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HLF (gene)

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HLF
Identifiers
AliasesHLF, PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
External IDsOMIM: 142385; MGI: 96108; HomoloGene: 31074; GeneCards: HLF; OMA:HLF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002126
NM_001330375

NM_172563

RefSeq (protein)

NP_001317304
NP_002117

Location (UCSC)Chr 17: 55.26 – 55.33 MbChr 11: 90.23 – 90.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[5][6]

Function

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This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108924Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003949Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. Bibcode:1992Sci...257..531I. doi:10.1126/science.1386162. PMID 1386162.
  6. ^ a b "Entrez Gene: HLF hepatic leukemia factor".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.