CN106943142A - A kind of electroretinogram（ERG）The signal amplifier of portable detection system - Google Patents
A kind of electroretinogram（ERG）The signal amplifier of portable detection system Download PDFInfo
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- CN106943142A CN106943142A CN201710155513.3A CN201710155513A CN106943142A CN 106943142 A CN106943142 A CN 106943142A CN 201710155513 A CN201710155513 A CN 201710155513A CN 106943142 A CN106943142 A CN 106943142A
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- 238000001514 detection method Methods 0.000 title claims abstract description 33
- 238000005259 measurement Methods 0.000 claims abstract description 4
- 230000003321 amplification Effects 0.000 claims description 15
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 15
- 210000001508 eye Anatomy 0.000 claims description 11
- 230000005611 electricity Effects 0.000 claims description 8
- 210000005252 bulbus oculi Anatomy 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 4
- 238000007493 shaping process Methods 0.000 claims description 2
- 230000005540 biological transmission Effects 0.000 claims 1
- 238000013461 design Methods 0.000 abstract description 6
- 238000005452 bending Methods 0.000 abstract description 3
- 238000010586 diagram Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 4
- 210000001525 retina Anatomy 0.000 description 4
- 210000004087 cornea Anatomy 0.000 description 3
- 210000001061 forehead Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002001 electrophysiology Methods 0.000 description 2
- 230000007831 electrophysiology Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000002207 retinal effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- 208000034700 Vitreous opacities Diseases 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/398—Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Eye Examination Apparatus (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The invention provides a kind of signal amplifier of electroretinogram (ERG) portable detection system, including 2 gain-adjusted knobs, built-in signal amplifying circuit, 2 measuring electrode magnetic interfaces are located at signal amplifier input, reference electrode is connected on signal amplifier by 1 reference electrode magnetic interfaces, also set up common reference electrode interface, 2 measuring electrodes and 2 output plugs, being shaped as signal amplifier main part is J-shaped, it is connected one end with measuring electrode for bending, accuracy of the new design in measurement, it can be improved a lot in simplification, cost is also very low.
Description
[technical field]
The present invention relates to ophthalmic medical technical field, more particularly to a kind of electroretinogram (ERG) portable detection system
Signal amplifier.
[background technology]
Electroretinogram (ERG) existing 40 years history since clinic from Karpe (1945) first Application, it is by one
Leading electrode and Corneal Contact, by the reference electrode that another area is larger, also referred to as ground electrode is placed on forehead, when to retina
During with light stimulus, the retina summation electricity reaction that retinal electrode recorded from cornea or corresponding site can be shown in detection device
A series of vision Electrical changes, i.e. electroretinogram (ERG) are recorded on ripple device.Flash of light ERG, part are had according to incentive condition difference
ERG and multifocal VEP.Electroretinogram is usually used in retinal ganglial cells disease such as eyeground pathological changes, ARM, green light
The diseases such as eye, cataract, vitreous opacity carry out effective detection, have considerable make among the diagnosis of early stage to patient
With.
The detection means of electroretinogram generally comprises three part compositions：
1. detecting electrode：Recording electrode uses cornea contact electrode, gold-foil electrode or microfibre electrode.Ground electrode passes through skin
Skin is placed in forehead center or auricle portion.
2. stimulator：Using full visual field different frequency, different wave length, different shape, the photic stimulator of different stimulated pattern.
3.ERG record and data processing equipment：Record the vision potential diagram with time (be typically ms) change, due to regarding
Feel that electricity is all very faint curtage signal, it usually needs have signal amplifier.In recent years, electro physiology and vision physiological are ground
The progress studied carefully and the extensive use of electronic computer technology, tape deck are all typically now computer electro physiology instruments.
Fig. 2 is ERG detecting system composition schematic diagrams.
Fig. 3 is the detects schematic diagram of ERG electrographs.
ERG electricity reaction is by 4 wave components：
A ripples：Cathodic wave, the mainly negative wave by being produced on cornea；
B ripples：Cationic potential, M ü ller cells and rod bipolar in retina；
C ripples：One slow positive ripple, originating from retinal pigment epithelium；
D ripples：Reaction after blacking out.
Fig. 4 is typical ERG electrographs.
Retina electric signal is small electrical signals, and signal amplifier after electrical signal detection and enhanced processing to exporting to view
Film electrographic recording instrument, recorder is by DAS formation electroretinogram, for analyzing.
