CN102961200B - With the valve of pulmonary trunk membrane support of anchor mechanism - Google Patents
With the valve of pulmonary trunk membrane support of anchor mechanism Download PDFInfo
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- CN102961200B CN102961200B CN201210500044.1A CN201210500044A CN102961200B CN 102961200 B CN102961200 B CN 102961200B CN 201210500044 A CN201210500044 A CN 201210500044A CN 102961200 B CN102961200 B CN 102961200B
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Abstract
The present invention relates to a kind of valve of pulmonary trunk membrane support with anchor mechanism, comprise the valve section of making (1) and artificial valve (2), described artificial valve (2) is connected in the described valve section of making (1), the described valve section of making (1) is positioned on outflow tract of right ventricle or main pulmonary artery (10) upon discharge, described valve of pulmonary trunk membrane support also comprises anchor mechanism (3), being connected proximally by the far-end of transition connecting rod (4) with the described valve section of making (1) of described anchor mechanism (3), pulmonary artery branch blood vessel (30) is positioned at after described anchor mechanism (3) release.The present invention, by placing anchor mechanism at pulmonary artery branch blood vessel and being connected with the valve section of making being positioned at outflow tract of right ventricle or main pulmonary artery blood vessel by transition connecting rod, can be significantly improved valve bracket steadiness, avoid cusps of pulmonary valve stent migration.
Description
Technical field:
The invention belongs to medical instruments field, be specifically related to a kind of valve of pulmonary trunk membrane support with anchor mechanism.
Background technology:
Congenital heart disease is the cardiovascular malformation caused by fetal period cardiovascular abnormal development, is the modal heart disease of children's.Its sickness rate accounts for 0.8% of natus, and wherein 60% is dead at 1 years old.The annual natus of China is suffered from various congenital heart disease and is estimated at 150,000, wherein about 30% may be dead at infancy stage.Tetralogy of Fallot is modal Children with Cyanotic Congenital Heart Disease in survival baby, and its sickness rate accounts for the 10%-15% of all kinds of congenital heart disease.Namely the tetralogy of Fallot patient of 10,000 examples is had at least successfully to survive to about 20 years old every year.
It is plump that typical tetralogy of Fallot comprises stenosis of pulmonary artery, aortic overriding, ventricular septal defect and right ventricle, and palliative treatment in early stage comprises increases pulmonary circulation blood flow amount, improves the operations such as cardio-pulmonary function.After infant is grown up, its valve of pulmonary trunk and periphery blood vessel can be expanded, and various deformity appears in shape of blood vessel, and blood vessel wall is thinning.Generally adopt surgical operation to effect a radical cure at present, but adopt secondary surgical operation can increase the risk of complications of patients undergoing, even threat to life.
Percutaneous intervening mode repairs valve of pulmonary trunk can reduce harm to patient, but can expand due to the valve of pulmonary trunk of the patient after palliative treatment and periphery blood vessel, and the diameter specifications of lung arterial support on the market can not meet.And various deformity appears in the shape of blood vessel of patient, support is inserted rear easily appearance and is backflowed and be shifted, and patient will be caused to die suddenly once stent migration falls into right ventricle.Except problems such as stent migration, because the blood vessel wall of individual with pulmonary is very thin, balloon expandable or in the process of swollen expansion, excessive radial support power can cause the severe complications such as vascular tear.
Current clinical effectiveness tells us, and not yet occur that a percutaneous is got involved lung arterial support and can thoroughly be solved the problem, the defect that supporting structure form Design exists constrains the curative effect that should obtain to a great extent.Research staff has to constantly provide technical scheme and apparatus innovation, to improve patient's survival rate, improves minimal invasive treatment's situation.
Patent CN101961274 describes a kind of blood vessel reduced mouth part and controlled release system, it comprises the network of a contractile multilamellar, the network of this contractile multilamellar props up frame peripheral crimping in overlay film straight tube and has caused certain elastic foldable structure, object is to implant in the outflow tract of right ventricle expanded, then is inserted in this blood vessel reduced mouth part by existing valve of pulmonary trunk membrane support.This blood vessel reduced mouth part to some extent solves the too small problem of existing valve of pulmonary trunk membrane support specification, but it still exists the risk of stent migration.
Patent CN101057796 discloses a kind of band valve lung arterial support, it is that two is large, middle little tubular expansile braided support, its appearance profile can better with the mating shapes of the outflow tract of right ventricle expanded, reduce stent migration risk, the mesh grid of flexible relative can be fitted blood vessel wall preferably, alleviates and backflows, but also be not easy to cause vascular tear.However, it does not still solve the problem of stent migration better.
