CN105167885B - Without support bovine pericardium bioprosthetic valves - Google Patents
Without support bovine pericardium bioprosthetic valves Download PDFInfo
- Publication number
- CN105167885B CN105167885B CN201510577664.9A CN201510577664A CN105167885B CN 105167885 B CN105167885 B CN 105167885B CN 201510577664 A CN201510577664 A CN 201510577664A CN 105167885 B CN105167885 B CN 105167885B
- Authority
- CN
- China
- Prior art keywords
- parabola
- lobe leaf
- body weight
- bovine pericardium
- bioprosthetic valves
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Prostheses (AREA)
Abstract
Without support bovine pericardium bioprosthetic valves, including single-lobe leaf, the edge wheel profile of single-lobe leaf is parabola, and parabola is divided into four kinds according to age, body weight, and parabola cuts form in accordance with the following methods：According to age, the information of body weight, corresponding parabola is generated, single-lobe leaf is cut out according to the parabola of generation.Connected when the quantity of single-lobe leaf is two or three, between single-lobe leaf by straight transition wire, and limit parabolical span, made the need for the bioprosthetic valves cut out meet sufferer.The present invention designs cutting track of four kinds of parabolas as single-lobe leaf according to all ages and classes, body weight, and being resulted in without support bovine pericardium bioprosthetic valves for making to cut out meets all ages and classes, the demand of body weight sufferer.
Description
Technical field
The present invention relates to artificial organs, in particular for aortic valve replacement without support bovine pericardium bioprosthetic valves.
Background technology
So far, heart surgical department patient both domestic and external mainly uses valve replacement and the class method pair of aortic valvuloplasty two
Aortic incompetence carries out Surgical correction.Active cardiac valvoplasty is that the aortic valve of lesion is folded and suspended in midair
To reach the purpose for recovering valvular function, its advantage is that operating difficulty is small, remains original leaflet and its anatomical structure.But it is postoperative
Aorta petal functional rehabilitation is poor, and operative chance is high again.Thus to patient and its family members economical and mentally cause huge pressure
Power.With the development of biomedical engineering, the bovine pericardium biovalve handled at present through biotechnology is widely used in sustainer
The displacement of valve.But it is due to that sufferer personal considerations are different, meets in surgical procedure, it is necessary to which bovine pericardium biovalve is cut into
The size and dimension of the leaflet to be replaced, then carry out operation stitching.This requires that heart surgical department patient can accurately measure the chi of leaflet
Very little and profile, while accurately and rapidly being cut, not only the requirement to heart surgical department patient is high, also extends the time of operation.
The content of the invention
It is an object of the invention to provide without support bovine pericardium bioprosthetic valves, the shape and size of its single-lobe leaf are according to not the same year
Age, the sufferer of body weight are set, and heart surgical department patient can be made quickly and accurately to cut out suitable biology in surgical procedure
Valve.
In order to achieve the above object, the present invention provides following technical scheme：
Without support bovine pericardium bioprosthetic valves, including single-lobe leaf, the edge wheel profile of the single-lobe leaf is parabola, the parabolic
Line includes the first parabola, the second parabola, the 3rd parabola, or the 4th parabola, the single-lobe leaf is cut in accordance with the following methods
Cut and form,
According to age, the information of body weight, corresponding parabola is generated,
First parabolical cutting track meets curve Y1Track：
Y1=a1X1 2+b1, b1=13+1.75n1,(n1=0,1,2), a1=-4b1/(15.6+2.1n1)2；
Second parabolical cutting track meets curve Y2Track：
Y2=a2X2 2+b2, b2=18+1.75n2,(n2=0,1,2), a2=-4b2/(21.6+2.1n2)2；
3rd parabolical cutting track meets curve Y3Track：
Y3=0.121X3 2-23.52；
4th parabolical cutting track meets curve Y4Track：
Y4=a4X4 2+b4, b4=25+1.75n4,(n4=0,1,2), a4=-4b4/(30+2.1n4)2,
The n1、n2、n4Value according to body weight depending on；
Single-lobe leaf is cut out according to the corresponding parabola of generation.
