature drying tunnel, which is dried, covers volume；
(6) it is required after non-woven fabrics obtained is applied core cutting according to preparation, is adhered on polyethylene film (pH >=8.0) substrate using adhesive (pH=5.2) and forms the antibacterial dressing that changes colour.
Through detecting, the change colour bacteriostasis rate of antibacterial dressing of gained is staphylococcus aureus: 94%, Escherichia coli: and 93%, pylori: 91%.
Embodiment 4
A kind of preparation of polyurethane (for substrate) wound dressing
(1) amination of silica is handled with embodiment 1；
(2) citric acid-sodium hydroxide-hydrochloride buffer (0.05mol/L, 1.5mL) is added into the deionized water of 500mL, triethanolamine (0.8mL) adjusts pH to 5.5；At room temperature, which is placed in magnetic stirrer 2h, obtains prefabricated acid solution；
(4) amination treated silica (2g is added in prefabricated acid solution, pH≤4.5, aperture is 10nm), continue to stir 2h and is placed on the centrifuges of 5000 revolving speeds and is centrifuged, filter out insoluble matter, reindeer moss (0.01g, pH >=6.1) are added in the solution obtained after centrifugation；Acquired solution pH is 5.5 at this time；
(5) deionized water 1000mL is added in above-mentioned solution obtained, forms soak.Initial contaminating bacteria polyurethane film non-woven fabrics (pH >=7.4) up to standard is added in soak and applies core, it is 5.0-5.5 that entire volume, which is dipped to soak pH value, then impregnates to take out after 30min and drain, and low temperature drying tunnel, which is dried, covers volume；
(6) it is required after non-woven fabrics obtained is applied core cutting according to preparation, is adhered on polyurethane film (pH >=7.4) substrate using adhesive (pH=5.2) and forms the antibacterial dressing that changes colour.
Through detecting, the change colour bacteriostasis rate of antibacterial dressing of gained is staphylococcus aureus: 94%, Escherichia coli: and 92%, pylori: 95%.
Embodiment 5
Change colour bacteriostatic hydrocolloid dressing
(1) by organosilicon quaternary ammonium salt DC-5700 solution, (0.12g, 4mL are added in the deionized water of 90mL.It is added citric acid (3.4g) simultaneously, triethanolamine (1.5mL) adjusts pH to 3.0-6.9 that the mixed solution is placed in magnetic stirrer 4h, obtains prefabricated acid solution at room temperature；
(2) amination being added in prefabricated acid solution treated silica (1g, pH≤4.5, aperture 30nm) continues 3000 revolving speed of centrifuge after stirring 1h and is centrifuged, filtering, and acid-base indicator (0.01g) is added in filtrate；
(3) it 1.5kg styrene-isoprene block copolymer, 2.3kg polyisobutene, 1.0kg pentalyn and the medical grade white oil of 1.2kg is weighed is put into vacuum kneader and normally mediate 1-2 hours, then vacuumize (vacuum degree 0.07MPa) again and mediate 1 hour.Investment temperature of reaction kettle rises to 140~170 DEG C, after dissolving completely, 37.65kg sodium carboxymethylcellulose is added, is then slowly added in reaction kettle, is stirred continuously, and after being mixed thoroughly, cool down deaeration, spare；
(4) by above-mentioned hydrocolloid rubber cement in mixer in 80 DEG C of stirring 30min, when temperature is down to 45 DEG C, be added (1) acquired solution, with rubber cement stir 20min.By the pH value of calculating (1) solution and hydrocolloid rubber cement, citric acid (3g) adjusts after mixing pH value to 3.5-6.5.20min is stirred with rubber cement.After, mixture is removed from mixer, moisture content is removed into low temperature drying tunnel, is coated on separate paper, average rate coating stamps out the discoloration bacteriostatic hydrocolloid dressing of different size.
Through detecting, the change colour bacteriostasis rate of antibacterial dressing of gained is staphylococcus aureus: 92%, Escherichia coli: and 94%, pylori: 95%.
Embodiment 6
Change colour antibacterial aerogel dressing
(1) quaternary ammonium salt solution (0.12g, 10mL) that epoxy group is reacted to synthesis quaternary ammonium salt structure with organic amine, is added in the deionized water of 80mL.Buffer citric acid 3.4g, which is added, is adjusted to pH 3.0-6.9 simultaneously, at room temperature, which is placed in magnetic stirrer 3h, obtains prefabricated acid solution；
(2) 1kg polyvinyl alcohol is put into 8.9L deionized water and is dissolved 20 minutes；It places into 90 DEG C of water and dissolves；Magnetic agitation 1 hour.The step cannot contact metal.
(3) it is added prefabricated acid solution after poly-vinyl alcohol solution (10g) room temperature, magnetic agitation 1 hour.Mixed solution is cast in mold and freezes molding in 12 hours, cryogenic temperature is at -20 DEG C.Then it thaws 2 hours at room temperature；It freezes 12 hours for -20 DEG C again, then thaw at RT 2 hours；Third time is placed in -20 DEG C and freezes 12 hours, third time thaw at RT 2 hours；4th -20 DEG C of freezings 12 hours, the 4th time thaw at RT 2 hours.By calculating prefabricated acidity The pH value of solution and poly-vinyl alcohol solution, pH value is to 3.5-6.5 after citric acid adjusts mixing.Up to the antibacterial aerogel dressing that changes colour.
Through detecting, the change colour bacteriostasis rate of antibacterial dressing of gained is staphylococcus aureus: 95%, Escherichia coli: and 94%, pylori: 92%.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that the ordinary skill of this field according to the present invention can be conceived without creative work makes many modifications and variations.Therefore, all technician in the art, all should be within the scope of protection determined by the claims under this invention's idea on the basis of existing technology by the available technical solution of logical analysis, reasoning, or a limited experiment.