A kind of ascending aorta inner cavity insulation support fixing capsule with filled-type is proposed in patent CN201120022195, it is sewed up at overlay film straight tube stent outer or is bonded with filled-type and fixes capsule, capsule is built with water absorbing material, can in Ink vessel transfusing imbibition, thus play fixed support, prevent the effect be shifted.
In sum, how quite a few research avoids cusps of pulmonary valve stent migration and solves reflux problem if concentrating on, many researcheres also propose some schemes solved, but limited success.Vacancy for the intervention apparatus needed for tetralogy of Fallot patient radical operation is very large, how to solve at the outflow tract of right ventricle expanded and pulmonary artery secure valve support, and how support adapts to the key factor that the series of problems such as various lopsided blood vessel and balance radial support power becomes left and right curative effect.
Summary of the invention:
The object of the invention is to improve and make up the defect of prior art and propose a kind of valve of pulmonary trunk membrane support that effectively can solve the band anchor mechanism of cusps of pulmonary valve stent migration.The present invention is by placing anchor mechanism at pulmonary artery branch blood vessel and being connected with the valve section of making being positioned at outflow tract of right ventricle or main pulmonary artery blood vessel by the transition connecting rod arranged thereon, the steadiness of valve bracket can be significantly improved, avoid cusps of pulmonary valve stent migration.
To achieve these goals, the present invention adopts following concrete technical scheme:
A kind of valve of pulmonary trunk membrane support with anchor mechanism, comprise the valve section of making and artificial valve, described artificial valve is connected in the described valve section of making, the described valve section of making is positioned on outflow tract of right ventricle or main pulmonary artery when discharging, described valve of pulmonary trunk membrane support also comprises anchor mechanism, being connected proximally by the far-end of transition connecting rod with the described valve section of making of described anchor mechanism, after described anchor mechanism release, be positioned at pulmonary artery branch Ink vessel transfusing.
Object of the present invention can also be realized further by following technical scheme:
Preferably, described anchor mechanism is the latticed support of self-inflated with tubular profile, or described anchor mechanism is made up of along the equally distributed support ring of vessels axis several, or described anchor mechanism is turn.
Preferably, described anchor mechanism is made by laser engraving, or described anchor mechanism is braided support.
Preferably, described support ring is formed by one or more strands of shape-memory alloy wire coiling.
Preferably, described transition connecting rod is made up of the straight section of near-end and the bending section of far-end, forms angle theta between described straight section and described bending section, and described angle theta is between 30 ~ 100 °.
Preferably, described transition connecting rod is single or many, and described anchor mechanism is connected with the described valve section of making by the mode of welding, grappling, stitching by it.
Preferably, the described valve section of making is self-expandable stent, and all or part of overlay film of outer surface of the described valve section of making, the material of described film comprises politef, polyethylene, polypropylene, polyurethane, silica gel.The described valve section of making can select the structure of lung arterial support well known in the prior art, and preferably, the structure of the described valve section of making is straight tube shape, cydariform etc., and preferred, the structure of the described valve section of making is that large centre, two is little.
Preferably, in the external circumferential ground continuous distribution or be arranged at intervals with cryptomere component equably of the described valve section of making, described cryptomere component is woven by shape-memory alloy wire and forms, or described cryptomere component is inflation or topping up sacculus, or described cryptomere component is the hollow member that inside is filled with water uptake expansion material.Preferred, described water uptake expansion material is acrylic acid, propylene, acrylic amide, polyvinyl alcohol or cellulose family.
Preferably, described cryptomere component is connected with the valve section of making by modes such as stitching, stickup, welding.
Preferably, described anchor mechanism or cryptomere component arrange respectively or are provided with multiple barb simultaneously, one end of described barb is connected on described anchor mechanism or described cryptomere component, and the other end of described barb outwards opens, and the angle of opening is between 5 ~ 45 °.
Preferably, the material of described anchor mechanism, transition connecting rod and the valve section of making is shape-memory material or elastomeric material, is preferably niti-shaped memorial alloy.
Preferably, described anchor mechanism, transition connecting rod and the valve section of making adopt shape-memory material pipe one engraving to make, or are formed by shape-memory material silk integrated woven.
Preferably, described artificial valve adopts three-lobed structure, is made up of animal tissue or high molecular polymer.Preferred described animal tissue is Cor Sus domestica bag, bovine pericardium, Cor Equi bag etc., and described high molecular polymer is politef, polyurethane, silica gel.
