GPR26

GPR26
Identifiers
Aliases	GPR26, G protein-coupled receptor 26
External IDs	OMIM: 604847; MGI: 2441758; HomoloGene: 17764; GeneCards: GPR26; OMA:GPR26 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	123,697,399 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	131,596,134 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; Pars compacta; ; pars reticulata; ; tendon of biceps brachii; ; middle temporal gyrus; ; Brodmann area 46; ; buccal mucosa cell; ; myocardium; ; myocardium of left ventricle;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; dentate gyrus of hippocampal formation granule cell; ; Islands of Calleja; ; amygdalohippocampal area; ; medial septal nucleus; ; dorsal cochlear nucleus; ; cortical amygdaloid nucleus; ; paraventricular nucleus of thalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane; intracellular anatomical structure;
Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2849
	233919
	ENSG00000154478
	ENSMUSG00000040125
	Q8NDV2
	Q8BZA7
	NM_153442
	NM_173410
	NP_703143
	NP_775586
	Wikidata
View/Edit Human	View/Edit Mouse

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Probable G-protein coupled receptor 26 is a protein that in humans is encoded by the GPR26 gene.^[5] GPR26 expression is found to peak perinatally, when the visual system is first challenged, and contains a 53 kb LD-block enriched for association with introgressed Neanderthal-derived SNPs. Additionally, it is known to form oligomeric structures with the 5-HT1a receptor.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154478 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040125 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR26 G protein-coupled receptor 26".
^ Gregory MD, Kippenhan JS, Eisenberg DP, Kohn PD, Dickinson D, Mattay VS, et al. (July 2017). "Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain". Scientific Reports. 7 (1): 6308. Bibcode:2017NatSR...7.6308G. doi:10.1038/s41598-017-06587-0. PMC 5524936. PMID 28740249.

Adams MD, Soares MB, Kerlavage AR, Fields C, Venter JC (August 1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library". Nature Genetics. 4 (4): 373–380. doi:10.1038/ng0893-373. PMID 8401585. S2CID 12612300.
Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, et al. (February 2000). "Cloning and characterization of additional members of the G protein-coupled receptor family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 311–323. doi:10.1016/s0167-4781(99)00241-9. PMID 10684976.
Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, et al. (May 2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". The Journal of Biological Chemistry. 277 (18): 15482–15485. doi:10.1074/jbc.M201539200. PMID 11854302.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154478 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040125 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR26 G protein-coupled receptor 26".

[6] Gregory MD, Kippenhan JS, Eisenberg DP, Kohn PD, Dickinson D, Mattay VS, et al. (July 2017). "Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain". Scientific Reports. 7 (1): 6308. Bibcode:2017NatSR...7.6308G. doi:10.1038/s41598-017-06587-0. PMC 5524936. PMID 28740249.

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References

Further reading