CN105536085B - A kind of continous way CRRT machine capability bascules - Google Patents
A kind of continous way CRRT machine capability bascules Download PDFInfo
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- CN105536085B CN105536085B CN201610059233.8A CN201610059233A CN105536085B CN 105536085 B CN105536085 B CN 105536085B CN 201610059233 A CN201610059233 A CN 201610059233A CN 105536085 B CN105536085 B CN 105536085B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1615—Control or regulation using measurements made at different flow rates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1635—Constructional aspects thereof with volume chamber balancing devices between used and fresh dialysis fluid
- A61M1/1637—Constructional aspects thereof with volume chamber balancing devices between used and fresh dialysis fluid containing the whole volume of dialysis fluid used during a treatment session
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
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Abstract
A kind of continous way CRRT machine capability bascules, including the blood circulation system by entering blood vessel road, blood pump, hollow fiber dialyzer, blood back pipeline form；The first fluid circulation system being made up of drain pipe road, liquid pump, displacement liquid/dialysis fluid container, hollow fiber dialyzer, liquid back pipe road, displacement liquid/dialysis fluid container have two.Increase the second liquid circulatory system being made up of exogenous displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container drain pipe road, tripper, liquid pump, displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container liquid back pipe road.First fluid circulation system contacts with blood circulation system carries out mass exchange, and because its volume is fixed, volume change is not related in exchange process.The second liquid circulatory system, opposed two are changed liquid/dialysis fluid container progress fluid exchange in turn, are allowed to refill clean fresh displacement liquid, are realized and solute purpose is constantly removed under mobile environment.
Description
Technical field
The invention belongs to continuous blood purification device, specifically a kind of continous way CRRT machine capabilities balance dress
Put.
Background technology
The English of CRRT (i.e. continuous renal replacement therapy) continuous renal replacement therapy
Abbreviation.Also known as CBP (continuous blood purification)；Bedside hemo-filtration.It is to use daily 24 hours or connect
A kind of long-time of nearly 24 hours, continuous extracorporeal blood purify therapy to substitute impaired renal function.
Nineteen ninety-five, in the international CRRT academic conferences of the first that San Diego, USA is held, CRRT is by formal definition：
It is all can continuity remove solute, and to organ function rise supporting function blood purification technology.The World War II phase
Between, Canadian Murray and Delmore succeed in developing First artificial kidney machine, and are used for clinical treatment renal failure in l946
Exhaust, later blood purification technology is rapidly developed.Blood purification is that blood samples of patients is led to external and filled by one kind purification
Put, remove the purpose that some of which morbid substance purification blood reaches treatment disease.It mainly includes haemodialysis, blood is filtered
Cross, hemodiafiltration, blood perfusion, plasma exchange, immuno absorbence etc..Blood purification therapy is not provided purely for treating at present
Acute and chronic patients with renal failure, also it has been widely applied in the rescue of Severe acute disease patient.
CRRT clinical practice targets are to remove internal excess moisture, remove internal metabolic waste, poisonous substance, correct Water-Electrolyte
It is disorderly, it is ensured that nutritional support, to promote graft function and remove various cell factors, inflammatory mediator.It can be used for：Various angiocarpy
Acute and chronic renal failure functional lability, Metabolism or with encephaledema, and Multiple Organ Dysfunction Syndrome, it is acute
Respiratory Distress Syndrome(RDS), crush syndrome, acute necrotic pancreatitis, chronic heart failure, hepatic encephalopathy, medicine and toxic poisoning etc.
Treatment.
At present, the CRRT machines clinically produced mostly using German Bei Lang companies, or the life of German Fresenius group
The CRRT machines of production, or the CRRT machines of some other brand carry out Continuous Renal Replace Threapy.
CRRT machines in the course of the work, it is necessary to accurately control disengaging cardiopulmonary bypass in patients liquid speed and amount, disengaging
The difference of amount of liquid is net ultrafiltration, i.e., from the moisture content removed in vivo.Usual CRRT machines are controlled by displacement liquid/dialysis liquid pump
Into the liquid velocity of extracorporal circulatory system, the speed of extracorporal circulatory system liquid is controlled out by waste drains pump, while also passes through CRRT machines
Scale inside device carrys out the amount of accurate dynamic measurement disengaging liquid, and feedback regulation displacement liquid/dialyzate, waste liquid pump speed reach
To the purpose of control disengaging extracorporal circulatory system amount of liquid.
It will be apparent that control disengaging fluid balance existing defects by way of scale dynamic measurement liquid weight：First, scale needs
Often calibration, precision can be also gradually reduced during use, second, scale measurement can only be carried out in inactive state, it is right in therapeutic process
The collision of machine can cause scale not work, therefore existing CRRT machines can not work in mobile environment.