The method of testing of electroretinogram never updates in recent years, and all electrodes are all to be put by dynamic circuit connector to preposition
The wire that amplifier, i.e. electrode come out, is directly connected on detection device, does not carry out the processing of early stage to signal.And it is a whole set of
Equipment is very complicated, operates inconvenient.Without selecting rational wire rod and line length in terms of wire, electrode and equipment room are led
Line is long, is influenceed larger by space magnetic field, and wire does not use shielding line, although signal amplifier is appointed so can be to electricity
Signal is necessarily handled, but the ERG electrograph waveforms formed can not be recognized and analyzed very well in digital processing, to suffering from
The eye diseases of person judge just not accurate enough.
[content of the invention]
In order to solve the above-mentioned technical problem, the present invention provides a kind of signal of electroretinogram (ERG) portable detection system
Amplifier.Present invention employs following technical scheme：
A kind of signal amplifier of electroretinogram (ERG) portable detection system, it is characterised in that adjusted including 2 gains
Save knob, signal amplification circuit, 2 detecting electrode magnetic interfaces, reference electrode, 1 reference electrode magnetic interfaces, common reference
Electrode interface, 2 detecting electrodes and 2 output plugs, wherein：
2 gain-adjusted knobs, are arranged on the resistance on signal amplifier surface, connection signal amplification circuit, use
In the different multiplication factor of Regulate signal；
The signal amplification circuit, is arranged inside signal amplifier, the telecommunications for amplifying the detecting electrode detection
Number；
Wherein, signal amplification circuit, including the first amplifier, the second amplifier and the 3rd amplifier, the first amplifier correspondence detection electricity
The electric signal of pole 5, the electric signal of second group of amplifier correspondence detecting electrode 51, the effect of the first amplifier and the second amplifier is to suppress altogether
Mould interference signal, amplifies difference mode signal, the 3rd amplifier is further to carry out differential amplification to the difference mode signal being exaggerated, by increasing
Beneficial knob adjusts electric signal size, changes the resistance of circuit, you can the gain amplifier of two channel signals of regulation；
2 detecting electrode magnetic interfaces, are arranged on signal amplifier input, are connected with detecting electrode, for passing
The electric signal of 2 detecting electrodes on defeated connection eyes；
The reference electrode, is connected by 1 reference electrode magnetic interfaces with signal amplifier；
The common reference electrode interface, is arranged on signal amplifier side, be it is some measurement occasions need to use it is many
Individual signal amplifier, multiple signal amplifiers can take common reference point by common reference electrode；
2 detecting electrodes are respectively placed at the right and left eyes of patient, and signal amplification circuit is connected to by magnetic interfaces.
Wherein, electric signal is connected on hand-held mobile display device by output plug, and passes through hand-held mobile
The program pre-installed on display device, image is converted into electric signal, is shown on device screen.
Wherein, the reference electrode bottom carries self-adhesive, can paste on the skin near eyeball, is fixed while rising
Effect.Wherein, the face shaping of signal amplifier main part is J-shaped, i.e., the one end that is connected with detecting electrode is bending,
All connecting wires use twisted-pair feeder.
By using such scheme, following beneficial effect is generated：Signal amplifier is directly against the eyeball of person of modern times, detection electricity
Pole is connected with signal amplifier, from the interference of environment, while can also shield interference signal using twisted-pair feeder, signal amplifier with
Detecting electrode compact, is convenient for people to carrying and uses, and the present invention is simple in construction, is adapted to batch production.
[brief description of the drawings]
Fig. 1 is a kind of signal amplifier schematic diagram of electroretinogram (ERG) portable detection system；
Fig. 2 is ERG detecting system composition schematic diagrams；
Fig. 3 is ERG detects schematic diagrams；
Fig. 4 is typical ERG electrographs；
The ERG electrographs that Fig. 5 contrasts for the ERG electrodes of the present invention with tradition ERG electrodes in same detection time；
Fig. 6 for the present invention the ERG electrodes ERG electrographs multiplicity that repeated detection is obtained in same detection time more
It is good；
Fig. 7 is the design principle block diagram of binary channels preamplifier；
Wherein, in Fig. 11 and 11 be output plug；2 be reference electrode；3 and 31 be gain-adjusted knob；4 be common reference
Electrode interface；5 and 51 be detecting electrode, and 6 and 61 be magetic indicator joint.
[embodiment]
In order that the technological means that the present invention is realized is clear, the present invention is expanded on further with reference to accompanying drawing.
