Clopamide: Difference between revisions
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'''Clopamide''' (trade name '''Brinaldix''') is a [[piperidine]] [[diuretic]].<ref>{{ |
'''Clopamide''' (trade name '''Brinaldix''') is a [[piperidine]] [[diuretic]].<ref>{{cite journal | vauthors = McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ | title = Clopamide: plasma concentrations and diuretic effect in humans | journal = Clinical Pharmacology and Therapeutics | volume = 42 | issue = 3 | pages = 299–304 | date = September 1987 | pmid = 3621784 | doi = 10.1038/clpt.1987.151 }}</ref> |
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| last1 = McNeil | first1 = J. J. |
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| last2 = Conway | first2 = E. L. |
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| last3 = Drummer | first3 = O. H. |
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| last4 = Howes | first4 = L. G. |
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| last5 = Christophidis | first5 = N. |
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| last6 = Louis | first6 = W. J. |
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| title = Clopamide: Plasma concentrations and diuretic effect in humans |
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| journal = Clinical Pharmacology and Therapeutics |
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| volume = 42 |
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| issue = 3 |
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| pages = 299–304 |
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| year = 1987 |
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| pmid = 3621784 | doi=10.1038/clpt.1987.151 |
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}}</ref> |
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==Mechanism of action== |
==Mechanism of action== |
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Revision as of 18:38, 1 May 2020
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| AHFS/Drugs.com | International Drug Names |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.010.238 |
| Chemical and physical data | |
| Formula | C14H20ClN3O3S |
| Molar mass | 345.846 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]
Mechanism of action
Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.
References
- ^ McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ (September 1987). "Clopamide: plasma concentrations and diuretic effect in humans". Clinical Pharmacology and Therapeutics. 42 (3): 299–304. doi:10.1038/clpt.1987.151. PMID 3621784.