RNF2

RNF2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2H0D, 3GS2, 3H8H, 3IXS, 3RPG, 4R8P, 4S3O
معین‌کننده‌ها
نام‌های دیگر	RNF2, BAP-1, BAP1, DING, HIPI3, RING1B, RING2, ring finger protein 2, ring1B, LUSYAM
شناسه‌های بیرونی	OMIM: 608985 MGI: 1101759 HomoloGene: 2199 GeneCards: RNF2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	151,376,706 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:1904264، GO:1904822، GO:0090622، GO:0090302 ubiquitin protein ligase activity; • chromatin binding; • RING-like zinc finger domain binding; • metal ion binding; • GO:0050372 ubiquitin-protein transferase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • transferase activity; • zinc ion binding;
ترکیبات سلولی	• GO:0035327 euchromatin; • sex chromatin; • ubiquitin ligase complex; • نوکلئوپلاسم; • کروموزوم; • GO:0035328 هتروکروماتین; • MLL1 complex; • PRC1 complex; • PcG protein complex; • هسته یاخته; • nuclear body;
فرایند زیستی	• germ cell development; • histone H2A-K119 monoubiquitination; • GO:0009373 regulation of transcription, DNA-templated; • gastrulation with mouth forming second; • histone H2A monoubiquitination; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of DNA-binding transcription factor activity; • transcription, DNA-templated; • protein ubiquitination; • GO:0007067 رشتمان; • anterior/posterior axis specification; • histone ubiquitination; • negative regulation of G0 to G1 transition;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6045
	19821
	ENSG00000121481
	ENSMUSG00000026484
	Q99496
	Q9CQJ4
	NM_007212، XM_005245413، XM_011509851 XM_011509852، NM_007212، XM_005245413، XM_011509851
	XM_006529269، NM_001360844، NM_001360845، NM_001360847، XM_036162866، XM_036162867 NM_011277، XM_006529269، NM_001360844، NM_001360845، NM_001360847، XM_036162866، XM_036162867
	XP_005245470، XP_011508153، XP_011508154 NP_009143، XP_005245470، XP_011508153، XP_011508154
	XP_006529332، NP_001347773، NP_001347774، NP_001347776، XP_036018759، XP_036018760 NP_035407، XP_006529332، NP_001347773، NP_001347774، NP_001347776، XP_036018759، XP_036018760
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

لیگاز RING2 پروتئین E3 یوبیکوتین (انگلیسی: E3 ubiquitin-protein ligase RING2) یک پروتئین است که در انسان توسط ژن «RNF2» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین با پروتئینِ HIP2، تعامل پروتئین-پروتئین دارد.^[۴]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026484 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ ^۴٫۰ ^۴٫۱ Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (August 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855.
↑ "Entrez Gene: RNF2 ring finger protein 2".

مشارکت‌کنندگان ویکی‌پدیا. «RNF2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۵ ژوئن ۲۰۱۹.

پیوند به بیرون

RNF2 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

برای مطالعهٔ بیشتر

García E, Marcos-Gutiérrez C, del Mar Lorente M, et al. (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
Tuckfield A, Clouston DR, Wilanowski TM, et al. (2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Mol. Cell. Biol. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618. PMID 11865070.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol. Cell. Biol. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. PMID 12183370.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Voncken JW, Roelen BA, Roefs M, et al. (2003). "Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2468–73. Bibcode:2003PNAS..100.2468V. doi:10.1073/pnas.0434312100. PMC 151364. PMID 12589020.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
Wang H, Wang L, Erdjument-Bromage H, et al. (2004). "Role of histone H2A ubiquitination in Polycomb silencing". Nature. 431 (7010): 873–8. Bibcode:2004Natur.431..873W. doi:10.1038/nature02985. PMID 15386022.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Voncken JW, Niessen H, Neufeld B, et al. (2005). "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1". J. Biol. Chem. 280 (7): 5178–87. doi:10.1074/jbc.M407155200. PMID 15563468.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153.
Lee SJ, Choi D, Rhim H, Kang S (2005). "E3 ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit and increases the ATP hydrolysis activity of S6'". Biochem. J. 389 (Pt 2): 457–63. doi:10.1042/BJ20041982. PMC 1175123. PMID 15773819.
Glinsky GV, Berezovska O, Glinskii AB (2005). "Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer". J. Clin. Invest. 115 (6): 1503–21. doi:10.1172/JCI23412. PMC 1136989. PMID 15931389.
Dou Y, Milne TA, Tackett AJ, et al. (2005). "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j.cell.2005.04.031. PMID 15960975.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Cao R, Tsukada Y, Zhang Y (2006). "Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing". Mol. Cell. 20 (6): 845–54. doi:10.1016/j.molcel.2005.12.002. PMID 16359901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Li Z, Cao R, Wang M, et al. (2006). "Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex". J. Biol. Chem. 281 (29): 20643–9. doi:10.1074/jbc.M602461200. PMID 16714294.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026484 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11513855-4] ۴٫۰ ^۴٫۱ Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (August 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855.

[entrez-5] "Entrez Gene: RNF2 ring finger protein 2".

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