Weighed to overcome using scale, the defects of CRRT machines can not be used in mobile environment, someone's research uses flow
The method of monitoring dynamically determines to realize the volume controlled of CRRT machines and flows into, flows out extracorporal circulatory system flow rate of liquid simultaneously basis
Sectional area calculates outflow.The method of dynamic measurement flow velocity includes magnetic current method and ultrasonic method.Although this method can avoid scale
The defects of can not being worked under mobile condition, but the defects of precision is inadequate, and error is big still be present.Instant flow measurement needs the several seconds
A flow is measured, need to be measured tens times in one minute, then each measurement result is added up and obtains the liquid in the unit interval
Amount.Even if therefore single measurement error very little, but the additive effect of measuring result error necessarily causes overall error very big many times.
It is that direct measurement obtains some period every time although also dynamic measures scale system for instant flow measurement
Interior total liquid output, rather than by the cumulative of multiple measurement results, therefore additive effect is not present.It is in addition, micro- in liquid
The change of minute bubbles and pipe section product in use can all influence flow measurement precision.
For CRRT treatments, daily fluid exchange amount reaches as high as more than 100L, such as error typically in more than 20L
Within 1%, the liquid margin of error is 200ml-1000ml, if the treatment absolute error amount of continuous a few days is bigger.And flowmeter
Control capability balance error is difficult to reach less than 1%.
In addition, existing CRRT machines can not be useful in the Moveable type vehicles such as aircraft, automobile, train, steamer and carry out
CRRT is treated, and this just gives urgent need CRRT treatments, and due to the limitation in distance and the vehicles, CRRT treatments can not be carried out and brought
Challenge, such as the injured soldier in battlefield can only transport medical base rescue and treatment back, and patient with severe symptoms can not be enterprising in ambulance
Rob and rescue and treat.
Therefore CRRT machines need more convenient use, more accurate capacity control device and system.
The content of the invention
In order to solve the above-mentioned technical problem, a kind of continous way CRRT machine capability bascules of present invention proposition, including by
Enter blood vessel road, blood pump, hollow fiber dialyzer, the blood circulation system of blood back pipeline composition, by drain pipe road, liquid pump, put
Change liquid/dialysis fluid container, hollow fiber dialyzer, the first fluid circulation system of liquid back pipe road composition.
Blood circulation system and the first fluid circulation system use common hollow fiber dialyzer, in blood circulation system
Blood and the first fluid circulation system in displacement liquid/dialyzate pass through common hollow fiber dialyzer and carry out solute friendship
Change.
Hollow fiber dialyzer includes blood inlet, blood outlet, displacement liquid/dialyzate exports, displacement liquid/dialyzate enters
Mouthful.Displacement liquid/dialyzate outlet, displacement liquid/dialyzate entrance are commonly referred to as hollow fiber dialyzer fluid port.
It is described enter blood vessel road one end introduce patient vessel after, hollow fiber dialyzer is coupled through the other end by blood pump
Blood inlet, the blood outlet of one end connection hollow fiber dialyzer of the blood back pipeline, the other end is by blood recovery patient
In vivo.
Displacement liquid/dialysis fluid container in first fluid circulation system has two, is that the first displacement liquid/dialyzate holds
Device, the second displacement liquid/dialysis fluid container；One end connection a certain fluid port of hollow fiber dialyzer on the drain pipe road, separately
One end couples the first displacement liquid/dialysis fluid container, another way connection all the way by being divided into two-way after liquid pump, the first tripper
Connect the second displacement liquid/dialysis fluid container；Another fluid port of liquid back pipe road one end connection hollow fiber dialyzer or blood back
Pipeline enters blood vessel road, and the other end couples the first displacement liquid/dialyzate and held all the way by being divided into two-way after the second tripper
Device, another way connection the second displacement liquid/dialysis fluid container.
Also include by exogenous displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container drain pipe road, liquid
Pump, the 3rd tripper, displacement liquid/dialysis fluid container, the 4th tripper, exogenous displacement liquid/dialysis fluid container liquid back pipe
The second liquid circulatory system of road composition；Exogenous displacement liquid/dialysis fluid container drain pipe the road from exogenous displacement liquid/thoroughly
Analyse liquid container to draw, by being divided into two-way after liquid pump, the 3rd tripper, couple the first displacement liquid/dialysis fluid container all the way,
Another way couples the second displacement liquid/dialysis fluid container；Put from exogenous on the exogenous displacement liquid/dialysis fluid container liquid back pipe road
Change liquid/dialysis fluid container to draw, by being divided into two-way after the 4th tripper, couple the first displacement liquid/dialysis fluid container all the way,
Another way couples the second displacement liquid/dialysis fluid container.
First tripper, the second tripper, the 3rd tripper, the 4th tripper are three-dimensional control open circuit
Device, first tripper, the second tripper are one group of tripper, while linkage is opened or closed, the described 3rd
Tripper, the 4th tripper are one group of tripper, while linkage is opened or closed.
The ultrafiltration system being made up of ultrafiltration pipeline, ultrafiltrate pump, ultrafiltration container is additionally provided with the front end on drain pipe road.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline, to super
Flow rate of liquid and flow in chimney filter road are monitored.
First tripper, the second tripper, the 3rd tripper, the 4th tripper are tubing clamp.
First displacement liquid/dialysis fluid container and the second displacement liquid/dialysis fluid container are with two on a container
The individual cavity being isolated from each other.