Because the cross-sectional length of the human aortic in all ages and classes stage is different, the shape of the corresponding single-lobe leaf of sustainer,
Size is also different.The contour line of single-lobe leaf is divided into four kinds by the present invention according to age, body weight, then the n values in formula are carried out
Choose, cutting track is met the single-lobe leaf shape and size of different sufferers.Heart surgical department patient in the preoperative, for the year of sufferer
Age, body weight can input corresponding age, weight data in advance, in art, and it is suitable to be generated according to corresponding age, weight data
Cutting track, makes the single-lobe leaf cut out meet the actual conditions of sufferer, eliminate that patient cut to bioprosthetic valves when
Between, operating time is reduced, procedure efficiency is improved.
In a preferred embodiment, the quantity of the single-lobe leaf be two or three, the two ends of the single-lobe leaf
Be all connected with connecting by the straight transition wire between straight transition wire, the adjacent single-lobe leaf, the single-lobe leaf with it is described
Straight transition wire formation leaflet.
In a preferred embodiment, the straight transition wire cutting distance between first parabola is 1.56+
0.21n1,(n1=0,1,2), unit is mm；
Straight transition wire cutting distance between second parabola is 2.16+0.21n2,(n2=0,1,2), unit is
mm；
Straight transition wire cutting distance between 3rd parabola is 2.79mm；
Straight transition wire cutting distance between 4th parabola is 3+0.21n4,(n4=0,1,2), unit is mm,
The n1、n2、n4Value according to body weight depending on.
Quantity if necessary to the single-lobe leaf of displacement is multi-disc, and the distance between single-lobe leaf also has to comply with the active of human body
Arteries and veins.According to the four of single-lobe leaf kinds of contour lines, for every kind of corresponding single-lobe leaf spacing of design, make to cut out without support OX-heart
Bag bioprosthetic valves meet the anatomic form of human aortic leaflet.
In a preferred embodiment, the two ends distance of the single-lobe leaf cut out according to first parabola is L1
=15.6+2.1n1, (n1=0,1,2), unit is mm；
The two ends distance of the single-lobe leaf cut out according to second parabola is L2=21.6+2.1n2, (n2=0,1,
2), unit is mm；
The two ends distance of the single-lobe leaf cut out according to the 3rd parabola is L3=27.9；
The two ends distance of the single-lobe leaf cut out according to the 4th parabola is L4=30+2.1n4, (n4=0,1,2),
Unit is mm.
By controlling parabolical span, and then control to cut out the two ends distance of single-lobe leaf, realize control single-lobe leaf
Size, make its size meet it is actually used the need for.
In a preferred embodiment, also including substrate, the contour line of the substrate is a rectangle, the rectangle
Two ends are connected to the two ends of the leaflet.
In a preferred embodiment, the substrate and leaflet are cut using infrared ray or cutter.
Beneficial effects of the present invention are：
The present invention designs cutting track of four kinds of parabolas as single-lobe leaf, makes to cut out according to all ages and classes, body weight
Being resulted in without support bovine pericardium bioprosthetic valves for coming meets all ages and classes, the demand of body weight sufferer.
According to the differently contoured of single-lobe leaf, corresponding single-lobe leaf spacing is designed, makes what is cut out to be given birth to without support bovine pericardium
Thing valve meets the anatomic form of human aortic leaflet.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
The accompanying drawing to be used needed for having technology description is briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, can be with
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is the structural representation of one embodiment of the present invention；
Fig. 2 is the cutting flow chart of the present invention.
Embodiment
Below in conjunction with the accompanying drawing of the present invention, technical scheme is clearly and completely described, it is clear that institute
The embodiment of description is only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention,
The every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, belongs to this hair
The scope of bright protection.
With reference to shown in Fig. 1, no support bovine pericardium bioprosthetic valves, including three single-lobe leaves, the edge wheel profile of single-lobe leaf is throwing
Thing line 1, the two ends of parabola 1 are connected to another parabola 1 by straight transition wire 3, and the end points outwardly of parabola 1 of end
Connect straight transition wire 3.Parabola 1 and the formation leaflet of straight transition wire 3.In order that the profile without support bovine pericardium bioprosthetic valves being made
The need for meeting operation, in cutting process, in addition it is also necessary to cut out substrate 2, the contour line of substrate 2 is a rectangle, the two of rectangle
End is connected to leaflet.
Such as Fig. 2, the present invention is cut in the following manner：
Step S101, according to the situation of different sufferers, the age of input sufferer, body weight, single-lobe number of sheets amount；
Step S102, according to age, the information of body weight, the function of parabola 1 that generation operation needs.
