Clopamide
Appearance
Clinical data | |
---|---|
AHFS/Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.010.238 |
Chemical and physical data | |
Formula | C14H20ClN3O3S |
Molar mass | 345.846 g/mol g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]
Mechanism of action
Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.
References
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 3621784, please use {{cite journal}} with
|pmid=3621784
instead.