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S-formylglutathione hydrolase

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S-formylglutathione hydrolase
Identifiers
EC no.3.1.2.12
CAS no.50812-21-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PubMedarticles
NCBIproteins

The enzyme S-formylglutathione hydrolase (EC 3.1.2.12) catalyzes the reaction

S-formylglutathione + H2O glutathione + formate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is S-formylglutathione hydrolase. It participates in Methane Metabolism.

References

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  • Uotila L (1973). "Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases". Biochemistry. 12 (20): 3938–43. doi:10.1021/bi00744a024. PMID 4200890.
  • Uotila L, Koivusalo M (1974). "Purification and properties of S-formylglutathione hydrolase from human liver". J. Biol. Chem. 249 (23): 7664–72. PMID 4436331.
  • Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH (1996). "S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?". J. Bacteriol. 178 (21): 6296–9. PMC 178503. PMID 8892832.