As shown in figure 1, the present invention is a kind of signal amplifier of electroretinogram (ERG) portable detection system, including 2
Gain-adjusted knob 3 and 31, signal amplification circuit, 2 detecting electrode magnetic interfaces 6 and 61,2,1 reference electrode of reference electrode
Magnetic interfaces, 4,2 detecting electrodes 5 and 51 of common reference electrode interface, output plug 1 and 11, wherein：2 gains are adjusted
Save the electric signal that knob 3 and 31 corresponds to 2 detecting electrodes 5 and 51 respectively, the multiplication factor different for Regulate signal；
The signal amplification circuit, is arranged inside signal amplifier, the telecommunications for amplifying the detecting electrode detection
Number；
2 detecting electrode magnetic interfaces, are arranged on signal amplifier input, are connected with detecting electrode, for passing
The electric signal of 2 detecting electrodes 5 and 51 on defeated connection eyes；
The reference electrode 2, is connected by 1 reference electrode magnetic interfaces with signal amplifier；
The common reference electrode interface 4, is arranged on signal amplifier side, be it is some measurement occasions need to use it is many
Individual signal amplifier, multiple signal amplifiers can take common reference point by common reference electrode；
2 detecting electrodes 5 and 51 are respectively placed at the right and left eyes of patient, and letter is connected to by magnetic interfaces 6 and 61
Number amplifying circuit.
Electric signal is connected on hand-held mobile display device by output plug, and is shown and set by hand-held mobile
The program of standby upper prepackage, is converted into image to electric signal, is shown on device screen；
The bottom of reference electrode 2 carries self-adhesive, can paste on the skin near eyeball, while playing fixed make
With.
Being shaped as main formula amplifier body part is J-shaped, i.e., the one end that is connected with detecting electrode 5 and 51 is bending,
All connecting wires use twisted-pair feeder.
Optionally, magnetic texure and magnetic interfaces surface have one layer it is gold-plated.
As shown in fig. 7, signal amplification circuit, including the first amplifier, the second amplifier and the 3rd amplifier, the correspondence inspection of the first amplifier
The electric signal of survey electrode 5, the electric signal of second group of amplifier correspondence detecting electrode 51, the effect of the first amplifier and the second amplifier is suppression
Common mode interference signal processed, amplifies difference mode signal, the 3rd amplifier is further to carry out differential amplification to the difference mode signal being exaggerated, and leads to
Gain knob regulation electric signal size is crossed, changes the resistance of circuit, you can the gain amplifier of two channel signals of regulation.
The present invention the course of work be：
A, the eyelid different parts that detecting electrode 5 and 51 is placed on to human eye or so eyeball, detecting electrode 5 are placed on right eye,
Detecting electrode 51 is placed on left eye.
B, reference electrode 2 is close in the middle of forehead, with self-adhesive, skin surface can be affixed on.
C, the end of detecting electrode 5 and 51 is connected on magetic indicator joint, the correspondence magetic indicator joint 6 of detecting electrode 5, detecting electrode
51 correspondence magetic indicator joints 61.
D, the output plug 1 of signal amplifier is connected to 11 on the jack of hand held mobile terminals (similar mobile phone)；It is defeated
Go out the correspondence output signal of detecting electrode 5 of plug 1, the correspondence output signal of detecting electrode 51 of output plug 11；
F, the flash lamp setting for opening hand held mobile terminals, by built-in APP or software, the suitable flash of light of selection
Pattern；
G, flash lamp alignment eye is positive, selection suitable distance, operation hand-held mobile terminal progress flash stimulation；
H, the electric signal by adjusting the adjustment detecting electrode 5 of gain-adjusted knob 3, and regulation gain-adjusted knob 31 are adjusted
The electric signal of whole detecting electrode 51, by output plug, records electroretinogram waveform, and show in hand held mobile terminals
Come.
By above scheme, signal amplifier is directly against the eyeball of person of modern times, and detecting electrode is directly connected with amplifier, it is to avoid
Disturbed by environment.After signal is handled through signal amplifier, it is connected, is then remembered again by APP with personal mobile phone by handset port
Record signal, the flash lamp of mobile phone can as conventional test device light source, new design is in the accuracy of detection, simplification
It can improve a lot, cost is also very low, Detection results are as shown in Figure 5, Figure 6.
In addition, signal amplifier can compatible traditional test equipment, now signal amplifier between electrode and equipment it
Between, equivalent to follower, mainly strobe.Signal amplifier carries out early stage processing to the tiny signal of detection, strengthens it
Jamproof ability, while, when rear end equipment multiplication factor is inadequate, can give and supplement with the gain of Regulate signal amplifier.