First tripper, the second tripper, the 3rd tripper, the 4th tripper respectively have 2, right respectively
Couple the drain pipe road of the first displacement liquid/dialysis fluid container, the drain pipe road of the second displacement liquid/dialysis fluid container is exogenous to put
Liquid/dialysis fluid container drain pipe road is changed, exogenous displacement liquid/dialysis fluid container liquid back pipe road is controlled.
It is 100-500ml that first fluid circulation system, which exchanges volume,.
First tripper, the second tripper, the 3rd tripper, the 4th tripper are provided with fault alarm
Device.
Flow monitor is additionally provided with the drain pipe road or liquid back pipe road.
Beneficial effect：
Continous way CRRT machine capabilities bascule of the present invention fixes liquid system using enclosed positive displacement and carries out solute friendship
Change, guaranteed capacity is unchanged, reaches saturation or during close to saturation when exchanging liquid, is carried out again by exogenous displacement liquid/dialyzate
It is raw, to ensure to continue Solute removal ability, existing CRRT machines are efficiently solved using the shortcomings that scale control balance and can not be
The problem of being used in mobile environment.Meanwhile the present invention devises two displacement liquid/dialysis fluid containers, when the first displacement liquid/dialysis
When liquid container the first fluid circulation system of connection is treated, the second displacement liquid/dialysis fluid container connection second liquid cyclic system
System is swapped and regenerated；When the second displacement liquid/dialysis fluid container, which couples the first fluid circulation system, is treated, first puts
Liquid/dialysis fluid container connection second liquid circulatory system is changed to swap and regenerate；Thus achieve mobile environment continuity from below
Treatment.
Continous way CRRT machine capability bascules of the present invention can be widely applied under mobile environment and usually continuous dynamic
CWH (CAVH), failure by CVVH (CVVH), continuous slowly ultrafiltration (SCUF), continuous arteriovenous
Haemodialysis (CAVHD), Continuous Veno-venous haemodialysis (CVVHD), continuous arteriovenous hemodiafiltration (CAVHDF),
Continuous Veno-venous hemodiafiltration (CVVHDF).
Brief description of the drawings
Fig. 1 is dilution filtration mode configuration schematic diagram after continous way CRRT machine capability bascules；
Fig. 2 is dilution filtration mode configuration schematic diagram after the band ultrafiltration of continous way CRRT machine capabilities bascule；
Fig. 3 is dilution filtration mode configuration schematic diagram before continous way CRRT machine capability bascules；
Fig. 4 is dilution filtration mode configuration schematic diagram before the band ultrafiltration of continous way CRRT machine capabilities bascule；
Fig. 5 is continous way CRRT machine capability bascule dialysis mode structural representations；
Fig. 6 is continous way CRRT machine capabilities bascule band ultrafiltration dialysis mode configuration schematic diagram；
Fig. 7 is hollow fiber dialyzer structural representation；
Wherein：Enter blood vessel road 1, blood pump 2, hollow fiber dialyzer 3, blood back pipeline 4, drain pipe road 5, liquid pump 6, displacement
Liquid/dialysis fluid container 7, the first displacement liquid/dialysis fluid container 7-1, the second displacement liquid/dialysis fluid container 7-2, liquid back pipe road 8, blood
Liquid import 9, blood outlet 10, displacement liquid/dialyzate outlet 11, displacement liquid/dialyzate entrance 12, the first tripper 13, the
Two trippers 14, the 3rd tripper 15, the 4th tripper 16, exogenous displacement liquid/dialysis fluid container 17, exogenous put
Change liquid/dialysis fluid container drain pipe road 18, exogenous displacement liquid/dialysis fluid container liquid back pipe road 19, ultrafiltration pipeline 20, ultrafiltrate pump
21st, ultrafiltration container 22.
Embodiment
Embodiment 1, as shown in Fig. 1,7, dilution filtration mode configuration after being, when to filter pattern, displacement liquid/dialyzate
Container commonly referred to as replaces liquid container；Exogenous displacement liquid/dialysis fluid container is commonly referred to as exogenous displacement liquid container, displacement liquid
It is identical liquid with dialyzate, the container for containing the liquid is also identical container.The call that container respectively forms component is related to
To " displacement ", " dialysis " two word, according to the difference of Therapeutic mode, " displacement " call different from " dialysis " is selected.
A kind of continous way CRRT machine capability bascules, including by enter blood vessel road 1, blood pump 2, hollow fiber dialyzer 3,
Blood back pipeline 4 form blood circulation system, by drain pipe road 5, liquid pump 6, displacement liquid container 7, hollow fiber dialyzer 3,
The first fluid circulation system that liquid back pipe road 8 forms.
Blood circulation system and the first fluid circulation system use common hollow fiber dialyzer 3, blood circulation system
In blood and the displacement liquid in the first fluid circulation system solute carried out by common hollow fiber dialyzer 3 exchanged.
Hollow fiber dialyzer 3 includes blood inlet 9, blood outlet 10, displacement liquid outlet 11, displacement liquid entrance 12.Put
Change liquid outlet 11, displacement liquid entrance 12 is commonly referred to as the fluid port of hollow fiber dialyzer 3.
