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XCL2

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XCL2
Identifiers
AliasesXCL2, SCM-1b, SCM1B, SCYC2, chemokine (C motif) ligand 2, X-C motif chemokine ligand 2
External IDsOMIM: 604828; MGI: 104593; HomoloGene: 130513; GeneCards: XCL2; OMA:XCL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003175

NM_008510

RefSeq (protein)

NP_003166

NP_032536

Location (UCSC)Chr 1: 168.54 – 168.54 MbChr 1: 164.76 – 164.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1.[5] It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.[6] Its gene is located on chromosome 1 in humans.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143185Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026573Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol. 155 (1): 203–9. doi:10.4049/jimmunol.155.1.203. PMID 7602097.
  6. ^ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
  7. ^ Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett. 395 (1): 82–8. Bibcode:1996FEBSL.395...82Y. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.