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Leylah Fernandez defeated Viktorija Golubic in the final, 6–1, 6–4 to win the singles tennis title at the 2021 Monterrey Open. Fernandez did not drop a set en route to her first WTA Tour singles title.
Elina Svitolina was the reigning champion, but decided not to participate.[1]
Bold denotes the mandatory tournaments (WTA 1000) † – Tournaments are affected by the COVID-19 pandemic * – Tournaments are introduced due to the impact of the COVID-19 pandemic