Jump to content

Aliphatic aldoxime dehydratase

From Wikipedia, the free encyclopedia
Aliphatic aldoxime dehydratase
Identifiers
EC no.4.99.1.5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an aliphatic aldoxime dehydratase (EC 4.99.1.5) is an enzyme that catalyzes the chemical reaction

an aliphatic aldoxime an aliphatic nitrile + H2O

This dehydratase converts an aldoxime on an aliphatic substrate to a nitrile as the product structure with water as byproduct.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming). Other names in common use include OxdA, and aliphatic aldoxime hydro-lyase.

See also

[edit]

References

[edit]
  • Kobayashi M; Hashimoto, Y; Konishi, K; Goda, M; Noguchi, T; Higashibata, H; Kobayashi, M (2003). "Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23. Sequencing, gene expression, purification, and characterization". J. Biol. Chem. 278 (32): 29600–8. doi:10.1074/jbc.M211832200. PMID 12773527.
  • Xie SX, Kato Y, Komeda H, Yoshida S, Asano Y (2003). "A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4". Biochemistry. 42 (41): 12056–66. CiteSeerX 10.1.1.513.2481. doi:10.1021/bi035092u. PMID 14556637.
  • Kato Y, Yoshida S, Xie SX, Asano Y (2004). "Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771". J. Biosci. Bioeng. 97 (4): 250–9. doi:10.1016/S1389-1723(04)70200-5. PMID 16233624.