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Marcia Haigis

From Wikipedia, the free encyclopedia
Marcia Carmen Haigis
Born
Alma materUniversity of Wisconsin–Madison
University of New Hampshire
Scientific career
InstitutionsMassachusetts Institute of Technology
Harvard Medical School
ThesisDissecting the mechanisms of a toxic ribonuclease (2002)
Academic advisorsLeonard P. Guarente
Doctoral studentsLydia W. S. Finley

Marcia Carmen Haigis is an American biologist and Professor in the Department of Cell Biology at Harvard Medical School. Her research looks to understand the metabolic circuitry of mitochondria, and how it impacts human health and disease. She was elected to the National Academy of Medicine in 2024.

Early life and education

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Haigis was born in Las Vegas and moved to South Korea as a child. Her father was an officer in the United States Air Force. Haigis spent her early life moving between Nebraska and Alabama, before settling in Portsmouth, New Hampshire.[1] She was a freshman at the University of New Hampshire.[1] Here she trained as an emergency medicine technician, accumulating hours of experience to be a member of the ambulance corps.[1] During her undergraduate studies Haigis discovered medical research, and spent her summers as a lab intern working on protein chemistry. Haigis trained in biochemistry at the University of Wisconsin–Madison. Her doctoral research looked to understand the mechanisms of toxic ribonuclease.[2] She learned a lot about protein folding and Sirtuin 1.[1] She was a postdoctoral researcher at the Massachusetts Institute of Technology, where she specialised in mitochondrial metabolics with Leonard P. Guarente.[1] Here she started working on SIRT3, SIRT4 and SIRT5. Amongst her many findings, she showed that SIRT4 repressed glutamate dehydrogenase 1, which suppressed insulin secretion.[1]

Research and career

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Haigis looks to understand the role of mitochondria in human health.[3] In particular, Haigis has studied how the enzymatic networks in the mitochondrion modulate a cell's metabolism.[1] She joined the Harvard Medical School in 2006. One of her first graduate students, Lydia W. S. Finley, demonstrated that expression of genes critical to glycolysiswas boosted when SIRT3 decreased.[1] The SIRT3 gene is the most depleted in tumour cells – it drives cancel cell proliferation, and mice lacking in SIRT3 result in mice spontaneously developing breast tumours.

Haigis has demonstrated the role of mitochondrial sirtuins (a protein family involved in the regulation of biological processes) in metabolism and disease. She revealed that ammonia, a metabolic waste product that is lethal to most biological tissue, was used to boost the growth of cancer cells.[1] She has shown that damage to DNA (which can accelerate cancer) activates the SIRT4 gene, and mice lacking SIRT4 developed spontaneous lung tumours.[1] Her lab also demonstrated that prolyl-hydroxylase 3 (PHD3), a signalling enzyme, breaks down fats inside the mitochondrion, and is suppressed in a subset of cancers (including acute myeloid leukemia).[1]

Awards and honours

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Select publications

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  • Sejal Vyas; Elma Zaganjor; Marcia C Haigis (1 July 2016). "Mitochondria and Cancer". Cell. 166 (3): 555–566. doi:10.1016/J.CELL.2016.07.002. ISSN 0092-8674. PMC 5036969. PMID 27471965. Wikidata Q53198693.
  • Marcia C Haigis; Raul Mostoslavsky; Kevin M Haigis; et al. (1 September 2006). "SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells". Cell. 126 (5): 941–954. doi:10.1016/J.CELL.2006.06.057. ISSN 0092-8674. PMID 16959573. Wikidata Q24301843.
  • Haigis MC; Sinclair DA (2010). "Mammalian sirtuins: biological insights and disease relevance". Annual Review of Pathology: Mechanisms of Disease. 5: 253–95. doi:10.1146/ANNUREV.PATHOL.4.110807.092250. ISSN 1553-4006. PMC 2866163. PMID 20078221. Wikidata Q29614496.

References

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  1. ^ a b c d e f g h i j k "Ludwig Cancer Research". Retrieved 2024-12-23.
  2. ^ "Dissecting the mechanisms of a toxic ribonuclease". search.worldcat.org. Retrieved 2024-12-23.
  3. ^ "Marcia Haigis – Giovanni Armenise Harvard Foundation". Retrieved 2024-12-23.
  4. ^ "Marcia Haigis – Giovanni Armenise Harvard Foundation". Retrieved 2024-12-23.
  5. ^ "Marcia C. Haigis, PhD". Academy for Health & Lifespan Research. Retrieved 2024-12-23.
  6. ^ "9 HMS Faculty Elected to National Academy of Medicine | Harvard Medical School". hms.harvard.edu. 2024-10-21. Retrieved 2024-12-23.