The profile of parabola 1 is divided into four kinds according to age, body weight：First, second, third, fourth.First was 10 one full year of life
Below；Second is 10-20 one full year of life；3rd is that 20 more than one full year of life, body weight is less than 120 jin；4th is that body weight is 20 more than one full year of life
More than 120 jin.Except the third, remaining function of parabola 1 is subdivided into three kinds further according to body weight.Without support bovine pericardium bioprosthetic valves
When carrying out cutting processing, according to the age of input, body weight, the cutting track of generation parabola 1 meets following curve respectively
Function.
The cutting track of first parabola 1 is according to curve Y1Track cut：
Y1=a1X1 2+b1, b1=13+1.75n1,(n1=0,1,2), a1=-4b1/(15.6+2.1n1)2.Body weight is at 20 jin
When following, n1Take 0；Body weight is at 20-40 jins, n1Take 1；Body weight is at 40-60 jins, n1Take 2.
The cutting track of second parabola 1 is according to curve Y2Track cut：
Y2=a2X2 2+b2, b2=18+1.75n2,(n2=0,1,2), a2=-4b2/(21.6+2.1n2)2.Body weight is in 60-80
During jin, n1Take 0；Body weight is at 80-100 jins, n1Take 1；Body weight is at 100-120 jins, n1Take 2.
The cutting track of 3rd parabola 1 is according to curve Y3Track cut：
Y3=0.121X3 2-23.52；
The cutting track of 4th parabola 1 is according to curve Y4Track cut：
Y4=a4X4 2+b4, b4=25+1.75n4,(n4=0,1,2), a4=-4b4/(30+2.1n4)2.Body weight is in 120-140
During jin, n1Take 0；Body weight is at 140-160 jins, n1Take 1；When body weight is more than 160 jin, n1Take 2.
Step S103, according to the information of body weight, determines parabolical two ends apart from L, to determine the cutting of parabolic function
Length.
Except the shape of parabola 1, in addition it is also necessary to control the size of parabola 1, therefore in cutting, to the two ends of parabola 1
10 sizes are divided into according to above-mentioned curve apart from L, each single-lobe leaf L sized data is specific such as table 1.
Table 1
Step S104, according to the quantity of single-lobe leaf, generates straight transition wire l length.
When the quantity for the single-lobe leaf for needing to replace is two panels or three, according to age, body weight to the parabolic of different model
Spacing l between line 1 is defined, by cutting out straight transition wire between two parabola 1, make cutting complete without support
Bovine pericardium bioprosthetic valves meet the actual conditions of sufferer.The length of straight transition wire is specific such as table 2.
Table 2
Step S105, according to the information of body weight, generates the length L1 and height h of rectangle, to determine the cutting track of rectangle,
And the cutting track of rectangle and the straight transition wire at leaflet two ends is connected, form the cutting track of a closing.
The length of rectangle is L1, is highly h, and according to the difference of body weight, the size for cutting the rectangle completed is specific such as table 3.
Table 3
Step S106, the cutting track generated using infrared ray according to step S105 is cut, and cuts out the nothing of needs
Support bovine pericardium bioprosthetic valves.
The shape without support bovine pericardium bioprosthetic valves that infrared ray is cut out, size are accurate, and can be rapidly cut out
Different shape, size without support bovine pericardium bioprosthetic valves.
76 patients are carried out with clinical test, these patients are that dry mo(u)ld bottom half interventricular septum lacks defect with aortic right coronary corolla lobes
Prolapsus, and cause aortic regurgitation.Above-mentioned patient is performed the operation without support bovine pericardium bioprosthetic valves using of the invention, merely
The case of subarterial VSD right flap prolapsus can remain normal left corolla lobes and without corolla lobes in art, it is ensured that aorta petal
Growth.In art at once esophagus ultrasound show successful surgery repair aorta petal, leaflet can normal pair and, the master of all patients
Arterial valve backflows within 1 grade, and across aorta petal peak pressure difference is 14.2 ± 2.8mmHg.By average 27 ± 13 months with
Visit, aortic regurgitation degree and pressure gradient are without significant change, and the 98.3% postoperative aorta petal of patient is not seen
Valve made of cattle pericardium impeller structure is observed to decay phenomenon.