Claims (16)

  1. A kind of antibacterial dressing, which is characterized in that including antibacterial dressing composition, the antibacterial dressing composition is located in the buffer solution system that pH value is 3.5-6.5.
  2. Antibacterial dressing according to claim 1, it is characterised in that: the antibacterial dressing composition includes organosilicon antibacterial agent, buffer stabilizer, solvent.
  3. Antibacterial dressing according to claim 2, which is characterized in that by mass percentage, organosilicon antibacterial agent content is 0.01%-3%, and buffer stabiliser content is 0.001%-3%；Preferably, organosilicon antibacterial agent content is 0.01%-1.5%, it is highly preferred that organosilicon antibacterial agent content is 0.01%-1%.
  4. Antibacterial dressing according to claim 1 to 3, it is characterised in that: the buffer solution system is citric acid/disodium hydrogen phosphate, citric acid/sodium citrate or acetic acid/acetate buffer system.
  5. Antibacterial dressing according to claim 2, it is characterised in that: the organosilicon antibacterial agent is organosilicone quaternary ammonium salt compound and/or silica.
  6. Antibacterial dressing according to claim 1, it is characterised in that: the pH value of the buffer is 4.4-5.5.
  7. Antibacterial dressing according to claim 5, it is characterised in that: the silica is preferably mesoporous SiO of the aperture in 2nm-50nm range2；The mesoporous SiO that more preferable aperture is 20nm-50nm2。
  8. Antibacterial dressing according to claim 5, it is characterised in that: the organosilicon antibacterial agent is organosilicone quaternary ammonium salt compound and silica；By mass percentage, the ratio of the silica and organosilicone quaternary ammonium salt compound is 1: 30-10: 1.
  9. Antibacterial dressing according to claim 5, it is characterised in that: the organosilicone quaternary ammonium salt compound is mono-quaternaries, bi-quaternary ammonium salt, three quaternary ammonium salts, the multi-quaternary ammonium salt, hyperbranched quaternary ammonium salt of organo-silicon compound；The ammonium salt is monoalkyltrimethyl ammonium salts, dialkyl dimethyl ammonium salt or monoalkyl monobenzyl dimethyl ammonium；Wherein silicon compound is ethyl orthosilicate or 3- chloropropyl triethoxysilane.
  10. Antibacterial dressing according to claim 2, it is characterised in that: the buffer stabilizer is triethanolamine.
  11. - 6 any antibacterial dressing according to claim 1, it is characterised in that: the antibacterial dressing of the discoloration also contains soda acid instruction component.
  12. A method of preparing the antibacterial dressing as described in claim 1-6 is any, which comprises the following steps:
    (1) at room temperature, buffer is added into the aqueous solution of organosilicone quaternary ammonium salt compound and is adjusted to pH3.0-6.9, stir to get prefabricated acid solution；
    (2) amination treated silica is added in prefabricated acid solution, continues to stir 1-4h, be centrifuged, acid-base indicator is added to filtrate in filtering；
    (3) deionized water is added in solution obtained, forms soak, dressing substrate is added in soak, adjusted Soak pH value is saved to 3.5-6.5 to get the antibacterial dressing of discoloration.
  13. The preparation method of antibacterial dressing according to claim 12, it is characterized in that, the dressing substrate is one of non-woven fabrics, polyurethane film, polyethylene film, cotton, cellulose derivative class, polysulfones, polyamide-based, polyimide, polyesters, polyolefins, polyvinyls, silicon-containing polymer, fluoropolymer or chitin kind.
  14. A kind of described in any item antibacterial dressing of claim 1-11 are preparing the application in Medical dressing equipment.
  15. A kind of application of described in any item antibacterial dressing of claim 1-11 in amenities, daily necessities.
  16. Antibacterial dressing according to claim 14 is in the application for preparing Medical dressing equipment, it is characterized in that, the Medical dressing equipment is one of bandage, bandage, hydrocolloid, hydrogel, scar plaster, adhesive-bonded fabric dressing, gauze dressing, oily yarn dressing, inviscid dressing, transparent film dressing, hydrogel, bearing hydrocolloid dressing, alginate dressing, hydrophilic fibre, super-absorbert wound pad, dressing containing collagen, hypertonic salt dressing, foam dressing, carbon containing dressing, silver dressings, soft silicone dressing or liquid dressing.
CN201680079420.0A 2016-05-20 2016-05-20 A kind of antibacterial dressing and the preparation method and application thereof Pending CN109069687A (en)

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CN115212339A (en) * 2022-07-20 2022-10-21 浙江红雨医药用品有限公司 Active carbon polyurethane foam dressing and preparation method thereof

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Application publication date: 20181221