The connection of electrode and signal amplifier uses magetic indicator joint, therefore it is convenient to change electrode.In order to meet multi-point sampler
Requirement, signal amplifier also uses multi-passage design, while there is reference electrode port, connects and joins for other signal amplifiers
Examine.
Fig. 5 is the single detection contrast in same detection time, and the electroretinogram of system is than former inspection after improvement
The threshold values for surveying electroretinogram is higher, and the sensitivity of detection is improved.Fig. 6 is the electricity of repeated detection in same detection time
The threshold values multiplicity of figure is more preferable.Meanwhile, this big device of signal shortens line length using J-shaped shape design, also complies with the mankind
The structure design of forehead arc, makes detecting electrode with signal amplifier closer to skin, reduces because to letter caused by line length
Number interference.
The preferred embodiment of the present invention is the foregoing is only, protection scope of the present invention is not limited in above-mentioned embodiment party
Formula, every technical scheme for belonging to the principle of the invention belongs to protection scope of the present invention.For those skilled in the art
Speech, some improvement carried out on the premise of the principle of the present invention is not departed from, these improvement also should be regarded as the protection model of the present invention
Enclose.
Claims (4)
1. a kind of signal amplifier of electroretinogram (ERG) portable detection system, it is characterised in that including 2 gain-adjusteds
Knob, signal amplification circuit, 2 detecting electrode magnetic interfaces, reference electrode, 1 reference electrode magnetic interfaces, common reference electricity
Pole interface, 2 detecting electrodes and 2 output plugs, wherein：
2 gain-adjusted knobs, are arranged on the resistance on signal amplifier surface, connection signal amplification circuit, for adjusting
Save the different multiplication factor of signal；
The signal amplification circuit, is arranged inside signal amplifier, the electric signal for amplifying the detecting electrode detection；
2 detecting electrode magnetic interfaces, are arranged on signal amplifier input, are connected with detecting electrode, for the company of transmission
Connect the electric signal of 2 detecting electrodes on eyes；
The reference electrode, is connected by 1 reference electrode magnetic interfaces with signal amplifier；
The common reference electrode interface, is arranged on signal amplifier side, is that some measurement occasions need to use multiple letters
Number amplifier, multiple signal amplifiers can take common reference point by common reference electrode；
2 detecting electrodes are respectively placed at the right and left eyes of patient, and signal amplification circuit is connected to by magnetic interfaces.
2. a kind of signal amplifier of electroretinogram (ERG) portable detection system according to claim 1, its feature exists
In, electric signal is connected on hand-held mobile display device by output plug, and by hand-held mobile display device
The program of prepackage, image is converted into electric signal, is shown on device screen.
3. a kind of signal amplifier of electroretinogram (ERG) portable detection system according to claim 1, its feature exists
In the reference electrode bottom carries self-adhesive, can paste on the skin near eyeball, while playing fixation.
4. a kind of signal amplification of electroretinogram (ERG) portable detection system according to any one of claims 1 to 3
Device, it is characterised in that the face shaping of signal amplifier main part is J-shaped, i.e., the one end that is connected with detecting electrode is curved
Curved, all connecting wires use twisted-pair feeder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710155513.3A CN106943142A (en) | 2017-03-16 | 2017-03-16 | A kind of electroretinogram（ERG）The signal amplifier of portable detection system |
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| CN201710155513.3A CN106943142A (en) | 2017-03-16 | 2017-03-16 | A kind of electroretinogram（ERG）The signal amplifier of portable detection system |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582053A (en) * | 2017-09-12 | 2018-01-16 | 深圳麦格米特电气股份有限公司 | A kind of active electrode detection means of electroretinogram and dynamic electroculogram |
| CN107898459A (en) * | 2017-09-12 | 2018-04-13 | 深圳麦格米特电气股份有限公司 | A kind of portable visual electrophysiology detecting system |
| CN111818839A (en) * | 2018-02-28 | 2020-10-23 | 洛林大学 | Device for determining visual system |
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| CN1414701A (en) * | 2002-08-30 | 2003-04-30 | 天津大学 | High common mode rejection ratio preamplifier |
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| CN101828919A (en) * | 2010-04-28 | 2010-09-15 | 上海诺诚电气有限公司 | Surface electromyographic electrode with amplifying function |
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| CN111818839A (en) * | 2018-02-28 | 2020-10-23 | 洛林大学 | Device for determining visual system |
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Application publication date: 20170714 |