Dilute afterwards under filtration pattern, the displacement liquid outlet of one end connection hollow fiber dialyzer 3 on the drain pipe road 5
11 or the end of displacement liquid entrance 12, liquid back pipe road 8 couples blood back pipeline 4；If drain pipe road 5 is coupled into hollow fiber dialyzer 3
Displacement liquid exports 11 ends, then seals the corresponding end of displacement liquid entrance 12 of hollow fiber dialyzer 3；If by drain pipe road 5
The end of displacement liquid entrance 12 of hollow fiber dialyzer 3 is connect, then it is close the corresponding displacement liquid of hollow fiber dialyzer to be exported into 11 ends
Envelope；
It is described enter blood vessel road 1 one end introduce patient vessel after, by blood pump 2 through the other end couple hollow fiber dialyzer
3 blood inlet 9, the blood outlet 10 of one end connection hollow fiber dialyzer 3 of the blood back pipeline 4, the other end is by blood
Feed back patient's body.
Displacement liquid container 7 in first fluid circulation system has two, is put for the first displacement liquid container 7-1, second
Change liquid container 7-2；The displacement liquid import 11 or displacement liquid outlet of one end connection hollow fiber dialyzer 3 on the drain pipe road 5
12, the other end after liquid pump 6, the first tripper 13 by being divided into two-way, and the displacement liquid container of connection first 7-1, another all the way
The second displacement liquid container of road connection 7-2；The one end of liquid back pipe road 8 connection blood back pipeline 4, the other end passes through the second tripper
It is divided into two-way after 14, couples the first displacement liquid container 7-1, the second displacement liquid container of another way connection 7-2 all the way.The feed tube
If road 5 couples displacement liquid import 11, by the closing of displacement liquid outlet 12；If couple displacement liquid outlet 12, by displacement liquid import
11 closings.
Also include being broken by exogenous displacement liquid container 17, exogenous displacement liquid container drain pipe road 18, liquid pump the 6, the 3rd
Road device 15, displacement liquid container 7, the 4th tripper 16, the second liquid of the exogenous composition of displacement liquid container liquid back pipe road 19
The circulatory system；The exogenous displacement liquid container drain pipe road 18 is drawn from exogenous displacement liquid container 17, by liquid pump 6,
It is divided into two-way after 3rd tripper 15, couples the first displacement liquid container 7-1, the second displacement liquid container of another way connection 7- all the way
2；The exogenous displacement liquid container liquid back pipe road 19 is drawn from exogenous displacement liquid container 17, after the 4th tripper 16
It is divided into two-way, couples the first displacement liquid container 7-1, the second displacement liquid container of another way connection 7-2 all the way.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are three-dimensional
Tripper is controlled, first tripper 13, the second tripper 14 are one group of tripper, while linkage is opened or closed
Close, the 3rd tripper 15, the 4th tripper 16 are one group of tripper, while linkage is opened or closed.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are pipeline
Folder.
First displacement liquid/dialysis fluid container and the second displacement liquid/dialysis fluid container are with two on a container
The individual cavity being isolated from each other.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are three-dimensional
Control, or two to control, or individual event controls, when being controlled for individual event, can be used as by 2 independent trippers one group come
Two effects to control are realized, liquid container 7-2's is replaced to the displacement liquid container of connection first 7-1 drain pipe road 5, second respectively
Drain pipe road 5, exogenous displacement liquid container drain pipe road 18, exogenous displacement liquid liquid back pipe road 19 is controlled.
It is 100-500ml that first fluid circulation system, which exchanges volume,.
First tripper 13, the second tripper 14, the 3rd tripper 15, also set on the 4th tripper 16
Faulty alarm.
Flow monitor is additionally provided with the drain pipe road 5 or liquid back pipe road 8.
When the first fluid circulation system is treated using the first displacement liquid container 7-1, the first tripper 13, second
Tripper 14 opens the pipeline for entering the first displacement liquid container 7-1, closes the pipeline for entering the second displacement liquid container 7-2, the
Three trippers 15, the 4th tripper 16 open the pipeline for entering the second displacement liquid container 7-2, and closing enters the first displacement liquid
Container 7-1 pipeline, the second displacement liquid container 7-2 connection second liquid circulatory systems are entered with exogenous displacement liquid container 17
Line replacement liquid fluid exchange and regeneration.
When the first fluid circulation system is treated using the second displacement liquid container 7-2, the first tripper 13, second
Tripper 14 opens the pipeline for entering the second displacement liquid container 7-2, closes the pipeline for entering the first displacement liquid container 7-1, the
Three trippers 15, the 4th tripper 16 open the pipeline into the first displacement liquid 7-1 containers, and closing enters the second displacement liquid
Container 7-2 pipeline, the first displacement liquid container connection second liquid circulatory system is put with exogenous displacement liquid container 17
Change liquid fluid exchange and regeneration.
Embodiment 2：As shown in Fig. 2,7, the basic phase such as the present embodiment and the structure of embodiment 1, connected mode, operation mode
Together, it is with the difference of embodiment 1, is additionally provided with the front end on drain pipe road 5 by ultrafiltration pipeline 20, ultrafiltrate pump 21, ultrafiltration container
The ultrafiltration system of 22 compositions.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline 20, right
Flow rate of liquid and flow in ultrafiltration pipeline 20 are monitored.
