Jump to content

Neuropeptide Y receptor Y1

From Wikipedia, the free encyclopedia
NPY1R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNPY1R, NPY1-R, NPYR, Neuropeptide Y receptor Y1
External IDsOMIM: 162641; MGI: 104963; HomoloGene: 700; GeneCards: NPY1R; OMA:NPY1R - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000909

NM_010934
NM_001358955

RefSeq (protein)

NP_000900

NP_035064
NP_001345884

Location (UCSC)Chr 4: 163.32 – 163.34 MbChr 8: 67.15 – 67.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[5][6]

Selective ligands

[edit]

Agonists

[edit]

Antagonists

[edit]
Peptide
  • BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
  • GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Non-peptide
  • BIBO-3304 (CAS# 191868-14-1)
  • BIBP-3226 (CAS# 159013-54-4)
  • PD-160,170 (CAS# 181468-88-2)

Available Structures

[edit]
  • 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)[7]
  • 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)[7]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164128Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036437Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. doi:10.1016/S0021-9258(18)53306-8. PMID 8095935.
  6. ^ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".
  7. ^ a b Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.

Further reading

[edit]
[edit]
  • "Neuropeptide Y Receptors: Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
  • Overview of all the structural information available in the PDB for UniProt: P25929 (Neuropeptide Y receptor type 1) at the PDBe-KB.