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L-3-cyanoalanine synthase

From Wikipedia, the free encyclopedia
L-3-cyanoalanine synthase
Identifiers
EC no.4.4.1.9
CAS no.9059-53-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Gene OntologyAmiGO / QuickGO
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The enzyme L-3-cyanoalanine synthase (EC 4.4.1.9) catalyzes the chemical reaction

L-cysteine + hydrogen cyanide L-3-cyanoalanine + hydrogen sulfide

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide L-3-cyanoalanine-forming). Other names in common use include β-cyanoalanine synthase, β-cyanoalanine synthetase, β-cyano-L-alanine synthase, and L-cysteine hydrogen-sulfide-lyase (adding HCN). This enzyme participates in cyanoamino acid metabolism.

References

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  • Akopyan TN, Braunstein AE, Goryachenkova EV (1975). "β-Cyanoalanine synthase: purification and characterization". Proc. Natl. Acad. Sci. U.S.A. 72 (4): 1617–21. Bibcode:1975PNAS...72.1617A. doi:10.1073/pnas.72.4.1617. PMC 432590. PMID 1055433.
  • Castric PA, Conn EE (1971). "Formation of β-cyanoalanine by O-acetylserine sulfhydrylase". J. Bacteriol. 108 (1): 132–6. doi:10.1128/jb.108.1.132-136.1971. PMC 247041. PMID 5001194.
  • Hendrickson HR (1968). "The β-cyanoalanine synthase of blue lupine". Fed. Proc. 27: 593.
  • Hendrickson HR, Conn EE (1969). "Cyanide metabolism in higher plants. IV. Purification and properties of the β-cyanolanine synthase of blue lupine". J. Biol. Chem. 244 (10): 2632–40. doi:10.1016/S0021-9258(18)83446-9. PMID 5769995.