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PRKACG

From Wikipedia, the free encyclopedia

PRKACG
Identifiers
AliasesPRKACG, KAPG, PKACg, BDPLT19, protein kinase cAMP-activated catalytic subunit gamma
External IDsOMIM: 176893; HomoloGene: 55677; GeneCards: PRKACG; OMA:PRKACG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002732

n/a

RefSeq (protein)

NP_002723

n/a

Location (UCSC)Chr 9: 69.01 – 69.01 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.[3][4][5]

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.[5]

Interactions

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PRKACG has been shown to interact with Ryanodine receptor 2.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165059Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T (June 1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase". Mol Endocrinol. 4 (3): 465–75. doi:10.1210/mend-4-3-465. PMID 2342480.
  4. ^ Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K (August 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics. 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317.
  5. ^ a b "Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma".
  6. ^ Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. 101 (4). UNITED STATES: 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164. S2CID 6496567.

Further reading

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