Compared with the existing technology, the invention has the advantages that:
1, the present invention places anchor mechanism at pulmonary artery branch blood vessel, the physiology elasticity taking full advantage of pulmonary artery branch blood vessel, this is because tetralogy of Fallot second phase patient expands with main pulmonary artery usually, its blood vessel expanded loses this due elasticity, thus it reduces the frictional force of valve bracket; The elasticity of pulmonary artery branch blood vessel is then relatively good, and the frictional force provided by branch vessel will significantly improve the steadiness of valve bracket, avoid cusps of pulmonary valve stent migration.
2, the present invention places anchor mechanism at pulmonary artery branch blood vessel, take full advantage of the approximately perpendicular physiological structure of pulmonary artery branch blood vessel and main pulmonary artery uniqueness, it can decompose to minimum degree when being delivered to described anchor mechanism close to the angle of 90 ° by the blood flow impact force suffered by the valve bracket on main pulmonary artery well, avoids valve bracket to be shifted.In order to play better positioning action, the anchor mechanism described in can placing in Pulmonic left/right branch individually or simultaneously.
3, the cryptomere component that the present invention adopts at the valve section of making periphery can provide a supporting role when support discharges, avoid valve periphery to backflow and avoid support to come off further, and guarantee that the shape of the artificial valve in the valve section of making does not change with periphery blood vessel profile variations, make it to open or close to keep ideal form.
4, the transition connecting rod that the present invention adopts is made up of the straight section of near-end and the bending section of far-end.Be designed with like this and be beneficial to described anchor mechanism and the valve section of making is released to belonging positions respectively, and the mechanics transitive relation optimized between the two, when the valve section of making being positioned at outflow tract of right ventricle or main pulmonary artery is subject to blood flow impact, suffered impulsive force decomposition alleviates when being passed to anchor mechanism greatly, enhances anchoring effect.
5, the present invention is by all or part of overlay film of the outer surface of the valve section of making, and effectively reduces perivalvular leakage.
6, the anchor mechanism in the present invention or cryptomere component arrange respectively or are provided with multiple barb simultaneously, and barb release is thrust in blood vessel wall and played anticreep and fixing effect.
Accompanying drawing illustrates:
Fig. 1 is the schematic diagram of a kind of valve of pulmonary trunk membrane support with anchor mechanism of the present invention.
Fig. 2 is the carved pattern schematic diagram of anchor mechanism of the present invention.
Fig. 3 is the schematic diagram of transition connecting rod of the present invention.
Fig. 4 is the connected mode schematic diagram of transition connecting rod of the present invention and anchor mechanism and the valve section of making.
Fig. 5 a is the carved pattern schematic diagram of the valve section of making of the present invention.
Fig. 5 b and 5c is the schematic diagram of the valve section of making of the present invention.
Fig. 6 is a kind of schematic diagram preferred embodiment of the present invention.
Fig. 7 a-c is the preferred enforcement schematic diagram of anchor mechanism of the present invention.
Fig. 8 a is the schematic diagram of another preferred embodiment of the present invention.
Fig. 8 b-d is the schematic diagram preferred embodiment of anchor mechanism of the present invention.
Fig. 9 a is the schematic diagram of another preferred embodiment of the present invention.
Fig. 9 b-d is the schematic diagram preferred embodiment of anchor mechanism of the present invention.
Figure 10 a is the schematic diagram preferred embodiment of the valve section of making of the present invention.
Figure 10 b and 10c is the schematic diagram preferred embodiment of the valve section of making of the present invention.
Figure 11 is the carved pattern schematic diagram of the valve of pulmonary trunk membrane support of the band anchor mechanism of the one engraving of another preferred embodiment of the present invention.
Figure 12 is the schematic diagram of the valve of pulmonary trunk membrane support of a kind of band barb preferred embodiment of the present invention.
Detailed description of the invention:
For making object of the present invention, technical scheme and advantage clearly understand, to develop simultaneously embodiment referring to accompanying drawing, the present invention is described in more detail.
Near-end of the present invention refers to the one end close to outflow tract of right ventricle mouth, and described far-end refers to the one end away from outflow tract of right ventricle mouth.