By clinical test, the aorta petal of the shape without support bovine pericardium bioprosthetic valves of different model, size and sufferer
Shape and size after dissection are essentially identical.Patient can be carried out according to the situations of different sufferers to age of sufferer, body weight
After measurement, it is suitable without support bovine pericardium bioprosthetic valves to be rapidly cut out, time saving, laborsaving, improves procedure efficiency and success rate；Together
When reduce operation in bioprosthetic valves shape be not inconsistent caused risk；Repaired suitable for the sufferer aorta petal of children and different weight
Operation, the anatomical structure and function of at utmost reservation aorta petal are capable of using the present invention.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention described should be defined by scope of the claims.
Claims (6)
1. without support bovine pericardium bioprosthetic valves, including single-lobe leaf, the edge wheel profile of the single-lobe leaf is parabola, and its feature exists
Include the first parabola, the second parabola, the 3rd parabola, or the 4th parabola in, the parabola, the single-lobe leaf according to
Following methods cutting is formed,
According to age, the information of body weight, corresponding parabola is generated,
First parabolical cutting track meets curve Y1Track：
Y1=a1X1 2+b1, b1=13+1.75n1, wherein, n1=0,1,2, a1=-4b1/(15.6+2.1n1)2；
Second parabolical cutting track meets curve Y2Track：
Y2=a2X2 2+b2, b2=18+1.75n2, wherein, n2=0,1,2, a2=-4b2/(21.6+2.1n2)2；
3rd parabolical cutting track meets curve Y3Track：
Y3=0.121X3 2-23.52；
4th parabolical cutting track meets curve Y4Track：
Y4=a4X4 2+b4, b4=25+1.75n4, wherein, n4=0,1,2, a4=-4b4/(30+2.1n4)2,
The n1、n2、n4Value according to body weight depending on；
Single-lobe leaf is cut out according to the corresponding parabola of generation.
2. it is according to claim 1 without support bovine pericardium bioprosthetic valves, it is characterised in that：The quantity of the single-lobe leaf is two
Or three, the two ends of the single-lobe leaf are all connected between straight transition wire, the adjacent single-lobe leaf connecting by the straight transition wire
Pick up and, the single-lobe leaf and the straight transition wire formation leaflet.
3. it is according to claim 2 without support bovine pericardium bioprosthetic valves, it is characterised in that：It is straight between first parabola
Transition wire cutting distance is 1.56+0.21n1, wherein, n1=0,1,2, unit is mm；
Straight transition wire cutting distance between second parabola is 2.16+0.21n2, wherein, n2=0,1,2, unit is mm；
Straight transition wire cutting distance between 3rd parabola is 2.79mm；
Straight transition wire cutting distance between 4th parabola is 3+0.21n4, wherein, n4=0,1,2, unit is mm,
The n1、n2、n4Value according to body weight depending on.
4. it is any described without support bovine pericardium bioprosthetic valves according to claim 1-3, it is characterised in that：
The two ends distance of the single-lobe leaf cut out according to first parabola is L1=15.6+2.1n1, wherein, n1=0,1,2,
Unit is mm；
The two ends distance of the single-lobe leaf cut out according to second parabola is L2=21.6+2.1n2, wherein, n2=0,1,2,
Unit is mm；
The two ends distance of the single-lobe leaf cut out according to the 3rd parabola is L3=27.9；
The two ends distance of the single-lobe leaf cut out according to the 4th parabola is L4=30+2.1n4, wherein, n4=0,1,2, it is single
Position is mm.
5. according to Claims 2 or 3 without support bovine pericardium bioprosthetic valves, it is characterised in that：Also include substrate, the substrate
Contour line be a rectangle, the two ends of the rectangle are connected to the two ends of the leaflet.