Embodiment 3, as shown in Fig. 3,7, mode configuration is filtered for preceding dilution, when to filter pattern, displacement liquid/dialyzate
Container commonly referred to as replaces liquid container；Exogenous displacement liquid/dialysis fluid container is commonly referred to as exogenous displacement liquid container, displacement liquid
It is different liquid from dialyzate, but the container for containing the liquid is identical container.The call that container respectively forms component is related to
To " displacement ", " dialysis " two word, according to the difference of Therapeutic mode, " displacement " call different from " dialysis " is selected.
A kind of continous way CRRT machine capability bascules, including by enter blood vessel road 1, blood pump 2, hollow fiber dialyzer 3,
Blood back pipeline 4 form blood circulation system, by drain pipe road 5, liquid pump 6, displacement liquid container 7, hollow fiber dialyzer 3,
The first fluid circulation system that liquid back pipe road 8 forms.
Blood circulation system and the first fluid circulation system use common hollow fiber dialyzer 3, blood circulation system
In blood and the displacement liquid in the first fluid circulation system solute carried out by common hollow fiber dialyzer 3 exchanged.
Hollow fiber dialyzer 3 includes blood inlet 9, blood outlet 10, displacement liquid outlet 11, displacement liquid entrance 12.
Under preceding dilution filtration pattern, the one end on the drain pipe road 5 directly couples the fluid port of hollow fiber dialyzer 3
11 or 12, liquid back pipe road 8 couples the blood inlet 9 of hollow fiber dialyzer 3；If drain pipe road 5 is coupled into hollow fibre dialysis
The displacement liquid of device 3 exports 11 ends, then seals the corresponding end of displacement liquid entrance 12 of hollow fiber dialyzer 3；If by drain pipe
Road 5 couples the end of displacement liquid entrance 12 of hollow fiber dialyzer 3, then by the corresponding displacement liquid outlet 11 of hollow fiber dialyzer
End sealing.
It is described enter blood vessel road 1 one end introduce patient vessel after, by blood pump 2 through the other end couple hollow fiber dialyzer
3 blood inlet 9, the blood outlet 10 of one end connection hollow fiber dialyzer 3 of the blood back pipeline 4, the other end is by blood
Feed back patient's body.
Displacement liquid container 7 in first fluid circulation system has two, is put for the first displacement liquid container 7-1, second
Change liquid container 7-2；The fluid port 11 or 12 of one end connection hollow fiber dialyzer 3 on the drain pipe road 5, passes through liquid pump
6th, it is divided into two-way after the first tripper 13, couples the first displacement liquid container 7-1, another way connection the second displacement liquid container all the way
7-2；The blood inlet 9 of the one end of liquid back pipe road 8 connection hollow fiber dialyzer 3, by being divided into after the second tripper 14
Two-way, couple the first displacement liquid container 7-1, the second displacement liquid container of another way connection 7-2 all the way.If the drain pipe road 5 joins
Displacement liquid import 11 is connect, then by the closing of displacement liquid outlet 12, if connection displacement liquid outlet 12, displacement liquid import 11 is closed.
Also include being broken by exogenous displacement liquid container 17, exogenous displacement liquid container drain pipe road 18, liquid pump the 6, the 3rd
Road device 15, displacement liquid container 7, the 4th tripper 16, the second liquid of the exogenous composition of displacement liquid container liquid back pipe road 19
The circulatory system；The exogenous displacement liquid container drain pipe road 18 is drawn from exogenous displacement liquid container 17, by liquid pump 6,
It is divided into two-way after 3rd tripper 15, couples the first displacement liquid container 7-1, the second displacement liquid container of another way connection 7- all the way
2；The exogenous displacement liquid container liquid back pipe road 19 is drawn from exogenous displacement liquid container 17, after the 4th tripper 16
It is divided into two-way, couples the first displacement liquid container 7-1, the second displacement liquid container of another way connection 7-2 all the way.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are three-dimensional
Tripper is controlled, first tripper 13, the second tripper 14 are one group of tripper, while linkage is opened or closed
Close, the 3rd tripper 15, the 4th tripper 16 are one group of tripper, while linkage is opened or closed.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are pipeline
Folder.
First displacement liquid/dialysis fluid container and the second displacement liquid/dialysis fluid container are with two on a container
The individual cavity being isolated from each other.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are three-dimensional
Control, or two to control, or individual event controls, when being controlled for individual event, can be used as by 2 independent trippers one group come
Two effects to control are realized, liquid container 7-2's is replaced to the displacement liquid container of connection first 7-1 drain pipe road 5, second respectively
Drain pipe road 5, exogenous displacement liquid container drain pipe road 18, exogenous displacement liquid liquid back pipe road 19 is controlled.
It is 100-500ml that first fluid circulation system, which exchanges volume,.
First tripper 13, the second tripper 14, the 3rd tripper 15, also set on the 4th tripper 16
Faulty alarm.