Specific embodiment one:
As shown in Figure 1, a kind of valve of pulmonary trunk membrane support with anchor mechanism, comprise the valve section of making 1 and artificial valve 2, described artificial valve 2 is connected in the described valve section of making 1, the described valve section of making 1 is positioned at when discharging on outflow tract of right ventricle or main pulmonary artery 10, described valve of pulmonary trunk membrane support also comprises anchor mechanism 3, being connected proximally by the far-end of transition connecting rod 4 with the described valve section of making 1 of described anchor mechanism 3, described anchor mechanism 3 is positioned at pulmonary artery branch blood vessel 30 after discharging.Why place anchor mechanism 3 at pulmonary artery branch blood vessel 30, reason has two, the first due to tetralogy of Fallot second phase patient usually expand with main pulmonary artery 10, its blood vessel expanded loses this due elasticity, thus it reduces the frictional force of valve bracket; The elasticity of pulmonary artery branch blood vessel 30 is then relatively good, the physiology elasticity that anchor mechanism then takes full advantage of pulmonary artery branch blood vessel 30 is placed in this, the frictional force provided by branch vessel 30 will significantly improve the steadiness of valve bracket, avoid cusps of pulmonary valve stent migration; It two is the approximately perpendicular physiological structures taking full advantage of pulmonary artery branch blood vessel 30 and main pulmonary artery 10 uniqueness, it can decompose to minimum degree when being delivered to described anchor mechanism close to the angle of 90 ° by the blood flow impact force suffered by the valve bracket on main pulmonary artery 10 well, avoids valve bracket to be shifted.Described anchor mechanism 3 can be placed in pulmonary artery left/right branch individually or simultaneously.
Described anchor mechanism 3 is latticed support, and preferably, the self-inflated latticed support of described anchor mechanism 3 for having tubular profile, as shown in Figure 2, its material is shape-memory material or elastomeric material, is preferably niti-shaped memorial alloy.Preferred, described anchor mechanism 3 adopts shape-memory material pipe one engraving to make, or is formed by shape-memory material silk integrated woven, is preferably nickel-titanium shape memory alloy material.
As shown in Figure 3, described transition connecting rod 4 is made up of the straight section 41 of near-end and the bending section 42 of far-end, and the two forms angle theta, and described angle theta is between 30 ~ 100 °.Be designed with like this and be beneficial to described anchor mechanism 3 and the valve section of making 1 is released to belonging positions respectively, and the mechanics transitive relation optimized between the two is (when both angle theta, its impulsive force becomes original cos θ doubly), when the valve section of making being positioned at outflow tract of right ventricle or main pulmonary artery is subject to blood flow impact, suffered impulsive force decomposition alleviates when being passed to anchor mechanism greatly, enhances anchoring effect.Simultaneously, such design more meets the physiological structure of pulmonary artery branch blood vessel and main pulmonary artery, make described anchor mechanism 3 after pulmonary artery branch blood vessel 30 discharges, the described valve section of making 1 can be seated outflow tract of right ventricle or main pulmonary artery 10 automatically, facilitates doctor's subsequent operation.Preferably, described transition connecting rod 4 is single or many, preferably single (farthest can avoid having thrombosis to build up on it in blood flow scour process like this), anchor mechanism 3 is connected with the valve section of making 1 by welding (solder joint 43), grappling (rivet 44), modes such as (sutures 45) of sewing up by described transition connecting rod 4, as shown in figures 4 a-c.
The described valve section of making 1 is self-expandable stent, the described valve section of making 1 can select the structure of lung arterial support well known in the prior art, be preferably straight tube shape, cydariform etc., preferred, the described valve section of making 1 is the little structure in large centre, two, as shown in figure 5a and 5b, design like this can cater to outflow tract of right ventricle or the main pulmonary artery shape of blood vessel of the various deformityization of tetralogy of Fallot second phase patient to the full extent, make it to be adjacent to blood vessel, enough support forces are provided and prevent internal hemorrhage due to trauma, its material is shape-memory material or elastomeric material, be preferably niti-shaped memorial alloy.Preferred, the described valve section of making 1 adopts shape-memory material pipe one engraving to make, and is preferably niti-shaped memorial alloy pipe one engraving and makes.The all or part of overlay film 11 of outer surface of the described valve section of making 1, as shown in Figure 5 c.The material of described film 11 comprises politef, polyethylene, polypropylene, polyurethane, silica gel etc., and overlay film effectively can prevent perivalvular leakage.
Specific embodiment two:
As shown in Figure 6, a kind of valve of pulmonary trunk membrane support with anchor mechanism, comprise the valve section of making 1 and artificial valve 2, described artificial valve 2 is connected in the described valve section of making 1, the described valve section of making 1 is positioned at when discharging on outflow tract of right ventricle or main pulmonary artery 10, described valve of pulmonary trunk membrane support also comprises anchor mechanism 3, being connected proximally by the far-end of transition connecting rod 4 with the described valve section of making 1 of described anchor mechanism 3, described anchor mechanism 3 is positioned at pulmonary artery branch blood vessel 30 after discharging.
As shown in Figure 7a, described anchor mechanism 3 is braided support, and material is shape-memory material or elastomeric material, is preferably niti-shaped memorial alloy.
As shown in Fig. 7 b and 7c, all or part of overlay film 31 of outer surface of described anchor mechanism 3.The material of described film 31 comprises politef, polyethylene, polypropylene, polyurethane, silica gel etc.
As one preferred embodiment, as shown in Fig. 8 a-d, described anchor mechanism is made up of along the equally distributed support ring 32 of vessels axis several.Preferably, described support ring 32 is formed by one or more strands of shape-memory alloy wire coiling.
As another preferred embodiment, as shown in Fig. 9 a-d, preferably, described anchor mechanism is turn.
As shown in Figure 3, described transition connecting rod 4 is made up of the straight section 41 of near-end and the bending section 42 of far-end, and the two forms angle theta, and described angle theta is between 30 ~ 100 °.Described transition connecting rod 4 is single, farthest can avoid having thrombosis to build up on it in blood flow scour process like this, described transition connecting rod 4 is connected with anchor mechanism 1 and the valve section of making 3 by welding (solder joint 44), grappling (rivet 45), modes such as (sutures 43) of sewing up, as shown in figures 4 a-c.
The described valve section of making 1 is self-expandable stent, and concrete structure as described in Example 1.
As one preferred embodiment, the external circumferential of the described valve section of making cryptomere component 5 is provided with, as shown in Figure 10 a.This cryptomere component 5 can provide a supporting role when the valve section of making 1 discharges, avoid valve periphery to backflow and avoid support to come off further, and the shape of the artificial valve 2 guaranteed in the valve section of making 1 does not change with periphery blood vessel profile variations, make it to open or close to keep ideal form.Preferably, described cryptomere component 5 is in the valve section of making 1 external circumferential continuous distribution or uniform intervals distribution.Preferably, described cryptomere component 5 is connected with the valve section of making 1 by modes such as stitching, stickup, welding.
Preferably, described cryptomere component 5 is woven by shape-memory alloy wire 51 and forms.
Preferably, described cryptomere component 5 is inflation or topping up sacculus, as shown in fig. lob, sacculus is provided with the valve 52 of inflation or topping up.The described valve section of making 5, after the release of target location, makes inflation play a supportive role by inflation or topping up.
Preferably, described cryptomere component 5 hollow, is filled with water uptake expansion material 53, as shown in figure l oc in it.Described water uptake expansion material is acrylic acid, propylene or acrylic amide; Polyvinyl alcohol; Cellulose family etc.The described valve section of making 1 is after the release of target location, and the moisture in described water uptake expansion material 53 absorbing blood and expanding, speed of expansion is controlled, mildly can support the valve section of making 1, avoids too fast expansion to cause vascular tear.
Described artificial valve 2 adopts three-lobed structure, is made up of animal tissue or high molecular polymer.Preferred described animal tissue is Cor Sus domestica bag, bovine pericardium, Cor Equi bag etc., and described high molecular polymer is politef, polyurethane, silica gel etc.
Specific embodiment three:
The difference of the present embodiment and specific embodiment two is, described anchor mechanism 3, transition connecting rod 4 and the valve section of making 1 adopt shape-memory material pipe one engraving to make, be more preferably niti-shaped memorial alloy pipe one engraving to make, as shown in figure 11.
Specific embodiment four:
The present embodiment is from the different of specific embodiment two, and described anchor mechanism 3 or cryptomere component 5 are arranged respectively, or is provided with multiple barb 6 simultaneously, as shown in figure 12; Described barb 6 one end is connected on described anchor mechanism 3 or cryptomere component 5, and the other end outwards opens, and the angle of opening is between 5 ~ 45 °.Barb 6 release is thrust in blood vessel wall and is played anticreep and fixing effect.
Finally should be noted that; the foregoing is only preferred embodiment of the present invention; not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. the valve of pulmonary trunk membrane support with anchor mechanism, comprise the valve section of making and artificial valve, described artificial valve is connected in the described valve section of making, be positioned on outflow tract of right ventricle or main pulmonary artery after the described valve section of making release, it is characterized in that, the described valve section of making is the little tubular construction in large centre, two, described valve of pulmonary trunk membrane support also comprises anchor mechanism, being connected proximally by the far-end of transition connecting rod with the described valve section of making of described anchor mechanism, pulmonary artery branch Ink vessel transfusing is positioned at after described anchor mechanism release, described anchor mechanism is made up of along the equally distributed support ring of vessels axis several.
2. the valve of pulmonary trunk membrane support of band anchor mechanism according to claim 1, is characterized in that, described support ring is formed by one or more strands of shape-memory alloy wire coiling.
3. the valve of pulmonary trunk membrane support of band anchor mechanism according to claim 1 and 2, it is characterized in that, described transition connecting rod is made up of the straight section of near-end and the bending section of far-end, forms angle theta between described straight section and described bending section, and described angle theta is between 30 ~ 100 °.
4. the valve of pulmonary trunk membrane support of band anchor mechanism according to claim 3, is characterized in that, described transition connecting rod is single or many, and described anchor mechanism is connected with the described valve section of making by the mode of welding, grappling, stitching by it.
5. the valve of pulmonary trunk membrane support of band anchor mechanism according to claim 3, it is characterized in that, the described valve section of making is self-expandable stent, the all or part of overlay film of outer surface of the described valve section of making, the material of described film comprises politef, polyethylene, polypropylene, polyurethane, silica gel.
6. the valve of pulmonary trunk membrane support of band anchor mechanism according to claim 5, it is characterized in that, in the external circumferential ground continuous distribution or be arranged at intervals with cryptomere component equably of the described valve section of making, described cryptomere component is woven by shape-memory alloy wire and forms, or described cryptomere component is inflation or topping up sacculus, or described cryptomere component is the hollow member that inside is filled with water uptake expansion material.
7. the valve of pulmonary trunk membrane support of band anchor mechanism according to claim 6, it is characterized in that, described anchor mechanism or described cryptomere component arrange respectively or are provided with multiple barb simultaneously, one end of described barb is connected on described anchor mechanism or described cryptomere component, the other end of described barb outwards opens, and the angle of opening is between 5 ~ 45 °.
8. the valve of pulmonary trunk membrane support of band anchor mechanism according to claim 1, it is characterized in that, described anchor mechanism, transition connecting rod and the valve section of making adopt shape-memory material pipe one engraving to make, or are formed by shape-memory material silk integrated woven.
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| CN201210500044.1A CN102961200B (en) | 2012-11-30 | 2012-11-30 | With the valve of pulmonary trunk membrane support of anchor mechanism |
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| CN201210500044.1A CN102961200B (en) | 2012-11-30 | 2012-11-30 | With the valve of pulmonary trunk membrane support of anchor mechanism |
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| CN102961200A CN102961200A (en) | 2013-03-13 |
| CN102961200B true CN102961200B (en) | 2015-08-12 |
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| US12138185B2 (en) | 2021-07-13 | 2024-11-12 | Restore Medical Ltd. | Pulmonary artery implant apparatus and methods of use thereof |
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| CN103892940B (en) * | 2013-12-02 | 2016-08-17 | 北京工业大学 | A kind of topping up type cage ball formula aorta petal mounting system |
| WO2016013006A1 (en) | 2014-07-20 | 2016-01-28 | Elchanan Bruckheimer | Pulmonary artery implant apparatus and methods of use thereof |
| US9848983B2 (en) * | 2015-02-13 | 2017-12-26 | Millipede, Inc. | Valve replacement using rotational anchors |
| US11771434B2 (en) | 2016-09-28 | 2023-10-03 | Restore Medical Ltd. | Artery medical apparatus and methods of use thereof |
| CN108720972A (en) * | 2017-04-19 | 2018-11-02 | 北京航空航天大学 | A kind of self expandable for avoiding coronary artery from blocking intervention valve bracket |
| US11364132B2 (en) | 2017-06-05 | 2022-06-21 | Restore Medical Ltd. | Double walled fixed length stent like apparatus and methods of use thereof |
| CN109172043B (en) * | 2018-09-12 | 2020-11-10 | 于存涛 | Dissected proximate ascending aortic stent anchored by innominate artery and delivery system |
| CN112535561A (en) * | 2020-12-22 | 2021-03-23 | 上海腾复医疗科技有限公司 | Pulmonary artery stent |
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| CN102961200A (en) | 2013-03-13 |
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