6. it is according to claim 5 without support bovine pericardium bioprosthetic valves, it is characterised in that：The substrate and leaflet are using infrared
Line or cutter are cut.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510577664.9A CN105167885B (en) | 2015-09-11 | 2015-09-11 | Without support bovine pericardium bioprosthetic valves |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510577664.9A CN105167885B (en) | 2015-09-11 | 2015-09-11 | Without support bovine pericardium bioprosthetic valves |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105167885A CN105167885A (en) | 2015-12-23 |
| CN105167885B true CN105167885B (en) | 2017-07-11 |
Family
ID=54890681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510577664.9A Expired - Fee Related CN105167885B (en) | 2015-09-11 | 2015-09-11 | Without support bovine pericardium bioprosthetic valves |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105167885B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109276347A (en) * | 2018-10-22 | 2019-01-29 | 武汉开阖同立医疗科技有限公司 | It is a kind of for Annular reconstruction without the prefabricated valve of bracket macromolecule |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5123920A (en) * | 1990-06-13 | 1992-06-23 | Onx, Inc. | Prosthetic heart valve |
| CN101301229B (en) * | 2008-07-09 | 2010-10-13 | 天津大学 | Polyurethane artificial heart valve applied to heart chamber auxiliary device |
| US9358107B2 (en) * | 2011-06-30 | 2016-06-07 | Edwards Lifesciences Corporation | Systems, dies, and methods for processing pericardial tissue |
| CN102514119A (en) * | 2011-12-22 | 2012-06-27 | 山东大学 | Plane forming die for artificial heart valve support |
| EP2828372A1 (en) * | 2012-03-23 | 2015-01-28 | Cytograft Tissue Engineering, Inc. | Tissue-engineered heart valve for transcatheter repair |
| GB201207100D0 (en) * | 2012-04-23 | 2012-06-06 | Aortech Internat Plc | Valve |
| CN102641162B (en) * | 2012-04-25 | 2015-03-04 | 陶凉 | Bovine pericardial valve forming die |
| CN103239301B (en) * | 2013-04-23 | 2015-06-03 | 金仕生物科技（常熟）有限公司 | Equipment and method for cutting and selecting valves and valve leaflets |
-
2015
- 2015-09-11 CN CN201510577664.9A patent/CN105167885B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN105167885A (en) | 2015-12-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| David et al. | Aortic root aneurysm: principles of repair and long-term follow-up | |
| CN101605511B (en) | Progressively sized annuloplasty rings | |
| Loukas et al. | The anatomy of the aortic root | |
| US20120172983A1 (en) | Methods of repairing an abnormal mitral valve | |
| Yoshida et al. | Right ventricular outflow tract reconstruction with bicuspid valved polytetrafluoroethylene conduit | |
| Kawase et al. | Aortic valve reconstruction of unicuspid aortic valve by tricuspidization using autologous pericardium | |
| Bateman et al. | The clinical anatomy and pathology of the human atrioventricular valves: implications for repair or replacement | |
| CN105167885B (en) | Without support bovine pericardium bioprosthetic valves | |
| Pejković et al. | Anatomical variations of coronary ostia, aortocoronary angles and angles of division of the left coronary artery of the human heart | |
| AU2008213197B2 (en) | Separate aortic artificial valve leaflet and template for preparation thereof | |
| CN207949946U (en) | Artificial heart valve forming ring | |
| Yacoub et al. | A new technique for shaping the aortic sinuses and conserving dynamism in the remodeling operation | |
| Koirala et al. | Extending the usable size range of homografts in the pulmonary circulation: outcome of bicuspid homografts | |
| CN209075049U (en) | Novel compositions type aortic arch bracket | |
| CN210019455U (en) | Aorta root sewing and positioning die | |
| Kenny et al. | Personalized external aortic root support (PEARS) for aortic root aneurysm | |
| WO2022151892A1 (en) | Balloon-expandable interventional valve stent provided with foldable wingspan skirt | |
| CN108618869A (en) | Artificial heart valve forming ring | |
| CN109330741B (en) | Single-valve pipeline and manufacturing method thereof | |
| CN203263588U (en) | Adjustable artificial valve ring | |
| CN109966025A (en) | Valve cuts mold | |
| Yang et al. | Updates on Y-incision aortic annular enlargement | |
| CN104000670A (en) | Adjustable artificial valve ring | |
| CN110236733B (en) | Valved pipeline and preparation method thereof | |
| Bernstein et al. | Bicuspid-valved PTFE conduit optimization for pediatric RVOT reconstruction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180810 Address after: 430070 202 building, No. 2, No. 2, B9 building, 818 hi-tech Avenue, East Lake New Technology Development Zone, Wuhan, Hubei. Patentee after: WUHAN WEIKE MEDICAL TECHNOLOGY Co.,Ltd. Address before: 723000 room 605, unit 3, North Temple Lane, Hantai District, Hanzhoung, Shaanxi, 605 Patentee before: Shang Xiaoke |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170711 Termination date: 20210911 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |