CL2014000904A1 - Rupture-resistant oral pharmaceutical dosage form comprising i) a pharmacologically active ingredient, ii) an opioid antagonist and / or a repellent agent, iii) a polyalkylene oxide and iv) an anionic polymer. - Google Patents

Rupture-resistant oral pharmaceutical dosage form comprising i) a pharmacologically active ingredient, ii) an opioid antagonist and / or a repellent agent, iii) a polyalkylene oxide and iv) an anionic polymer.

Info

Publication number
CL2014000904A1
CL2014000904A1 CL2014000904A CL2014000904A CL2014000904A1 CL 2014000904 A1 CL2014000904 A1 CL 2014000904A1 CL 2014000904 A CL2014000904 A CL 2014000904A CL 2014000904 A CL2014000904 A CL 2014000904A CL 2014000904 A1 CL2014000904 A1 CL 2014000904A1
Authority
CL
Chile
Prior art keywords
rupture
iii
active ingredient
dosage form
pharmaceutical dosage
Prior art date
Application number
CL2014000904A
Other languages
Spanish (es)
Inventor
Lutz Barnscheid
Sebastian Schwier
Anja Geissler
Johannes Bartholomaus
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47191746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014000904(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of CL2014000904A1 publication Critical patent/CL2014000904A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Addiction (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2014000904A 2011-11-17 2014-04-10 Rupture-resistant oral pharmaceutical dosage form comprising i) a pharmacologically active ingredient, ii) an opioid antagonist and / or a repellent agent, iii) a polyalkylene oxide and iv) an anionic polymer. CL2014000904A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11009129 2011-11-17
EP12001295 2012-02-28

Publications (1)

Publication Number Publication Date
CL2014000904A1 true CL2014000904A1 (en) 2014-08-18

Family

ID=47191746

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014000904A CL2014000904A1 (en) 2011-11-17 2014-04-10 Rupture-resistant oral pharmaceutical dosage form comprising i) a pharmacologically active ingredient, ii) an opioid antagonist and / or a repellent agent, iii) a polyalkylene oxide and iv) an anionic polymer.

Country Status (17)

Country Link
US (1) US20130129826A1 (en)
EP (1) EP2780000B1 (en)
JP (1) JP6085307B2 (en)
KR (1) KR20140096062A (en)
CN (1) CN104066426A (en)
AR (1) AR088875A1 (en)
AU (1) AU2012338872B2 (en)
BR (1) BR112014011504A2 (en)
CA (1) CA2855718A1 (en)
CL (1) CL2014000904A1 (en)
CO (1) CO7210299A2 (en)
EA (1) EA201400590A1 (en)
HK (1) HK1200742A1 (en)
IL (1) IL232054A0 (en)
MX (1) MX349725B (en)
PE (1) PE20141671A1 (en)
WO (1) WO2013072395A1 (en)

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CA2931553C (en) 2013-11-26 2022-01-18 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
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WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
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Also Published As

Publication number Publication date
CN104066426A (en) 2014-09-24
JP6085307B2 (en) 2017-02-22
CO7210299A2 (en) 2015-03-09
EP2780000A1 (en) 2014-09-24
EA201400590A1 (en) 2014-11-28
MX2014005820A (en) 2014-06-04
HK1200742A1 (en) 2015-08-14
MX349725B (en) 2017-08-10
AU2012338872B2 (en) 2017-06-22
AR088875A1 (en) 2014-07-16
WO2013072395A1 (en) 2013-05-23
IL232054A0 (en) 2014-05-28
JP2014533668A (en) 2014-12-15
AU2012338872A1 (en) 2014-04-17
NZ623291A (en) 2016-01-29
BR112014011504A2 (en) 2017-05-09
CA2855718A1 (en) 2013-05-23
EP2780000B1 (en) 2019-04-03
US20130129826A1 (en) 2013-05-23
PE20141671A1 (en) 2014-11-22
KR20140096062A (en) 2014-08-04

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