Flow monitor is additionally provided with the drain pipe road 5 or liquid back pipe road 8.
When the first fluid circulation system is treated using the first displacement liquid container 7-1, the first tripper 13, second
Tripper 14 opens the pipeline for entering the first displacement liquid container 7-1, closes the pipeline for entering the second displacement liquid container 7-2, the
Three trippers 15, the 4th tripper 16 open the pipeline for entering the second displacement liquid container 7-2, and closing enters the first displacement liquid
Container 7-1 pipeline, the second displacement liquid container 7-2 connection second liquid circulatory systems are entered with exogenous displacement liquid container 17
Line replacement liquid fluid exchange and regeneration.
When the first fluid circulation system is treated using the second displacement liquid container 7-2, the first tripper 13, second
Tripper 14 opens the pipeline for entering the second displacement liquid container 7-2, closes the pipeline for entering the first displacement liquid container 7-1, the
Three trippers 15, the 4th tripper 16 open the pipeline into the first displacement liquid 7-1 containers, and closing enters the second displacement liquid
Container 7-2 pipeline, the first displacement liquid container connection second liquid circulatory system is put with exogenous displacement liquid container 17
Change liquid fluid exchange and regeneration.
Embodiment 4：As shown in Fig. 4,7, the basic phase such as the present embodiment and the structure of embodiment 3, connected mode, operation mode
Together, it is with the difference of embodiment 3, is additionally provided with the front end on drain pipe road 5 by ultrafiltration pipeline 20, ultrafiltrate pump 21, ultrafiltration container
The ultrafiltration system of 22 compositions.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline 20, right
Flow rate of liquid and flow in ultrafiltration pipeline 20 are monitored.
Embodiment 5：Be dialysis mode structure as shown in Fig. 5,7, when for dialysis mode when, displacement liquid/dialysis fluid container leads to
Frequently referred to dialysis fluid container；Exogenous displacement liquid/dialysis fluid container is commonly referred to as exogenous dialysis fluid container, displacement liquid and dialysis
Liquid is identical liquid, and the container for containing the liquid is also identical container, and the call that container respectively forms component is related to " putting
Change ", " dialysis " two word, according to the difference of Therapeutic mode, select " displacement " call different from " dialysis ".
A kind of continous way CRRT machine capability bascules, including by enter blood vessel road 1, blood pump 2, hollow fiber dialyzer 3,
Blood back pipeline 4 form blood circulation system, by drain pipe road 5, liquid pump 6, dialysis fluid container 7, hollow fiber dialyzer 3,
The first fluid circulation system that liquid back pipe road 8 forms.
Blood circulation system and the first fluid circulation system use common hollow fiber dialyzer 3, blood circulation system
In blood and the dialyzate in the first fluid circulation system solute carried out by common hollow fiber dialyzer 3 exchanged.
Hollow fiber dialyzer 3 includes blood inlet 9, blood outlet 10, dialyzate outlet 11, dialyzate entrance 12.
Under dialysis mode, the one end on the drain pipe road 5 directly couples the dialyzate outlet 11 of hollow fiber dialyzer 3,
Liquid back pipe road 8 couples the dialyzate entrance 12 of hollow fiber dialyzer 3.
It is described enter blood vessel road 1 one end introduce patient vessel after, by blood pump 2 through the other end couple hollow fiber dialyzer
3 blood inlet 9, the blood outlet 10 of one end connection hollow fiber dialyzer 3 of the blood back pipeline 4, the other end is by blood
Feed back patient's body.
Dialysis fluid container 7 in first fluid circulation system has two, is the first dialysis fluid container 7-1, second saturating
Analyse liquid container 7-2；The dialyzate outlet 11 of one end connection hollow fiber dialyzer 3 on the drain pipe road 5, the other end passes through liquid
It is divided into two-way after body pump 6, the first tripper 13, couples the first dialysis fluid container 7-1 all the way, another way couples the second dialyzate
Container 7-2；The dialyzate entrance 12 of the one end of liquid back pipe road 8 connection hollow fiber dialyzer 3, the other end pass through the second open circuit
It is divided into two-way after device 14, couples the first dialysis fluid container 7-1 all the way, another way couples the second dialysis fluid container 7-2.
Also include being broken by exogenous dialysis fluid container 17, exogenous dialysis fluid container drain pipe road 18, liquid pump the 6, the 3rd
Road device 15, dialysis fluid container 7, the 4th tripper 16, the second liquid of exogenous dialysis fluid container liquid back pipe road 19 composition
The circulatory system；The exogenous dialysis fluid container drain pipe road 18 is drawn from exogenous dialysis fluid container 17, by liquid pump 6,
It is divided into two-way after 3rd tripper 15, couples the first dialysis fluid container 7-1 all the way, another way couples the second dialysis fluid container 7-
2；The exogenous dialysis fluid container liquid back pipe road 19 is drawn from exogenous dialysis fluid container 17, after the 4th tripper 16
It is divided into two-way, couples the first dialysis fluid container 7-1 all the way, another way couples the second dialysis fluid container 7-2.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are three-dimensional
Tripper is controlled, first tripper 13, the second tripper 14 are one group of tripper, while linkage is opened or closed
Close, the 3rd tripper 15, the 4th tripper 16 are one group of tripper, while linkage is opened or closed.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are pipeline
Folder.
First displacement liquid/dialysis fluid container 7-1 and the second displacement liquid/dialysis fluid container 7-2 is with a container
On two cavitys being isolated from each other.
First tripper 13, the second tripper 14, the 3rd tripper 15, the 4th tripper 16 are three-dimensional
Control, or two to control, or individual event controls, when being controlled for individual event, can be used as by 2 independent trippers one group come
Realize two effects to control, respectively to couple the first dialysis fluid container 7-1 drain pipe road 5, the second dialysis fluid container 7-2's
Drain pipe road 5, exogenous dialysis fluid container drain pipe road 18, exogenous dialyzate liquid back pipe road 19 are controlled.
It is 100-500ml that first fluid circulation system, which exchanges volume,.
First tripper 13, the second tripper 14, the 3rd tripper 15, also set on the 4th tripper 16
Faulty alarm.
Flow monitor is additionally provided with the drain pipe road 5 or liquid back pipe road 8.
When the first fluid circulation system is treated using the first dialysis fluid container 7-1, the first tripper 13, second
Tripper 14 opens the pipeline into the first dialysis fluid container 7-1, closes the pipeline into the second dialysis fluid container 7-2, the
Three trippers 15, the 4th tripper 16 open the pipeline into the second dialysis fluid container 7-2, and closing enters the first dialyzate
Container 7-1 pipeline, the second dialysis fluid container 7-2 is coupled into the second liquid circulatory system, entered with exogenous dialysis fluid container 17
Row dialyzate fluid exchange and regeneration.
When the first fluid circulation system is treated using the second dialysis fluid container 7-2, the first tripper 13, second
Tripper 14 opens the pipeline into the second dialysis fluid container 7-2, closes the pipeline into the first dialysis fluid container 7-1, the
Three trippers 15, the 4th tripper 16 open the pipeline into the first dialyzate 7-1 containers, and closing enters the second dialyzate
Container 7-2 pipeline, the first dialysis fluid container is coupled into the second liquid circulatory system, carried out with exogenous dialysis fluid container 17
Analyse liquid fluid exchange and regeneration.
Embodiment 6：As shown in Figure 6,7, the basic phase such as the present embodiment and the structure of embodiment 5, connected mode, operation mode
Together, it is with the difference of embodiment 5, is additionally provided with the front end on drain pipe road 5 by ultrafiltration pipeline 20, ultrafiltrate pump 21, ultrafiltration container
The ultrafiltration system of 22 compositions.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline 20, right
Flow rate of liquid and flow in ultrafiltration pipeline 20 are monitored.
Embodiment 7：The dialysis fluid container 7, or dialysis fluid container chamber may be arranged as two or more, dialysis fluid container
7 quantity be 2 when, can meet the present invention realize continous way treat, be 3 or more than 3 when, except can realize continous way treat
Outside, it can also realize that rotation uses continuous treatment, or standby wherein several dialysis fluid container continous way treatments.
Claims (9)
1. a kind of continous way CRRT machine capability bascules, including by entering blood vessel road, blood pump, hollow fiber dialyzer, blood back
Pipeline composition blood circulation system, by drain pipe road, liquid pump, displacement liquid/dialysis fluid container, hollow fiber dialyzer, return
First fluid circulation system of liquid pipeline composition；
Blood circulation system and the first fluid circulation system use common hollow fiber dialyzer, the blood in blood circulation system
Liquid carries out solute by common hollow fiber dialyzer with displacement liquid/dialyzate in the first fluid circulation system and exchanged；
Hollow fiber dialyzer includes blood inlet, blood outlet, displacement liquid/dialyzate outlet, displacement liquid/dialyzate entrance；
It is described enter blood vessel road one end introduce patient vessel after, pass through blood pump through the other end couple hollow fiber dialyzer blood
Import, the blood outlet of one end connection hollow fiber dialyzer of the blood back pipeline, the other end is by blood recovery patient's body；
It is characterized in that：Displacement liquid/dialysis fluid container in first fluid circulation system has two, be the first displacement liquid/
Dialysis fluid container, the second displacement liquid/dialysis fluid container；One end connection hollow fiber dialyzer liquid outlet on the drain pipe road
End, the other end couples the first displacement liquid/dialysis fluid container by being divided into two-way after liquid pump, the first tripper all the way, another
Road couples the second displacement liquid/dialysis fluid container；Liquid back pipe road one end couples hollow fiber dialyzer fluid inlet end or returned
Blood vessel road is entered on blood vessel road, and the other end couples the first displacement liquid/dialyzate and held all the way by being divided into two-way after the second tripper
Device, another way connection the second displacement liquid/dialysis fluid container；
Also include by exogenous displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container drain pipe road, liquid pump, the
Three trippers, displacement liquid/dialysis fluid container, the 4th tripper, exogenous displacement liquid/dialysis fluid container liquid back pipe road composition
The second liquid circulatory system；Exogenous displacement liquid/dialysis fluid container drain pipe the road holds from exogenous displacement liquid/dialyzate
Device is drawn, and by being divided into two-way after liquid pump, the 3rd tripper, couples the first displacement liquid/dialysis fluid container, another way all the way
Couple the second displacement liquid/dialysis fluid container；Exogenous displacement liquid/dialysis fluid container liquid back pipe the road from exogenous displacement liquid/
Dialysis fluid container is drawn, and by being divided into two-way after the 4th tripper, couples the first displacement liquid/dialysis fluid container all the way, another
Road couples the second displacement liquid/dialysis fluid container；
First tripper, the second tripper, the 3rd tripper, the 4th tripper are three-dimensional control open circuit dress
Put, first tripper, the second tripper are one group of tripper, while linkage is opened or closed, and the described 3rd is disconnected
Road device, the 4th tripper are one group of tripper, while linkage is opened or closed.
2. continous way CRRT machine capability bascules according to claim 1, it is characterised in that：Before drain pipe road
End is additionally provided with the ultrafiltration system being made up of ultrafiltration pipeline, ultrafiltrate pump, ultrafiltration container.
3. continous way CRRT machine capability bascules according to claim 2, it is characterised in that：The ultrafiltration system is also
Including flow-monitoring device, the flow-monitoring device is arranged on ultrafiltration pipeline, to the flow rate of liquid and stream in ultrafiltration pipeline
Amount is monitored.
4. continous way CRRT machine capability bascules according to claim 1, it is characterised in that：The first open circuit dress
Put, the second tripper, the 3rd tripper, the 4th tripper are tubing clamp.
5. continous way CRRT machine capability bascules according to claim 1, it is characterised in that：First displacement
Liquid/dialysis fluid container and the second displacement liquid/dialysis fluid container are with two cavitys being isolated from each other on a container.
6. continous way CRRT machine capability bascules according to claim 1, it is characterised in that：The first open circuit dress
Put, the second tripper, the 3rd tripper, the 4th tripper respectively have 2, respectively to couple the first displacement liquid/dialyzate
The drain pipe road of container, the drain pipe road of the second displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container drain pipe
Road, exogenous displacement liquid/dialysis fluid container liquid back pipe road are controlled.
7. continous way CRRT machine capability bascules according to claim 1, it is characterised in that：First liquid circulation system
It is 100-500ml that system, which exchanges volume,.
8. continous way CRRT machine capability bascules according to claim 1, it is characterised in that：The first open circuit dress
Put, the second tripper, the 3rd tripper, the 4th tripper are provided with fault alarm.
9. continous way CRRT machine capability bascules according to claim 1, it is characterised in that：The drain pipe road or
Liquid back pipe is additionally provided with flow monitor on road.
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| CN106139286A (en) * | 2016-08-10 | 2016-11-23 | 尹良红 | A kind of regulation system for blood purification |
| CN106581792B (en) * | 2016-12-21 | 2020-02-07 | 广州大学 | Device for realizing flow balance control by using flow balance type peristaltic pump |
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|---|---|---|---|---|
| CN1879901A (en) * | 2005-03-24 | 2006-12-20 | 彭罗民 | Multifunctional easily-transportable artificial kidney |
| CN202122732U (en) * | 2010-03-25 | 2012-01-25 | 彭罗民 | Water-saving type artificial kidney |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2680975B1 (en) * | 1991-09-10 | 1998-12-31 | Hospal Ind | ARTIFICIAL KIDNEY WITH MEANS FOR DETERMINING A SUBSTANCE IN BLOOD. |
| US7744553B2 (en) * | 2003-12-16 | 2010-06-29 | Baxter International Inc. | Medical fluid therapy flow control systems and methods |
| CN2783995Y (en) * | 2005-03-11 | 2006-05-31 | 暨南大学 | Balanced liquid supply device |
| CN201186074Y (en) * | 2008-05-06 | 2009-01-28 | 重庆山外山科技有限公司 | Continuous blood purifying equipment with substitute fluid purifier |
| DE102009058681A1 (en) * | 2009-12-16 | 2011-06-22 | Fresenius Medical Care Deutschland GmbH, 61352 | Balancing device, external medical functional device, treatment device and method |
| EP2465555B1 (en) * | 2010-12-20 | 2014-01-15 | Gambro Lundia AB | Method and system for providing priming and restitution liquids for an extracorporeal blood treatment |
| DE102011010067A1 (en) * | 2011-02-01 | 2012-08-02 | Fresenius Medical Care Deutschland Gmbh | Method and device for controlling an extracorporeal blood treatment device |
| EP2666491B2 (en) * | 2012-05-22 | 2020-08-12 | D.Med Consulting GmbH | Haemodialysis device |
| CN205515732U (en) * | 2016-01-28 | 2016-08-31 | 龚德华 | Continuous type CRRT machine capacity balancing unit |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879901A (en) * | 2005-03-24 | 2006-12-20 | 彭罗民 | Multifunctional easily-transportable artificial kidney |
| CN202122732U (en) * | 2010-03-25 | 2012-01-25 | 彭罗民 | Water-saving type artificial kidney |
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